... granulosa and thecal cells → functional Sertoli-like and Leydig-like cells (-Foxl1) Transdifferentiation Induced stem cells ... A list of examples of in vivo transdifferentiation through transfection: mouse hepatocytes → B cells (Pdx1) exocrine cells → B ... Generating Desired Cell Types from Abundant and Accessible Cells". Stem Cells. 29 (12): 1933-1941. doi:10.1002/stem.760. PMID ... Cell. 139 (6): 1130-1142. doi:10.1016/j.cell.2009.11.021. PMID 20005806. (Histology, Induced stem cells). ...

Glial cells → neurons (Pax6) Erythorid-megakaryocytic cells → monocytic cells (SPI1/PU.1) B-cell progenitors → functional ... Generating Desired Cell Types from Abundant and Accessible Cells". Stem Cells. 29 (12): 1933-1941. doi:10.1002/stem.760. PMID ... A list of examples of transdifferentiation: Mouse fibroblasts, chondroblasts, and pigmented retinal epithelial cells → ... Xie, H.; Ye, M.; Feng, R.; Graf, T. (2004). "Stepwise reprogramming of B cells into macrophages". Cell. 117 (5): 663-676. doi: ...

... neural stem/progenitor cells (Oct4, Sox2, c-Myc, Klf4) Transdifferentiation Induced stem cells Pournasr, B.; Khaloughi, K.; ... Generating Desired Cell Types from Abundant and Accessible Cells". Stem Cells. 29 (12): 1933-1941. doi:10.1002/stem.760. PMID ... Nature Cell Biology. 13 (3): 215-222. doi:10.1038/ncb2164. PMID 21278734. S2CID 5310172. Kim, J.; Efe, J. A.; Zhu, S.; ... polygonal hyaline chondrogenic cells (Klf4, c-Myc, Sox9) Mouse dermal fibroblasts → cardiomyocytes (Oct4, Sox2, Klf4, JI1 and ...

... pancreatic beta-cell-like' cells. The cells induced a wide, functional and long-lasting transdifferentiation process that ... Generally transdifferentiation that occurs in mouse cells does not translate in effectiveness or speediness in human cells. ... Transdifferentiation requires fewer cell passages and would reduce the chance of mutations. Transdifferentiation can also be ... 1987 reported the first instance (sight) of transdifferentiation where a cell changed from one adult cell type to another. ...

Qin, H.; Zhao, A.; Fu, X. (2017). "Small molecules for reprogramming and transdifferentiation". Cellular and Molecular Life ... The second being a somatic cell, referring to the cells of the human body. Skin cells, fat cells, and liver cells are only a ... "Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer". Cell. 153 (6): 1228-38. doi:10.1016/j.cell.2013.05.006. ... The Scientist 19 June 2007 Human Somatic Cell Nuclear Transfer Using Adult Cells Cell Stem Cell. Retrieved 18 April 2014 Ariana ...

In 1995 he pioneered this technique permitting the transdifferentiation of white blood cells into red blood cell precursors and ... "Historical Origins of Transdifferentiation and Reprogramming". Cell Stem Cell. 9 (6): 504-516. doi:10.1016/j.stem.2011.11.012. ... Baker, Monya (2008-10-23). "Thomas Graf: Cellular identity and transdifferentiation". Nature Reports Stem Cells: 1. doi:10.1038 ... He is a pioneer in cell reprogramming, showing that blood cells can be transdifferentiated by transcription factors. He is also ...

... for transdifferentiation of human skin cells into beating heart cells. With this method, more than 97% of the cells began ... May 2013). "TAP-deficient human iPS cell-derived myeloid cell lines as unlimited cell source for dendritic cell-like antigen- ... June 2014). "Human somatic cell nuclear transfer using adult cells". Cell Stem Cell. 14 (6): 777-80. doi:10.1016/j.stem.2014.03 ... June 2013). "Human embryonic stem cells derived by somatic cell nuclear transfer". Cell. 153 (6): 1228-38. doi:10.1016/j.cell. ...

Two mammalian cell lines are commonly used as models of the proximal tubule: porcine LLC-PK1 cells and marsupial OK cells. Most ... undergoing epithelial mesenchymal trans-differentiation; necrosis or apoptosis.[citation needed] Urinary pole Brush border List ... Cuboidal epithelial cells lining the proximal tubule have extensive lateral interdigitations between neighboring cells, which ... The mitochondria are needed in order to supply the energy for the active transport of sodium ions out of the cells to create a ...

Transdifferentiation experiments were carried out. They tried to change the cell fate without proceeding through a pluripotent ... fibroblast cells to myoblast cells, fibroblast cells to cardiomyocyte cells, fibroblast cells to neurons Cell replacement ... In 2006, he and his team generated induced pluripotent stem cells (iPS cells) from adult mouse fibroblasts. iPS cells closely ... Therefore, non-differentiated egg/early embryo cells can only develop into specialized cells. However, stem cells with limited ...

Epithelial to mesenchymal transdifferentiation (EMT) of an epithelial cell. Perhaps the most studied pathway of myofibroblast ... Partial smooth muscle differentiation of a fibroblastic cell Activation of a stellate cell (e.g. hepatic Ito cells or ... A myofibroblast is a cell phenotype that was first described as being in a state between a fibroblast and a smooth muscle cell ... Pericytes and renal mesangial cells are some examples of modified myofibroblast-like cells. Myofibroblasts may interfere with ...

... cell regeneration through transdifferentiation of pancreatic α‐ to β‐cells". Cell Biology International. International ... Glucagonoma Beta cell Delta cell List of human cell types derived from the germ layers List of distinct cell types in the adult ... Alpha cells (α cells) are endocrine cells that are found in the Islets of Langerhans in the pancreas. Alpha cells secrete the ... Alpha cells are endocrine cells, meaning they secrete a hormone, in this case glucagon. Alpha cells store this glucagon in ...

Somatic expression of combined transcription factors can directly induce other defined somatic cell fates (transdifferentiation ... Cell potency is a cell's ability to differentiate into other cell types. The more cell types a cell can differentiate into, the ... In cell biology, a unipotent cell is the concept that one stem cell has the capacity to differentiate into only one cell type. ... A close synonym for unipotent cell is precursor cell. Biology portal Induced stem cells Cell totipotency was discovered by ...

SCR/SP11 - are small polymorphic peptides produced by the tapetal cells of anthers and is involved in self-incompatibility of ... PSK has been demonstrated to promote cellular proliferation and transdifferentiation. It has been demonstrated that PSK binds ... These proteins are secreted from cells in the floral abscission zone. Studies suggest that the HAESA membrane-associated LRR- ... February 2005). "Reduction of cell size induced by enod40 in Arabidopsis thaliana". J. Exp. Bot. 56 (412): 507-13. doi:10.1093/ ...

The coelomic fluid contains the coelomocytes, or immune cells. There are several types of immune cells, which vary among ... Direct transdifferentiation of one type of tissue to another during tissue replacement is also observed. Echinoderms become ... vibratile cells (for coelomic fluid movement and clotting), and crystal cells (which may serve for osmoregulation in sea ... "Regulation of dynamic pigment cell states at single-cell resolution". eLife. 9. doi:10.7554/elife.60388. PMC 7455242. PMID ...

Influence of embryonic stage on the transdifferentiation of chick neural retina cells in culture. J Embryol Exp Morphol. 1978 ... The expression of chick alpha A2-crystallin RNA during lens development and transdifferentiation. Biol Cell. 1985;54(2):101-8. ... The influence of the genotype on the process of ageing of chick lens cells in vitro. Exp Cell Res. 1988 Feb;174(2):330-43. ... Relationship between crystallin mRNA expression in retina cells and their capacity to re-differentiate into lens cells. Nature ...

Kaur K, Yang J, Eisenberg CA, Eisenberg LM (October 2014). "5-azacytidine promotes the transdifferentiation of cardiac cells to ... Azacitidine causes anemia (low red blood cell counts), neutropenia (low white blood cell counts), and thrombocytopenia (low ... doi:10.1089/cell.2014.0021. PMID 25090621. Wang X, Zou P, Wu F, Lu L, Jiang S (December 2017). "Development of small-molecule ... has a compromised efficacy as a cardiac differentiation factor because it promotes the transdifferentiation of cardiac cells to ...

"In vitro transdifferentiation of human skin keratinocytes to corneal epithelial cells". celltherapyjournal.org. Retrieved 30 ... Vidya Pradeep completed her PhD in Stem Cell Biology at an eye hospital in Chennai. She works on ocular stem cells, and her ... "Actress Vidya Pradeep gets doctorate in Stem Cell Biology; To head to US for job". The Times of India. Archived from the ... "Thadam Actress Vidya Pradeep Gets Doctorate In Stem Cell Biology, To Head For The US » GossipChimp , Trending K-Drama, TV, ...

... this transdifferentiation can form cells with a neural lineage. Induced somatic stem cells Mahla RS (2016). "Stem Cells ... these cells have the same ability as embryonic stem cells to develop into many different cell types. Olfactory stem cells hold ... such as mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, etc.). A great deal of adult stem cell ... Pluripotent stem cells, i.e. cells that can give rise to any fetal or adult cell type, can be found in several tissues, ...

Reprogrammed adult supporting cells show transdifferentiation into hair cell-like cells upon exposure to hair cell induction ... Claudius cells, inner phalangeal cells, and inner and outer pillar cells. Hensen's cells, Deiter's cells, and outer hair cells ... Direct transdifferentiation is when neighboring supporting cells convert into hair cells without cell division. Inner ear ... Supporting cells are also responsible for removing damaged hair cells from the inner ear. Hair cells and most supporting cells ...

However, there is also a second definition of transdifferentiation, in which cells can be directly induced into a new cell type ... differentiated cell. Re-entry into the cell cycle allows the cell to go through mitosis, dividing to make more cells that would ... Articles with short description, Short description matches Wikidata, Cells, Cell biology, Stem cells). ... as seen by an increase in cell cycle re-entry and loss of cellular adhesion. Cell plasticity [9] is the idea that cells can ...

May 2018). "Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged ... Molecular and Cell Biology of Lipids. 1821 (4): 694-705. doi:10.1016/j.bbalip.2012.01.009. PMID 22285325. Oka S, Toshida T, ...

"The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells". ... Fatty acids in the beta cells activate FOXO1, resulting in apoptosis of the beta cells. FOXO1 activation plays a role in cell ... It suppresses survival of tumor cells by inducing apoptosis in prostate cancer cells and glioma cells by upregulating the ... In pancreatic beta cells FOXO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. When the level of blood ...

May 2018). "Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged ... to cause host cell (macrophage) apoptosis through cytochrome C release. LPCs are present as minor phospholipids in the cell ... Invading T cells are also thought to mediate this process. Bacteria such as Legionella pneumophila utilize phospholipase A2 end ... LPC also acts as a find-me signal, released by apoptotic cells to recruit phagocytes, which then phagocytose the apoptotic ...

Diabetes, insulin, trans-differentiation, stem cells, and regenerative medicine are all search phrases. GRCh38: Ensembl release ... including pancreatic exocrine cells, hepatocytes, and pluripotent stem cells, in addition to their natural roles in beta cell ... PDX1, NEUROG3, and/or MAFA have been effectively used to convert numerous cell types into insulin-producing cells in vitro and ... PDX1 is required for the formation of exocrine and endocrine cells in the pancreas, especially beta cells. PDX1 also attaches ...

His lab also discovered and developed methods for the purification and culturing of retinal ganglion cells and the glial cells ... "Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth". ... doi:10.1038/d41586-017-08964-1. Raff, Martin C. (October 1993). "Programmed Cell Death and the Control of Cell Survival: ... understand the cell-to-cell interactions in the developmental regulation of nodes of Ranvier and myelin sheaths; 2) determine ...

This inhibitor specifically targets Rho GTPases to prevent cell growth related to cancer. When tested on breast cancer cells, ... January 2001). "Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA- ... We have used a stable retroviral RNA interference approach to generate invasive breast carcinoma cells (SUM-159 cells) that ... Chronic Myeloid Leukemia (CML), a stem cell disorder that prevents myeloid cells from functioning correctly, has been linked to ...

Transdifferentiation of MSCs into excitable neuron-like cells has been shown to be possible in vitro and these cells respond to ... The terminal differentiation of some somatic stem cells has recently been called into question after studies of transplanted ... However, it is unlikely that this degree of transdifferentiation occurs in vivo and that ... haematopoietic stem cells showed the development of myoblasts, endothelium, epithelium and neuroectodermal cells, suggesting ...

"A role for Id in the regulation of TGF-beta-induced epithelial-mesenchymal transdifferentiation". Cell Death and ... An increase in ID expression is seen in embryonic and adult stem cells. ID proteins also promote cell cycle progression, ... When ID proteins are overexpressed, cell proliferation is enhanced and cells become insensitive to growth factor depletion. ... When ID1 was knocked out, a defect in T-cell migration was seen. A knockout of ID2 showed that 25% of mice died perinatally, ...

"Cochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling". ... The supporting cells including Hensen's cells and Deiter's cells which surround the sensory cells in the organ of Corti are ... and reproduce both new hair cells and supporting cells into the cell cycle, one of the reasons is because the supporting cells ... Hensen's cells are a layer of tall cells arranged in the organ of Corti in the cochlea, which are part of the supporting cells ...

The ability of transdifferentiation, a non-stem cell which can morph into a different type of cell, in these cells is pivotal ... Medusae transforming into polyps and cell transdifferentiation in Turritopsis nutricula (Cnidaria, Hydrozoa)". The Biological ... It is unknown whether or not stem cells play a role in this process. Due to this regular transformation by T. nutricula, it is ... This regression from medusa to polyp has only been observed with the presence of differentiated cells from the outer umbrella ...