Atovaquone
... is a hydroxy-1,4-naphthoquinone, an analog of both ubiquinone and lawsone. Atovaquone is a medication used to treat ... "Atovaquone Oral SUSPENSION- atovaquone suspension". DailyMed. 10 December 2019. Retrieved 18 September 2020. Hughes W, Leoung G ... Preliminary research found that atovaquone could inhibit the replication of SARS-CoV-2 in vitro. Clinical trials of atovaquone ... Wikimedia Commons has media related to Atovaquone. "Atovaquone". Drug Information Portal. U.S. National Library of Medicine. ...
Trevor M. Jones
Atovaquone (PCP/Malaria); Exosurf (infant respiratory distress); Mivacron and Nuromax (neuromuscular blockade); Wellferon ( ...
Proguanil
The addition of proguanil has shown to reduce resistance to atovaquone and increase the ability of atovaquone to trigger a ... "Atovaquone And Proguanil (Oral Route) Side Effects". Mayo Clinic. Archived from the original on 2016-11-09. Retrieved 2016-11- ... "Atovaquone and Proguanil Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 20 ... In the United States and Canada it is only available in combination as atovaquone/proguanil. When the Japanese attack on Pearl ...
Pneumocystosis
Other options include pentamidine, dapsone and atovaquone. It is fatal in 10-20% of people with HIV/AIDS. Pneumocystosis in ...
Coenzyme Q - cytochrome c reductase
... atovaquone). Also propylhexedrine inhibits cytochrome c reductase. A small fraction of electrons leave the electron transport ...
Malaria
... or the combination of atovaquone/proguanil (Malarone)-are frequently used for prevention. Doxycycline and the atovaquone/ ... Atovaquone-proguanil is effective against uncomplicated falciparum with a possible failure rate of 5% to 10%; the addition of ... Blanshard A, Hine P (January 2021). "Atovaquone-proguanil for treating uncomplicated Plasmodium falciparum malaria". The ... except for atovaquone/proguanil, which only needs to be started two days before and continued for seven days afterward). The ...
Babesia
November 2000). "Atovaquone and azithromycin for the treatment of babesiosis". N. Engl. J. Med. 343 (20): 1454-1458. doi: ... treatment regimens have been increasingly leaning towards oral atovaquone with oral azithromycin. The latter are preferred, as ...
Buparvaquone
... is a naphthoquinone antiprotozoal drug related to atovaquone. It is a promising compound for the therapy and ... Its mode of action is thus likely to be similar to that of the antimalarial drug atovaquone, a similar 2-hydroxy-1,4- ...
Mefloquine
Doxycycline and atovaquone/proguanil provide protection within one to two days and may be better tolerated. If a person becomes ... October 2001). "Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: results from a ... In the mefloquine arm, 5% of the users reported severe events requiring medical attention, versus 1.2% in the atovaquone- ... Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the ...
Salicylhydroxamic acid
Anina D. Murphy & Naomi Lang-Unnasch (1999). "Alternative Oxidase Inhibitors Potentiate the Activity of Atovaquone against ...
Cycloguanil
However, more recent work has indicated that, while proguanil is synergistic with the drug atovaquone (as in the combination ... Thapar MM, Gupta S, Spindler C, Wernsdorfer WH, Björkman A (May 2003). "Pharmacodynamic interactions among atovaquone, ... "A mechanism for the synergistic antimalarial action of atovaquone and proguanil". Antimicrobial Agents and Chemotherapy. 43 (6 ... Malarone), cycloguanil is in fact antagonistic to the effects of atovaquone, suggesting that, unlike cycloguanil, proguanil may ...
Antimalarial medication
Atovaquone is recommended to be used only in combination with another anti-malarial compound as the selection of resistant ... A liquid oral suspension of Atovaquone is available under the name Mepron. Primaquine is a highly active 8-aminoquinolone that ... However it is useful in prophylaxis when combined with atovaquone or chloroquine (in areas where there is no chloroquine ... Atovaquone is available in combination with proguanil under the name Malarone, albeit at a price higher than Lariam. It is ...
COVID-19 drug repurposing research
Antiparasitics that have been investigated include chloroquine, hydroxychloroquine, mefloquine, ivermectin, and atovaquone. ...
Plasmodium vivax
Atovaquone-proguanil is an effective alternative in patients unable to tolerate chloroquine. Quinine may be used to treat vivax ... "Atovaquone and proguanil hydrochloride followed by primaquine for treatment of Plasmodium vivax malaria in Thailand". ...
Cytauxzoonosis
Cohn, L.A.; Birkenheuer, A.J.; Brunker J.D.; Ratcliff E.R.; Craig, A.W. (2011). "Efficacy of Atovaquone and Azithromycin or ... Cohn, L.A.; Birkenheuer, A.J.; Brunker, J.D.; Ratcliff, E.R.; Craig, A.W. (2011). "Efficacy of Atovaquone and Azithromycin or ... 60% of sick cats treated with supportive care and the combination of the anti-malarial drug atovaquone and the antibiotic ... The most often used treatments for cytauxzoonosis are imidocarb dipropionate and a combination of atovaquone and azithromycin. ...
Peter Gottfried Kremsner
Lell B, Luckner D, Ndjavé M, Scott T, Kremsner PG (March 1998). "Randomised placebo-controlled study of atovaquone plus ... He has been principal investigator on key studies for the development of atovaquone/proguanil, artesunate/amodiaquine, ...
Malaria prophylaxis
Mefloquine, doxycycline, and atovaquone-proguanil appear to be equally effective at reducing the risk of malaria for short-term ... Mefloquine (Lariam), doxycycline, or the combination of atovaquone and proguanil (Malarone) are frequently recommended. In ... atovaquone/proguanil (Malarone) 1 tablet daily (started one day before travel, and continued for one week after returning). Can ... however mefloquine is not always as well tolerated when compared with atovaquone-proguanil. There is low-quality evidence ...
Plasmodium ovale
The combination atovaquone-proguanil may be used in those patients who are unable to take chloroquine for whatever reason. An ... Radloff PD, Philipps J, Hutchinson D, Kremsner PG (1996). "Atovaquone plus proguanil is an effective treatment for Plasmodium ...
Babesiosis
In mild-to-moderate babesiosis, the treatment of choice is a combination of atovaquone and azithromycin. This regimen is ...
Global health
International travelers to endemic zones are advised chemoprophylaxis with antimalarial drugs like Atovaquone-proguanil, ...
Chloroquine
In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. The Centers ...
Toxoplasmosis
The medications prescribed for latent toxoplasmosis are: Atovaquone - an antibiotic that has been used to kill Toxoplasma cysts ... Djurković-Djaković O, Milenković V, Nikolić A, Bobić B, Grujić J (2002). "Efficacy of atovaquone combined with clindamycin ... inside AIDS patients Clindamycin - an antibiotic that, in combination with atovaquone, seemed to optimally kill cysts in mice ...
Plasmodium falciparum
For travellers returning to nonendemic countries, atovaquone/proguanil, artemether/lumefantrineany and quinine plus doxycycline ...
Pneumocystis pneumonia
Other medications that are used, alone or in combination, include pentamidine, trimetrexate, dapsone, atovaquone, primaquine, ... atovaquone, or regular pentamidine inhalations may help prevent PCP. Antipneumocystic medication is used with concomitant ...
Quinine
... proguanil with atovaquone), are often used when oral therapy is required. Quinine ethyl carbonate is tasteless and odourless, ...
Fitness to dive
Malarone (a combination of atovaquone and proguanil) seldom has side effects, but headache, nausea, vomiting and abdominal pain ...
Cytochrome b
"Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone binding domain 2 (Qo(2)) of the cytochrome b ... berghei are associated with resistance to the anti-malarial drug atovaquone. Human genes encoding cytochrome b proteins include ...
Metabolic pathway
Some of these inhibitors, such as lonidamine and atovaquone, which inhibit Complex II and Complex III, respectively, are ...
Mitochondrion
... and atovaquone. Mitochondria that lack their own DNA have been found in a marine parasitic dinoflagellate from the genus ...
Institute for Tropical Medicine Tübingen
The institute's achievements include contributions to the development of malaria drugs, such as atovaquone-proguanil, ...