Simian adenoviruses do not suffer from the same disadvantages. Therefore, investigators have tested new vaccines using the ... December 2017). "Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic ... Morris SJ, Sebastian S, Spencer AJ, Gilbert SC (September 2016). "Simian adenoviruses as vaccine vectors". Future Virology. 11 ... The vector is a chimpanzee adenovirus modified to avoid its replication. Adenoviruses are effective vectors for inducing and ...

Kidd, AH; Garwicz D; Oberg M (1995). "Human and simian adenoviruses: phylogenetic inferences from analysis of VA RNA genes". ... These two VA RNA genes are distinct genes in the adenovirus genome. VA RNAI is the major species with VA RNAII expressed at a ... The VA (viral associated) RNA is a type of non-coding RNA found in adenovirus. It plays a role in regulating translation. There ... Ma, Y; Mathews MB (1996). "Secondary and tertiary structure in the central domain of adenovirus type 2 VA RNA I". RNA. 2 (9): ...

Yamamoto, Hiroshi; Shimojo, H (August 1971). "Multiplicity reactivation of human adenovirus type 12 and simian virus 40 ... SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and ... "Simian Virus 40 (SV40) - 1955 - 1963" in "Historical Safety Concerns". Vaccine Safety. CDC. 30 March 2022. Simian Virus 40 ( ... Vera, Maria; Fortes, Puri (May 2004). "Simian Virus-40 as a Gene Therapy Vector". DNA and Cell Biology. 23 (5): 271-282. doi: ...

Kelly, T J; Rose, J A (1971). "Simian virus 40 integration site in an adenovirus 7-simian virus 40 hybrid DNA molecule". ... adenovirus and SV40, which cause tumors in animals. He joined the faculty in the Department of Microbiology at the Johns ... "Replication of adenovirus and SV40 chromosomes in vitro". Phil. Trans. R. Soc. Lond. B. 317 (1187): 429-438. Bibcode:1987RSPTB. ... "The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA ...

2012). "Vaccine Vectors Derived from a Large Collection of Simian Adenoviruses Induce Potent Cellular Immunity Across Multiple ... 2012). "Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man". Science Translational ... 2015). "Chimpanzee adenovirus- and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults". Science ... 2017). "Chimpanzee Adenovirus Vector Ebola Vaccine". The New England Journal of Medicine. 376 (10): 928-938. doi:10.1056/ ...

The adenovirus E1B protein (55K) prevents p53 from regulating genes by binding to the site on p53 which binds to the genome. In ... Simian virus 40 (SV40), a polyomavirus, can cause tumors in rodent models but is not oncogenic in humans. This phenomenon has ... Adenoviruses can lead to tumors in rodent models but do not cause cancer in humans; however, they have been exploited as ... The adenovirus early region 1A (E1A) is an oncoprotein which binds to Rb and can stimulate transcription and transform cells. ...

Schuitemaker demonstrated the efficacy of the adenovirus/protein vaccines against simian immunodeficiency virus in rhesus ... "Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys". Science. 349 (6245): 320-324. ...

A number of vectors based on other type of viruses like Adenoviruses and Papilloma virus have been used to clone genes in ... A vector based on Simian virus 40 (SV40) was used in first cloning experiment involving mammalian cells. ...

16 October 2017). "Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic ... 28 January 2015). "A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA". The New England Journal of Medicine. 374 ... 5 February 2016). "Chimpanzee Adenovirus Vaccine Provides Multispecies Protection against Rift Valley Fever". Scientific ...

... which was originally discovered as a contaminant in a sample of simian adenovirus. Though AAV is considered to be dependent on ... Alba, R; Bosch, A; Chillon, M (2005). "Gutless adenovirus: Last-generation adenovirus for gene therapy". Gene Therapy. 12: S18- ... 1965). "Adenovirus-Associated Defective Virus Particles". Science. 149 (3685): 754-6. Bibcode:1965Sci...149..754A. doi:10.1126/ ... "Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus". Journal of Virology. ...

Simian foamy viruses (SFV) is an enzootic retrovirus that has high rates of cross-species transmission and has been known to ... Diseases such as HIV and human adenoviruses have been associated with NHP interactions. In places where contact between humans ... titi monkey adenovirus) is a highly divergent, sharing ...

Throughout his career, Major has conducted research on viruses including BK virus, adenoviruses, JC virus, simian virus 40 ( ... Major, E. O.; Matsumura, P. (1984). "Human embryonic kidney cells: stable transformation with an origin-defective simian virus ... Bourne, KA; Major, EO; Khoobyarian, N (1978). "A variant of adenovirus 12 producing cytoplasmic accumulation of capsid proteins ...

... starting with studying DNA replication of human adenovirus as a model. He then began to study how the genome of simian virus 40 ...

The agent was later identified as a monkey virus and named Simian Virus 40 (SV40). Sweet & Hilleman published their work in ... Hilleman at Merck observed a similar agent in the same kind of medium that they were using to develop a vaccine for adenovirus ... Maryland to attend a workshop of the National Institutes of Health entitled Simian Virus 40: A Possible Human Polyomavirus. ...

Graham, F L (1973). "A New Technique for the Assay of Infectivity of Human Adenovirus 5 DNA". Virology. 52 (2): 456−467. doi: ... McCutchan, J H (1968). "Enhancement of Infectivity of Simian Virus 40 Deoxyribonucleic Acid with Diethylaminoethyl-Dextran". J ... Nearly 70% of gene therapy clinical trials have utilized viral vectors for the gene delivery step . Adenovirus, Adeno- ... adenovirus or adeno-associated virus, and other viruses . While highly efficient for DNA delivery, notable weaknesses of viral ...

... adenoviruses, human MeSH B04.280.030.500.675 - adenoviruses, porcine MeSH B04.280.030.500.700 - adenoviruses, simian MeSH ... adenoviruses, human MeSH B04.909.204.097.500.675 - adenoviruses, porcine MeSH B04.909.204.097.500.700 - adenoviruses, simian ... simian immunodeficiency virus MeSH B04.820.650.805.851 - simian t-lymphotropic virus 1 MeSH B04.820.650.805.855 - simian t- ... simian t-lymphotropic virus 1 MeSH B04.909.777.731.805.855 - simian t-lymphotropic virus 2 MeSH B04.909.777.731.850 - ...

... a simian adenovirus used to develop ChAdOx1 Chad-e Bala or Upper Chad, a village in Iran Chad-e Pain or Lower Chad, a village ...

Multiplicity reactivation has been found to occur with pathogenic viruses including influenza virus, HIV-1, adenovirus simian ...

More specifically, the vector used is the simian group C adenovirus GRAd32, isolated from a captive gorilla, with a genome ... It is based on a novel replication defective Gorilla Adenovirus and encodes for SARS-COV-2 full length prefusion stabilized ... April 2021). "Immunogenicity of a new gorilla adenovirus vaccine candidate for COVID-19". Molecular Therapy. 29 (8): 2412-2423 ... deleted of the entire E1 and E3 regions and the native E4 region replaced with the E4 orf6 of human adenovirus 5 (hAd5). "GRAd- ...

Ginsberg showed the process by which the adenovirus caused disease after entering host cells, leading to the creation of ... At the National Institute of Allergy and Infectious Diseases, Ginsberg performed research on Simian immunodeficiency virus, a ... He was on the faculty of Western Reserve University starting in 1951, where research he conducted showed that adenoviruses, ... "he had accomplished all he could with adenoviruses" before moving on to study HIV. A resident of both Woods Hole, Massachusetts ...

1991 Chellappan, S.; Kraus, V. B.; Kroger, B.; Munger, K.; Howley, P. M.; Phelps, W. C.; Nevins, J. R. (1992). "Adenovirus E1A ... simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between ...

... adenovirus simian virus 40, vaccinia virus, reovirus, poliovirus and herpes simplex virus. When HSV particles are exposed to ...

Whyte, P (1988). "Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma ... "Monoclonal antibodies specific for simian virus 40 tumor antigens." Journal of Virology 39.3 (1981): 861-869. Tsai, Li-Huei, et ... "Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product." ( ... Harlow, E (1981). "Monoclonal antibodies specific for simian virus 40 tumor antigens". J Virol. 39: 861-9. PMC 171319. PMID ...

... is an adenovirus protein of 14kDa which regulates growth in all stages of the adenovirus (Ad) infection. E4orf4 partners mainly ... Toolan, H.W. and Ledinko, N. (1965) Growth and cytopathogenicity of H-viruses in human and simian cell cultures. Nature 208, 8 ... It was seen in one Phase I clinical trial that injecting mda-7 via an adenovirus directly into a tumor resulted in safe tumor ... Toolan, H.W. and Ledinko, N. (1968) Inhibition by H-l virus of the incidence of tumors produced by adenovirus 12 in hamsters. ...

... and could be preferentially transformed by adenovirus. Adenoviruses transform neuronal lineage cells much more efficiently than ... Stillman BW, Gluzman Y (August 1985). "Replication and supercoiling of simian virus 40 DNA in cell extracts from human cells". ... The cells were cultured by van der Eb; the transduction by adenovirus was performed by Frank Graham, a post-doc in van der Eb's ... However, the original adenovirus transformation was inefficient, suggesting that the cell that finally produced the HEK 293 ...

Simian mastadenovirus A Simian mastadenovirus B Simian mastadenovirus C Simian mastadenovirus D Simian mastadenovirus E Simian ... can cause potentially fatal adenovirus infections.[citation needed] Canine mastadenovirus A (formerly canine adenovirus-1, CAdV ... mastadenovirus F Simian mastadenovirus G Simian mastadenovirus H Simian mastadenovirus I Skunk mastadenovirus A Squirrel ... The name Mastadenovirus is derived from the Greek word mastos 'breast' (hence mammal) and adenovirus, named for the human ...

Many RNA viruses including SV40, adenovirus, herpes virus, Rous sarcoma virus, and influenza virus have been known to contain ... Aloni Y, Dhar R, Khoury G (October 1979). "Methylation of nuclear simian virus 40 RNAs". Journal of Virology. 32 (1): 52-60. ...

... consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication. Monoallelic variants in this ... "Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor". PLOS Pathog. 8 (10): e1002949. doi: ...

Yamamoto H, Shimojo H (August 1971). "Multiplicity reactivation of human adenovirus type 12 and simian virus 40 irradiated by ... Tupaia adenovirus (TAV) (tree shrew adenovirus 1) has been isolated from tree shrews. Otarine adenovirus 1 has been isolated ... In babies, adenoviruses can also cause coughing fits that look almost exactly like whooping cough. Adenoviruses can also cause ... Adenoviruses are also known to cause respiratory infections in horses, cattle, pigs, sheep, and goats. Equine adenovirus 1 can ...

It was found that in the absence of the E1B-55Kd viral protein, adenovirus caused very rapid apoptosis of infected, p53(+) ... For example, the most popular retroviral vector for use in gene therapy trials has been the lentivirus Simian immunodeficiency ... Concerns about the safety of adenovirus vectors were raised after the 1999 death of Jesse Gelsinger while participating in a ... Retroviruses have limited natural host cell ranges, and although adenovirus and adeno-associated virus are able to infect a ...