Bi- and tri-cyclic aza compounds and their uses. ɑIC50 for displacement of [3H]cocaine. IC50 for cocaine = 67.8 ± 8.7 (nM) ... U.S. Patent 6,150,376 WO 0007994, Kozikowski, Alan P. & Smith, Miles P., "Novel bi- and tri-cyclic aza compounds and their uses ... N.B. In the case of both nocaine and pethidine, N-demethyl compounds are more toxic and have a decreased seizure threshold. ... Therefore it is to be expected that within different contexts a compound or chemical of the same name very possibly could be in ...
Aza-steroids. Part VII. 3-aza-A-homopregn-4a-ene and related compounds". Journal of the Chemical Society (Resumed): 3388. doi: ...
... (AzA) is an organic compound with the formula HOOC(CH2)7COOH. This saturated dicarboxylic acid exists as a white ... In a comparative review of effects of topical AzA, Salicylic acid, Nicotinamide, Sulfur, Zinc, and alpha-hydroxy acid, AzA had ... AzA inhibits tyrosinase. Azelaic acid is industrially produced by the ozonolysis of oleic acid. The side product is nonanoic ... The effectiveness of long term use is unclear, but it's been recommended that AzA be used for at least 6 months continuously ...
Silicon-nitrogen compounds with alternating silicon- ("sila") and nitrogen atoms ("aza") are designated as silazanes. Simple ... the compound would actually be named poly[aza(dimethylsilylene)], and according to the preliminary rules for inorganic ... After compounding, casting and curing, the thermoset material can be pyrolyzed in one step to give a ceramic component in high ... macromolecules catena-poly[(dimethylsilicon)-m-aza]. The labels normally used to describe the structure of silicones (M, D, T, ...
tosylimines react with α,β-unsaturated carbonyl compound to give allylic amines in the Aza-Baylis-Hillman reaction. Somewhat ... When R = H, the compound is a primary imine, when R is hydrocarbyl, the compound is a secondary imine. If this group is not a ... For obviously piperidine also belongs in the class of compounds that are sought by me, for which the name "imines" is indicated ... In the older literature, imine refers to the aza-analogue of an epoxide. Thus, ethylenimine is the three-membered ring species ...
... hence the prefix aza does not imply an aza compound, but refers to the scientific species name). Many more compounds, related ... Azadirachtin, a chemical compound belonging to the limonoid group, is a secondary metabolite present in neem seeds. It is a ... If the insect ingests the compound, the substance further inhibits digestive enzymes and could leave an aversive taste memory ... Hence, the first total synthesis was published over 22 years after the compound's discovery: this first synthesis was completed ...
... to form various N-heterocyclic compounds through the aza-Diels-Alder reaction. Nitroso compounds (R-N=O) can react with dienes ... Bradsher cycloaddition Wagner-Jauregg reaction Imine Diels-Alder reaction Aza-Diels-Alder reaction Diels-Alderases, enzymes ... Behr, Arno (2000). "Organometallic Compounds and Homogeneous Catalysis". Ullmann's Encyclopedia of Industrial Chemistry. doi: ...
In one study, a [4.5.5.5]fenestrane was synthesized with one carbon atom replaced by nitrogen because aza- compounds and their ... A fenestrane in organic chemistry is a type of chemical compound with a central quaternary carbon atom which serves as a common ... They can be regarded as spiro compounds twice over. Because of their inherent strain and instability, fenestranes are of ... salts are more likely to form crystalline compounds suitable for X-ray analysis than low-molecular-weight alkanes. In step 1 ...
This compound serves as a building block for macrocyclizations. Many kinds of aza crown ethers exist. Variable length linkers ... In organic chemistry, an aza-crown ether is an aza analogue of a crown ether (cyclic polyether). That is, it has a nitrogen ... 2.2.2-Cryptand is an aza-crown of the mixed ether-amine variety. The synthesis of aza crown ethers are subject to the ... Well-studied aza crowns include triazacyclononane (n = 3), cyclen (n = 4), and hexaaza-18-crown-6 (n = 6). Selected aza-crowns ...
... react with carbonyl compounds to give imines 24 (the aza-Wittig reaction), or undergo other transformations. Thermal ... Chemistry of Heterocyclic Compounds: A Series Of Monographs. New York, USA: John Wiley & Sons, Inc. doi:10.1002/0471221902. ... The azo-transfer compounds, trifluoromethanesulfonyl azide and imidazole-1-sulfonyl azide react with amines to give the ... On a new class of compounds in which nitrogen is substituted for hydrogen". Proceedings of the Royal Society of London. 13: 375 ...
In addition, aza-Friedel-Crafts reactions of furans, amidoalkylations of diazocarbonyl compounds, asymmetric ... For example, in a typical acyl substitution reaction, the starting carbonyl compound is coordinated to the catalyst through one ... Furthermore, analogous reactions involving oxyanion intermediates such as enolate addition to nitroso compounds or opening of ... attractive strategy since the anionic tetrahedral intermediates are better hydrogen-bond acceptors than the starting compound. ...
The word Azakhel Payan is a linguistic compound consisting of three words. Aza is probably the name of its founder. The word ... Instead, the name Aza Khel may derive from Za Khel, a town in Kondoz, Afghanistan. Azakhel Payan is bordered by the Cherat ... According to one theory, the name Aza Khel was given to the village by its founder. The founder may have been Raza Khan. Raza ... Khan, also spelled Aza Khan, is considered a legendary Afghan warrior.[by whom?] Raza Khan had seven brothers, one of whom was ...
Bis-(dimesitylboryl)-azaborine, a boron nitrogen aromatic compound similar in structure to 9-aza-10-boraanthracene, was shown ... 10-Dihydro-9-aza-10-boraanthracene as a Precursor for Various Boron- and Nitrogen-Containing π-Conjugated Compounds". Organic ... The compound overall is highly reactive to air and needs to be stored under inert atmosphere. For the boraacenes possessing an ... 9-aza-10-boraanthracene has peak absorption around 427 nm and broad emission around 513 nm, with HOMO-LUMO gap of 3.075 eV, ...
The prefix aza- is used in organic chemistry to form names of organic compounds where a carbon atom is replaced by a nitrogen ... While the above figure gives examples of 4-aza steroids, 6-aza steroids have also been developed by GSK, although none of these ... compounds, as yet, are available for sale commercially. IUPAC nomenclature of organic chemistry "Chemical Identifier Search , 4 ...
DEAD is an aza-dienophile and an efficient dehydrogenating agent, converting alcohols to aldehydes, thiols to disulfides and ... Safety hazards have resulted in rapid decline of DEAD usage and replacement with DIAD and other similar compounds. Diethyl azo ... It has also been used to generate aza-Baylis-Hillman adducts with acrylates. DEAD can be used for synthesis of heterocyclic ... Thus, in general DEAD is an aza-dienophile and dehydrogenating agent, converting alcohols to aldehydes, thiols to disulfides ...
... although other silver and copper compounds have been used. This added step allows for more precise control of iminium ion ... Thus the 3-aza Cope's large activation barriers are kinetically based. Research on both the 1 and 3-aza-Cope rearrangements has ... The 3-aza-Cope rearrangement (and thus also the 1-aza-Cope rearrangement, which goes through the same transition state) is ... The 3-aza-Cope reaction was discovered soon after the 2-aza-Cope rearrangement was identified, due to its analogous ...
The more recent x-ray crystal structure of 1-aza-3,5,7-trimethyladamantan-2-one is a good model for cationic tetrahedral ... compounds with donor groups that are poorly conjugated with the potential carbonyl group (e.g. cyclol) compounds with sulfur ... 3.0.co;2-u. Bell, R. P. (1966). "The reversible hydration of carbonyl compounds". Adv. Phys. Org. Chem. Advances in Physical ... The chart below shows the extent of hydration of some carbonyl compounds. Hexafluoroacetone is probably the most hydrated ...
... a village or town section in the Japanese addressing system Aza-, prefix used in chemistry to name compounds that contain a ... Aza or AZA may refer to: Aza, Azerbaijan, a village and municipality Azadkənd, Nakhchivan or Lower Aza, Azerbaijan Aza, ... Aza of Mannea, king, reigned c. 710-700 BC Alejandro De Aza (born 1984), Dominican baseball outfielder Vital Aza (1851-1912), ... Look up aza in Wiktionary, the free dictionary. ... AZA': drug and methylation inhibitor) Aza (slang), Nigerian ...
Aromatic compounds can also react in DAINV reactions, such as triazines and tetrazines. Other common classes of dienes are oxo ... and aza- butadienes. The key quality of a good DAINV diene is a significantly lowered HOMO and LUMO, as compared to standard DA ... DAINV reactions have been utilized for the synthesis of several natural products, including (-)-CC-1065, a parent compound in ... DAINV reactions often involve heteroatoms, and can be used to form heterocyclic compounds. This makes the DAINV reaction ...
... (1,4,8,11-tetraazacyclotetradecane) is an organic compound with the formula (NHCH2CH2NHCH2CH2CH2)2. Classified as an aza ... The compound was first prepared by the reaction of 1,3-dibromopropane and ethylenediamine. The compound features four secondary ...
... or imidazo[1,2-a][1,3,5]triazine is a heterocyclic aromatic organic compound that consists of a s-triazine ... However, in 5-aza-7-deazapurine, N-9 of five-membered ring does not bond with hydrogen. So 5-aza-7-deazapurine derivatives must ... 5-Aza-7-deazapurine nucleosides may have an oxo, thioxo, or a imine group. Notable derivatives of this molecule include 5-aza-7 ... "5-Aza-7-deazaguanine DNA: Recognition and Strand Orientation of Oligonucleotides Incorporating Anomeric Imidazo[1,2-a]-1,3,5- ...
Organic compound stubs). ... one is a 5-Aza-7-deazapurine base that is an isomer of guanine ... 5-Aza-7-deazaguanine or 2-aminoimidazo[1,2-a][1,3,5]triazin-4(1H)- ...
Organotin compounds, Heterocyclic compounds with 3 rings, Tin(IV) compounds, Atranes). ... Jurkschat, K.; Tzschach, A. (1984). "1-Aza-5-stanna-5,5-dimethylbicyclo[3.3.01,5] octan und 1-aza-5-stanna-5-methyltricyclo[3.3 ... A stannatrane (IUPAC: 1-aza-5-stannabicyclo[3.3.3]undecane) is a tin-based atrane belonging to the larger class of ... Evidence for a transannular donor−acceptor interaction in a tetraorganotin compound". Journal of Organometallic Chemistry. 315 ...
... and on-site feed and medical compounds. The zoo became an institutional member of the AZA in 1957. In 1965 Paul S. Chaffee was ... aza.org. AZA. Retrieved 27 June 2011. "Zoos and Aquariums of the World". waza.org. WAZA. Retrieved 27 June 2011. "Species". ... The zoo is accredited by the Association of Zoos and Aquariums (AZA) and is a member of the World Association of Zoos and ... AZA) officially recognized the park opening in 1929 as the Roeding Park Zoo. Only few animals were seen, but that number would ...
98%, 2018 Crown ether Cyclen, a similar molecule with N atoms (aza groups) instead of O atoms (ethers) (Chemical articles with ... multiple compound IDs, Multiple chemicals in an infobox that need indexing, Articles without KEGG source, ECHA InfoCard ID from ...
... to give an allylic alcohol Aza-Baylis-Hillman reaction, the reaction of an α,β-unsaturated carbonyl compound with an imine in ...
Convulsions in humans can be readily antagonized with this compound. Boorsma,. Meded. vits Lands Plant 1894, 13. Levya,; ... Several developed antidotes are aza-bridged bicyclic amine derivatives. An anesthetic, pentobarbital sodium, was often ... Pubchem.ncbi.nlm.nih.gov,. Aza-bridged bicyclic amine derivatives for use as novel cholinergic receptor ligands https://pubchem ... Pubchem.ncbi.nlm.nih.gov,. DIOSCORINE , C13H19NO2 - PubChem https://pubchem.ncbi.nlm.nih.gov/compound/442635#section=Chemical- ...
... the universal precursor for monoterpenoid indole alkaloid compounds. It also catalyses the formation of 12-aza-strictosidine, ... One such investigation found (21S)-12-aza-nacycline, a 12-aza-strictosidine derivative, to exhibit potent cytotoxicity to the ... Unlike the mechanisms behind the formation of several Pictet-Spengler compounds, a spiroindolenine intermediate containing a ... an important intermediate for cytotoxic alkaloids, from coupling secologanin with 7-aza-tryptamine. The enzyme is encoded by a ...
It is used as a reagent in the production of many organic compounds. It is often used in the Mitsunobu reaction, where it ... It has also been used to generate aza-Baylis-Hillman adducts with acrylates. It can also serve as a selective deprotectant of N ... One notable use of this compound is in the synthesis of Bifenazate (Floramite®).[citation needed] "luka DIAD on Sigma-Aldrich ... Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Articles without EBI source ...
It can also be used as a precursor for 5-aza-2′-deoxycytidine, a treatment for MDS patients. This compound slows the cell cycle ... Hydroxymethyl compounds, All stub articles, Biochemistry stubs). ...