... is a member of the gastrin/cholecystokinin family of peptide hormones and is very similar in structure to ... Media related to Cholecystokinin at Wikimedia Commons Cholecystokinin at the U.S. National Library of Medicine Medical Subject ... "Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor". The Journal of Neuroscience. 25 ( ... Cholecystokinin, Anxiogenics, Hepatology, Intestinal hormones, Neuropeptides, Cholecystokinin agonists). ...

Cholecystokinin+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ... Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones ... Beinfeld M, Chen Q, Gao F, Liddle RA, Miller LJ, Rehfeld J (2019-09-16). "Cholecystokinin receptors (version 2019.4) in the ... There are two different subtypes CCKA and CCKB which are ~50% homologous: Various cholecystokinin antagonists have been ...

A cholecystokinin receptor antagonist is a specific type of receptor antagonist which blocks the receptor sites for the peptide ... Cholecystokinin". Best Practice & Research. Clinical Endocrinology & Metabolism. 18 (4): 569-86. doi:10.1016/j.beem.2004.07.002 ... hormone cholecystokinin (CCK). There are two subtypes of this receptor known at present, defined as CCKA and CCKB (also called ...

Wang J, Si YM, Liu ZL, Yu L (Jun 2003). "Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene ... "Entrez Gene: CCKAR cholecystokinin A receptor". Pellegrini M, Mierke DF (Nov 1999). "Molecular complex of cholecystokinin-8 and ... It is required for interaction of the cholecystokinin A receptor with its corresponding hormonal ligand. Cholecystokinin CCK-4 ... "Met-195 of the cholecystokinin-A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor ...

Cholecystokinin also stimulates the flow of bile and causes the gall bladder to contract and thus determine if the gall bladder ... Cholecystokinin, a hormone secreted by the APUD cells located in the proximal mucosa of the small intestine is administered ... The secretin-cholecystokinin test (aka Secretin-CCK test, Secretin-Pancreozymin test) is a combination of the secretin test and ... the cholecystokinin test and is used to assess the function of both the pancreas and gall bladder. ...

Wang J, Si YM, Liu ZL, Yu L (Jun 2003). "Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene ... The cholecystokinin B receptor is stimulated by CCK and gastrin in the stomach during digestion. The cholecystokinin B receptor ... "Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin". The ... The cholecystokinin B receptor also known as CCKBR or CCK2 is a protein that in humans is encoded by the CCKBR gene. This gene ...

... specifically the release of cholecystokinin (CCK). One of the primary functions of monitor peptide is to stimulate the release ... Effect of Monitor Peptide and Human Pancreatic Secretory Trypsin Inhibitor on Pancreatic Secretion and Cholecystokinin Release ...

The sphincter of Oddi is relaxed by the hormone cholecystokinin via vasoactive intestinal peptide. Pancreatitis can result from ... Liddle, Rodger A. (2003-01-01). "CCK (Cholecystokinin)". Encyclopedia of Endocrine Diseases: 485-489. doi:10.1016/B0-12-475570- ... Wiley JW, O'Dorisio TM, Owyang C (June 1988). "Vasoactive intestinal polypeptide mediates cholecystokinin-induced relaxation of ...

... of proteins is defined by the peptide hormones gastrin and cholecystokinin. Gastrin and cholecystokinin (CCK) are structurally ... Watson S, Arkinstall S (1994). "Cholecystokinin (CCK) and gastrin". The G-protein linked receptor factsbook. London: Academic ... CCK; GAST; Baldwin GS, Patel O, Shulkes A (February 2010). "Evolution of gastrointestinal hormones: the cholecystokinin/gastrin ... The gastrin family (also known as the gastrin/cholecystokinin family) ...

ISBN 978-981-31446-3-7. Jorpes, Johan Erik; Mutt, Viktor (1973). Secretin, Cholecystokinin, Pancreozymin and Gastrin. Berlin: ...

de Tullio P, Delarge J, Pirotte B (June 1999). "Recent advances in the chemistry of cholecystokinin receptor ligands (agonists ... Berna MJ, Tapia JA, Sancho V, Jensen RT (December 2007). "Progress in developing cholecystokinin (CCK)/gastrin receptor ligands ... de Tullio P, Delarge J, Pirotte B (January 2000). "Therapeutic and chemical developments of cholecystokinin receptor ligands". ... November 1987). "Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists". ...

Gastrin Cholecystokinin (CCK) The Secretin family are peptides that act as local hormones which regulate activity of G-protein ... Jens F. Rehfeld; Lennart Friis-Hansen; Jens P. Goetze; Thomas V. O. Hansen (2007-06-01). "The Biology of Cholecystokinin and ... 2007). "The biology of cholecystokinin and gastrin peptides". Curr Top Med Chem. 2007;7(12):1154-65. Henriksen JH, de Muckadell ...

Cholecystokinin tetrapeptide (CCK-4, tetragastrin, Trp-Met-Asp-Phe-NH2) is a peptide fragment derived from the larger peptide ... February 1997). "Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor". Journal of ... Anokhina IP, Proskuriakova TV, Bespalova Z, Pal'keeva ME, Shokhonova VA, Petrichenko OB (2006). "[Effect of a cholecystokinin ... Bradwejn J (July 1993). "Neurobiological investigations into the role of cholecystokinin in panic disorder". Journal of ...

Benzodiazepine Cholecystokinin antagonist US 4820834, Evans, Ben E.; Freidinger, Roger M. & Bock, Mark G., "Benzodiazepine ... Hill DR, Woodruff GN (September 1990). "Differentiation of central cholecystokinin receptor binding sites using the non-peptide ... Cooper SJ, Dourish CT (December 1990). "Multiple cholecystokinin (CCK) receptors and CCK-monoamine interactions are ... December 1988). "Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists". ...

... is the ability of some endogenous chemicals (notably cholecystokinin and neuropeptide Y) to counter the effects ... Wiertelak, EP; Maier, SF; Watkins, LR (8 May 1992). "Cholecystokinin antianalgesia: safety cues abolish morphine analgesia" ( ...

Marshall, Fiona Hamilton (1990). Cholecystokinin/dopamine interactions in the rat basal ganglia. cam.ac.uk (PhD thesis). ...

2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of ... April 1996). "Characterization and inhibition of a cholecystokinin-inactivating serine peptidase". Nature. 380 (6573): 403-409 ...

... cholecystokinin, and secretin all inhibit production. The production of gastric acid in the stomach is tightly regulated by ...

... is similar in action and composition to cholecystokinin. It stimulates gastric, biliary, and pancreatic secretion; ...

Sjölund K, Ekman R, Lindgren S, Rehfeld J (1996): Disturbed motilin and cholecystokinin release in the irritable bowel syndrome ... These include serotonin, neurotensin, cholecystokinin, prostaglandin E1, and gastrin. Coffee can induce a significant response ...

Examples include: Secretin Cholecystokinin You C, Chey W (1987). "Secretin is an enterogastrone in humans". Dig Dis Sci. 32 (5 ... Lloyd K, Maxwell V, Chuang C, Wong H, Soll A, Walsh J (1994). "Somatostatin is released in response to cholecystokinin by ...

It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of ... Gaudreau P, Lavigne GJ, Quirion R (May 1990). "Cholecystokinin antagonists proglumide, lorglumide and benzotript, but not L- ... McCleane GJ (November 1998). "The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans ... McCleane GJ (2003). "The cholecystokinin antagonist proglumide enhances the analgesic effect of dihydrocodeine". The Clinical ...

This causes RB-101 to be strongly synergistic with cholecystokinin antagonists, such as proglumide. Unlike the more commonly ... Noble F, Smadja C, Roques BP (December 1994). "Role of endogenous cholecystokinin in the facilitation of mu-mediated ... Valverde O, Maldonado R, Fournie-Zaluski MC, Roques BP (July 1994). "Cholecystokinin B antagonists strongly potentiate ... are enhanced by a cholecystokinin type B receptor antagonist, as revealed by noxiously evoked spinal c-Fos expression in rats ...

The hormone cholecystokinin is secreted by the duodenum, and it controls the rate at which the stomach is emptied. This hormone ... Little, TJ; Horowitz, M; Feinle-Bisset, C. (2005). "Role of cholecystokinin in appetite control and body weight regulation". ... Hormones such as cholecystokinin, bombesin, neurotensin, anorectin, calcitonin, enterostatin, leptin and corticotropin- ...

"Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor". The Journal of Neuroscience. 25 ( ... cholecystokinin A receptors, and catecholamines, as well as to ghrelin, leptin, and glucose. Orexinergic neurons themselves ...

cholecystokinin antagonists, such as proglumide Newer agents such as the phosphodiesterase inhibitor ibudilast have also been ... McCleane GJ (2003). "The cholecystokinin antagonist proglumide enhances the analgesic effect of dihydrocodeine". The Clinical ...

... (PD-134,308) is a drug which acts as a cholecystokinin antagonist, selective for the CCKB subtype. In animal studies it ... van Megen HJ, Westenberg HG, den Boer JA, Slaap B, van Es-Radhakishun F, Pande AC (February 1997). "The cholecystokinin-B ... Bradwejn J, Koszycki D, Paradis M, Reece P, Hinton J, Sedman A (December 1995). "Effect of CI-988 on cholecystokinin ... Valverde O, Roques BP (March 1998). "Cholecystokinin modulates the aversive component of morphine withdrawal syndrome in rats ...

Other neurons in the superior lateral parabrachial nucleus that contain cholecystokinin have been found to prevent hypoglycemia ... "A parabrachial-hypothalamic cholecystokinin neurocircuit controls counterregulatory responses to hypoglycemia". Cell Metabolism ...

Marshall, Fiona (1990). Cholecystokinin/dopamine interactions in the rat basal ganglia (PhD thesis). University of Cambridge. ...

It acts as a selective antagonist for the cholecystokinin receptor CCKA, and has been used as a lead compound for the ... Cholecystokinin antagonists. Synthesis of asperlicin analogues with improved potency and water solubility. Journal of Medicinal ... PMID 2885419 Van der Bent A, Ter Laak AM, IJzerman AP, Soudijn W. Molecular modelling of asperlicin derived cholecystokinin A ... A potent nonpeptide cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceus. Science. ...

Wank, SA (Nov 1995). "Cholecystokinin receptors". The American Journal of Physiology. 269 (5 Pt 1): G628-46. doi:10.1152/ajpgi. ... Takai, N; Shida, T; Uchihashi, K; Ueda, Y; Yoshida, Y (Apr 15, 1998). "Cholecystokinin as neurotransmitter and neuromodulator ... such as cholecystokinin) can be used. The ACh acts on two types of receptors, the muscarinic and nicotinic cholinergic ...

In this study, cholecystokinin-tetrapeptide (CCK-4) and placebo were administered to 11 panic disorder patients. CCK-4 (but not ... Bradwejn, J; Koszycki, D; Meterissian, G (1990). "Cholecystokinin-tetrapeptide induces panic attacks in patients with panic ...