... is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage. ... side-chain-cleaving). Other names include: The highest level of the cholesterol side-chain cleavage system is found in the ... Cholesterol side-chain cleavage enzyme inhibitors include aminoglutethimide, ketoconazole, and mitotane, among others. ... Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL (December 1986). "Human cholesterol side-chain cleavage enzyme, ...

Cholesterol side-chain cleavage enzyme (P450scc; CYP11A1) (~20,000 nM). Inhibits the conversion of cholesterol into ... In terms of the latter property, it inhibits enzymes such as cholesterol side-chain cleavage enzyme (CYP11A1, P450scc) and ... Cholesterol side-chain cleavage enzyme inhibitors, Glutarimides, Hepatotoxins, Hormonal antineoplastic drugs, Withdrawn drugs) ... AG has many side effects and is a relatively toxic medication, although its side effects are described as usually relatively ...

... cholesterol side-chain cleavage enzyme), STAR (steroidogenic acute regulatory protein; StAR), CYB5A (cytochrome b5), and CYPOR ... It results from the deficiency of one of the five enzymes required for the synthesis of cortisol in the adrenal cortex. Most of ... The clinical presentation of each form is different and depends to a large extent on the underlying enzyme defect, its ... In 75% of cases of severe enzyme deficiency, insufficient aldosterone production can lead to salt wasting, failure to thrive, ...

Pregnenolone itself is produced from cholesterol via cholesterol side-chain cleavage enzyme. Pregnenolone sulfate, also known ... as pregn-5-en-3β-ol-20-one 3β-sulfate, is a naturally occurring pregnane steroid and a derivative of cholesterol. It is the C3β ...

DHEA is synthesized from cholesterol via the enzymes cholesterol side-chain cleavage enzyme (CYP11A1; P450scc) and 17α- ... DHEA is transformed into DHEA-S by sulfation at the C3β position via the sulfotransferase enzymes SULT2A1 and to a lesser ... including the enzymes CYP2C11 and 11β-HSD1 - the latter of which is essential for the biosynthesis of the glucocorticoids such ...

Examples of desmolases are: Cholesterol side-chain cleavage enzyme, also called 20,22-desmolase; converts cholesterol to ... Steroidogenic enzyme Wallerstein, Leo (1939). "Enzyme Preparations from Microorganisms: Commercial Production and Industrial ... These enzymes play a significant role in cellular respiration and in fermentation. Desmolases are involved in steroidogenesis. ... A desmolase is any of various enzymes that catalyze the formation or destruction of carbon-carbon bonds within a molecule. ...

"Comparison of the immunochemical properties of human placental and bovine adrenal cholesterol side-chain cleavage enzyme ... The FAD and NADP binding sites of the enzyme were predicted by sequence analysis of the enzyme. While the FAD-binding site has ... Immmunofluorescent staining shows that enzyme is localized in mitochondria. The enzyme is also expressed in the liver, the ... "Conservation of the Enzyme-Coenzyme Interfaces in FAD and NADP Binding Adrenodoxin Reductase-A Ubiquitous Enzyme". Journal of ...

In the corpus luteum, cholesterol side-chain cleavage enzyme converts cholesterol to pregnenolone, which is converted to ... An enzyme called plasmin breaks up the blood clots in the menstrual fluid, which eases the flow of blood and broken down lining ... which is converted to estrogen by the enzyme aromatase. The estrogen inhibits further production of FSH and LH by the pituitary ...

... a CYP450 enzyme responsible for cholesterol side chain cleavage. FDX-1 has the capability to bind to metals and proteins. ... This conserved region is also found as a domain in various metabolic enzymes and in multidomain proteins, such as aldehyde ... The energy converting hydrogenases (Ech) are a family of enzymes that reversibly couple the transfer of electrons between Fd ... Since the cyclase is a ferredoxin dependent enzyme this may provide a mechanism for coordination between photosynthesis and the ...

... and ambiguous genitalia Steroidogenic acute regulatory protein Cholesterol side-chain cleavage enzyme Cholesterol, sex hormone ... cholesterol side chain cleavage enzyme). However, few cases of lipoid CAH due to a mutation and defect of P450scc have been ... "Heterozygous mutation in the cholesterol side chain cleavage enzyme (p450scc) gene in a patient with 46,XY sex reversal and ... "Severe combined adrenal and gonadal deficiency caused by novel mutations in the cholesterol side chain cleavage enzyme, P450scc ...

Chung, B. C; Matteson, K. J; Voutilainen, R; Mohandas, T. K; Miller, W. L (1986). "Human cholesterol side-chain cleavage enzyme ... To enter mitochondria, where the P450scc enzyme resides, cholesterol requires the action of a protein called StAR, ( ... rate-limiting enzyme in steroid hormone production from cholesterol and CYP17A1 (also known as P450c17), which catalyzes two ... He systematically studied and cloned many genes for enzymes involved in steroid metabolism. Most notable were CYP11A1 (also ...

This family contains many enzymes involved in steroidogenesis, such as Cholesterol side-chain cleavage enzyme (CYP11A1), ... Roles of promiscuity and co-evolution of enzymes and steroid receptors". The Journal of Steroid Biochemistry and Molecular ...

... has also been found to inhibit CYP11A1 (cholesterol side-chain cleavage enzyme) and CYP51A1 (lanosterol-14α- ... Cholesterol side-chain cleavage enzyme inhibitors, CYP3A4 inhibitors, CYP17A1 inhibitors, Dioxolanes, Enantiopure drugs, ... Levoketoconazole is the levorotatory or (2S,4R) enantiomer of ketoconazole, and it is an inhibitor of the enzymes CYP11B1 (11β- ... cholesterol 7α-hydroxylase), theoretically resulting in further reduced interference with bile acid production and metabolite ...

... that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, ...

Effect of vitamin A deprivation on the cholesterol side chain cleavage enzyme activity of testes and ovaries of rats: M. ... Fatty acid specificity for the etherification of vitamin A and cholesterol by intestinal and pancreatic enzymes in rats: S. K. ... 1961 High cholesterol diet and esterification of cholesterol by the intestinal mucosa of rats: S. K. Murthy, S. Mahadevan and J ... 1985 Mechanism of conversion of carotene to vitamin A: Central cleavage versus random cleavage: J. Ganguly and P. S. Sastry, ...

Specifically, ketoconazole has been shown to inhibit cholesterol side-chain cleavage enzyme, which converts cholesterol to ... Cholesterol side-chain cleavage enzyme inhibitors, CYP2D6 inhibitors, CYP3A4 inhibitors, CYP17A1 inhibitors, Dioxolanes, ... Common side effects when applied to the skin include redness. Common side effects when taken by mouth include nausea, headache ... All of these enzymes are mitochondrial cytochrome p450 enzymes. Based on these antiandrogen and antiglucocorticoid effects, ...

It acts as an inhibitor of cholesterol side-chain cleavage enzyme (P450scc, CYP11A1), and also of 11β-hydroxylase (CYP11B1), 18 ... Cholesterol side-chain cleavage enzyme inhibitors, CYP3A4 inducers, Organochlorides, Orphan drugs, Steroidogenesis inhibitors) ... The use of mitotane is unfortunately limited by side effects, which, as reported by Schteinberg et al., include anorexia and ...

Cholesterol ((3β)-cholest-5-en-3-ol) is hydroxylated by cholesterol side-chain cleavage enzyme (P450scc) to form 22R- ... "The catalytic cycle of cytochrome P-450scc and intermediates in the conversion of cholesterol to pregnenolone". European ... metabolic intermediate in the biosynthesis of the steroid hormones from cholesterol. ...

Cholesterol ((3β)-cholest-5-en-3-ol) is hydroxylated by cholesterol side-chain cleavage enzyme (P450scc) to form 22R- ... "The catalytic cycle of cytochrome P-450scc and intermediates in the conversion of cholesterol to pregnenolone". European ... metabolic intermediate in the biosynthesis of the steroid hormones from cholesterol. ...

Steroid desmolases Cholesterol side-chain cleavage enzyme (20,22-desmolase) - steroid synthesis 17,20-Lyase (17,20-desmolase ... Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". ... Steroidogenic enzymes are enzymes that are involved in steroidogenesis and steroid biosynthesis. They are responsible for the ... from cholesterol. Steroidogenic enzymes are most highly expressed in classical steroidogenic tissues, such as the testis, ovary ...

... c Cytochrome c oxidase F-ATPase ATP-ADP translocase ATP-binding cassette transporter Cholesterol side-chain cleavage enzyme ... Cristae membranes are studded on the matrix side with small round protein complexes known as F1 particles, the site of proton- ... Electron transport chain NADH dehydrogenase (ubiquinone) Electron-transferring-flavoprotein dehydrogenase Electron-transferring ...

... and does not affect other steroidogenesis enzymes such as cholesterol side-chain cleavage enzyme (P450scc), 17α-hydroxylase/17, ... 1, 34), a synthetic 19-nor-17α-ethynyl testosterone derivative, which also undergoes enzyme-mediated 5α-reduction and exerts ... and its effect on steroid-producing enzymes". European Journal of Endocrinology. 130 (6): 634-640. doi:10.1530/eje.0.1300634. ...

Cells Through Suppression of Steady-State Messenger Ribonucleic Acid Levels of the Cholesterol Side-Chain Cleavage Enzyme". ... Some metabolites may have unwanted side effects. The use of methoxychlor as a pesticide was banned in the United States in 2003 ... Methoxychlor is ingested and absorbed by living organisms, and it accumulates in the food chain. ...

... and androstenediol into more potent androgens like and testosterone Cholesterol side-chain cleavage enzyme inhibitors (P450SCC/ ... androgens like testosterone Inhibitors of cholesterol synthesis can also reduce androgen production by inhibiting cholesterol ... CYP11A1 inhibitors): inhibit the synthesis of pregnenolone from cholesterol, thereby inhibiting the synthesis of most steroid ...

... cholesterol side-chain cleavage enzyme MeSH D08.811.600.250 - electron transport chain complex proteins MeSH D08.811.600.250. ... cholesterol 7 alpha-hydroxylase MeSH D08.811.682.690.708.783.212 - cholesterol side-chain cleavage enzyme MeSH D08.811.682.690. ... cholesterol 7 alpha-hydroxylase MeSH D08.244.453.915.212 - cholesterol side-chain cleavage enzyme MeSH D08.244.453.915.400 - 25 ... cholesterol 7 alpha-hydroxylase MeSH D08.811.682.690.708.170.915.212 - cholesterol side-chain cleavage enzyme MeSH D08.811. ...

... an inhibitor of cholesterol side-chain cleavage enzyme and to a lesser extent of other steroidogenic enzymes, which ... was found to cause adrenal insufficiency in patients due to inhibition of cholesterol side-chain cleavage enzyme and ... as well as of cholesterol side-chain cleavage enzyme, thereby inhibiting the production of steroid hormones including ... ISBN 978-0-323-15511-3. Hiroshi I, Bun-Ichi T (April 1970). "Studies on enzyme reactions related to steroid biosynthesis: II. ...

... thereby inhibiting the synthesis of estrogens Cholesterol side-chain cleavage enzyme inhibitors (P450SCC/CYP11A1 inhibitors): ... estrogens like estradiol Inhibitors of cholesterol synthesis can also reduce estrogen production by inhibiting cholesterol ... inhibit the synthesis of pregnenolone from cholesterol, thereby inhibiting the synthesis of most steroid hormones (which are ...

Cholesterol side-chain cleavage enzyme inhibitors, CYP17A1 inhibitors, Ethyl esters, GABAA receptor positive allosteric ... The most common side effects include venous pain on injection and skeletal muscle movements. In emergency settings, etomidate ... Etomidate suppresses corticosteroid synthesis in the adrenal cortex by reversibly inhibiting 11β-hydroxylase, an enzyme ...

Inhibitors of cholesterol side-chain cleavage enzyme (P450scc), such as aminoglutethimide and ketoconazole, may block ... Traish AM, Mulgaonkar A, Giordano N (June 2014). "The dark side of 5α-reductase inhibitors' therapy: sexual dysfunction, high ... Steroidogenic enzyme Steroidogenesis inhibitor List of steroid metabolism modulators Reddy, Doodipala Samba (2010). " ... Inhibitory neurosteroids are biosynthesized from steroid hormones by the action of two enzymes, 5α-reductase and 3α- ...

... and does not affect cholesterol side-chain cleavage enzyme (P450scc), 17α-hydroxylase/17,20-lyase, 21-hydroxylase, or 11β- ... including significant elevations in liver enzymes. These liver enzymes included lactate dehydrogenase and glutamate pyruvate ... The enzymes involved in these metabolic processes are 5α- and 5β-reductase as well as 3α- and 3β-hydroxysteroid dehydrogenase ( ... These findings suggest little to no risk of androgenic side effects with norethisterone at a dosage of 5 mg/day. A study of 194 ...

DHEA is synthesized from cholesterol via the enzymes cholesterol side-chain cleavage enzyme (CYP11A1; P450scc) and 17α- ... Then, DHEA-S is formed by sulfation of DHEA at the C3β position via the sulfotransferase enzymes SULT2A1 and to a lesser extent ...

They include: Cholesterol side-chain cleavage enzyme inhibitors (P450SCC/CYP11A1 inhibitors): inhibit the synthesis of ... into progesterone Inhibitors of cholesterol synthesis can also reduce progesterone production by inhibiting cholesterol ... pregnenolone from cholesterol, thereby inhibiting the synthesis of most steroid hormones (which are derived from pregnenolone) ...

... cholesterol 7 alpha-hydroxylase MeSH D12.776.422.220.453.915.212 - cholesterol side-chain cleavage enzyme MeSH D12.776.422.220. ... alpha-crystallin b chain MeSH D12.776.306.366.300.100 - beta-crystallin a chain MeSH D12.776.306.366.300.200 - beta-crystallin ... myosin heavy chains MeSH D12.776.210.500.600.200 - myosin light chains MeSH D12.776.210.500.600.300 - myosin subfragments MeSH ... myosin heavy chains MeSH D12.776.220.525.475.200 - myosin light chains MeSH D12.776.220.525.475.300 - myosin subfragments MeSH ...

... in the biosynthesis involves the oxidative cleavage of the side-chain of cholesterol by cholesterol side-chain cleavage enzyme ... Common side effects from testosterone medication include acne, swelling, and breast enlargement in males. Serious side effects ... Certain cytochrome P450 enzymes such as CYP2C9 and CYP2C19 can also oxidize testosterone at the C17 position to form ... It is biosynthesized in several steps from cholesterol and is converted in the liver to inactive metabolites. It exerts its ...

Cholesterol side-chain cleavage enzyme inhibitors, CYP17A1 inhibitors, Ketones, Nitriles, All stub articles, Steroid stubs). ... an enzyme that is responsible for the conversion of pregnenolone into progesterone, 17α-hydroxypregnenolone into 17α- ...

... including cholesterol side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase, 17α-hydroxylase, 17,20-lyase ... Cholesterol side-chain cleavage enzyme inhibitors, CYP17A1 inhibitors, Glucocorticoids, Hepatotoxins, Isoxazoles, Progestogens ... Due to their improved side-effect profiles, particularly their lack of masculinizing side effects, danazol has largely been ... Elevated liver-enzyme levels and muscle cramps (known adverse effects) of grade 2 or less occurred in 41% and 33% of the ...