An organic cation transport protein mediates the transport of organic cations across the cell membrane. These proteins are ... This family of proteins can also transport zwitterions and anions, though it is a different subfamily of solute carrier ... proteins than the organic anion transporters. (Solute carrier family, Transmembrane transporters, Transport proteins). ...

One transport protein or many?". Pharmacology & Therapeutics. 239: 108283. doi:10.1016/j.pharmthera.2022.108283. PMID 36162727 ... Cocaine crosses the blood-brain barrier via a proton-coupled organic cation antiporter and (to a lesser extent) via passive ... Cocaine crosses the blood-brain barrier via both a proton-coupled organic cation antiporter and (to a lesser extent) via ... It also functions on the binding sites to the dopamine and serotonin sodium dependent transport area as targets as separate ...

K. muelleri" makes include a couple of transport proteins; the microbe creates organic cation transport proteins, antibiotic- ... Of the 227 different polypeptides, 99 of them are enzymes and another 9 are transport proteins. The GC-content is 22.4%. A ... The tree was constructed by comparing the peptide sequences of ten different types of proteins. The proteins used were the DNA ... 21.3% of its protein-coding genes are dedicated to creating amino acids, while another 33% is dedicated to translation-related ...

October 2008). "Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1". ... "Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein". Journal of Medicinal Chemistry. 46 (17): ...

... transporting one sodium ion with one molecule of carnitine. Organic cations transported by this protein include ... SLC22A5 is a membrane transport protein associated with primary carnitine deficiency. This protein is involved in the active ... an organic cation/carnitine transporter, with differential effects on the organic cation transport function and the carnitine ... The SLC22A5 gene codes for a plasma integral membrane protein which functions as both an organic cation transporter and a ...

Organic cation transport proteins Organic anion-transporting polypeptide Solute carrier family Osmoregulation Organic anion ... Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane proteins). ... The generalized transport reaction catalyzed by OSTα/OSTβ is: organic anion (out) ⇌ organic anion (in) Each transport system ... The two proteins are highly expressed in many human tissues. The β-subunit is not required to target the α-subunit to the ...

Some examples of proteins that mediate this process are glucose transporters, organic cation transport proteins, urea ... The carrier protein at the membrane binds to the glucose and alters its shape such that it can easily to be transported. ... the transport relies on molecular binding between the cargo and the membrane-embedded channel or carrier protein. the rate of ... Their transport must therefore be "facilitated" by proteins that span the membrane and provide an alternative route or bypass ...

... or a transport protein. It also serves as an important regulator in a variety of surface proteins, both on the cell surface and ... Putrescine serves an important role in a multitude of ways, which include: a cation substitute, an osmolyte, ...

Solute carrier family Organic cation transport proteins GRCh38: Ensembl release 89: ENSG00000175003 - Ensembl, May 2017 GRCm38 ... This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains ... Solute carrier family 22 member 1 is a protein that in humans is encoded by the gene SLC22A1. Polyspecific organic cation ... "Properties and regulation of organic cation transport in freshly isolated human proximal tubules". The Journal of Biological ...

... the ANDI/netCDF scientific data interchange file format Cation diffusion facilitator, transport protein Channel Definition ...

... or OCT may refer to: Optical coherence tomography, an imaging method Organic cation transport protein, a type of protein ...

... sodium-independent organic cation transport proteins (OCTs) and/or carnitine/organic cation transporters (OCTNs), and do not ... Choline kinase (CK) is a cytosolic protein that catalyzes the following reaction:: 418 choline + ATP ⇌ phosphocholine + ADP In ... Michel V, Yuan Z, Ramsubir S, Bakovic M (May 2006). "Choline transport for phospholipid synthesis". Experimental Biology and ... which include the choline transporter-like protein 1 (CTL1). The fate of internalized choline depends on the cell type. In pre- ...

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic ... Potassium-transporting ATPase alpha chain 2 is a protein that in humans is encoded by the ATP12A gene. ... "ATP12A - Potassium-transporting ATPase alpha chain 2 - Homo sapiens (Human) - ATP12A gene & protein". www.uniprot.org. ... 2002). "Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1". Am. J. Physiol ...

... altering cellular functions and ultimately influencing cation transport through the plasma membrane and stimulating the proton ... Metabolic: protein catabolism which causes negative nitrogen balance. Musculoskeletal: muscle weakness, loss of muscle mass, ... The metabolic effects of taking methylprednisolone involve the continuous breakdown of proteins for gluconeogenesis increase ... This association changes physiochemical properties of the membrane; activating membrane proteins, ...

... a molecule that transports a single potassium cation. Carrier ionophores may be proteins or other molecules. Channel formers ... Gräfe, U.; Reinhardt, G.; Miosga, N. (1989). "Monovalent cation specificity of passive transport mediated by laidlomycin and 26 ... Ionophores facilitate the transport of ions across biological membranes most commonly via passive transport, which is affected ... Many ionophores are lipid-soluble entities that transport ions across the cell membrane. Ionophores catalyze ion transport ...

... of transport proteins includes members that function as solute:cation symporters and solute:solute antiporters. They occur in ... Protein families, Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane ... The larger eukaryotic and archaeal proteins possess N- and C-terminal hydrophilic extensions. Some animal proteins, for example ... APC Superfamily Transporter Classification Database Membrane transport protein Saier MH (August 2000). "Families of ...

"The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis". PLOS ONE. 10 (10): e0137184. Bibcode: ... Note that this family differs from the calcium:cation antiporter (CaCA) family which belongs to the cation diffusion ... Portal: Biology v t e (Protein families, Solute carrier family, All stub articles, Membrane protein stubs). ... CaCA2 family proteins are found in bacteria, archaea, yeast, plants and animals. This family, previously called the ...

TrkH from Escherichia coli is a transmembrane protein and determines the specificity and kinetics of cation transport by the ... This protein family consists of various potassium transport proteins (Trk) and V-type sodium ATP synthase subunit J or ... This protein interacts with TrkA and requires TrkE for transport activity. Schlosser A, Meldorf M, Stumpe S, Bakker EP, Epstein ... determine the specificity and kinetics of cation transport by the Trk system of Escherichia coli". J. Bacteriol. 177 (7): 1908- ...

... escort protein, acid transport protein, cation transport protein, or anion transport protein) is a protein that serves the ... A membrane transport protein (or simply transporter) is a membrane protein that acts as such a carrier. A vesicular transport ... There are several different kinds of transport proteins. Carrier proteins are proteins involved in the movement of ions, small ... Carrier proteins are integral membrane proteins; that is, they exist within and span the membrane across which they transport ...

Protein families, Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane ... The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC# 2.A.36) is a large family of proteins derived from Gram-positive ... M4 and M9 therefore contain critical sites for both drug and cation recognition. The generalized transport reaction catalyzed ... The bacterial proteins have 520-550 amino acyl residues (aas) while eukaryotic proteins are generally larger, varying in size ...

The generalized transport reaction for Na+ channels is: Na+ (out) → Na+ (in) That for the degenerins is: Cation (out) → cation ... CFTR is a transmembrane channel responsible for chloride transport and defects in this protein cause cystic fibrosis, partly ... "ATP-gated P2X Receptor Cation Channel (P2X Receptor) Family". Functional and Phylogenetic Classification of Membrane Transport ... Toczyłowska-Mamińska R, Dołowy K (February 2012). "Ion transporting proteins of human bronchial epithelium". Journal of ...

Many ionophores are lipid-soluble proteins that catalyze the transport of monovalent and divalent cations across the ... active site active transport Transport of a substance (such as a protein or drug) across a cell membrane against a ... but transfer from protein to protein, or from protein back to either type of nucleic acid, is impossible and does not occur ... homodimer A protein or protein domain composed of two identical polypeptides which are paired with each other in the quaternary ...

Protein families, Protein domains, Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, ... The Nucleobase:Cation Symporter-1 (NCS1) Family (TC# 2.A.39) consists of over 1000 currently sequenced proteins derived from ... providing the structural basis of the alternating access model for membrane transport. NCS1 proteins are H+/Na+ symporters ... The latter three proteins are likely to be closely related thiamin permease isoforms. The yeast cytosine-purine and vitamin B6 ...

... but efficiency of transport for organic cations (e.g., tetraethylammonium) is very low. The transport efficiency for carnitine ... The first functional designation of this protein was OCTN1 ("organic cation transporter, novel, type 1"), ... The encoded protein is an integral protein of the plasma membrane containing 12 transmembrane segments. ... and pH-dependent transport of organic cations". The Journal of Pharmacology and Experimental Therapeutics. 289 (2): 768-73. ...

The protein encoded by ATP10A belongs to the family of P-type cation transport ATPases, and to the subfamily of ... "ATP10A - Phospholipid-transporting ATPase VA - Homo sapiens (Human) - ATP10A gene & protein". www.uniprot.org. Retrieved 9 ... Phospholipid-transporting ATPase VA also known as ATPase class V type 10A or aminophospholipid translocase VA is an enzyme that ... The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31-9. doi ...

Chen Y, Zhang S, Sorani M, Giacomini KM (2007). "Transport of paraquat by human organic cation transporters and multidrug and ... 2007). "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations". Trends Pharmacol. Sci. 27 ( ... 2006). "A human transporter protein that mediates the final excretion step for toxic organic cations". Proc. Natl. Acad. Sci. U ... Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans ...

July 2008). "The DHR1 Domain of DOCK180 Binds to SNX5 and Regulates Cation-independent Mannose 6-phosphate Receptor Transport ... Dedicator of cytokinesis protein 1 (Dock1), also (DOCK180), is a large (~180 kDa) protein encoded in the human by the DOCK1 ... Subsequently it was reported that DOCK180 was able to activate the small GTP-binding protein (G protein) Rac1 and this was ... and this interaction promoted retrograde transport of the cation-independent mannose 6-phosphate receptor to the trans-Golgi ...

The cation:proton antiporter (CPA) superfamily is a superfamily of transport proteins named after one of its constituent ... Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane proteins, Protein ... 2011). "Phylogenetic Characterization of Transport Protein Superfamilies: Superiority of SuperfamilyTree Programs over Those ... "Phylogeny as a guide to structure and function of membrane transport proteins". Molecular Membrane Biology. 21 (3): 171-181. ...

... cation exchangers or co-transport proteins). Stein collaborated with Felix Bronner, an authority on the physiology of calcium ... Cation occlusion is now considered an essential property of all ATP-driven cation pumps and also other coupled cation transport ... Intra-protein interactions across a fluid membrane as a model for biological transport. The Journal of general physiology 1969 ... Cotransport of salt and water in membrane proteins: membrane proteins as osmotic engines. J Membr Biol. 1994 Feb;137(3):179-95 ...

The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to ... This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the ... Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene. ... "The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of ...