Cyclic ADP-ribose
Hon Cheung Lee, the discoverer of cyclic ADP-ribose. Cyclic ADP-ribose and NAADP. The first book on these two second messengers ... "Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase". ... Cyclic ADP-ribose, frequently abbreviated as cADPR, is a cyclic adenine nucleotide (like cAMP) with two phosphate groups ... NAADP IP3 ADP-ribose Lee HC, Walseth TF, Bratt GT, Hayes RN, Clapper DL (1989). "Structural determination of a cyclic ...
Nicotinic acid adenine dinucleotide phosphate
Like its mechanistic cousins, IP3 and cyclic adenosine diphosphoribose (Cyclic ADP-ribose), NAADP binds to and opens Ca2+ ... Lee HC, Zhao YJ (2019). "Resolving the topological enigma in Ca 2+ signaling by cyclic ADP-ribose and NAADP". Journal of ... In contrast to IP3 and cyclic ADP-ribose which predominantly mobilize Ca2+ from the neutral and abundant endoplasmic reticulum ... Cyclic ADP-ribose IP3 Clapper, David L.; Walseth, Timothy F.; Dargie, Peter J.; Lee, Hon Cheung (1987). "Pyridine Nucleotide ...
Nicotinamide adenine dinucleotide
... as a donor of ADP-ribose moieties in ADP-ribosylation reactions, as a precursor of the second messenger molecule cyclic ADP- ... Poly(ADP-ribosyl)ation is carried out by the poly(ADP-ribose) polymerases. The poly(ADP-ribose) structure is involved in the ... Another function of this coenzyme in cell signaling is as a precursor of cyclic ADP-ribose, which is produced from NAD+ by ADP- ... ADP-ribosylation involves either the addition of a single ADP-ribose moiety, in mono-ADP-ribosylation, or the transferral of ...
ADP-ribosyl cyclase
The reaction proceeds through cyclic ADP-ribose (cADPR) as intermediate, which is then hydrolyzed into ADP-ribose. This makes ... In enzymology, a ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC 3.2.2.6) is a bifunctional enzyme that catalyzes the ... "ENZYME - 3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase". enzyme.expasy.org. Retrieved 2022-07-11. ALIVISATOS SG, ... ADP-ribose + nicotinamide The 3 substrates of this enzyme are NAD+ and H2O, whereas its two products are ADP-ribose and ...
NAD+ glycohydrolase
... whereas its two products are ADP-ribose and nicotinamide. Unlike ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC 3.2.2.6), ... "ENZYME - 3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase". enzyme.expasy.org. Retrieved 2022-07-11. Hofmann EC, ... which catalyzes the same reaction, this reaction does not proceed through a cyclic ADP-ribose. This enzyme belongs to the ... ADP-ribose + nicotinamide Thus, the two substrates of this enzyme are NAD+ and H2O, ...
Adenosine diphosphate ribose
... is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase. ADPR is created from cyclic ADP-ribose (cADPR ... Adenosine diphosphate ADP-ribosylation Ribose Poly (ADP-ribose) polymerase Braidy N, Berg J, Clement J, Sachdev P (2019). "Role ... Lee HC (2011). "Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling". Science China Life Sciences. 54 ... September 2004). "TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) ...
SARM1
May 2019). "A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death". ... Lee HC, Zhao YJ (December 2019). "Resolving the topological enigma in Ca2+ signaling by cyclic ADP-ribose and NAADP". The ... SARM1 can hydrolyze NAD+ into nicotinamide and adenosine diphosphate ribose (ADPR), generate cyclic ADPR (cADPR), or mediate a ...
CD38
... is a multifunctional enzyme that catalyzes the synthesis of ADP ribose (ADPR) (97%) and cyclic ADP-ribose (cADPR) (3%) ... ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1) at the PDBe-KB. CD38 (Articles with short description, Short description ... ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15". Cytogenetics and Cell Genetics. 69 (1-2): 38-9. doi: ... ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing". Gene. 186 (2): ...
Wallerian degeneration
SARM1 catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. SARM1 activation locally ... Lee HC, Zhao YJ (2019). "Resolving the topological enigma in Ca 2+ signaling by cyclic ADP-ribose and NAADP". Journal of ...
TRPM2
Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y, Tominaga M (2006). "TRPM2 activation by cyclic ADP-ribose at body ... The TRPM2 ion channel is activated by free intracellular ADP-ribose in synergy with free intracellular calcium. ADP-Ribose is ...
Antony Galione
FKBP1B
Noguchi N, Takasawa S, Nata K, Tohgo A, Kato I, Ikehata F, Yonekura H, Okamoto H (February 1997). "Cyclic ADP-ribose binds to ...
Ryanodine receptor
Physiological agonist: Cyclic ADP-ribose can act as a physiological gating agent. It has been suggested that it may act by ... In heart and pancreas cells, another second messenger (cyclic ADP-ribose) takes part in the receptor activation. The localized ...
ADP-ribose diphosphatase
... and cyclic-ADP ribose. ADP-ribose is a protein-glycating agent, and excess levels of ADP-ribose in the cell can cause non- ... Other common names for ADP-ribose diphosphatase include ADP-ribose pyrophosphatase and ADPRase. ADP-ribose is commonly referred ... ADP-ribose diphosphatase, in particular, hydrolyzes ADP-ribose into AMP and D-ribose 5-phosphate, both of which are ... "Human placenta hydrolases active on free ADP-ribose: an ADP-sugar pyrophosphatase and a specific ADP-ribose pyrophosphatase". ...
Oxocarbenium
An example of this reaction can be seen in the cyclization cyclic ADP ribose, which is an important molecule for intracellular ... Since sugars are present in the structure of nucleic acids, with a ribose sugar present in RNA and a deoxyribose present in the ...
Formyl peptide receptor
BST1
Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2) at the PDBe-KB. Ortolan E, Vacca P, Capobianco A, et al. (2003). " ... or cyclic ADP-ribose (cADPR) from NAD+, although CD157 is a much weaker catalyst than CD38. cADPR is required for regulation of ... Bst1 (Bone marrow stromal cell antigen 1, ADP-ribosyl cyclase 2, CD157) is an enzyme that in humans is encoded by the BST1 gene ... CD157 and CD38 are both members of the ADP-ribosyl cyclase family of enzymes that catalyze the formation of nicotinamide and ...
List of MeSH codes (D09)
... o-acetyl-adp-ribose MeSH D09.408.620.569.070.125.195 - cyclic adp-ribose MeSH D09.408.620.569.070.125.600 - poly adenosine ... ribose MeSH D09.546.627.867 - xylose MeSH D09.546.627.885 - xylulose MeSH D09.546.894.200 - dihydroxyacetone MeSH D09.546. ... diphosphate ribose MeSH D09.408.620.569.200 - cytidine diphosphate diglycerides MeSH D09.408.620.569.400 - guanosine ... adenosine diphosphate ribose MeSH D09.408.620.569.070.125.040 - ...
List of EC numbers (EC 3)
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase EC 3.2.2.7: adenosine nucleosidase EC 3.2.2.8: ribosylpyrimidine nucleosidase ... 2-cyclic phosphate 1,2-diphosphodiesterase * EC 3.1.4.58: RNA 2′,3′-cyclic 3′-phosphodiesterase * EC 3.1.4.59: cyclic-di-AMP ... O-acetyl-ADP-ribose deacetylase * EC 3.1.1.107: apo-salmochelin esterase * EC 3.1.1.108: iron(III)-enterobactin esterase * EC ... ADP-ribose) glycohydrolase EC 3.2.1.144: 3-deoxyoctulosonase EC 3.2.1.145: galactan 1,3-β-galactosidase EC 3.2.1.146: β- ...
Interleukin-1 receptor family
... as many TIR domain-containing proteins from bacteria and archaea can degrade NAD+ into the products nicotinamide and ADP-ribose ... ADPR) (or cyclic-ADPR). Ig-like domain is the part of receptor which is located extracellularly. There are minimal homologies ...
List of MeSH codes (D13)
... o-acetyl-adp-ribose MeSH D13.695.827.708.070.125.195 - cyclic adp-ribose MeSH D13.695.827.708.070.125.600 - poly adenosine ... o-acetyl-adp-ribose MeSH D13.695.667.138.124.070.125.195 - cyclic adp-ribose MeSH D13.695.667.138.180 - adenosine monophosphate ... o-acetyl-adp-ribose MeSH D13.695.827.068.124.070.125.195 - cyclic adp-ribose MeSH D13.695.827.068.180 - adenosine monophosphate ... cyclic cmp MeSH D13.695.462.275 - cyclic gmp MeSH D13.695.462.275.325 - dibutyryl cyclic gmp MeSH D13.695.462.300 - cyclic imp ...
Nidovirales
ADP-ribose/poly(ADP-ribose)-binding or ADP-ribose 1''-phosphate phosphatase activities and cyclic nucleotide phosphodiesterase ...
ADP-ribosylation
During the late 1980s, ADP-ribosyl cyclases, which catalyze the addition of cyclic-ADP-ribose groups to proteins, were ... ADP-ribose)glycohydrolase, an enzyme that hydrolyses poly(ADP-ribose) to produce free ADP-ribose. Studies have shown poly(ADP- ... ADP-ribosyl)ation and poly(ADP-ribosyl)ation. Mono(ADP-ribosyl)transferases commonly catalyze the addition of ADP-ribose to ... Poly(ADP-ribose)polymerases (PARPs) are found mostly in eukaryotes and catalyze the transfer of multiple ADP-ribose molecules ...
List of EC numbers (EC 2)
... phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase (*) EC 2.4.99.21: dolichyl-phosphooligosaccharide-protein ... α-D-ribose-1-phosphate 5-kinase (ADP) EC 2.7.1.213: cytidine kinase EC 2.7.1.214: C7-cyclitol 7-kinase EC 2.7.1.215: erythritol ... ADP-D-ribose pyrophosphorylase EC 2.7.7.97: 3-hydroxy-4-methylanthranilate adenylyltransferase EC 2.7.7.98: Now EC 6.2.1.50, 4- ... ADP-dependent phosphofructokinase EC 2.7.1.147: ADP-dependent glucokinase EC 2.7.1.148: 4-(cytidine 5′-diphospho)-2-C-methyl-D- ...
Adenosine
Its derivatives include the energy carriers adenosine mono-, di-, and triphosphate, also known as AMP/ADP/ATP. Cyclic adenosine ... The molecule consists of an adenine attached to a ribose via a β-N9-glycosidic bond. Adenosine is one of the four nucleoside ... Caffeine also increases cyclic AMP levels through nonselective inhibition of phosphodiesterase. "Caffeine has a three- ...
40S ribosomal protein S3a
Song D, Sakamoto S, Taniguchi T (2002). "Inhibition of poly(ADP-ribose) polymerase activity by Bcl-2 in association with the ... Goodin JL, Rutherford CL (2003). "Characterization of human ribosomal S3a gene expression during adenosine 3':5' cyclic ...
Ribose
Like most sugars, ribose exists as a mixture of cyclic forms in equilibrium with its linear form, and these readily ... Metabolically-important species that include phosphorylated ribose include ADP, ATP, coenzyme A,: 228-229 and NADH. cAMP and ... Ribokinase catalyzes the conversion of d-ribose to d-ribose 5-phosphate. Once converted, d-ribose-5-phosphate is available for ... Supplemental d-ribose can bypass part of the pentose phosphate pathway, an energy-producing pathway, to produce d-ribose-5- ...
Ribonucleotide
DNA is defined by containing 2'-deoxy-ribose nucleic acid while RNA is defined by containing ribose nucleic acid. In some ... Ribonucleotides can be converted to cyclic adenosine monophosphate (cyclic AMP) to regulate hormones in organisms as well. In ... dATP and dGTP are synthesized from ADP and GDP, respectively. They are first reduced by RNR and then phosphorylated by ... The pathway begins with the conversion of Ribose-5-Phosphate(R5P) to phosphoribosyl pyrophosphate (PRPP) by enzyme ribose- ...
Adenosine monophosphate
2 ADP → ATP + AMP Or AMP may be produced by the hydrolysis of one high energy phosphate bond of ADP: ADP + H2O → AMP + Pi AMP ... AMP can also exist as a cyclic structure known as cyclic AMP (or cAMP). Within certain cells the enzyme adenylate cyclase makes ... AMP consists of a phosphate group, the sugar ribose, and the nucleobase adenine. It is an ester of phosphoric acid and the ... Though the γ-subunit can bind AMP/ADP/ATP, only the binding of AMP/ADP results in a conformational shift of the enzyme protein ...
Mark Cushman
Later, it was found these molecules can also affect other targets including the retinoid X receptor (RXR), poly [ADP-ribose] ... he reported and studied in detail the condensation of cyclic anhydrides with imines (work that was based on a previous report ... ADP-ribose) Polymerase-1 Inhibitors from the Modification of Indeno[1,2-c]isoquinolinone". Journal of Medicinal Chemistry. 48 ( ...