Burd C, Cullen PJ (2014). "Retromer: a master conductor of endosome sorting". Cold Spring Harbor Perspectives in Biology. 6 (2 ... In the AP complexes, there are two large proteins (~100 kD) and two smaller proteins. One of the large proteins is termed β ( ... Protein complexes, Protein families, Molecular evolution, Vesicular transport proteins). ... PTBs are protein domains that include NUMB, DAB1 and DAB2. Epsin and AP180 in the ANTH domain are other adaptor proteins that ...

NEDD8 is best known for its role in regulating cullin proteins, which in turn regulate ubiquitin-mediated protein degradation, ... Ubiquitin-like proteins (UBLs) are a family of small proteins involved in post-translational modification of other proteins in ... "The dual role of ubiquitin-like protein Urm1 as a protein modifier and sulfur carrier". Protein & Cell. 2 (8): 612-9. doi: ... One additional protein, known as FUBI, is encoded as a fusion protein in the FAU gene, and is proteolytically processed to ...

Harpel, D.; Cullen, D. A.; Ott, S. R.; Jiggins, C. D.; Walters, J. R. (2015). "Pollen feeding proteomics: Salivary proteins of ... During this phase, the cuticle, a tough outer layer made of a mixture of chitin and specialized proteins, is released from the ... it begins as a pale yellow granular secretion containing acidophilic proteins. This is viscous and darkens when exposed to air ...

Cull, M. G.; Schatz, P. J. (2000-01-01). Biotinylation of proteins in vivo and in vitro using small peptide tags. Methods in ... More recently, in vivo protein biotinylation was developed to study protein-protein interactions and proximity in living cells ... the purification of biotinylated proteins has been a widely used approach to identify protein-protein interactions and post- ... If isolation of the tagged protein is needed, it is better to tag the protein with iminobiotin. This biotin analogue gives ...

The RING protein appears to function as a docking site for ubiquitin-conjugating enzymes (E2s). Other proteins contain a cullin ... Cullin family - Sanger Institute website. Cullin+Proteins at the U.S. National Library of Medicine Medical Subject Headings ( ... The catalytic core of CRLs consists of a RING protein and a cullin family member. For Cul1, the C-terminal cullin-homology ... Cullin-RING ubiquitin ligases (CRLs), such as Cul1 (SCF) play an essential role in targeting proteins for ubiquitin-mediated ...

... stabilized by protein-protein interactions with other Rev molecules (in addition to the RNA-protein interactions). Biochemical ... Ahmed, Y F; Hanly, S M; Malim, M H; Cullen, B R; Greene, W C (1990). "Structure-function analyses of the HTLV-I Rex and HIV-1 ... Assembly of this Rev-RRE complex is followed by the recruitment of a human protein complex containing the proteins exportin-1 ( ... In the presence of the HIV-1 accessory protein Rev, HIV-1 mRNAs that contain the RRE can be exported from the nucleus to the ...

Cullen DK, Simon CM, LaPlaca MC (July 2007). "Strain rate-dependent induction of reactive astrogliosis and cell death in three- ... Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans. It is a type III intermediate ... GFAP can polymerize with other type III proteins. GFAP and other type III IF proteins cannot assemble with keratins, the type I ... "A new splice variant of glial fibrillary acidic protein, GFAP epsilon, interacts with the presenilin proteins". The Journal of ...

Pan ZQ, Kentsis A, Dias DC, Yamoah K, Wu K (March 2004). "Nedd8 on cullin: building an expressway to protein destruction". ... Liakopoulos D, Büsgen T, Brychzy A, Jentsch S, Pause A (May 1999). "Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 ... Morimoto M, Nishida T, Honda R, Yasuda H (April 2000). "Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the ... NEDD8 is a protein that in humans is encoded by the NEDD8 gene. (in saccharomyces cerevisiae this protein is known as Rub1) ...

The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), ... Ng RW, Arooz T, Yam CH, Chan IW, Lau AW, Poon RY (November 1998). "Characterization of the cullin and F-box protein partner ... and Fbxos containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by ... Yam CH, Ng RW, Siu WY, Lau AW, Poon RY (January 1999). "Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein ...

SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases ... F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene. Members of the F-box protein ... F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ...

Ng RW, Arooz T, Yam CH, Chan IW, Lau AW, Poon RY (1998). "Characterization of the cullin and F-box protein partner Skp1". FEBS ... This gene encodes a protein that is a member of the SCF ubiquitin ligase protein complex. It binds to F-box proteins (proteins ... Ng RW, Arooz T, Yam CH, Chan IW, Lau AW, Poon RY (November 1998). "Characterization of the cullin and F-box protein partner ... The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level ...

SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases ... F-box only protein 28 is a protein that in humans is encoded by the FBXO28 gene. Members of the F-box protein family, such as ... F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ...

SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases ... F-box only protein 31 is a protein that in humans is encoded by the FBXO31 gene. Members of the F-box protein family, such as ... F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein ... the F-box protein FBXO31, a candidate tumor suppressor encoded in 16q24.3 for which there is loss of heterozygosity in various ...

SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases ... F-box protein 40 is a protein that in humans is encoded by the FBXO40 gene. Fbxo40 induces ubiquitination of IRS1, thus ... F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein ... Fbxo40 in particular engages a unique substrate, IRS1, which is a protein in the IGF1 signaling pathway. In this way, Fbxo40 ...

In molecular biology, Tat is a protein that is encoded for by the tat gene in HIV-1. Tat is a regulatory protein that ... Hauber J, Malim MH, Cullen BR (March 1989). "Mutational analysis of the conserved basic domain of human immunodeficiency virus ... 2001). "Protein Transduction Domain of HIV-1 Tat Protein Promotes Efficient Delivery of DNA into Mammalian Cells". Journal of ... RNA binding proteins. Tat contains a protein transduction domain (PTD), which is also known as a cell-penetrating peptide. ...

Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein ... Morimoto M, Nishida T, Honda R, Yasuda H (2000). "Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the ... 1998). "Characterization of the cullin and F-box protein partner Skp1". FEBS Lett. 438 (3): 183-9. doi:10.1016/S0014-5793(98) ... 2000). "Covalent modification of all members of human cullin family proteins by NEDD8". Oncogene. 18 (48): 6829-34. doi:10.1038 ...

Cullin-4A is a protein that in humans is encoded by the CUL4A gene. CUL4A belongs to the cullin family of ubiquitin ligase ... protein is a CRL4A substrate only when directed by viral proteins §protein is a CRL4A substrate only when directed by IMiDs ... At the C-terminal end, CUL4A interacts with the RBX1/ROC1 protein via its RING domain. RBX1 is a core component of Cullin-RING ... Shiyanov P, Nag A, Raychaudhuri P (Dec 1999). "Cullin 4A associates with the UV-damaged DNA-binding protein DDB". The Journal ...

Each subunit is composed of a protein chain tightly associated with a non-protein prosthetic heme group. Each protein chain ... Perutz, M.F.; Rossmann, M.G.; Cullis, A.F.; Muirhead, H.; Will, G.; North, A.C.T. (1960). "Structure of haemoglobin: a three- ... and heme-bearing protein subunits bound together into a single protein complex with a molecular mass greater than 3.5 million ... Improperly degraded hemoglobin protein or hemoglobin that has been released from the blood cells too rapidly can clog small ...

Fridell RA, Bogerd HP, Cullen BR (1996). "Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway". ... Arf-GAP domain and FG repeat-containing protein 1 is a protein that in humans is encoded by the AGFG1 gene. The protein encoded ... Chen D, Li X, Zhai Z, Shu HB (2002). "A novel zinc finger protein interacts with receptor-interacting protein (RIP) and ... a novel protein-protein interaction module". Genes Dev. 11 (17): 2239-49. doi:10.1101/gad.11.17.2239. PMC 275390. PMID 9303539 ...

The Cullin 7 gene contains instructions for making the protein Cullin-7. Cullin-7 acts as scaffold protein in the E3 ubiquitin ... Mutations in the CUL7 gene blocks the ability of the cullin-7 protein to bring together the components of this E3 ubiquitin ... Disruption of the protein degradation process plays a role in the pathogensis of prenatal growth retardation in humans, a key ... However, the implications of 3M syndrome suggest that both these genes encode for proteins that play a role in the CUL7 ...

Feng L, Allen NS, Simo S, Cooper JA (November 2007). "Cullin 5 regulates Dab1 protein levels and neuron positioning during ... "A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein ... "A protein related to extracellular matrix proteins deleted in the mouse mutant reeler". Nature. 374 (6524): 719-23. Bibcode: ... "Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein". The ...

Cullin-2 is a protein that in humans is encoded by the CUL2 gene. CUL2 has been shown to interact with: CAND1, DCUN1D1, RBX1, ... "Entrez Gene: CUL2 cullin 2". Menon S, Tsuge T, Dohmae N, Takio K, Wei N (2008). "Association of SAP130/SF3b-3 with Cullin-RING ... structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein". Proc ... "Covalent modification of all members of human cullin family proteins by NEDD8". Oncogene. 18 (48): 6829-34. doi:10.1038/sj.onc. ...

2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302-12. doi:10.1093 ... an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029-33. doi:10.1038/ncb1203-1029 ... This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein ... 1997). "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein ...

Cullin-4B is a protein that in humans is encoded by the CUL4B gene which is located on the X chromosome. CUL4B has high ... protein is a CRL4 substrate only when directed by viral proteins §protein is a CRL4 substrate only when directed by IMiDs ... At the C-terminal end, CUL4B interacts with the RBX1/ROC1 protein via its RING domain. RBX1 is a core component of Cullin-RING ... This modification appears to induce conformational changes which promotes flexibility in the RING domain of cullin proteins and ...

Feng L, Allen NS, Simo S, Cooper JA (2007). "Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical ... 2009). "Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells". Proc. Natl. Acad. Sci. U. ... DAB1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with short description, ... Such an increase in the expression of a protein that virtually functions as a receptor is expected to occur when the specific ...

Cullin-5 is a protein that in humans is encoded by the CUL5 gene. The mammalian gene product was originally discovered by ... Since then, VACM-1 has been shown to be homologous to the Cullin family of proteins, and was subsequently dubbed cul5. Studies ... Feng L, Allen NS, Simo S, Cooper JA (November 2007). "Cullin 5 regulates Dab1 protein levels and neuron positioning during ... 2000). "Covalent modification of all members of human cullin family proteins by NEDD8". Oncogene. 18 (48): 6829-34. doi:10.1038 ...

"Covalent modification of all members of human cullin family proteins by NEDD8". Oncogene. 18 (48): 6829-34. doi:10.1038/sj.onc. ... The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface ... APPBP1 (Amyloid Precursor Protein-Binding Protein 1) binds to the Amyloid Precursor Protein (APP) carboxy terminal domain. ... In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This ...

Chonn A, Semple SC, Cullis PR (15 September 1992). "Association of blood proteins with large unilamellar liposomes in vivo. ... Some of these proteins are linked to the exterior of the cell membrane. An example of this is the CD59 protein, which ... The most common class of this type of protein is the G protein-coupled receptor (GPCR). GPCRs are responsible for much of the ... The first of these proteins to be studied were the viral fusion proteins, which allow an enveloped virus to insert its genetic ...

DNA dC->dU-editing enzyme APOBEC-3F is a protein that in humans is encoded by the APOBEC3F gene. This gene is a member of the ... Wiegand HL, Doehle BP, Bogerd HP, Cullen BR (2004). "A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 ... It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively ... Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine ...

Ho, Jo-Hao; Stahl, Edward L.; Schmid, Cullen L.; Scarry, Sarah M.; Aubé, Jeffrey; Bohn, Laura M. (2018-08-07). "G protein ... is a G protein-coupled receptor located in the central nervous system. KOR is also a G-protein coupled receptor. Humans and ... The μ-opioid receptor is a G-protein coupled receptor. When the μ-opioid receptor is activated, it causes pain relief, euphoria ... The GHB receptor is an excitatory G protein-coupled receptor (GPCR). Its endogenous ligand is GHB, since GHB is also a ...