Connexins are commonly named according to their molecular weights, e.g. Cx26 is the connexin protein of 26 kDa. A competing ... Media related to connexins at Wikimedia Commons Connexins at the U.S. National Library of Medicine Medical Subject Headings ( ... Kamasawa N, Sik A, Morita M, Yasumura T, Davidson KG, Nagy JI, Rash JE (2005). "Connexin-47 and connexin-32 in gap junctions of ... As of this edit, this article uses content from "1.A.24 The Gap Junction-forming Connexin (Connexin) Family", which is licensed ...
The interaction between connexin 43 and PTPmu increases gap junction communication. PTPµ is expressed in human umbilical cord ... Giepmans BN, Feiken E, Gebbink MF, Moolenaar WH (2003). "Association of connexin43 with a receptor protein tyrosine phosphatase ... PTPmu also dephosphorylates another cell junction protein, connexin 43. ... GJA1 connexin43 (gap junction protein, alpha 1), IQGAP1, PVRL3 (nectin3), PIPKIγ90, PRKCD (PKCδ), and PLCG1 (PLCγ1). GRCh38: ...
... acts at connexins, preferentially to connexin 43 (Cx43). Treatment with rotigaptide has been shown to activate ... Each connexon is made up of 6 functional units (connexins) that associate together to form a channel between adjacent cells. ... increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin 43. British Journal ... Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide ...
The connexin-43 internal ribosome entry site is an RNA element present in the 5' UTR of the mRNA of GJA1. This internal ... Gap junction alpha-1 protein (GJA1), also known as connexin 43 (Cx43), is a protein that in humans is encoded by the GJA1 gene ... Page for Connexin-43 internal ribosome entry site (IRES) at Rfam (Articles with short description, Short description matches ... GJA1 is the most ubiquitously expressed connexin and is detected in most cell types. It is the major protein in heart gap ...
Shore L, McLean P, Gilmour SK, Hodgins MB, Finbow ME (July 2001). "Polyamines regulate gap junction communication in connexin ... 43-expressing cells". The Biochemical Journal. 357 (Pt 2): 489-495. doi:10.1042/0264-6021:3570489. PMC 1221976. PMID 11439099. ...
Hoptak-Solga, A. D; Nielsen, S; Jain, I; Thummel, R; Hyde, D. R; Iovine, M. K (2008). "Connexin43 (GJA1) is required in the ... Britz-Cunningham, S. H; Shah, M. M; Zuppan, C. W; Fletcher, W. H (1995). "Mutations of the Connexin43 gap-junction gene in ... Kanady, J. D; Dellinger, M. T; Munger, S. J; Witte, M. H; Simon, A. M (2011). "Connexin37 and Connexin43 deficiencies in mice ... Iovine, M. K; Higgins, E. P; Hindes, A; Coblitz, B; Johnson, S. L (2005). "Mutations in connexin43 (GJA1) perturb bone growth ...
It is generally believed to be caused by a mutation in the gene GJA1, which codes for the gap junction protein connexin 43. ... 2003). "Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia". Am. J. Hum. Genet. 72 (2 ... "A nonsense mutation in the first transmembrane domain of connexin 43 underlies autosomal recessive oculodentodigital syndrome ... 43 (7): e37. doi:10.1136/jmg.2005.037655. PMC 2564566. PMID 16816024. Jones KL, Smith DW, Harvey MA, Hall BD, Quan L (1975). " ...
Finally, other proteins under study are connexin 43 and anti-AQP1, although, as of 2015, there are only initial reports about ... Masaki K (October 2015). "Early disruption of glial communication via connexin gap junction in multiple sclerosis, Baló's ... of total cases Connexin-43 NMO Aquaporin-1 associated NMO which could be related to pattern III MS Idiopathic NMO, defined by ... "Connexin 43 astrocytopathy linked to rapidly progressive multiple sclerosis and neuromyelitis optica". PLOS ONE. 8 (8): e72919 ...
During this process, connexin 43 (Cx43) regulates cell interaction by regulating the formation of channels known as gap ... Huang GY, Wessels A, Smith BR, Linask KK, Ewart JL, Lo CW (1998). "Alteration in connexin 43 gap junction gene dosage impairs ... "Modulation of mouse neural crest cell motility by N-cadherin and connexin 43 gap junctions". Journal of Cell Biology. 154 (1): ...
Masaki K, Suzuki SO, Matsushita T, Matsuoka T, Imamura S, Yamasaki R, Suzuki M, Suenaga T, Iwaki T, Kira J (2013). "Connexin 43 ... Masaki K (October 2015). "Early disruption of glial communication via connexin gap junction in multiple sclerosis, Baló's ...
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of ... 2003). "Comparison of connexin 43, 40 and 45 expression patterns in the developing human and mouse hearts". Cell Commun. Adhes ... Gap junction gamma-1 protein (GJC1), also known as gap junction alpha-7 protein (GJA7) and connexin 45 (Cx45) - is a protein ... "Entrez Gene: GJA7 gap junction protein, alpha 7, 45kDa". Andrew L Harris; Darren Locke (2009). Connexins, A Guide. New York: ...
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of ... Gap junction alpha-5 protein (GJA5), also known as connexin 40 (Cx40) - is a protein that in humans is encoded by the GJA5 gene ... 2003). "Comparison of connexin 43, 40 and 45 expression patterns in the developing human and mouse hearts". Cell Commun. Adhes ... 2002). "Connexin expression in Huntington's diseased human brain". Cell Biol. Int. 22 (11-12): 837-47. doi:10.1006/cbir. ...
Hatakeyama T, Dai P, Harada Y, Hino H, Tsukahara F, Maru Y, Otsuji E, Takamatsu T (2013). "Connexin43 functions as a novel ... Hatakeyama T, Dai P, Harada Y, Hino H, Tsukahara F, Maru Y, Otsuji E, Takamatsu T (2013). "Connexin43 functions as a novel ... 3 (9): 839-43. doi:10.1038/ncb0901-839. PMID 11533664. S2CID 21164493. Zhang B, Rong R, Li H, Peng X, Xiong L, Wang Y, Yu X, ... 22 (8): 2536-43. doi:10.1128/MCB.22.8.2536-2543.2002. PMC 133739. PMID 11909948. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann ...
This kind of MS was previously reported to behave different that the standard progressive course, being linked to Connexin 43 ... 2013). "Connexin 43 astrocytopathy linked to rapidly progressive multiple sclerosis and neuromyelitis optica". PLOS ONE. 8 (8 ... Mutations in GJB1 coding for connexin 32, a gap junction protein expressed in Schwann cells and oligodendrocytes, that usually ... First 14 cases were reported together in the first report, and 3 new cases were reported later inside a cohort of 43 patients. ...
"Regulation of cell-cell communication mediated by connexin 43 in rabbit myometrial cells". Biology of Reproduction 50(2):377-89 ... Research Interest Basic Science: Gap junction physiology, cell-to-cell communication modulated by connexin protein, tissue ...
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF (April 1998). "Regulation of connexin-43 gap junctional intercellular ... May 2003). "Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated ... "Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein". The ...
WH Connexin channels, connexin mimetic peptides and ATP release - Le "Informa's global locations". informa.com. Archived from ... An update on connexin genes and their nomenclature in mouse and man - Sohl, G; Willecke, K Identification of cells expressing ... Connexin-43 interactions with ZO-1 and alpha-and beta-tubulin - Giepmans, BNG; Verlaan, I; Moolenaar, ...
Genetic loci associated with HLHS include GJA1 (connexin 43), HAND1, NKX2.5, 10q22, and 6q23. There is a slight risk of ... "Identification of connexin43 (alpha1) gap junction gene mutations in patients with hypoplastic left heart syndrome by ...
"Vascular endothelial growth factor secretion by nonmyocytes modulates Connexin-43 levels in cardiac organoids". Tissue ...
The connexin genes (DNA) are transcribed to RNA, which is then translated to produce a connexin. One connexin protein has four ... How the connexins may be transported to the plaques using tubulin is becoming clearer. The formation plaque and non-connexin ... By study of connexins still in membranes lipids associated with the connexins have been studied. It was found that specific ... Connexin proteins expressed in neuronal gap junctions include: mCX36 mCX57 mCX45 with mRNAs for at least five other connexins ( ...
"Role of Rev-erbα domains for transactivation of the connexin43 promoter with Sp1". FEBS Letters. 587 (1): 98-103. doi:10.1016/j ... 43 (12): 2172-9. doi:10.1194/jlr.M200386-JLR200. PMID 12454280. Chopin-Delannoy S, Thénot S, Delaunay F, Buisine E, Begue A, ... 43 (12): 2172-9. doi:10.1194/jlr.M200386-JLR200. PMID 12454280. Ruano EG, Canivell S, Vieira E (2014-08-04). "REV-ERB ALPHA ... 40 (43): 12833-43. doi:10.1021/bi011086r. PMID 11669620. Coste H, Rodríguez JC (Jul 2002). "Orphan nuclear hormone receptor Rev ...
Intercalated disc architecture was severely impaired and connexin 43-resident gap junctions were markedly reduced. ... 12 (1): 43-49. doi:10.1038/embor.2010.185. PMC 3024124. PMID 21132015. Bauer A, Huber O, Kemler R (December 1998). "Pontin52, ... 116 (43): 21545-21555. doi:10.1073/pnas.1911489116. PMC 6815173. PMID 31591245. Röper JC, Mitrossilis D, Stirnemann G, Waharte ...
48:457-476, 2005 Ohara PT, Vit JP, Bhargava A, Jasmin L (December 2008). "Evidence for a role of connexin 43 in trigeminal pain ...
These cardiomyocytes expressed connexin 43, myosin, actin, and α-actinin, which are markers of cardiomyocytes. Through the use ...
Oxford EM, Musa H, Maass K, Coombs W, Taffet SM, Delmar M (September 2007). "Connexin43 remodeling caused by inhibition of ... including connexin 43, the major component of cardiac gap junctions; the voltage-gated sodium channel Na(V)1.5 and its ... Decreased expression of plakophilin-2 via siRNA leads to a decrease in and redistribution of connexin 43 protein, as well as a ... and Connexin43 at the cardiac intercalated disc". Circulation Research. 109 (2): 193-201. doi:10.1161/CIRCRESAHA.111.247023. ...
Rosselló, RA; Wang, Z; Kizana, E; Krebsbach, PH; Kohn, DH (2009). "Connexin 43 as a signaling platform for increasing the ...
... connexin43) gene from bats (Chiroptera)". Genetics Research. 91 (2): 101-109. doi:10.1017/s0016672309000032. PMID 19393126. ... 43-62. ISBN 978-0-1950-9951-5. Geiser, F.; Stawski, C. (2011). "Hibernation and Torpor in Tropical and Subtropical Bats in ... 43 (2): 266-269. JSTOR 30055364. Fenton & Simmons 2015, pp. 76. Cui, J.; Yuan, X.; Wang, L.; Jones, G.; Zhang, S. (2011). " ... They generally drop their body temperature in this state to 6-30 °C (43-86 °F), and may reduce their energy expenditure by 50 ...
Borke JL, Yu JC, Isales CM, Wagle N, Do NN, Chen JR, Bollag RJ (November 2003). "Tension-induced reduction in connexin 43 ...
Prostaglandins are also related to the changes in gap junction formation and connexin-43 expression during labor. Uterine and ...
The assembly of connexins destined for gap junction plaques begins with synthesis of connexins within the cell and ends with ... Connexin types can be further differentiated by using their predicted molecular weight (ex: Connexin 43 is Cx 43 due to its ... In biology, a connexon, also known as a connexin hemichannel, is an assembly of six proteins called connexins that form the ... Connexons made of the same type of connexins are considered homomeric, while connexons made of differing types of connexins are ...