Pu WT, Krapivinsky GB, Krapivinsky L, Clapham DE (1999). "pICln inhibits snRNP biogenesis by binding core spliceosomal proteins ... Tang CJ, Tang TK (1998). "The 30-kD domain of protein 4.1 mediates its binding to the carboxyl terminus of pICln, a protein ... "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln". Curr. Biol. 11 (24): ... "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243-7. doi:10.1074/jbc. ...

This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a ... protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63-9. doi:10.1006/excr. ... protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63-9. doi:10.1006/excr. ... charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic ...

Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1997). "Multiple protein: protein interactions between the snRNP common core ... "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". ... protein heteromer and the intact snRNP core". J. Mol. Biol. 265 (2): 87-94. doi:10.1006/jmbi.1996.0713. PMID 9020971. ... "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1-2): 187-96. ...

Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core ... The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre- ... "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1-2): 187-96. ... and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013-21. doi:10.1016/S0092- ...

Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core ... Small nuclear ribonucleoprotein-associated protein N is a protein that in humans is encoded by the SNRPN gene. The protein ... The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame ( ... The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual ...

... protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63-9. doi:10.1006/excr. ... protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63-9. doi:10.1006/excr. ... protein heteromer and the intact snRNP core". Journal of Molecular Biology. 265 (2): 87-94. doi:10.1006/jmbi.1996.0713. PMID ... "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". The EMBO Journal. 20 (1-2 ...

... protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63-9. doi:10.1006/excr. ... protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63-9. doi:10.1006/excr. ... "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". ... protein heteromer and the intact snRNP core". Journal of Molecular Biology. 265 (2): 87-94. doi:10.1006/jmbi.1996.0713. PMID ...

Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1997). "Multiple protein: protein interactions between the snRNP common core ... and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013-21. doi:10.1016/S0092- ... is a protein that in humans is encoded by the SNRPB gene. The protein encoded by this gene is one of several nuclear proteins ... van Dam A, Winkel I, Zijlstra-Baalbergen J, Smeenk R, Cuypers HT (1989). "Cloned human snRNP proteins B and B' differ only in ...

Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core ... protein interactions between the snRNP common core proteins". Exp. Cell Res. UNITED STATES. 237 (1): 63-9. doi:10.1006/excr. ... "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1-2): 187-96. ... and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013-21. doi:10.1016/S0092- ...

... snRNP) involved in this process. All of the snRNPs together contribute about 50 proteins to the core spliceosome. The Prp8 gene ... The Prp8 protein is a large, highly conserved, and unique protein that resides in the catalytic core of the spliceosome and has ... encodes for a protein that is a central part of the U5 snRNP and the U5-U4/U6 tri-snRNP. The U5-U4/U6 tri-snRNP is involved ... Prp8 protein is a major central component of the catalytic core in the spliceosome, and the spliceosome is responsible for ...

The completed core snRNP-snurportin 1 complex is transported into the nucleus via the protein importin β. Inside the nucleus, ... human U11/U12 di-snRNP, human U5 snRNP, U4/U6 di-snRNP, U4/U6∙U5 tri-snRNP. The further progress determining the structures and ... "Organization of Core Spliceosomal Components U5 snRNA Loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as Revealed by ... the human U1 snRNP core structure was determined by X-ray crystallography (3CW1, 3PGW), followed by a structure of the U4 core ...

Each snRNP particle is composed of a snRNA component and several snRNP-specific proteins (including Sm proteins, a family of ... All of these uridine-rich snRNA, with the exception of U7, form the core of the spliceosome. Splicing, or the removal of ... The initial step of splicing is the bonding of the U1 snRNP and its associated proteins to the 5' splice end to the hnRNA. This ... Then, U2 snRNP is recruited to the spliceosome binding site and forms complex A, after which the U5.U4/U6 tri-snRNP complex ...

Protein-Protein and Protein-RNA Contacts both Contribute to the 15.5K-Mediated Assembly of the U4/U6 snRNP and the Box C/D ... The 15.5-kDa protein also exists as one of the four core proteins of the C/D small nucleolar ribonucleoprotein that mediates ... and L30 and the snoRNP protein NHP2. The U4/U6 snRNP contains 15.5-kDa protein. The 15.5-kDa protein also exists in a ... The 15.5-kDa protein has sequence similarity to other RNA-binding proteins such as ribosomal proteins S12, L7a, ...

"Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1-2): 187-96. ... bound to proteins as a small nuclear Ribo-Nuclear Protein snRNP, involved with the U6 snRNA in the di-snRNP, as well as ... Over 100 proteins have been identified that participate in spliceosomal pathway, several proteins of varying size are also ... A recycling process involving protein Brr2 releases U4 from U6, while protein Prp24 re-anneals U4 and U6. The crystal structure ...

"Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1-2): 187-96. ... became known as the Sm core proteins, or simply Sm proteins. The snRNAs are complexed with the Sm core proteins and with other ... "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". ... and consisted of seven proteins clearly homologous to the Sm proteins. These proteins were denoted LSm (like Sm) proteins (LSm1 ...

The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor ... The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. ... 2003). "SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta". Hum. ... 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi: ...

The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced ... The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA ... Gem-associated protein 4 is a protein that in humans is encoded by the GEMIN4 gene. The product of this gene is part of the SMN ... protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. 9 (13): 1977-86. doi:10.1093/hmg/9.13.1977. PMID ...

ESSs silence splice sites adjacent to them by interfering with the components of the core splicing complex, such as the snRNP's ... To elicit the silencing effect, ESSs recruit proteins that will negatively affect the core splicing machinery. Exonic splicing ... mRNA lacking this exon folds a truncated protein (a protein shortened by a mutation). Exclusion of exon 9 is mediated by a ... The TDP-43 protein is responsible for physically silencing the exon splicing site once it is recruited by the exonic splicing ...

... the core components of U1 snRNP (namely, the Sm proteins and U1 snRNA) were found to co-mislocalize to the cytoplasm with the ... Stem-loop I binds to the U1-70K protein, stem-loop II binds to the U1 A protein, stem-loops III and IV bind to the core RNP ... especially in those characterized by the presence of misfolded proteins. For instance, a protein component of U1 snRNP called ... U1 spliceosomal RNA is the small nuclear RNA (snRNA) component of U1 snRNP (small nuclear ribonucleoprotein), an RNA-protein ...

Anti-nRNP antibodies recognise the A and C core units of the snRNPs and because of this they primarily bind to the U1-snRNP. ... CENP-E is a 312kDa protein from the kinesin motor protein family. CENP-F is a 367kDa protein from the nuclear matrix that ... The retroviral gag protein shows similarity to the La protein and is proposed as a possible example for molecular mimicry in ... CENP-B is an 80kDa DNA binding protein involved in the folding of heterochromatin. CENP-C is a 140kDa protein involved in ...

... namely U1 snRNP and U2AF snRNP. However, RBPs are also part of the splicesome itself. The splicesome is a complex of snRNA and ... Other than core splicesome complex, RBPs also bind to the sites of Cis-acting RNA elements that influence exons inclusion or ... DNA-binding protein RNA-binding protein database Ribonucleoprotein Wikimedia Commons has media related to RNA-binding proteins ... These structures illustrate the intricacy of protein-RNA recognition of RRM as it entails RNA-RNA and protein-protein ...

"A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre- ... Pillai RS, Grimmler M, Meister G, Will CL, Lührmann R, Fischer U, Schümperli D (Sep 2003). "Unique Sm core structure of U7 ... U7 snRNA-associated Sm-like protein LSm10 is a protein that in humans is encoded by the LSM10 gene. LSM10 has been shown to ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...

"U1 SnRNP association with HnRNP involves an initial non-specific splice-site independent interaction of U1 SnRNP protein with ... snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of ... Spritz RA, Strunk K, Surowy CS, Hoch SO, Barton DE, Francke U (December 1987). "The human U1-70K snRNP protein: cDNA cloning, ... Romac JM, Graff DH, Keene JD (July 1994). "The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported ...

"U1 SnRNP association with HnRNP involves an initial non-specific splice-site independent interaction of U1 SnRNP protein with ... Kumar A, Williams KR, Szer W (1986). "Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship ... The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM ... and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts". Proc. Natl. Acad. Sci. U.S.A. 86 ( ...

"A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre- ... Schümperli D, Pillai RS (2004). "The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ... Azzouz TN, Gruber A, Schümperli D (2005). "U7 snRNP-specific Lsm11 protein: dual binding contacts with the 100 kDa zinc finger ... Godfrey AC, White AE, Tatomer DC, Marzluff WF, Duronio RJ (2009). "The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are ...

"Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome ... Pillai RS, Grimmler M, Meister G, Will CL, Lührmann R, Fischer U, Schümperli D (2003). "Unique Sm core structure of U7 snRNPs: ... "Unrip is a component of SMN complexes active in snRNP assembly". FEBS Lett. 579 (11): 2348-54. doi:10.1016/j.febslet.2005.03. ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038/ ...

The spliceosome is another RNP often known as the snRNP or tri-snRNP. There are two different forms of the spliceosome, the ... expressed in mammalian testes and somatic cells form RNA-protein complexes with Piwi proteins. These piRNA complexes (piRCs) ... B2 RNA inhibits transcription by binding to core Pol II. Through this interaction, B2 RNA assembles into preinitiation ... As with proteins, mutations or imbalances in the ncRNA repertoire within the body can cause a variety of diseases. Many ncRNAs ...

Binding of TIA-1 protein to an intronic splicing enhancer site stabilizes binding of the U1 snRNP. The resulting 5' donor site ... In this particular case, these exon definition interactions are necessary to allow the binding of core splicing factors prior ... Most of the activator proteins that bind to ISEs and ESEs are members of the SR protein family. Such proteins contain RNA ... When the RNA attached to that protein is isolated and cloned, it reveals the target sequences for that protein. Another method ...

U6 snRNA is the non-coding small nuclear RNA (snRNA) component of U6 snRNP (small nuclear ribonucleoprotein), an RNA-protein ... Butcher SE, Brow DA (June 2005). "Towards understanding the catalytic core structure of the spliceosome". Biochemical Society ... The association of U6 snRNP with U2 snRNP via base-pairing forms the U6-U2 complex, a structure that comprises the active site ... The approximate location of these protein binding domains was determined, and the proteins were later visualized by electron ...

"A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre- ... 2003). "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in ... "Entrez Gene: ZNF473 zinc finger protein 473". Wagner EJ, Marzluff WF (2006). "ZFP100, a component of the active U7 snRNP ... Zinc finger protein 473 is a protein that in humans is encoded by the ZNF473 gene. GRCh38: Ensembl release 89: ENSG00000142528 ...