After absorption in the bone, alendronate has an estimated terminal elimination half-life of 10 years. "Alendronate Use During ... decrease the absorption of alendronate. At least half an hour should pass after intake of alendronate before eating dairy ... "Alendronate - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022. Sun K, Liu JM, Sun HX, Lu N, Ning G (January 2013). " ... Bone: alendronate has been linked in long-term users to the development of low-impact femoral fractures. Further, studies ...

EB (2015). "In Brief: Effervescent Alendronate". The Medical Letter on Drugs and Therapeutics. October 15, 2012. Awad, Atheer; ...

"Weekly oral alendronate in mevalonate kinase deficiency". Orphanet Journal of Rare Diseases. 8: 196. doi:10.1186/1750-1172-8- ...

November 2007). "Teriparatide or alendronate in glucocorticoid-induced osteoporosis". The New England Journal of Medicine. 357 ...

This compound became known as Alendronate or Fosamax. He also examined the role of steroid in bone metabolism and the ...

Alendronate, a common bisphosphonate drug, has a three carbon length side chain for example. Risedronate has heterocyclic ... Alendronate localization in rat bone and effects on osteoclast ultrastructure". Journal of Clinical Investigation. 88 (6): 2095 ... Masarachia, P.; Weinreb, M.; Balena, R.; Rodan, G. A. (1996-09-01). "Comparison of the distribution of 3H-alendronate and 3H- ...

Brand names include Actonel (risedronate/alendronate), made by Merck Pharmaceuticals. Other drugs include Pamidronate, made by ...

In the other, one year of romosozumab followed by one year of alendronate had a 50% vertebral fracture reduction compared to ... In one trial, more patients in the romosozumab group had serious cardiovascular events compared to the alendronate group (0.8% ... October 2017). "Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis". The New England Journal of ... two years of alendronate. Common side effects include headache, joint pain, and pain at the site of injection. ...

Alendronate sodium is given as tablets once daily for six months; patients should wait at least 30 minutes after taking before ...

The bisphosphonate alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%; zoledronate reduces the risk ... In the 1990s their actual mechanism of action was demonstrated with the initial launch of alendronate by Merck & Co. Not sold ... Wysowski D, Chang J (2005). "Alendronate and risedronate: reports of severe bone, joint, and muscle pain". Arch Intern Med. 165 ... In osteoporosis and Paget's, the most popular first-line bisphosphonate drugs are alendronate and risedronate. If these are ...

"Alendronate binds to tooth root surfaces and inhibits progression of feline tooth resorption: a pilot proof-of-concept study". ... Use of alendronate has been studied to decrease progression of existing lesions. True dental caries are uncommon among ...

For this reason, other bisphosphonates, such as alendronate, are preferred when fighting osteoporosis. To prevent bone ...

Bragdon, C. R.; Doherty, A. M.; Jasty, M; Rubash, H; Harris, W. H. (2005). "Effect of oral alendronate on net bone ingrowth ...

Alendronate decreases fractures of the spine but does not have any effect on other types of fractures. Half stop their ... That being said, alendronate was identified as the most efficacious for secondary prevention of vertebral and hip fractures ... Wells GA, Cranney A, Peterson J, Boucher M, Shea B, Robinson V, Coyle D, Tugwell P (January 2008). "Alendronate for the primary ... Certain medications like alendronate, etidronate, risedronate, raloxifene, and strontium ranelate can help to prevent ...

Common examples are alendronate (a bisphosphonate, commonly prescribed for osteoporosis), cytotoxic drugs (e.g. methotrexate, i ... Kharazmi M, Sjöqvist K, Warfvinge G (April 2012). "Oral ulcers, a little known adverse effect of alendronate: review of the ...

74-. ISBN 978-0-936923-24-6. Agarwala S, Jain D, Joshi VR, Sule A (March 2005). "Efficacy of alendronate, a bisphosphonate, in ...

Alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%. In December 2013, Merck agreed to pay a total of ... Fosamax (alendronate) is a bisphosphonate used for the treatment of post-menopausal osteoporosis and for the prevention of ... "Systematic review and meta-analysis of the efficacy and safety of alendronate and zoledronate for the treatment of ... the North American Menopause Society and the UK National Osteoporosis Guideline Group recommend alendronate and certain other ...

The bisphosphonate drug alendronate may decrease the risk of a fracture, in women that have both bone loss and a previous ... Wells GA, Cranney A, Peterson J, Boucher M, Shea B, Robinson V, Coyle D, Tugwell P (January 2008). "Alendronate for the primary ...

FPPS is the target of bisphosphonate drugs such as Fosamax (alendronate) and Actonel (risedronate). Bisphosphonate drugs are ...

Tomlin JL, Sturgeon C, Pead MJ, Muir P (29 July 2000). "Use of the bisphosphonate drug alendronate for palliative management of ... Some current studies indicate osteoclast inhibitors such as alendronate and pamidronate may have beneficial effects on the ...

Combined abaloparatide and alendronate therapy reduced significantly the incidence of vertebral and nonvertebral fractures. A ... received additional 2 years of 70 mg of alendronate, Vitamin D (400 to 800 IU), and calcium (500-1000 mg) supplementation daily ... "Eighteen Months of Treatment With Subcutaneous Abaloparatide Followed by 6 Months of Treatment With Alendronate in ...

Duque G, Rivas D (October 2007). "Alendronate has an anabolic effect on bone through the differentiation of mesenchymal stem ... along with alendronate, residronate, strontium and zoledronic acid which have proven efficacy in primary and secondary hip ...

... placebo-controlled trial of alendronate treatment for fibrous dysplasia of bone". The Journal of Clinical Endocrinology and ...

Alendronate-loaded OCP also showed enhancement of osteoblast differentiation markers compared to HA-loaded alendronate. In- ... Alendronate, a commonly used BP, has been combined with OCP in some studies, demonstrating inhibited osteoclastogenesis and ...

S2CID 19316414.Free full text DiMeglio LA, Peacock M (January 2006). "Two-year clinical trial of oral alendronate versus ... February 2006). "Effects of oral alendronate on BMD in adult patients with osteogenesis imperfecta: a 3-year randomized placebo ... Some studies have found oral and intravenous bisphosphonates, such as oral alendronate and intravenous pamidronate, equivalent ...

Medication such as nonsteroidal anti-inflammatory drug and alendronate can induce esophagitis if not swallowed properly. ...

Finally, osteoclast inhibition by the bisphosphonate alendronate has correlated with decreased HSCs and bone marrow engraftment ...

"Differential Effects of Teriparatide and Alendronate on Bone Remodeling in Postmenopausal Women Assessed by Histomorphometric ...

This type of drug has a high affinity for hydroxyapatite and stays in bone tissue for a long period of time, with alendronate, ... Examples of bisphosphonates: : Zoledronic acid (Reclast, Zometa), Risedronate (Actonel), Alendronate (Fosamax), Etidronate ( ... zoledronic acid and pamidronate and alendronate, risedronate, and ibandronate. Despite the fact that it remains vague as to ...

... results from the randomized clinical trials of alendronate and zoledronic acid". JAMA Internal Medicine. 174 (10): 1550-7. doi: ...