Purchase (1982). "An appraisal of predictive tests for carcinogenicity". Mutation Research. 99 (1): 53-71. doi:10.1016/0165- ... The umu test, using only a single Salmonella strain, could potentially test a greater range of new chemicals with the same ... "Bacterial systems for carcinogenicity testing". Mutation Research. 87 (2): 191-210. doi:10.1016/0165-1110(81)90032-4. PMID ... A simple colorimetric test is possible by adding a lactose analog which is degraded by β-galactosidase, producing a colored ...

Hottendorf, Girard H. (1985). "Carcinogenicity Testing of Antitumor Agents". Toxicologic Pathology. 13 (3): 192-199. doi: ... Chlornaphazine was discontinued as a clinical drug due to sufficient evidence for carcinogenicity in humans. The drug caused ... Many studies have shown that rodents are inappropriate animal models to study the carcinogenicity of chlornaphazine due to ... "Lifetime carcinogenicity study of 1- and 2-naphthylamine in dogs". British Journal of Cancer. 44 (6): 892-901. doi:10.1038/bjc. ...

ICPEMC working paper 2/6. An appraisal of predictive tests for carcinogenicity". Mutat. Res. 99 (1): 53-71. doi:10.1016/0165- ... The test is performed over a few hours in columns of a 96-well microplate with increasing concentrations of test samples. This ... Mohn GR (September 1981). "Bacterial systems for carcinogenicity testing". Mutat. Res. 87 (2): 191-210. doi:10.1016/0165-1110( ... The test is a colorimetric assay which measures the expression of genes induced by genotoxic agents in Escherichia coli, by ...

The carcinogenicity is estimated by animal testing. The regulation of Sudan 1 in Europe started in 2003 after repeated ... The mutagenicity and genetic hazard has been evaluated with the Ames-test and animal experiments. Furthermore, it is suspected ... Comparisons between experimental animals and human Cytochrome P450 (CYP) strongly suggest animal carcinogenicity data can be ... Toxicology and toxicological testing of colorants. Review of Progress in Coloration and Related Topics 2005, 35 (1), 76-89 http ...

Tests of carcinogenicity in this range yielded differing results. It is moderately toxic to fish. "Extension Toxicology Network ...

... is not teratogenic and carcinogenicity and mutagenicity testing has proven inconclusive. King, Gregory S.; Smialek, John E.; ... but later studies showed that although the thinner was toxic there was no evidence of carcinogenicity. There were several ...

... was not generally active in short-term tests for genetic activity. There is sufficient evidence of its carcinogenicity in ... IARC (1979) evaluated mirex's carcinogenic hazard and concluded that "there is sufficient evidence for its carcinogenicity to ... the lowest dose tested. At higher dose levels, it is fetotoxic (25 mg/kg in diet) and teratogenic (6.0 mg/kg per day). ...

48, p-Chloro-o-Toluidine and its strong salts Weisburger E.K. et al., Testing of twenty-one environ. aromatic amines or ... Med., 1992, 49, 529-531 Stasik M.J., Current studies of 4-chloro-o-toluidine and chlordimeform carcinogenicity, 26th Intern. ... derivatives for long-term toxicity or carcinogenicity, J. Environ. Pathol. Toxicol., 1987, 2, 326-356 Bentley P. et al., ...

No tumors were observed in rat and mouse carcinogenicity studies up to the highest doses tested. In both the rat and mouse ... Prallethrin tested negative in the majority of the genotoxicity studies. It also tested negative in an in vitro chromosomal ... In the developmental studies, no toxic effects were noted in fetuses up to the highest doses tested. Maternal effects in the ... In the subchronic rat neurotoxicity study, a higher arousal rate was observed in animals at the highest dose tested. Clinical ...

In 1915, Yamaigiwa Katsusaburo and Koichi Ichikawa tested the carcinogenicity of coal tar using the inner surface of rabbit's ... These procedures, called whole effluent toxicity tests, include acute toxicity tests as well as chronic test methods. The ... Home pregnancy tests use ELISA to detect the increase of human chorionic gonadotropin (hCG) during pregnancy. HIV tests also ... Many early examples of bioassays used animals to test the carcinogenicity of chemicals. ...

PhIP has been tested for carcinogenicity in both mice and rats by oral administration. Increases in lymphomas were seen in mice ... PhIP was positive in bacterial (Ames) test and induced chromosomal abnormalities in human and Chinese hamster cells in vitro. ... for the carcinogenicity of PhIP. PhIP has been found in cooked beef, pork, chicken, and fish products. Exposure to PhIP depends ...

These newer materials have been tested for carcinogenicity and most are found to be noncarcinogenic. IARC elected not to make ... This decision was made in part because no human data were available, although such fibers that have been tested appear to have ... The findings in this volume are not a determination of non-carcinogenicity or overall safety.) IARC Monographs on the ... The International Agency for Research on Cancer (IARC) reviewed the carcinogenicity of man-made mineral fibers in October 2002 ...

It is widely used to test the respiratory toxicity of a substance as an alternative to inhalation in animal testing. ... Intratracheal instillation was reported as early as 1923 in studies of the carcinogenicity of coal tar. Modern methodology was ... Their results provide a quick screen of potential toxicity and can be used to test its mechanism, but may not be directly ... A wide range of substances can be tested, including both soluble materials and insoluble particles or fibers, including ...

... of bacterial mutagenicity as a screen for carcinogenicity confirmed the use of this methodology as a rapid and efficient test, ... The availability of such simpler tests in turn gave rise to greater government oversight and testing of compounds to which the ... Nomura, Taisei (1975). "Carcinogenicity of the food additive furylfuramide in foetal and young mice". Nature. 258 (5536): 610- ... This was confirmed later when animal testing found it to cause benign and malignant tumors in the mammary glands, stomachs, ...

Her dissertation, The Weighted Normal Plot II: Efficiency of Tests for Carcinogenicity, was supervised by Arthur P. Dempster. ...

Studies regarding the carcinogenicity of DCPA have produced mixed results. A study by ISK Biotech Corp. in 1993 showed DCPA ... Environmental Protection Agency testing in New York showed "measurable residues of DCPA and degradates" on land that had ... In the study done on these river basin locations, roughly 39% of the fish tested had stored DCPA concentrations that exceeded ... Rats whose mothers were exposed to DCPA during pregnancy had impaired higher-level learning test scores than those whose ...

The longer term toxicity and carcinogenicity is ambiguous. Eye and throat sensitivity can occur when high level exposure to ... Ethylbenzene exposure can be determined by testing for the breakdown products in urine. As of September 2007, the United States ...

The micronucleus test in vivo is similar to the in vitro one because it tests for structural and numerical chromosomal ... Cancer Carcinogen Carcinogenesis Carcinogenicity Mutagen Mutagenesis Kolle S (2012-06-01). "Genotoxicity and Carcinogenicity". ... In a specific mammalian tissue, one can perform a mouse lymphoma TK+/- assay to test for changes in the genetic material. Gene ... The Bacterial Reverse Mutation Assay, also known as the Ames Assay, is used in laboratories to test for gene mutation. The ...

Due to the lack of information, EPA has determined that HMX is not classifiable as to its human carcinogenicity. The available ... In one study, volunteers submitted to patch testing, which produced skin irritation. Another study of a cohort of 93 workers at ...

Theiss, Jeffrey C.; Stoner, Gary D.; Shimkin, Michael B.; Weisburger, Elizabeth K. (1977). "Test for Carcinogenicity of Organic ... EPA tested drinking water quality on commercial aircraft and found that 15 percent of tested aircraft water systems tested ... 86 FR 4198 Friedman, Lisa (2020-09-27). "E.P.A. to Promote Lead Testing Rule as Trump Tries to Burnish His Record". The New ... Improvements in chemical testing methods in the 1970s, particularly for synthetic organic chemicals, allowed for the detection ...

Since the 1960s, the animal most used in testing the carcinogenicity of tobacco smoke has been the Syrian Golden Hamster due to ... Although the carcinogenicity of tobacco smoke was first established in humans, various types of animals have also been exposed ... As set out in the IARC monographs, the carcinogenicity of cigarette smoke is determined in two ways. The first is through the ... Once the condensate is collected, it is painted onto the skin of the animal test subjects, which are then examined at set ...

In a 1977 study using a human maximization test, 76% of subjects acquired a contact sensitization to benzoyl peroxide. ... A 1999 IARC review of carcinogenicity studies found no evidence linking BPO acne medication to skin cancers in humans. However ...

Ten diets were tested separately on the males and females. The diets comprised 11 percent, 22 percent and 33 percent ... and 50 rats for carcinogenicity studies.: 5-6 In addition, if the survival of the rats is less than 50% at 104 weeks (which is ... A 2015 reanalysis of multiple animal studies found that Seralini chose to forgo statistical tests in the main conclusions of ... For the study to achieve such separation (statistical power), each control and test group would have to include sufficiently ...

The carcinogenicity was tested on rats in mice, via intraperitoneal administration and subcutaneous administration, of newborns ... 1,2-Dihydroxynaphthalene has been used as a potential biomarker of excessive exposure to naphthalene levels and was tested on ... however the tests were considered inefficient to substantiate a diagnosis resulting in naphthalene as a potential carcinogen ... as there is inadequate evidence in humans for the carcinogenicity of naphthalene, however there is sufficient evidence in ...

These results strongly suggest that there is a threshold for the carcinogenicity of nickel sulfate via inhalation. In a 2-year ... In 2005-2006, nickel sulfate was the top allergen in patch tests (19.0%). Nickel sulfate is classified as a human carcinogen ... Heim, K. E.; Bates, H. K.; Rush, R. E.; Oller, A. R. (2007). "Oral Carcinogenicity Study with Nickel Sulfate Hexahydrate in ... The human and animal data consistently indicate a lack of carcinogenicity via the oral route of exposure and limit the ...

This is in accord with ICH guidelines, which do not require carcinogenicity testing in nongenotoxic drugs intended for ... Eder R (20 April 1982). "Birth control: 4-day pill is promising in early test". The New York Times. p. C1. Archived from the ... In October 1981, Étienne-Émile Baulieu, a consultant to Roussel-Uclaf, arranged tests of its use for medical abortion in 11 ... Gordon M (22 March 2019). "Controversial 'Abortion Reversal' Regimen Is Put To The Test". NPR. Archived from the original on 18 ...

These rodent tests may not directly translate to carcinogenicity in humans, as the observed mechanism of cancer involves the ... Laboratory tests by the U.S. National Toxicology Program have shown that only sustained exposure to high concentrations (100- ...

In scientific tests, only about 10% of people could detect a field intensity in the range of 2-5 kV/m. Such voltage differences ... for human carcinogenicity. Shortwave (1.6 to 30 MHz) diathermy (where EM waves are used to produce heat) can be used as a ... When receiving such a shock at 5 kV/m, it was reported as painful by only 7% of test participants and by 50% of participants at ... In 2019, reporters from the Chicago Tribune tested the level of radiation from smartphones and found that certain models ...

It is highly potent in its progestogenic activity, with about 330 times the potency of progesterone in the Clauberg test and ... CMA appears to show less potential for liver genotoxicity and carcinogenicity than CPA in bioassays. This seems to be related ... No abnormalities in liver function tests have been observed in women taking combined birth control pills containing CMA or CPA ...

Achieved a high level of accuracy in carcinogenicity testing for drugs and reduced the testing period to six months from the ... ICLAS Monitoring Center was established in the CIEA in 1979 and is the only center in the world for testing and verifying the ... used as a safety testing for oral polio vaccine. Establishment of Tg-rasH2 mouse, in which a human prototype c-Ha-ras oncogene ... and development of its applications to various animal experiments and testing systems. ...