Centromere
Instability of centromere repetitive DNA was recently shown in cancer and aging. When DNA breaks occur at centromeres in the G1 ... "Regional centromeres" is the term coined to describe most centromeres, which typically form on regions of preferred DNA ... When the centromeres are metacentric, the chromosomes appear to be "x-shaped." Submetacentric means that the centromere is ... In regional centromeres, DNA sequences contribute to but do not define function. Regional centromeres contain large amounts of ...
Centromere protein E
Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene. Centromere-associated protein E is a ... Unlike other centromere-associated proteins, it is not present during interphase and first appears at the centromere region of ... "Entrez Gene: CENPE centromere protein E, 312kDa". "OMIM Entry - # 616051 - MICROCEPHALY 13, PRIMARY, AUTOSOMAL RECESSIVE; ... 1991). "CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase". EMBO J. 10 (5 ...
Centromere protein B
... also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, ... Centromere protein B is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is ... Centromere protein B is a potential biomarker of small-cell lung cancer. Centromere GRCh38: Ensembl release 89: ENSG00000125817 ... It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. ...
Anti-centromere antibodies
... (ACAs; often styled solid, anticentromere) are autoantibodies specific to centromere and kinetochore ... Anti-centromere antibodies are found in approximately 60% of patients with limited systemic scleroderma and in 15% of those ... Anti-centromere antibodies present early in the course of disease and are notably predictive of limited cutaneous involvement ... The specificity of this test is >98%. Thus, a positive anti-centromere antibody finding is strongly suggestive of limited ...
Repeated sequence (DNA)
Centromeres are the highly compact regions of chromosomes which join sister chromatids together and also allow the mitotic ... Centromeres are composed of a 177 base pair tandem repeat named the α-satellite repeat. Pericentromeric heterochromatin, the ... "Centromere". Genome.gov. Retrieved 2022-09-30. Miga KH (September 2015). "Completing the human genome: the progress and ... In the 1950s, Barbara McClintock first observed DNA transposition and illustrated the functions of the centromere and telomere ...
Chromosome 16
... acen Centromere. var: Variable region; stalk: Stalk. Gilbert F (1999). "Disease genes and chromosomes: disease maps of the ...
Chromosome 6
The centromere of chromosome 6 illustrates an interesting example of centromere evolution. It was known that in a Catarrhini ... In case of humans, the old centromere went defunct and a more recent form emerged near the modern position of human cen6 (size ... In Macaca mulatta, this old centromere went defunct and repositioned to a different chromosomal location. ... "Complete genomic and epigenetic maps of human centromeres". Science. 376 (6588): eabl4178. doi:10.1126/science.abl4178. ISSN ...
Chromosome 13
... acen Centromere. var: Variable region; stalk: Stalk. Wikimedia Commons has media related to Human chromosome 13. National ...
Chromosome 22
... acen Centromere. var: Variable region; stalk: Stalk. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R ...
Chromosome 2
Normally a chromosome has just one centromere, but in chromosome 2 there are remnants of a second centromere in the q21.3-q22.1 ... acen Centromere. var: Variable region; stalk: Stalk. Wikimedia Commons has media related to Human chromosome 2. National ...
Chromosome 7
... acen Centromere. var: Variable region; stalk: Stalk. Lee, Victor Robert (2013-01-15). Performance Anomalies: A Novel. Perimeter ...
Chromosome 10
... acen Centromere. var: Variable region; stalk: Stalk. Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, ...
Chromosome 5
... acen Centromere. var: Variable region; stalk: Stalk. Mainardi PC, Perfumo C, Cali A, Coucourde G, Pastore G, Cavani S, Zara F, ...
Chromosome 21
... acen Centromere. var: Variable region; stalk: Stalk. Antonarakis SE, Lyle R, Dermitzakis ET, Reymond A, Deutsch S (2004). " ...
Chromosome 3
... acen Centromere. var: Variable region; stalk: Stalk. Wikimedia Commons has media related to Human chromosome 3. National ...
Chromosome 8
... acen Centromere. var: Variable region; stalk: Stalk. Gilbert F (2001). "Chromosome 8". Genet Test. 5 (4): 345-54. doi:10.1089/ ...
Chromosome 19
... acen Centromere. var: Variable region; stalk: Stalk. Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U ...
Chromosome 9
... acen Centromere. var: Variable region; stalk: Stalk. Gilbert F, Kauff N (2001). "Disease genes and chromosomes: disease maps of ...
Chromosome 17
... acen Centromere. var: Variable region; stalk: Stalk. Gilbert F (1998). "Disease genes and chromosomes: disease maps of the ...
Chromosome 15
... acen Centromere. var: Variable region; stalk: Stalk. General references: Bittel DC, Butler MG (2005). "Prader-Willi syndrome: ...
Chromosome 11
... acen Centromere. var: Variable region; stalk: Stalk. Gilbert F (2000). "Disease genes and chromosomes: disease maps of the ...
INCENP
... two broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and ' ... Inner centromere protein is a protein that in humans is encoded by the INCENP gene. It is a regulatory protein in the ... The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages ... Choo, K. H. Andy (1997). The centromere. Oxford [Oxfordshire]: Oxford University Press. ISBN 978-0-19-857780-5. Earnshaw WC, ...
Y chromosome
... acen Centromere. var: Variable region; stalk: Stalk. Science Daily, Apr. 3, 2008. Pertea M, Salzberg SL (2010). "Between a ...
X chromosome
... acen Centromere. var: Variable region; stalk: Stalk. "Scientists achieve first complete assembly of human X chromosome". phys. ...
Chromosome 4
... acen Centromere. var: Variable region; stalk: Stalk. Goldfrank D, Schoenberger E, Gilbert F (2003). "Disease genes and ... Centromere protein U MMAA: methylmalonic aciduria (cobalamin deficiency) cblA type MTHFD2L: NAD-dependent ...
Neocentromere
All centromeres are associated with centromere protein A (CENPA). CENPA also been widely studied as an important player in ... Centromere repositioning and evolutionary new centromeres are also thought to be involved in speciation as incompatibility ... Sullivan, B. A. (2013-01-01). "Centromeres". In Lane, M. Daniel (ed.). Centromeres A2 - Lennarz, William J. Waltham: Academic ... Another striking thing in centromere evolution is that while centromere function is conserved among all eukaryotes the ...
Chromosome 18
... acen Centromere. var: Variable region; stalk: Stalk. Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker ...
Chromosome 14
The centromere of chromosome 14 is positioned approximately at position 17.2 Mbp. The following are some of the gene count ... acen Centromere. var: Variable region; stalk: Stalk. Campo E (2003). "Genetic and molecular genetic studies in the diagnosis of ...
Chromosome 12
... acen Centromere. var: Variable region; stalk: Stalk. Gilbert F, Kauff N (2000). "Disease genes and chromosomes: disease maps of ...
Chromosome 1
... acen Centromere. var: Variable region; stalk: Stalk. Murphy WJ, Fronicke L, O'Brien SJ, Stanyon R (2003). "The Origin of Human ... Centromere protein L CENPF (1q41) CHTOP: Chromatin target of prmt1 CNIH4: cornichon homolog 4 CNST: Consortin CREG1: Cellular ...