Bence Jones protein
The Bence Jones protein was described by the English physician Henry Bence Jones in 1847 and published in 1848. Bernier, G. M ... Bence Jones protein is a monoclonal globulin protein or immunoglobulin light chain found in the urine, with a molecular weight ... Bence Jones proteins are present in 2/3 of multiple myeloma cases. The proteins are immunoglobulin light chains (paraproteins) ... "What Is a Bence-Jones Protein Test?". WebMD. Retrieved 27 September 2023. Hoffbrand V, Moss P, Pettit J (2006). Essential ...
Henry Bence Jones
Bence Jones protein Kyle, Robert A. (October 2001). "Henry Bence Jones - physician, chemist, scientist and biographer: A man ... Wikimedia Commons has media related to Henry Bence Jones. Henry Bence Jones at Who Named It? Dr Bence Jones and the History of ... In 1847, he described the Bence Jones protein, a globulin protein found in blood and urine, suggestive of multiple myeloma or ... Henry Bence Jones FRS (31 December 1813 - 20 April 1873) was an English physician and chemist. Bence Jones was born at ...
Antibody
... and their realization that this protein is the same as the Bence-Jones protein described in 1845 by Henry Bence Jones. Edelman ... Stevens FJ, Solomon A, Schiffer M (July 1991). "Bence Jones proteins: a powerful tool for the fundamental study of protein ... Edelman GM, Gally JA (August 1962). "The nature of Bence-Jones proteins. Chemical similarities to polypetide chains of myeloma ... and produce different intracellular and secretable proteins. They are also used in immunoprecipitation to separate proteins and ...
IGL@
Makino DL, Henschen-Edman AH, McPherson A (2006). "Four crystal forms of a Bence-Jones protein". Acta Crystallographica Section ... Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The ... v t e (Articles with short description, Short description matches Wikidata, Human genes, All stub articles, Protein stubs). ... IGLV5-52 IGLV6-57 IGLV7-43 IGLV9-49 IGLV10-54 Ig lambda chain C regions is a protein that in humans is encoded by the IGLC2 ...
Bone tumor
Urine may be sent for Bence Jones protein. Other tests that might be requested include a CT scan, MRI, PET scan and bone ... Urine may be tested for Bence Jones protein. For confirmation of diagnosis, a biopsy for histological evaluation might be ...
Serum free light-chain measurement
Meittinen, TA (1967). "Effect of imparied hepatic and renal function in [131I] Bence Jones Protein catabolism in human subjects ... 1 April 2002). "Correlation of serum immunoglobulin free light chain quantification with urinary Bence Jones protein in light ... Bence Jones protein). The passage of large amounts of immunoglobulin light chains through the kidneys may cause inflammation or ... bence jones protein catabolism in human subjects". Clinica Chimica Acta. 18 (3): 395. doi:10.1016/0009-8981(67)90036-8. Russo ...
IGKC
Titani K, Shinoda T, Putnam FW (1969). "The amino acid sequence of a kappa type Bence-Jones protein. 3. The complete sequence ... The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The ... Hilschmann N (1968). "[The complete amino acid sequence of Bence Jones protein Cum (kappa-type)]". Hoppe-Seyler's Z. Physiol. ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 2, Proteins, All stub ...
Schnitzler syndrome
The immunoglobulins may show up in the urine as Bence Jones proteins. Signs of inflammation are often present: these include an ... high levels of white blood cells or C-reactive protein. Other conditions which can cause periodic fevers, paraproteins or ... increased white blood cell count (leukocytosis) and a raised erythrocyte sedimentation rate and C-reactive protein. There can ...
List of Wesleyan University people
Kresge, Nicole; Simoni, Robert D.; Hill, Robert L. (November 9, 2007). "The Structure of Bence-Jones Proteins: the Work of ... and teacher Kaylie Jones - novelist Sebastian Junger (1984) - author of The Perfect Storm, War; DuPont-Columbia Award; Time ... Dow Jones & Company (1990-00); founding partner, ZelnickMedia (2001-11); founding partner, Empirical Media Advisors (since 2011 ...
AL amyloidosis
An abnormal light chain in urine is known as Bence Jones protein. AL amyloidosis can affect a wide range of organs, and ... Daratumumab, a monoclonal antibody to CB38, a protein that is expressed on plasma cells, was approved in US and EU for AL ... The tissue is stained with red dye, and under a microscopic examination, amyloid proteins can be detected if the tissue turns ... The disease is caused when a person's antibody-producing cells do not function properly and produce abnormal protein fibers ...
Serum protein electrophoresis
As a positive acute phase reactant, AAT is increased in acute inflammation.[citation needed] Bence Jones protein may bind to ... The net charge on a protein is based on the sum charge of its amino acids, and the pH of the buffer. Proteins are applied to a ... Of note, any protein migrating in the gamma region will be stained and appear on the gel, which may include protein ... Serum protein electrophoresis (SPEP or SPE) is a laboratory test that examines specific proteins in the blood called globulins ...
Myeloma protein
Monoclonal free light chains in the serum or urine are called Bence Jones proteins. Blood serum paraprotein levels of more than ... Other terms for such a protein are monoclonal protein, M protein, M component, M spike, spike protein, or paraprotein. This ... Paraproteins form a narrow band, or 'spike' in protein electrophoresis as they are all exactly the same protein. Unlike normal ... A myeloma protein is an abnormal antibody (immunoglobulin) or (more often) a fragment thereof, such as an immunoglobulin light ...
Uromodulin
... mainly consisting of immunoglobulin light chain known as Bence Jones protein, but often also containing Tamm-Horsfall protein. ... Huang ZQ, Kirk KA, Connelly KG, Sanders PW (December 1993). "Bence Jones proteins bind to a common peptide segment of Tamm- ... When this protein is concentrated at low pH, it forms a gel. Uromodulin represents the most abundant protein in normal human ... Tamm-Horsfall protein)--the most abundant protein in mammalian urine". Biochimica et Biophysica Acta (BBA) - Gene Structure and ...
Kabat numbering scheme
Wu, Tai Te; Kabat, Elvin A. (1970-08-01). "An Analysis of the Sequences of the Variable Regions of Bence Jones Proteins and ... The basis for the Kabat numbering scheme was laid out by a 1970s paper aligning 77 Bence-Jones protein sequences. This analysis ... who started collecting and aligning amino acid sequences of human and mouse Bence Jones proteins and immunoglobulin light ...
Urinalysis
... but they are markedly less sensitive to other proteins, such as Bence-Jones protein, which may occur in multiple myeloma. ... In multiple myeloma, Bence-Jones protein may be secreted into the urine, although this type of proteinuria is not as easily ... may be used to investigate the cause of proteinuria and to detect Bence-Jones protein. During pregnancy, dipstick testing may ... Urine protein electrophoresis, which identifies and measures the proportions of different types of protein in the urine, ...
Elvin A. Kabat
In 1969, he started collecting and aligning the amino acid sequences of human and mouse Bence Jones proteins and immunoglobulin ...
Frank W. Putnam
The majority of his career dealt with the study of the Bence-Jones proteins and their relation to the molecular structure of ... Putnam's research focused on the structure and function of blood proteins associated with the development of immunity to ... His early research involved the development of methods for determining the molecular structure of proteins. Later, Putnam's ...
Monoclonal gammopathy
... or Bence Jones protein). This may be associated with multiple myeloma or AL amyloidosis. Heavy chains only (also known as " ... where they take the name of Bence Jones protein.[citation needed] It is also possible for paraproteins (usually whole ... in the serum protein electrophoresis because there will be an excess of production of one protein. There are two large classes ... AL amyloidosis These are characterized by the presence of any abnormal protein that is involved in the immune system, which are ...
Armand Trousseau
... an archaic synonym for Bence Jones proteins). He is sometimes credited with the quip "use new drugs quickly, while they still ...
John Dalrymple (physician)
... in the discovery of the albumin that was to become known as Bence Jones protein. This protein is often found in the blood and ... Ophthalmology Hall of Fame (biography of John Dalrymple) The Discovery of Bence Jones Protein (Articles incorporating Cite DNB ... Dalrymple is remembered for his histological work done with Henry Bence Jones (1814-1873) ...
List of MeSH codes (D12.776)
... bence jones protein MeSH D12.776.377.715.548.900.225 - cryoglobulins MeSH D12.776.377.715.548.900.500 - myeloma proteins MeSH ... groel protein MeSH D12.776.602.500.500.100 - fusion proteins, bcr-abl MeSH D12.776.602.500.500.320 - fusion proteins, gag-onc ... oncogene protein v-maf MeSH D12.776.964.700.750.875 - oncogene proteins v-abl MeSH D12.776.964.700.750.882 - oncogene proteins ... fusion proteins, gag-pol MeSH D12.776.964.775.350.400 - hiv core protein p24 MeSH D12.776.964.775.375.325 - fusion proteins, ...
BJP (disambiguation)
BJP may also refer to: Bangladesh Jatiya Party, a Bangladeshi political party Bence Jones protein, a biomolecule Bharatiya ...
List of MeSH codes (D12.776.124)
... bence jones protein MeSH D12.776.124.486.485.900.225 - cryoglobulins MeSH D12.776.124.486.485.900.500 - myeloma proteins MeSH ... bence jones protein MeSH D12.776.124.790.651.900.225 - cryoglobulins MeSH D12.776.124.790.651.900.500 - myeloma proteins MeSH ... complement c1 inactivator proteins MeSH D12.776.124.486.274.920.250.500 - complement c1 inhibitor protein MeSH D12.776.124.486. ... This list covers blood proteins. For other protein-related codes, see List of MeSH codes (D12.776). Codes before these are ...
Monoclonal gammopathy of undetermined significance
... check the urine for Bence Jones protein and perform a bone marrow biopsy. If none of these tests are abnormal, a patient with ... Several other illnesses can present with a monoclonal gammopathy, and the monoclonal protein may be the first discovery before ... The protein electrophoresis test should be repeated annually, and if there is any concern for a rise in the level of monoclonal ... is a plasma cell dyscrasia in which plasma cells or other types of antibody-producing cells secrete a myeloma protein, i.e. an ...
Signal transduction
Biochemical experiments revealed that these so-called Bence Jones proteins consisted of 2 discrete domains -one that varied ... Most commonly, protein phosphorylation is catalyzed by protein kinases, ultimately resulting in a cellular response. Proteins ... Other activated proteins interact with adaptor proteins that facilitate signaling protein interactions and coordination of ... An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications ...
Immunoglobulin light chain
... can be called Bence Jones protein when detected in the urine, although there is a trend to refer to these as urinary free light ... that is important for binding antigen The approximate length of a light chain protein is from 211 to 217 amino acids. The ...
St George's, University of London
Mayor of Cambridgeshire and Peterborough Henry Bence Jones (1813-1873), English physician, described Bence Jones protein ...
Geraldine Ferraro
... a form of blood cancer where plasma cells secrete abnormal antibodies known as Bence-Jones proteins, which can cause bones to ...
Proteinuria
False negatives may also occur if the protein in the urine is composed mainly of globulins or Bence Jones proteins because the ... Albumin is a protein produced by the liver which makes up roughly 50%-60% of the proteins in the blood while the other 40%-50% ... Protein dipstick measurements should not be confused with the amount of protein detected on a test for microalbuminuria which ... Traditionally, dipstick protein tests would be quantified by measuring the total quantity of protein in a 24-hour urine ...
Dash
... the Lennard-Jones potential [hyphen] is named after one person (John Lennard-Jones), as are Bence Jones proteins and Hughlings ...