... called an axonal spheroid, may result. Because axonal transport can be disrupted in a multitude of ways, axonal spheroids can ... The basic mechanism of fast axonal transport has been understood for decades but the mechanism of slow axonal transport is only ... it is likely that axonal transport is a key player in mediating pathology. Dysfunctional axonal transport is also linked to ... Intraflagellar transport Sabry J, O'Connor TP, Kirschner MW (June 1995). "Axonal transport of tubulin in Ti1 pioneer neurons in ...

Growing evidence supports the concept that deficits in axonal transport contributes to pathogenesis in multiple ... Chevalier-Larsen E, Holzbaur EL (2006). "Axonal transport and neurodegenerative disease". Biochimica et Biophysica Acta (BBA ... The transport mechanism depends on the material being moved. Intracellular transport that requires quick movement will use an ... Intracellular transport is the movement of vesicles and substances within a cell. Intracellular transport is required for ...

The fast axonal transport has a rate of 50-500 mm per day, while the slow axonal transport was found to be 0.4 mm per day in ... The cargoes are transported by motor proteins that uses neurotubules as a 'track'. The axonal transport can be classified ... Transport of insoluble protein contributes to the fast movement while the slow transport is transporting up to 40% - 50% ... As a result, essential processes in the neuron such as axonal transport and neural communication will be disrupted, forming the ...

Saxton, William M.; Hollenbeck, Peter J. (2012). "The axonal transport of mitochondria". Journal of Cell Science. 125 (9): 2095 ... Once mitophagy is initiated, Atg32 binds to Atg11 and the Atg32-associated mitochondria are transported to the vacuole. Atg32 ... This distribution is maintained largely by motor protein-mediated mitochondrial transport along the axon. While neuronal ... Arduíno, DM; Esteves, AR; Cardoso, SM (2011). "Mitochondrial fusion/fission, transport and autophagy in Parkinson's disease: ...

The number of neurofilaments in the axon is thought to be determined by neurofilament gene expression and axonal transport. The ... Brown A (November 2000). "Slow axonal transport: stop and go traffic in the axon". Nature Reviews. Molecular Cell Biology. 1 (2 ... Thus on long time scales neurofilaments move in the slow component of axonal transport. Numerous specific antibodies to ... Hoffman PN, Lasek RJ (August 1975). "The slow component of axonal transport. Identification of major structural polypeptides of ...

... they may damage molecular motors and microtubules to interfere with normal axonal transport, leading to impaired transport of ... Impaired axonal transport of alpha-synuclein may also lead to its accumulation in Lewy bodies. Experiments have revealed ... Axonal transport can be disrupted by a variety of mechanisms including damage to: kinesin and cytoplasmic dynein, microtubules ... When axonal transport is severely disrupted a degenerative pathway known as Wallerian-like degeneration is often triggered. ...

Axonal transport continues up to the point of the break in the cytoskeleton, but no further, leading to a buildup of transport ... such as interrupted axonal transport, progressive swellings known as axonal varicosities, and degeneration. Recent studies have ... Since axonal damage in DAI is largely a result of secondary biochemical cascades, it has a delayed onset, so a person with DAI ... Diffuse axonal injury (DAI) is a brain injury in which scattered lesions occur over a widespread area in white matter tracts as ...

Axonal transport occurs either by fast or slow transport. Fast transport involves vesicular contents (like organelles) being ... In axonal transport (also known as axoplasmic transport) materials are carried through the axoplasm to or from the soma. The ... When an axon is damaged, both axonal translation and retrograde axonal transport are required to propagate a signal to the soma ... Young, Tang (2013). "Fast Vesicle Transport Is Required for the Slow Axonal Transport of Synapsin". Neuroscience. 33 (39): ...

Schindowski K, Belarbi K, Buée L (February 2008). "Neurotrophic factors in Alzheimer's disease: role of axonal transport". ... destroying the structure of the cell's cytoskeleton which collapses the neuron's transport system. A number of studies connect ... creating neurofibrillary tangles and disintegrating the neuron's transport system. Pathogenic tau can also cause neuronal death ...

"BPAG1n4 is essential for retrograde axonal transport in sensory neurons". The Journal of Cell Biology. 163 (2): 223-9. doi: ... "The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport". Proceedings of the National ... It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes ...

... conversion of a putative precursor during axonal transport". Science. 195 (4284): 1354-6. Bibcode:1977Sci...195.1354G. doi: ... It is well established that the finished vasopressin product is transported from the cell body to the terminals in the ...

January 2013). "Vesicular glycolysis provides on-board energy for fast axonal transport". Cell. 152 (3): 479-491. doi:10.1016/j ... and fast axonal, or axoplasmic transport. In sperm, a testis-specific isoenzyme GAPDHS is expressed. Under normal cellular ... GAPDH also appears to be involved in the vesicle transport from the endoplasmic reticulum (ER) to the Golgi apparatus which is ... nuclear tRNA transport, DNA replication, and DNA repair. In addition, nuclear translocation of GAPDH has been reported in ...

October 2003). "BPAG1n4 is essential for retrograde axonal transport in sensory neurons". The Journal of Cell Biology. 163 (2 ... In humans, loss of dystonin function can cause hereditary sensory and autonomic neuropathy type VI and axonal Charcot-Marie- ...

Jones CW, Pickering BT (December 1972). "Intra-axonal transport and turnover of neurohypophysial hormones in the rat". J. ... They are then transported in neurosecretory granules along axons within the hypothalamo-neurohypophysial tract by axoplasmic ...

Choi SI, Vidal R, Frangione B, Levy E (2004). "Axonal transport of British and Danish amyloid peptides via secretory vesicles ...

Yoo S, van Niekerk EA, Merianda TT, Twiss JL (2010). "Dynamics of axonal mRNA transport and implications for peripheral nerve ... In this process, new material is added at the growth cone while the remainder of the axonal cytoskeleton remains stationary. ... Actin filaments are also constantly being transported away from the leading edge by a myosin-motor driven process known as ... Axon guidance directs the initial wiring of the nervous system and is also important in axonal regeneration following an injury ...

A second mechanism of reaching the brain tissue is achieved through intra-axonal transport. In this mechanism, Listeria travels ... Dons L, Jin Y, Kristensson K, Rottenberg ME (2007). "Axonal transport of Listeria monocytogenes and nerve-cell-induced ... Similar to the mechanism seen in HIV, infected leukocytes in the blood cross the blood brain barrier and transport Listeria ... or tunneling nanotubes directed toward neighboring cells in a culture of rat PC12 cells have been shown to facilitate transport ...

"Rabies Virus Hijacks and accelerates the p75NTR retrograde axonal transport machinery". PLOS Pathogens. 10 (8): e1004348. doi: ... The virus then travels through the nerve cell axon via retrograde transport, as its P protein interacts with dynein, a protein ... and is then transported to the Golgi apparatus, where a sugar group is added to it (glycosylation). When there are enough viral ...

Her main area of interest is regulation of axonal transport within nerve cells. She is a recipient of the International Early ... Following this approach, her group is starting to uncover regulation of each of the various steps of axonal transport, such as ... Studying this process is challenging, partly because anesthetising model organism also suspends axonal transport. So, watching ... Through this approach, live worm is immobilised in a chip and axonal transport studied. ...

2001). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583-94. doi:10.1016/ ... "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. UNITED STATES. 103 (4): 583-94. doi: ... The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport, possibly by integrating JNK signaling ... 2002). "UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans". Neuron. 32 (5): 787-800. doi: ...

The function of huntingtin (Htt) is not well understood but it is involved in axonal transport. Huntingtin is essential for ... Vitet H, Brandt V, Saudou F (August 2020). "Traffic signaling: new functions of huntingtin and axonal transport in neurological ... These appear to indicate a functional role in cytoskeletal anchoring or transport of mitochondria. The Htt protein is involved ... Within cells, huntingtin may or may not be involved in signaling, transporting materials, binding proteins and other structures ...

2001). "Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of ... "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583-94. doi:10.1016/S0092- ... Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos ...

December 2008). "UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly". Genes Dev. 22 (23): 3292-307 ... The corresponding homologue to Atg1 in C. elegans is unc-51 (uncoordinated-51). Unc-51 also functions in proper axonal guidance ... October 1994). "Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase". ...

"Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583-94. doi:10.1016/S0092- ...

"Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583-94. doi:10.1016/S0092- ...

"Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583-94. doi:10.1016/S0092- ... "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583-94. doi:10.1016/S0092- ...

Gelsolin inhibition of fast axonal transport indicates a requirement for actin microfilaments. Nature, 1984; 310:56-58. 82. ... Calcium transport by macrophage plasma membranes. J Biol Chem. 1980; 255:5841-5846. 54. Amrein PC, Stossel TP. Prevention of ... Transport of Macromolecules in Biological Systems. Berlin: Dahlem Konferenzen, 1978:503-16. 36. Stossel TP, Hartwig JH, Yin HL ... In: Current Topics in Membranes and Transport. 1990; 36:97-107. 66. Stossel TP. How cells crawl. American Scientist. 1990; 78: ...

R2 vaccines retain native replication in epithelial cells but are incapable of retrograde axonal transport and invasion of the ... "The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion". PLOS Pathogens. 13 ( ...

"The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport". Proceedings of the National ... In addition to transport of various organelles in the cytoplasm, dynactin also links kinesin II to organelles. Motor protein ... Schroer TA, Sheetz MP (December 1991). "Two activators of microtubule-based vesicle transport". The Journal of Cell Biology. ... Carter AP, Diamant AG, Urnavicius L (April 2016). "How dynein and dynactin transport cargos: a structural perspective". Current ...

Kratchmarov R, Taylor MP, Enquist LW (2013). "Role of us9 phosphorylation in axonal sorting and anterograde transport of ... In the retrograde direction, SuHV-1-Bartha is transported to a neuronal cell body via its axon, where it is replicated and ... Koyuncu OO, Perlman DH, Enquist LW (Jan 16, 2013). "Efficient retrograde transport of pseudorabies virus within neurons ... the extent to which non-synaptic transneuronal transport may also occur is uncertain. Using temporal studies and/or genetically ...