"Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". The Journal of Biological ... "Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription". Molecular Cell. 6 (5): 1059- ... by TGF-beta and IL-1 beta via enhancement of the heat shock element binding activity of heat shock transcription factor 1". ... Razzaque MS, Ahmed AR (March 2002). "Collagens, collagen-binding heat shock protein 47 and transforming growth factor-beta 1 ...

"Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". The Journal of Biological ... "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". The Journal of Biological ... Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (Jan 1999). "RFLAT-1: a new zinc finger transcription factor that ... Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (Jan 1999). "RFLAT-1: a new zinc finger transcription factor that ...

"The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP". Nucleic Acids Res ... It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has ... growth factor-beta regulates DNA binding activity of transcription factor Fli1 by p300/CREB-binding protein-associated factor- ... CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear ...

ZZ-type zinc finger domains are found in: Transcription factors P300 and CBP. Plant proteins involved in light responses, such ... The site of interaction with the tumour suppressor protein p53 and the oncoprotein E1A with CBP/P300 is a Cys-rich region that ... utrophin and an 87kDa post-synaptic protein contain a ZZ-type zinc finger with high sequence identity to P300/CBP ZZ-type zinc ... CBP) and ADA2. CBP provides several binding sites for transcriptional coactivators. ...

"Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP ... "Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA ... is a member of the interferon regulatory factor family of transcription factors. IRF7 encodes interferon regulatory factor 7, a ... "Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A ...

... "p300/CBP acts as a coactivator of the cone-rod homeobox transcription factor". Biochemical and Biophysical Research ... The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of ... rod homeobox transcription factor". Proteins. doi:10.1002/prot.26332. PMID 35255174. Germot A, Lecointre G, Plouhinec JL, Le ... a photoreceptor transcription-factor gene". American Journal of Human Genetics. 63 (5): 1307-15. doi:10.1086/302101. PMC ...

"Human interleukin-5 expression is synergistically regulated by histone acetyltransferase CBP/p300 and transcription factors C/ ... "MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2". Oncogene. 21 (17): 2729-40. ... "MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2". Oncogene. 21 (17): 2729-40. ... Transcription factors, All stub articles, Human chromosome 10 gene stubs). ...

Promoter (biology) Activator (genetics) Operon Regulation of gene expression Transcription factor lac repressor P300/CBP ... Furthermore, a number of genes are cofactors act as negative transcription factors for FLC genes. FLC genes also have a large ... RNAP is then able to bind to the promoter and begin transcription of the lacZYA gene. An example of a repressor protein is the ... The above mechanism of repression is a type of a feedback mechanism because it only allows transcription to occur if a certain ...

The paralogous coactivators CBP (CREBBP) and P300 (EP300) are recruited to DNA-bound transcription factors to activate ... CBP[1191-1317], P300[1155-1280]. HAT domain, CBP[1323-1700], P300[1287-1663] CH3/ZZ domain, CBP[1701-1744], P300[1664-1707] CH3 ... CBP[347-433], P300[323-423] KIX domain, CBP[587-666], P300[566-645] Bromodomain, CBP[1103-1175], P300[1067-1139] CH2 domain ( ... CBP and P300 activate transcription synergistically in two ways: first, by remodelling and relaxing chromatin through their ...

"The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad ... transcription factors". The Journal of Biological Chemistry. 275 (12): 8825-34. doi:10.1074/jbc.275.12.8825. PMID 10722728. ... Miki K, Eddy EM (Apr 2002). "Tumor necrosis factor receptor 1 is an ATPase regulated by silencer of death domain". Molecular ... Nunes SL, Calderwood SK (Aug 1995). "Heat shock factor-1 and the heat shock cognate 70 protein associate in high molecular ...

2001). "Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein". Genes Dev. 15 (19): ... functions as a co-activator for transcription factor AP-2". J. Biol. Chem. 277 (10): 8559-65. doi:10.1074/jbc.M110850200. PMID ... Cbp/p300-interacting transactivator 1 is a protein that in humans is encoded by the CITED1 gene. CITED1 has been shown to ... "Entrez Gene: CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1". Yahata, T; de ...

Klf4 also interacts with the p300/CBP transcription co-activators. Klf5, also known as intestinal enriched Krüppel-like factor ... Such cross-regulation occurs extensively in transcription factor families. Many transcription factor genes regulate their own ... Kruppel-like+transcription+factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Generating iPS ... KLF4] is one of the so-called magic four transcription factors, KLF4, Oct4, Sox2 and Myc. KLF5, like KLF3, is important in ...

... activation of a transcription factor complex containing IRF-3 and CBP/p300". EMBO J. 17 (4): 1087-95. doi:10.1093/emboj/17.4. ... "Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 Are Subunits of Double-Stranded RNA-Activated Transcription Factor ... SphI postoctamer homology-binding factor/selenocysteine tRNA gene transcription activating factor, stimulates transcription of ... is an interferon regulatory factor. IRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was ...

CBP (also known as CREB-binding protein or CREBBP) Both p300 and CBP interact with numerous transcription factors and act to ... p300-CBP Transcription Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) NURSA C39 NURSA C54 ... p300 regulates transcription by directly binding to transcription factors (see external reference for explanatory image). This ... CBP and p300 are critical for normal embryonic development, as mice completely lacking either CBP or p300 protein, die at an ...

2007). "The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP". Nucleic ... Membrane transporters Transcription factors from the basic region/leucine zipper (bZIP) superfamily Growth factors Metabolic ... Articles with short description, Short description matches Wikidata, Transcription factors). ... and results in an increase in activating transcription factor ATF4, which in turn affects many processes by sundry pathways to ...

LT-HSC preference for glycolysis is encoded by the transcription factor MEIS1 and, to a lesser extent, the protein CBP/p300- ... "The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic ... Tothova, Zuzana; Gilliland, D. Gary (2007-08-16). "FoxO Transcription Factors and Stem Cell Homeostasis: Insights from the ... In addition to HIF1α, MEIS1 induces transcription of HIF2α. Though this enzyme is structurally similar to HIF1α, HIF2α has ...

CBP/p300)". The Biochemical Journal. 339 (3): 751-8. doi:10.1042/0264-6021:3390751. PMC 1220213. PMID 10215616. Biesiada E, ... Transcription factor Sp1, also known as specificity protein 1* is a protein that in humans is encoded by the SP1 gene. The ... The SP1 transcription factor contains two glutamine-rich activation domains at its N-terminus that are believed to be necessary ... "Entrez Gene: Sp1 transcription factor". Li, Lin; He, Shihua; Sun, Jian-Min; Davie, James R (2004-08-01). "Gene regulation by ...

Like many other transcription factors, STATs are capable of recruiting co-activators such as CBP and p300, and these co- ... Also, since many cytokines function through the STAT3 transcription factor, STAT3 plays a significant role in maintaining skin ... Serine phosphorylation of STATs has been shown to reduce gene transcription. It is also required for the transcription of some ... and Interferon-γ-stimulated Activation of STAT Transcription Factors in HeLa Cells". Journal of Biological Chemistry. 272 (37 ...

... its final effect on transcription depends on whether C-terminal domain is phosphorylated. Acetyltransferases CBP and p300 bind ... epidermal growth factor ligands, and inflammatory mediators. Ets1 directly interacts with various transcription factors. Their ... The protein encoded by this gene belongs to the ETS family of transcription factors. There are 28 ETS genes in humans and 27 in ... The degree to which the ETS1 transcription factor can bind to its binding sites on the PARP1 promoter depends on the ...

CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear ... "The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase ... CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear ... Studies show that EVI1 also binds to known coactivators cAMP responsive element binding protein (CBP) and p300/CBP-associated ...

"Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein ... p53 9aaTADs interact with TAF9, GCN5 and with multiple domains of CBP/p300 (KIX, TAZ1,TAZ2 and IBiD). The KIX domain of general ... Frietze S, Farnham PJ (14 April 2011). "Transcription Factor Effector Domains". A Handbook of Transcription Factors. ... is a transcription factor scaffold domain which contains binding sites for other proteins such as transcription coregulators. ...

... further supporting the idea that CBP is essential in the transcription of factors necessary G1/S phase transition. CBP is also ... CBP and p300 are used interchangeably as CBP/p300. This is a reasonable amalgamation given the sequence homology, structural ... which then binds to CBP as a coactivator for transcription of FOXO1. FOXO1 is a transcription factor for enzymes including ... also is the protein domain on CBP and p300 where heterodimers form from the interaction of CBP (or p300) with other ...

... and the forkhead family of transcription factors. SIRT1 can also regulate acetylates such as CBP/p300, and has been shown to ... essential nuclear factors. ERCs have not been observed in other species (nor even all strains of the same yeast species) of ...

Gcn5, p300/CBP, and TAFII250 are some examples of type A HATs that cooperate with activators to enhance transcription. Type B ... and the general transcription factors TFIIE and TFIIF. Other substrates include the transcription factors Sp1, KLF5, FOXO1, ... These include p300/CBP, nuclear receptor coactivators (e.g., ACTR/SRC-1), TAFII250, TFIIIC, Rtt109, and CLOCK. p300/CBP are ... PCAF (p300/CBP-associated factor) and GCN5 are mammalian GNATs that share a high degree of homology throughout their sequences ...

Thyroid transcription factor-1 (TTF-1) is a protein that regulates transcription of genes specific for the thyroid, lung, and ... Yi M, Tong GX, Murry B, Mendelson CR (January 2002). "Role of CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary ... G mismatch-specific thymine DNA glycosylase represses thyroid transcription factor-1-activated transcription". The Journal of ... containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription ...

TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L is an enzyme that in humans is ... The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position ... "Entrez Gene: TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa". Martinez E, Palhan ... "Cooperative activation of transcription by autoimmune regulator AIRE and CBP". Biochem. Biophys. Res. Commun. 333 (3): 944-53. ...

... is transcription coregulator and modulates functions of several hormonal receptors and transcription factors. PELP1 plays ... PELP1 has a histone binding domain and interacts with chromatin-modifying complexes, including CBP/p300, histone deacetylase 2 ... PELP1 also functions as a coregulator of several other transcription factors, including AP1, SP1, NFkB, STAT3, and FHL2. ... and transcription factor HMX3 is a protein that in humans is encoded by the PELP1 gene. is a transcriptional corepressor for ...

Other histone modifications have similar or opposite effects on transcription. The physiological role of SRC/p160s, CBP/p300 ... A comprehensive database of coregulators for nuclear receptors and other transcription factors was previously maintained at the ... The effects of these deletions range from the profound effects on viability characteristic of TRAP220, CBP and p300, to the ... Histone acetylase coactivators increase the rate of acetylation, opening the nucleosome to transcription factors; histone ...

Since Ngn1 is the limiting factor, CBP/p300/Smad1 is able to interact with STAT1/3 and induce gliogenesis. Activation of the ... The promotion of GFAP transcription induced glial differentiation. Neurogenin 2 (Ngn2) is a bHLH transcription factor involved ... Another transcription factor that may be a downstream target of Ngn3 is Nkx2.2 because it is often coexpressed with it. Studies ... Ngn2 is a transcription factor that both increases expression of proneural genes and drives neural fate by inhibiting ...

... p300 and CREB-binding protein (CBP) enhances the transcription of GH by binding to CREs cAMP-response elements in the promoter ... allowing the free catalytic subunits to translocate to the nucleus and phosphorylate the transcription factor cAMP response ... growth hormone-releasing factor (GHRF or GRF) somatotropin-releasing hormone (SRH) somatotropin-releasing factor (SRF) ... It also increases transcription of the GHRHR gene, providing positive feedback. In the phospholipase C pathway, GHRH stimulates ...