Among other roles in the cell, secretases act on the amyloid-beta precursor protein (APP) to cleave the protein into three ... Secretases are enzymes that "snip" pieces off a longer protein that is embedded in the cell membrane. ... BACE is a transmembrane protein with an extracellular aspartic acid protease domain. γ-secretase is actually a protein complex ... no amyloid beta is formed because α-secretase recognizes a target protein sequence closer to the cell surface than BACE. The ...

Alpha secretases are a family of proteolytic enzymes that cleave amyloid precursor protein (APP) in its transmembrane region. ... "Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the ... De Strooper, B; Annaert, W (2000). "Proteolytic processing and cell biological functions of the amyloid precursor protein". J ... "The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein". FASEB J. ...

His research interest are the secretases, proteases which cleave the amyloid precursor protein (APP), resulting in amyloid ... "Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein". Nature. 391 (6665): 387-90. doi:10.1038/ ... The amyloid peptide is the main constituent of the plaques in the brain of people with Alzheimer's disease. Together with ...

... and β-secretases which generate Aβ from its precursor protein, APP (amyloid precursor protein). Aβ circulates in plasma, ... Hiltunen M, van Groen T, Jolkkonen J (2009). "Functional roles of amyloid-beta protein precursor and amyloid-beta peptides: ... December 2014). "Amyloid-β precursor protein promotes cell proliferation and motility of advanced breast cancer". BMC Cancer. ... The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to ...

Aβ42 is generated by the enzymatic cleavage of the β-amyloid precursor protein (βΑPP) through β- and γ- secretases. Like other ... while up-regulating the α-secretase ADAM10 and the secreted amyloid precursor protein-α (sAPPα). Overall, the above mechanism ... Specifically, PD1 regulates this protein family by promoting the dephosphorylation of Bcl-xL by protein phosphatase 2A (PP2A) ... the release of Aβ42 down-regulates the anti-apoptotic proteins Bcl-2 and Bcl-xL and up-regulates the pro-apoptotic proteins Bax ...

The best-characterized gamma-secretase substrates are the Notch receptor and amyloid precursor protein (APP). Presenilins' role ... protein. To form Aβ, APP must be cut by two enzymes, beta secretases and gamma secretase. Presenilin is the sub-component of ... or the amyloid precursor protein (APP) can be found. The majority of these cases carry mutant presenilin genes. An important ... January 1997). "Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both ...

... protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor ... Li Q, Südhof TC (2004). "Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1". J. Biol ... 1998). "Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 ... precursor-like protein 1". Wasco W, Brook JD, Tanzi RE (January 1993). "The amyloid precursor-like protein (APLP) gene maps to ...

The amyloid precursor protein (APP) is consecutively transported from the ER after its synthesis to the plasma membrane via the ... The amyloidogenic pathway leads to APP processing by γ-secretases and β-secretases such as BACE1, resulting in production of ... are involved in protein-protein interactions. The SNX8 protein, even though is very similar to the other sorting nexins, ... SNX8 protein regulates cholesterol levels as an activator of the SREBPs (Sterol Regulatory Element Binding Proteins), which is ...

... amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo". Proceedings of the National Academy ... by proteases referred to as the β and γ secretases. The physiological role of this processing is unclear, though it may play a ... Aβ is a byproduct generated as the result of proteolytic processing of the amyloid precursor protein (APP) ... Kerr ML, Small DH (April 2005). "Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: function, ...

... and β-amyloid precursor protein secretases and therefore inhibits formation of the beta amyloid peptide that forms amyloid ... however it has been demonstrated that expression of TMEM59 protein inhibits Golgi glycosylation of amyloid precursor protein ( ... Transmembrane protein 59 is a protein that in humans is encoded by the TMEM59 gene. TMEM59 is a membrane bound protein that is ... and secretion of the amyloid precursor protein". The Journal of Biological Chemistry. 285 (27): 20664-74. doi:10.1074/jbc. ...

... generates from the 17-40 or 17-42 sequence of the amyloid precursor protein (APP), which is a type I integral ... Under normal physiological conditions, APP is processed with three different proteolytic enzymes: α-, β- and γ-secretases. At ... and γ-secretase cleavage from the amyloid precursor protein (APP). It is known to be the major constituent of diffuse plaques ... Integral membrane proteins, Human proteins, Enzymes, Alzheimer's disease, Down syndrome). ...

The amyloid-β precursor protein (AβPP), and all associated secretases, are expressed early in development and play a key role ... Amyloid-beta precursor protein is an ancient and highly conserved protein. In humans, the gene APP is located on chromosome 21 ... Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses ... Mutations in critical regions of amyloid precursor protein, including the region that generates amyloid beta (Aβ), cause ...

Selkoe, DJ (1999). "Chapter 19: Biology of β-amyloid precursor protein and the mechanism of Alzheimer disease". In Terry, RD; ... The sequential actions of these secretases results in Aβ protein fragments that are released into the extracellular space The ... Amyloid beta (Aβ) is a small protein, most often 40 or 42 amino acids in length, that is released from a longer parent protein ... Suh YH; Checler F (September 2002). "Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and ...

Amyloid beta is a short peptide that is an abnormal proteolytic byproduct of the transmembrane protein amyloid-beta precursor ... A delicate balance of the enzymes secretases regulate the amyloid-beta accumulation. Recently, a link between cholinergic ... March 2006). "The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production". Nature. ... is a short peptide that is a proteolytic byproduct of the transmembrane protein amyloid precursor protein (APP), whose function ...