Dedifferentiation also occurs in plants. Cells in cell culture can lose properties they originally had, such as protein ... fat cells, and types of bone cells Epithelial stem cells (progenitor cells) that give rise to the various types of skin cells ... Such cells, called somatic cells, make up most of the human body, such as skin and muscle cells. Cells differentiate to ... Hematopoietic stem cells (adult stem cells) from the bone marrow that give rise to red blood cells, white blood cells, and ...
This involves dedifferentiation to a pluripotent state; an example is the conversion of mouse somatic cells to an ... cell cycle cell division cell membrane cell signaling cell wall cell-free DNA (cfDNA) Any DNA molecule that exists outside of a ... germ cell Any cell that gives rise to the gametes of a sexually reproducing organism. Germ cells are the vessels for the ... Cells of the germ line are called germ cells. 2. The lineage of germ cells, spanning many generations, that contains the ...
Friedmann-Morvinski, Dinorah; Verma, Inder M (March 2014). "Dedifferentiation and reprogramming: origins of cancer stem cells ... two of which are by the combination of transcription factors the cells have and by the cell-cell interaction. Cells' fate ... If a cell is in a determined state, the cell's fate cannot be reversed or transformed. In general, this means that a cell ... Eur J Cell Biol 2010, 89:225-230. Lau, S.; Ehrismann, J.; Schlereth, A.; Takada, S.; Mayer, U.; Jürgens, G. (2010). "Cell-cell ...
... but they all came from one pluripotent cell. Induced pluripotent stem cell Directed differentiation Dedifferentiation " ... TH2 cells produce cytokines that will trigger certain B cells. B cells can differentiate into memory cells or plasma cells. The ... This stem cell can produce red blood cells, platelets, mast cells, dendritic cells, macrophages, lymphocytes, neutrophils, ... They divide into memory cells, TH1, TH17, and TH2 cells, to name a few. Memory cells are made solely for the purpose of having ...
... differentiated cell. Re-entry into the cell cycle allows the cell to go through mitosis, dividing to make more cells that would ... Cell plasticity is closely related to dedifferentiation, as it implies that a cell with 'plasticity' can dedifferentiate to ... After dedifferentiation, new cells can be generated by re-entering the cell cycle and proliferating, then redifferentiating to ... Dedifferentiation could spark innovation in regenerative medicine because it suggests that one's own cells can change cell ...
... used for stem cell dedifferentiation. It also has the potential to selectively induce cell death in cancer cells. Reversine is ... Chen, Shuibing; Zhang, Qisheng; Wu, Xu; Schultz, Peter G.; Ding, Sheng (2004). "Dedifferentiation of Lineage-Committed Cells by ... "The synthetic purine reversine selectively induces cell death of cancer cells". Journal of Cellular Biochemistry. 113 (10): ... The Journal of Cell Biology. 190 (1): 73-87. doi:10.1083/jcb.201001036. ISSN 1540-8140. PMC 2911657. PMID 20624901. Henry, ...
Collective cell migration Dedifferentiation Invasion (cancer) Krakhmal, N. V.; Zavyalova, M. V.; Denisov, E. V.; Vtorushin, S. ... Although once differentiated, cells typically do not change their migration mode, EMTs and CMTs are highly plastic with cells ... "Cell polarity signaling in the plasticity of cancer cell invasiveness". Oncotarget. 7 (18): 25022-25049. doi:10.18632/ ... Like EMTs, CATs are involved in the invasion of tumor cells into surrounding tissues, with amoeboid movement more likely to ...
... including the stimulation of activated B cell and T cell proliferation, and the differentiation of B cells into plasma cells. ... IL-4 has also been shown to drive mitogenesis, dedifferentiation, and metastasis in rhabdomyosarcoma. IL-4, along with other ... The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon ... Auxiliary T cells are a key element of HIV-1 infection. Several signs of immune dysregulation such as polyclonal B cell ...
"Dedifferentiation of committed epithelial cells into stem cells in vivo". Nature. 503 (7475): 218-223. Bibcode:2013Natur.503.. ... Schofield, R. (1978). "The relationship between the spleen colony-forming cell and the haemopoietic stem cell". Blood Cells. 4 ... His lab also demonstrated that a stem cell can serve as a niche for its own daughter cells, extending the fundamental concept ... "Parent stem cells can serve as niches for their daughter cells". Nature. 523 (7562): 597-601. Bibcode:2015Natur.523..597P. doi: ...
November 2013). "Dedifferentiation of committed epithelial cells into stem cells in vivo". Nature. 503 (7475): 218-23. Bibcode: ... May 2013). "TAP-deficient human iPS cell-derived myeloid cell lines as unlimited cell source for dendritic cell-like antigen- ... June 2014). "Human somatic cell nuclear transfer using adult cells". Cell Stem Cell. 14 (6): 777-80. doi:10.1016/j.stem.2014.03 ... June 2013). "Human embryonic stem cells derived by somatic cell nuclear transfer". Cell. 153 (6): 1228-38. doi:10.1016/j.cell. ...
Sugimoto K, Gordon SP, Meyerowitz EM (April 2011). "Regeneration in plants and animals: dedifferentiation, transdifferentiation ... Cell potency is a cell's ability to differentiate into other cell types. The more cell types a cell can differentiate into, the ... In cell biology, a unipotent cell is the concept that one stem cell has the capacity to differentiate into only one cell type. ... A close synonym for unipotent cell is precursor cell. Biology portal Induced stem cells Cell totipotency was discovered by ...
"Dedifferentiation of committed epithelial cells into stem cells in vivo". Nature. 503 (7475): 218-223. Bibcode:2013Natur.503.. ... Air liquid interface cell culture (ALI) is a method of cell culture by which basal stem cells are grown with their basal ... This method of cell culture aims to be used to study fundamental aspects of the respiratory epithelium, such as cell-to-cell ... One recent study has shown that differentiated cells in the respiratory epithelium (secretory cells and ciliated cells ...
by inducing a shift in the developmental fate of cells in the liver and converting them into 'pancreatic beta-cell-like' cells ... Despite the massive dedifferentiation - lineage tracing approach indeed demonstrates that transdifferentiation originates in ... In this approach, transcription factors from progenitor cells of the target cell type are transfected into a somatic cell to ... Patel, M.; Yang, S. (2010). "Advances in Reprogramming Somatic Cells to Induced Pluripotent Stem Cells". Stem Cell Reviews and ...
... as an alternative to plant stem cells. Callus, or dedifferentiated cells, are somatic cells that undergo dedifferentiation to ... Thus plant stem cell culture is the most ideal and productive method of cell culture and phytochemical production as cells are ... Plant stem cells are innately undifferentiated cells located in the meristems of plants. Plant stem cells serve as the origin ... These immortal cells divide infinitely. Plant cells are cultured to acquire plant useful compounds. However cell cultures are ...
In Physcomitrella patens the PcG protein FIE is specifically expressed in stem cells such as the unfertilized egg cell. Soon ... Consequently, loss of PcG causes de-differentiation and promotes embryonic development. Polycomb-group proteins also intervene ... Cell. 128 (4): 735-45. doi:10.1016/j.cell.2007.02.009. PMID 17320510. S2CID 6492075. Pirrotta V, Li HB (2012). "A view of ... Cell. 171 (1): 34-57. doi:10.1016/j.cell.2017.08.002. PMID 28938122. S2CID 43165761. Di Croce L, Helin K (2013). " ...
"Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling". Cell Stem Cell. 9 (5): 420-32. doi:10.1016 ... OSMR is widely expressed across non-haematopoietic, hepatocytes, mesothelial cells, glial cells and epithelial cell types ... Intracellular cell signalling occurs as a consequence of extracellular binding of the ligand OSM to OSMR complexes, formed from ... OSM and OSMRβ are co-expressed and lead to STAT 3 activation malignant human ovarian epithelial cells. The OSMR β promoter gene ...
... "enod40 induces dedifferentiation and division of root cortical cells in legumes". Proc Natl Acad Sci U S A. 94 (16): 8901-8906 ... for elicitation of a cell-specific growth response in the alfalfa root cortex". Mol Cell Biol. 21 (1): 354-366. doi:10.1128/MCB ... Guzzo F, Portaluppi P, Grisi R, Barone S, Zampieri S, Franssen H, Levi M (2005). "Reduction of cell size induced by enod40 in ... Plant Cell. 11 (10): 1953-1966. doi:10.1105/tpc.11.10.1953. PMC 144109. PMID 10521525. Kouchi H, Takane K, So RB, Ladha JK, ...
"Inducing cellular dedifferentiation: A potential method for enhancing endogenous regeneration in mammals". Seminars in Cell & ... Like stem cells in SGZ, progenitor cells in SVZ also differentiate into neurons and form an intermediate cell called a ... In the dentate gyrus, putative stem cells, called type 1 cells, proliferate into type 2 and type 3 cells, which are transiently ... Progenitor cells in the dentate gyrus of the hippocampus migrate to the nearby location and differentiate into granule cells. ...
"Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties". Cell. 152 (1-2): 25-38. ... In collaboration with Hans Clevers's laboratory, Owen's group showed that Lgr5-positive cells are an efficient cell of ... Cell Stem Cell. 12 (6): 761-73. doi:10.1016/j.stem.2013.04.006. PMC 3690525. PMID 23665120. Sansom, OJ; Stark, LA; Dunlop, MG; ... "Crypt stem cells as the cells-of-origin of intestinal cancer". Nature. 457 (7229): 608-11. Bibcode:2009Natur.457..608B. doi: ...
Instead dedifferentiation is observed [1-4]. These cell biological alterations arise after isolation of cells and proceed ... Cell Biol Int 34(11):1075-83. 5. Minuth WW and Denk L 2011 Advanced culture experiments with adherent cells. From single cells ... Due to these reasons a Minusheet tissue carrier with adherent cells is used only for the short period of cell seeding in a 24 ... Minusheet perfusion culture system is used for advanced cell culture experiments in combination with adherent cells and to ...
... which dedifferentiate into stem-like cells and proliferate into neural progenitor cells in response to retinal damage. While ... Wan, J; Ramachandran, R; Goldman, D (2012). "HB-EGF is necessary and sufficient for Müller glia dedifferentiation and retina ... The neural progenitor cell proliferates to form a cluster of neural progenitors, which migrate to the outer nuclear layer of ... The mice had suffered from a complete lack of photoreceptor cells in their retinas, and had been unable to tell light from dark ...
"Contribution of mesenterial muscle dedifferentiation to intestine regeneration in the sea cucumber Holothuria glaberrima". Cell ... Cells that contain the amino acid peptide, Stichopin, have been found within the connective tissues of the Chiridotidae. These ... Researchers have discovered that Chiridotidae reach their asymptotic range size at 10 cells. Sea cucumbers are a mostly ... "Stichopin-containing nerves and secretory cells specific to connective tissues of the sea cucumber". Proceedings of the Royal ...
The role of Tyrp1 in melanoma progression was determined by comparing "knockout" cell lines which have inactive Tyrp1 to cells ... Abe T, Sato M, Tamai M (December 1998). "Dedifferentiation of the retinal pigment epithelium compared to the proliferative ... Tyrp1 mRNA interacts with miR-16 and affects its ability to repress genes involved in melanoma cell production. Mutations in ... Such studies provide insight to possible clinical usage and treatment of melanoma via regulation of Tyrp1 expression in cells. ...
Particularly, ROCK inhibitor is used for cell culture practice, in part to limit cellular death and limited dedifferentiation, ... and non-small cell lung cancer (A549) cells independent of cell death induction. Fasudil, not currently approved by the U.S. ... On a cellular level, ROCK has multiple functions, including regulation of smooth muscle cell contraction, cell migration, and ... "Minimal Sustainability of Dedifferentiation by ROCK Inhibitor on Rat Nucleus Pulposus Cells In Vitro". Spine Surgery and ...
Sun T, Han X (2019). "Death versus dedifferentiation: The molecular bases of beta cell mass reduction in type 2 diabetes". ... Fatty acids in the beta cells activate FOXO1, resulting in apoptosis of the beta cells. FOXO1 activation plays a role in cell ... It suppresses survival of tumor cells by inducing apoptosis in prostate cancer cells and glioma cells by upregulating the ... In pancreatic beta cells FOXO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. When the level of blood ...
... dedifferentiation or self-renewal of ES cells". Nature Genetics. 24 (4): 372-376. doi:10.1038/74199. PMID 10742100. S2CID ... Also, Rex1−/Oct3/4+ cells differentiate into cells of primitive ectoderm, the somatic cell lineage. Studies have shown that ... Thus, the male germ cells undergoing meiosis are the specific cells in the testicles that express Rex1. It has not been ... During embryogenesis, the inner cell mass (ICM) is separated from the trophoblast. The stem cells derived from the ICM and ...
... dedifferentiation or self-renewal of ES cells". Nature Genetics. 24 (4): 372-6. doi:10.1038/74199. PMID 10742100. S2CID ... embryonic stem cell lines (which are cell lines derived from the inner cell mass), and induced pluripotent stem cells. While ... "Oct4 expression is not required for mouse somatic stem cell self-renewal". Cell Stem Cell. 1 (4): 403-15. doi:10.1016/j.stem. ... "Oct-4 expression in adult human differentiated cells challenges its role as a pure stem cell marker". Stem Cells. 25 (7): 1675- ...
2,4-D is used in plant cell cultures as a dedifferentiation (callus induction) hormone. It is classified as an auxin plant ... Endreb, Rudolf (1994). Plant Cell Biotechnology. Germany: Springer. pp. 17, 18. ISBN 978-0-387-56947-5. NIOSH. Updated June ... 4-D has been used in laboratories for plant research as a supplement in plant cell culture media such as MS medium since at ...
"Up-regulation of neural stem cell markers suggests the occurrence of dedifferentiation in regenerating spinal cord". ... Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. Stem cells can ... 2005). "Somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors". Stem Cells. 23 (6 ... Hirao A, Arai F, Suda T (December 2004). "Regulation of cell cycle in hematopoietic stem cells by the niche". Cell Cycle. 3 (12 ...
... however callus and somatic embryos are derived from mesophyll cells that undergo dedifferentiation. Plant hormones are used to ... Plant callus (plural calluses or calli) is a growing mass of unorganized plant parenchyma cells. In living plants, callus cells ... Regeneration of a whole plant that has some genetically transformed cells and some untransformed cells yields a chimera. In ... In Jatropha curcas callus cells, small organized callus cells became disorganized and varied in size after browning occurred. ...