Calcitonin
Wikimedia Commons has media related to Calcitonin. The Calcitonin Protein Calcitonin at the U.S. National Library of Medicine ... Calcitonin has clinically been used for metabolic bone disorders for more than 50 years. Salmon calcitonin is used for the ... Calcitonin also has significantly impacted molecular biology, as the gene encoding calcitonin was the first gene discovered in ... Calcitonin is secreted into the milk. Calcitonin was extracted from the ultimobranchial glands (thyroid-like glands) of fish, ...
Calcitonin receptor
The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in ... Pondel M (December 2000). "Calcitonin and calcitonin receptors: bone and beyond". International Journal of Experimental ... Calcitonin+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Webarchive template wayback ... Nakamura M, Hashimoto T, Nakajima T, Ichii S, Furuyama J, Ishihara Y, Kakudo K (April 1995). "A new type of human calcitonin ...
Calcitonin gene-related peptide
... (CGRP) is a member of the calcitonin family of peptides consisting of calcitonin, amylin, ... The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors". Pharmacological Reviews. 54 ... adrenomedullin, adrenomedullin 2 (intermedin) and calcitonin‑receptor‑stimulating peptide. Calcitonin is mainly produced by ... Regulation of the calcitonin gene-related peptide (CGRP) gene is in part controlled by the expression of the mitogen-activated ...
Calcitonin gene-related peptide receptor antagonist
Calcitonin gene-related peptide (CGRP) receptor antagonists are a class of drugs that act as antagonists of the calcitonin gene ... Nakasa, T; Ishikawa, M; Takada, T; Miyaki, S; Ochi, M (2015). "Attenuation of cartilage degeneration by calcitonin gene-related ... v t e (CS1 German-language sources (de), Antimigraine drugs, Receptor antagonists, Calcitonin gene-related peptide receptor ... an Oral Calcitonin Gene Related Peptide Receptor Antagonist". British Journal of Clinical Pharmacology. 79 (5): 831-7. doi: ...
Calcium cycle
"Calcitonin , You and Your Hormones from the Society for Endocrinology". www.yourhormones.info. Retrieved 2018-10-04. "What's ... Excess calcium then promotes the release of calcitonin from the thyroid gland, effectively reversing the process of PTH. ...
Receptor activity-modifying protein
When associated with the Calcitonin receptor (CTR) or Calcitonin receptor-like (CALCRL) (below), RAMPs can change the ... "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... "Calcitonin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ... calcitonin (CT), glucagon, and vasoactive intestinal peptide (VIP). There are three distinct types of RAMPs in mammals (though ...
RAMP1
"Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like ... "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... "Calcitonin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ... The RAMP1 protein can also interact with the calcitonin receptor (CT) protein, where heteromerisation of RAMP1 with CT converts ...
Ultimopharyngeal body
These secrete calcitonin. In other animals, the ultimopharyngeal body may produce calcitonin. The ultimopharyngeal body may not ... In humans, it develops from the fourth pharyngeal pouch into the parafollicular cells of the thyroid to produce calcitonin. It ... Agathos EA, Tomos PI, Kostomitsopoulos N, Koutsoukos PG (February 2019). "Calcitonin as an anticalcification treatment for ...
Vertebral compression fracture
"Calcitonin for osteoporotic fractures". Archived from the original on 2009-06-08. Retrieved 2012-09-03. Knopp, Jennifer A.; ... For osteoporotic patients, calcitonin may be helpful. Kyphoplasty and vertebroplasty are minimally invasive procedures that ... Diner, Barry M.; Blitz, Maurice; Lyritis, George P.; Rowe, Brian H. (2004). "Calcitonin for treating acute pain of osteoporotic ...
1964 in science
Foster, G. V.; Baghdiantz, A.; Kumar, M. A.; Slack, E.; Soliman, H. A.; MacIntyre, I. (1964). "Thyroid origin of Calcitonin". ... June 27 - Iain Macintyre's group reports it has isolated and sequenced the newly-discovered hormone calcitonin and demonstrates ...
Salcatonin
Synthetic salmon calcitonin may be used therapeutically in humans, as it is twenty times more active than human calcitonin and ... The structure of human calcitonin and salcatonin is as follows: Human calcitonin: H-Cys1-Gly-Asn-Leu-Ser-Thr-Cys7-Met-Leu-Gly- ... Calcitonin, as salmon calcitonin (sCT), is available in the pharmaceutical market as an injectable preparation for intravenous ... Salcatonin is the type of calcitonin hormone found in salmon. Similar to humans, salmon calcitonin is a peptide hormone ...
Iain Macintyre
Macintyre's laboratory also purified and then sequenced both porcine calcitonin and human calcitonin. His team also ... Along with H. R. Morris he isolated and sequenced calcitonin gene-related peptide. Later research centred on the role played by ... Copp, D. Harold; Cameron, E. C.; Cheney, Barbara A.; Davidson, A. George F.; Henze, K. G. (1962). "Evidence for Calcitonin-A ... Shortly after the hormone calcitonin had been described by Harold Copp, Macintyre's team was the first to isolate and sequence ...
Failed back syndrome
Hollo I, Gergely I, Boross M (June 1977). "Smoking results in calcitonin resistance". JAMA. 237 (23): 2470. doi:10.1001/jama. ... Nicotine appears to interfere with bone metabolism through induced calcitonin resistance and decreased osteoblastic function. ...
Stanton Cohn
"Treatment of osteoporosis with calcitonin". Seminars in Drug Treatment. 2 (1): 21-5. PMID 5065516. Cohn, S.H; Shukla, K.K; ...
Cafedrine
Fenethylline Theodrenaline Morton IK, Hall JM (1999). "Calcitonin gene-related peptide receptor antagonist". Concise Dictionary ...
Parathyroid adenoma
The action of calcitonin opposes PTH. When a parathyroid adenoma causes hyperparathyroidism, more parathyroid hormone is ...
Sclerostin
June 2010). "Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes ... Sclerostin production is increased by calcitonin. Thus, osteoblast activity is self regulated by a negative feedback system. ...
Thyroid
Parafollicular cells produce calcitonin in response to high blood calcium. Calcitonin decreases the release of calcium from ... These cells secrete calcitonin and so are also called C cells. In the development of the embryo, at 3-4 weeks gestational age, ... Calcitonin plays a role in calcium homeostasis. Secretion of the two thyroid hormones is regulated by thyroid-stimulating ... The effects of calcitonin are opposite those of the parathyroid hormone (PTH) produced in the parathyroid glands. However, ...
Stanniocalcin
Unlike calcitonin, it also regulates phosphate level. It inhibits excretion of phosphate from the kidney. Stanniocalcin was ... By the mid 1970s, it was confirmed that the corpuscles secrete a factor that can reduce calcium level, similar to calcitonin ... Even though other calcium-decreasing hormone, calcitonin, is also present, these fishes require more efficient hormone as ...
Genta (company)
A randomized, double-blind comparison to calcitonin". Annals of Internal Medicine. 108 (5): 669-74. doi:10.7326/0003-4819-108-5 ... including injectable calcitonin and intravenous etidronate. Concurrent studies also suggested clinical activity in patients ...
AKTIP
Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (Jun 1996). "A cDNA encoding the calcitonin gene-related ... Fluhmann B, Muff R, Hunziker W, Fischer JA, Born W (Feb 1995). "A human orphan calcitonin receptor-like structure". Biochem ...
S100A12
Maayan C, Becker Y, Gesundheit B, Girgis SI (2002). "Calcitonin gene related peptide in familial dysautonomia". Neuropeptides. ...
Bone metastasis
A Cochrane review of calcitonin for the treatment of metastatic bone pain suggests calcitonin yields no significant benefit in ... Martinez-Zapata, MJ (2012). "Calcitonin used to treat metastatic bone pain". Cochrane Database Syst Rev. 2006 (3): CD003223. ...
Parathyroid hormone
PTH is secreted when [Ca2+] is decreased (calcitonin is secreted when serum calcium levels are elevated). The G-protein-coupled ... Its action is opposed by the hormone calcitonin. There are two types of PTH receptors. Parathyroid hormone 1 receptors, ...
Susan Brain
Brain, S. D.; Williams, T. J.; Tippins, J. R.; Morris, H. R.; MacIntyre, I. (1985). "Calcitonin gene-related peptide is a ... In her early career she discovered the Calcitonin gene-related peptide receptor antagonist (CGRP) as a potent microvascular ...
Frans van Buchem
Van Buchem, FS (1970). "The pathogenesis of hyperostosis corticalis generalisata and calcitonin". Proceedings of the ...
Neurotransmission
ACh-calcitonin gene-related peptide (CGRP) co-release. Glutamate-dynorphin co-release (in hippocampus). Noradrenaline and ATP ...
Rodenticide
The hormone calcitonin is no longer commonly used. Other chemical poisons include: ANTU (α-naphthylthiourea; specific against ...
Endocrine gland
Calcitonin, produced by the parafollicular cells (C cells) of the thyroid gland in response to rising blood calcium levels, ... The parathyroid hormone is the antagonist of calcitonin. Parathyroid hormone release is triggered by falling blood calcium ...
Antimigraine drug
They are calcitonin gene-related peptide (CGRP) receptor antagonists. Gepants have been suggested to have less pain relief at 2 ... and Calcitonin-Gene-Related Peptide (CGRP) Receptor Monoclonal Antibodies". Pharmaceutics. 12 (12): 1180. doi:10.3390/ ...