Li N, Workman CJ, Martin SM, Vignali DA (Dec 2004). "Biochemical analysis of the regulatory T cell protein lymphocyte ... Maçon-Lemaître L, Triebel F (Jun 2005). "The negative regulatory function of the lymphocyte-activation gene-3 co-receptor ( ... molecular analysis of the negative regulatory function of lymphocyte activation gene-3". Journal of Immunology. 169 (10): 5392- ... "T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of ...

Tumor-infiltrating B lymphocytes consist of various phenotypes, including both effector and regulatory B cells. IL-10 or ... Regulatory B cells (Bregs or Breg cells) represent a small population of B cells that participates in immunomodulation and in ... Resting B lymphocytes do not produce cytokines. After the response to antigen or different stimuli such as lipopolysaccharide ( ... Likewise, regulatory B cell subsets have also been demonstrated to inhibit Th1 responses through IL-10 production during ...

Ley K, Smith E, Stark MA (2006). "IL-17A-producing neutrophil-regulatory Tn lymphocytes". Immunologic Research. 34 (3): 229-42 ... May 2006). "Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells". Proceedings of the National ... Increased concentration of IL-6 alters the epidermal environment by decreasing the ability of T regulatory cells to control the ... "First in the world regulatory approval of Novartis' Cosentyx(TM) in Japan for both psoriasis and psoriatic arthritis". Novartis ...

... is a regulatory protein on B lymphocytes. The cytoplasmic tail of CD72 contains two potential immunoreceptor tyrosine- ... These features suggest a negative regulatory role for CD72. CD72 is a nonredundant regulator of B-cell development and a ...

E proteins are involved in the development of lymphocytes. They initiate transcription by binding to regulatory E-box sequences ... E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. This ... E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and ... Quong MW, Romanow WJ, Murre C (2002). "E protein function in lymphocyte development". Annual Review of Immunology. 20: 301-22. ...

"Regulatory T‐lymphocytes mediate amyotrophic lateral sclerosis progression and survival". EMBO Molecular Medicine. 5 (1): 64-79 ... T regulatory (Treg) cells is also a safeguard against neuroinflammation, demonstrated by the evidence of inverse correlation of ... It is characterised by the activation of microglia and astrocytes, T lymphocyte infiltration, and the production of pro- ...

Microscopic examination will show infiltration of lymphocytes and plasma cells. The lymphocytes are predominately T-lymphocytes ... This gene is the second major immune-regulatory gene related to autoimmune thyroid disease. CTLA-4 gene polymorphisms may ... Thyroid autoantibodies appear mostly with the presence of lymphocytes in the targeted organ. Lymphocytes produce antibodies ... It is located on chromosome 1p13 and expressed in lymphocytes. It acts as a negative regulator of T-cell activation. Mutation ...

TNFRSF25 is also highly expressed by FoxP3 positive regulatory T lymphocytes. TNFRSF25 is activated by a monogamous ligand, ... This receptor is expressed preferentially by activated and antigen-experienced T lymphocytes. ... stimulates profound and highly specific proliferation of FoxP3+ regulatory T cells from their 8-10% of all CD4+ T cells to 35- ... the majority of T cells that regularly encounter cognate antigen are FoxP3+ regulatory T cells. Stimulation of TNFRSF25, in the ...

regulatory T-lymphocytes have a limited capability to control these cells. In the late stage, the extent of inflammation ... They are also involved in intensification of the function of regulatory T-lymphocytes and in the induction of apoptosis of ... leukocytes and lymphocytes), and red blood cells. Although some of these microvesicle populations occur in the blood of healthy ... cytotoxic T-lymphocytes, because microvesicles released from a tumor cell contain Fas ligand and TRAIL. They prevent ...

... and regulatory T lymphocytes. Thus, CCL1 mainly acts as a chemoattractant for monocytes/macrophages, T lymphocytes, specially ... CCL1 is secreted by activated monocytes/macrophages, T lymphocytes and endothelial cells. CCL1 binds to the chemokine receptor ... most likely leading to an influx of lymphocytes and monocytes and thus to an adaptive immune response. Because CCL1 binds to ... Th2-differentiated T cells and a subset of T regulatory cells in vitro into inflammatory siter. It can also attract NK cells, ...

González-Amaro R, Marazuela M (April 2016). "T regulatory (Treg) and T helper 17 (Th17) lymphocytes in thyroid autoimmunity". ... This in turn results in temporary lymphocyte retention in the lymph organs. It is thought that retention of lymphocytes in the ... is involved in lymphocyte proliferation and functions as a signal-transmitting receptor in lymphocytes, including natural ... Most lymphocytes express sphingosine-1-phosphate receptors (S1P1-5), which are G protein-coupled receptors located in the cell ...

Interleukin 10 is produced by regulatory T lymphocytes, B cells, and monocytes. It is a homodimer that functions through the IL ... is involved in immuno-regulatory responses IL-24 produced by activated monocytes and T-cells. IL-26 is a newly discovered ...

These results strongly support the regulatory role of TIRC7 signalling pathway in lymphocytes. TCIRG1 mutations affect the a3 ... Upon lymphocyte activation TIRC7 is upregulated to engage HLA-DRα2 and induce apoptotic signals in human CD4+ and CD8+ T-cells ... The negative immune regulatory role of TIRC7 is furthermore supported by the fact that TIRC7 knock out mice exhibits an ... The induction of TIRC7 in IL-10 secreting T regulatory cells and the prevention of colitis in the presence of TIRC7 positive T ...

"Entrez Gene: SIPA1 signal-induced proliferation-associated gene 1". Minato N (1997). "[Regulatory mechanisms of lymphocyte ... It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. ...

Removal of sialic acid residues from the surface of tumor cells makes them available to NK cells and cytotoxic T lymphocytes ... Below is a table that listed known PRRs and interferon regulatory factors that are getting activated upon SeV infection. SeV ... Barnes BJ, Moore PA, Pitha PM (June 2001). "Virus-specific activation of a novel interferon regulatory factor, IRF-5, results ... The persistent infection can also be established instantly in interferon regulatory factor 3 (IRF-3)-knockdown cells. IRF-3 is ...

Accordingly, they are divided into natural and induced T regulatory cells. Natural T regulatory lymphocytes (tTregs, nTregs) ... June 2015). "Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors". ... July 2018). "Expanded autologous regulatory T-lymphocyte infusions in ALS: A phase I, first-in-human study". Neurology. 5 (4): ... Another regulatory T cell subset is Treg17 cells. Regulatory T cells are involved in shutting down immune responses after they ...

Fanzo JC, Hu CM, Jang SY, Pernis AB (February 2003). "Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF ... October 1996). "Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to ... IRF4 is necessary for effector function of T regulatory cells due to its role as a regulatory factor for BLIMP-1. IRF4 is an ... The expression of IRF4 is essential for the differentiation of T lymphocytes and B lymphocytes as well as certain myeloid cells ...

Later was shown that the effect of monoclonal antibodies is formation of regulatory T lymphocytes. It has been shown that ... was originally used by Gershon and Kondo in 1970 for suppression of naive lymphocyte populations by cells with regulatory ... During a tolerant state potential effector cells remain but are tightly regulated by induced antigen-specific CD4+ regulatory T ... Gershon, R. K.; Kondo, K. (May 1970). "Cell interactions in the induction of tolerance: the role of thymic lymphocytes". ...

NKT cell Journal Screening Nature glossary on murine NKT cells Nature Reviews Web Focus on regulatory lymphocytes (Webarchive ... While iNKT cells are not very numerous, their unique properties makes them an important regulatory cell that can influence how ... In addition there are subtypes specialized in T follicular helper-like function and IL-10 dependent regulatory functions. Once ... They engage in cross talk with other immune cells, like dendritic cells, neutrophils and lymphocytes. Activation occurs by ...

"Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice". PLOS ONE. 6 (7): e22464. Bibcode:2011PLoSO ... By a similar regulatory mechanism, the development of B10pro cells is inhibited by TGF-β and IFN-γ. Through their inhibitory ... B10 cells are a sub-class of regulatory B-cells (Breg cell) that are involved in inhibiting immune responses in both humans and ... Wu H, Su Z, Barnie PA (January 2020). "The role of B regulatory (B10) cells in inflammatory disorders and their potential as ...

"Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments". ... Put shortly the function of IL-2 is to stimulate the growth of helper, cytotoxic and regulatory T cells. IL-2 is a member of a ... Oct1 is expressed in T-lymphocytes and Oct2 is induced after cell activation. NFAT has multiple family members, all of them are ... On the other hand, IL-2/JES6-1 highly selectively stimulate regulatory T cells and they could be potentially useful for ...

"IRF8 interferon regulatory factor 8 [Homo sapiens (human)] - Gene - NCBI". "MAP2K1 mitogen-activated protein kinase kinase 1 [ ... Shukla V, Lu R (August 2014). "IRF4 and IRF8: Governing the virtues of B Lymphocytes". Frontiers in Biology. 9 (4): 269-282. ... Follicular lymphoma (FL) is a cancer that involves certain types of white blood cells known as lymphocytes. The cancer ... These cells normally occupy the follicles (nodular swirls of various types of lymphocytes) in the germinal centers of lymphoid ...

... a set of non-B-cell lymphocytes; 2) IRF8 (10-50% of cases) which encodes the interferon regulatory factor 8 protein, a protein ... The following lymphocyte disorders may be confused with but can be distinguished from PTFL based on the following points: ... "IRF4 interferon regulatory factor 4 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. "IGH immunoglobulin heavy ... "IRF8 interferon regulatory factor 8 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. "MAP2K1 mitogen-activated ...

Regulatory macrophages produce Interleukin 10, which can inhibit cytotoxic responses of other lymphocytes to cancer cell ... or regulatory. Regulatory-phenotype macrophages have only recently been recognized as an important contributor to tissue ... Regulatory macrophages do not fit into the M1/M2 classification system, and they display different markers. After receiving ... Similar molecules may cause development of an inhibitory, regulatory phenotype. A MAF can also alter the ability of macrophages ...

"Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family". J. ... Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene. SIRPG has also recently been ... PDBe-KB provides an overview of all the structure information available in the PDB for Human Signal-regulatory protein gamma ( ... "Entrez Gene: SIRPG signal-regulatory protein gamma". Kharitonenkov A, Chen Z, Sures I, et al. (1997). "A family of proteins ...

"Induction of antigen-specific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine ... protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis". Blood. 104 (1): 215-23. doi:10.1182/blood-2003-12-4295 ...

... on T lymphocytes: activation-dependent up-regulation and regulatory function". Eur. J. Immunol. 31 (4): 1173-80. doi:10.1002/ ... Together, CR3 and CR4 are involved in various functions of the T and B lymphocytes and NK cells. For instance, while both CR3 ... is a human cell surface receptor found on B and T lymphocytes, polymorphonuclear leukocytes (mostly neutrophils), NK cells, and ...

Self antigens, in the right context, form a regulatory T-cell population that protects self tissues from immune attack or ... Alternatively, macrophages and other cytotoxic lymphocytes consume or destroy cells by apoptotic signaling and present self- ... and B-lymphocytes). Normally, these APC 'present' class II receptor/antigens to a great many T-cells, each with unique T-cell ...

Many regulatory processes can lead to allelic exclusion. In one instance, one allele of the gene can become transcriptionally ... This phenomenon is most notable for playing a role in the development of B lymphocytes, where allelic exclusion allows for each ... This is significant as the co-expression of both alleles in B lymphocytes is associated with autoimmunity and the production of ... mature B lymphocyte to express only one type of immunoglobulin. This subsequently results in each B lymphocyte being able to ...

Moreno CS, Rogers EM, Brown JA, Boss JM (Jun 1997). "Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a ... "Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex". Molecular ... "Entrez Gene: RFX5 regulatory factor X, 5 (influences HLA class II expression)". Hake SB, Masternak K, Kammerbauer C, Janzen C, ... Steimle V, Durand B, Barras E, Zufferey M, Hadam MR, Mach B, Reith W (May 1995). "A novel DNA-binding regulatory factor is ...