Biochemical cascade
"Interleukin-6 Mediates Angiotensinogen Gene Expression during Liver Regeneration". PLOS ONE. 8 (7): e67868. Bibcode:2013PLoSO ... Dzau, VJ; Herrmann, HC (15-22 February 1982). "Hormonal control of angiotensinogen production". Life Sciences. 30 (7-8): 577-84 ... Angiotensinogen expression Regenerate itself by hepatocyte mitosis Via STAT and Gab1: RAS/MAPK, PLC/IP3 and PI3K/FAK Cell ...
Serpin
Sethi AA, Nordestgaard BG, Tybjaerg-Hansen A (July 2003). "Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk ... December 1994). "Angiotensinogen-deficient mice with hypotension". The Journal of Biological Chemistry. 269 (50): 31334-31337. ... Jeunemaitre X, Gimenez-Roqueplo AP, Célérier J, Corvol P (1999). "Angiotensinogen variants and human hypertension". Current ... Dickson ME, Sigmund CD (July 2006). "Genetic basis of hypertension: revisiting angiotensinogen". Hypertension. 48 (1): 14-20. ...
African Society of Hypertension Initiative
Dickson ME, Sigmund CD (July 2006). "Genetic basis of hypertension: revisiting angiotensinogen". Hypertension. 48 (1): 14-20. ...
Essential hypertension
One of these genes is the angiotensinogen (AGT) gene, studied extensively by Kim et al. They showed that increasing the number ... Dickson ME, Sigmund CD (July 2006). "Genetic basis of hypertension: revisiting angiotensinogen". Hypertension. 48 (1): 14-20. ...
Angiotensin
Angiotensinogen is also known as renin substrate. It is cleaved at the N-terminus by renin to result in angiotensin I, which ... Angiotensinogen is an α-2-globulin synthesized in the liver and is a precursor for angiotensin, but has also been indicated as ... Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-... Plasma angiotensinogen levels are increased by plasma corticosteroid, ... In mice with a full body deficit of angiotensinogen, the effects observed were low newborn survival rate, stunted body weight ...
Randy Read
"A redox switch in angiotensinogen modulates angiotensin release". Nature. 468 (7320): 108-11. Bibcode:2010Natur.468..108Z. doi: ...
Renin inhibitor
... s bind to the active site of renin and inhibit the binding of renin to angiotensinogen, which is the rate- ... Renin is a circulating enzyme that acts on a circulating peptide, angiotensinogen. Renin cleaves the peptide at the Leu10-Val11 ... Renin is highly selective for its only naturally occurring substrate which is angiotensinogen, and the incidence of unwanted ... The first generation of renin inhibitors, such as H-142, were peptide analogues of angiotensinogen. However, these inhibitors ...
Pierre Corvol
Role of angiotensinogen. Cell 71 : 169-180, 1992. Rousseau A., Michaud A., Chauvet M-T., Lenfant M. and Corvol P. The ... Role of angiotensinogen". Cell. 71 (1): 169-80. doi:10.1016/0092-8674(92)90275-H. PMID 1394429. S2CID 12142319. Dive, V.; ...
Renin-angiotensin system
Outside the liver, angiotensinogen is picked up from the circulation or expressed locally in some tissues; with renin they form ... Plasma renin then carries out the conversion of angiotensinogen, released by the liver, to a decapeptide called angiotensin I. ... Renin cleaves a decapeptide from angiotensinogen, a globular protein. The decapeptide is known as angiotensin I. Angiotensin I ...
Losartan
Renin then acts by converting angiotensinogen to angiotensin I; angiotensin converting enzyme (ACE) converts angiotensin I to ...
Blood pressure
Renin converts angiotensinogen (inactive form) to angiotensin I (active form). Angiotensin I flows in the bloodstream until it ... Renin converts angiotensinogen to angiotensin I, which is converted by angiotensin converting enzyme to angiotensin II. ...
Renal tissue kallikrein
"Kinetic studies of rat renin and tonin on purified rat angiotensinogen". Canadian Journal of Biochemistry and Cell Biology. 62 ...
Pathophysiology of hypertension
February 1999). "Angiotensinogen gene polymorphisms M235T/T174M: no excess transmission to hypertensive Chinese". Hypertension ... It performs this function by breaking down (hydrolysing) angiotensinogen, secreted from the liver, into the peptide angiotensin ... angiotensinogen and epithelial sodium channel". Hypertension. 33 (6): 1324-31. doi:10.1161/01.hyp.33.6.1324. PMID 10373210. ...
Shaodong Guo
"Novel Mechanism of Blood Pressure Regulation By Foxo1-Mediated Transcriptional Control of Hepatic Angiotensinogen". ...
RREB1
2005). "Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene". Int. J. Mol. Med. 13 ...
Osteopontin
Ricardo SD, Franzoni DF, Roesener CD, Crisman JM, Diamond JR (May 2000). "Angiotensinogen and AT(1) antisense inhibition of ...
Aortic regurgitation
Renin, a proteolytic enzyme, cleaves angiotensinogen to angiotensin I, which is converted to angiotensin II. In the case of ...
Serge Carrière
"Effect of Renin-Angiotensin System Blockade on the Expression of the Angiotensinogen Gene and Induction of Hypertrophy in Rat ... "Effect of renin-angiotensin system blockade on the expression of the angiotensinogen gene and induction of hypertrophy in rat ... "RAS blockade decreases blood pressure and proteinuria in transgenic mice over-expressing rat angiotensinogen gene in the kidney ... "Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells". ...
Endothiapepsin
... endothiapepsin and its complex with an angiotensinogen fragment analogue, H-142". Biochemical Society Transactions. 13 (6): ...
Aliskiren
It cleaves angiotensinogen to angiotensin I, which is in turn converted by angiotensin-converting enzyme (ACE) to angiotensin ... Binding to this pocket prevents the conversion of angiotensinogen to angiotensin I. Aliskiren is also available as combination ...
Penbutolol
Under normal physiological conditions, the enzyme renin converts angiotensinogen to angiotensin I, which will then be converted ...
Fosinopril
Renin converts the inactive angiotensinogen into angiotensin I, which is converted to angiotensin II (AII) by angiotensin ...
Forasartan
"Upregulation of immunoreactive angiotensin II release and angiotensinogen mRNA expression by high-frequency preganglionic ...
BBSome
The deletion increased the vascular angiotensinogen gene expression in the aorta which activated the renin-angiotensin system ...
Renal artery stenosis
Juxtaglomerular cells secrete renin, which converts angiotensinogen to angiotensin I, which is then converted to angiotensin II ...
Renin receptor
Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I. This protein is associated with ...
Homeostasis
... from a plasma α-2-globulin called angiotensinogen. This decapeptide is known as angiotensin I. It has no known biological ...
Major basic protein
1995). "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic ... angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helmintho- ...
Subfornical organ
... participates in the control of body fluid homeostasis by regulating angiotensinogen gene transcription in the rat subfornical ...
Nephron
It produces and secretes into the circulation the enzyme renin (angiotensinogenase), which cleaves angiotensinogen and results ...