... raising doubts as to their authenticity as Cdc25 phosphatases. The Cdc25 family appears to have expanded in relation to the ... Cdc25 is a dual-specificity phosphatase first isolated from the yeast Schizosaccharomyces pombe as a cell cycle defective ... "Presentation on CDC25 PHOSPHATASES: A Potential Target for Novel Anticancer Agents". Archived from the original on 2016-03-03. ... The Cdc25 enzymes Cdc25A-C are known to control the transitions from G1 to S phase and G2 to M phase. The structure of Cdc25 ...

The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of ... Nilsson I, Hoffmann I (2000). "Cell cycle regulation by the Cdc25 phosphatase family". Progress in Cell Cycle Research. 4: 107- ... Galaktionov K, Beach D (1992). "Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple ... Draetta G, Eckstein J (1997). "Cdc25 protein phosphatases in cell proliferation". Biochim. Biophys. Acta. 1332 (2): M53-63. doi ...

Draetta G, Eckstein J (1997). "Cdc25 protein phosphatases in cell proliferation". Biochim. Biophys. Acta. 1332 (2): M53-63. doi ... Wee1, conserved among all eukaryotes phosphorylates Tyr15, whereas members of the Cdc25 family are phosphatases, counteracting ... Gyuris J, Golemis E, Chertkov H, Brent R (November 1993). "Cdi1, a human G1 and S phase protein phosphatase that associates ... Hannon GJ, Casso D, Beach D (March 1994). "KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases". ...

M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene. CDC25B is a member of the CDC25 family ... Hofmann K, Bucher P, Kajava AV (1998). "A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the ... Conklin DS, Galaktionov K, Beach D (1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. ... 1995). "CDC25 phosphatases as potential human oncogenes". Science. 269 (5230): 1575-7. Bibcode:1995Sci...269.1575G. doi:10.1126 ...

The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking ... Conklin DS, Galaktionov K, Beach D (August 1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U ... "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene. 19 (10): 1257-65. doi:10.1038/sj.onc. ... "Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein ...

... myosin phosphatase (MYPT), cardiac muscle troponin T (TnTc), etc. The retinoblastoma protein (pRb) and Cdc25 phosphatase were ... Huang TS, Shu CH, Yang WK, Whang-Peng J (July 1997). "Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331- ... Conklin DS, Galaktionov K, Beach D (August 1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U ... Galaktionov K, Jessus C, Beach D (May 1995). "Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to ...

It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to ... Conklin DS, Galaktionov K, Beach D (1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. ... Conklin DS, Galaktionov K, Beach D (August 1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U ... "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene. 19 (10): 1257-65. doi:10.1038/sj.onc. ...

... is a member of the CDC25 family of dual-specificity phosphatases. Dual-specificity protein phosphatases remove phosphate ... Huang TS, Shu CH, Yang WK, Whang-Peng J (Jul 1997). "Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331- ... Huang TS, Shu CH, Yang WK, Whang-Peng J (1997). "Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced ... Conklin DS, Galaktionov K, Beach D (Aug 1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S. ...

ISBN 978-0-12-324719-3. "Presentation on CDC25 PHOSPHATASES: A Potential Target for Novel Anticancer Agents". Archived from the ... Synthetic inhibitors of Cdc25 could also be useful for the arrest of cell cycle and therefore be useful as antineoplastic and ... cdc25 or cdc20. Cyclins form the regulatory subunits and CDKs the catalytic subunits of an activated heterodimer; cyclins have ...

Phosphatases from the Cdc25 family dephosphorylate both the threonine and the tyrosine. A cyclin-dependent kinase inhibitor ( ... Various kinases and phosphatases regulate their phosphorylation state. One of the kinases that place the tyrosine phosphate is ...

String/cdc25 is a phosphatase that stimulates mitotic cyclin-CDK complex activity. Upregulation of S-phase CDK activity is ... CDK activity is accomplished via transcriptional activation of Cdh/fzr and repression of the G2-M regulator string/cdc25. Cdh/ ...

... a germ line specific Cdc25 phosphatase that regulates meiotic entry; and demonstrated the roles of PP1 and PP2A protein ... phosphatases as negative mitotic regulators. His contribution to science in Scotland was recognised by his election to Fellow ...

The complex is activated by dephosphorylation by the phosphatase Cdc25. Cdc25 is always present in the cell but must be ... Galaktionov K, Beach D (1991). "Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple ... Zheng XF, Ruderman JV (1993). "Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25". ... Active Cdk1 is also capable of phosphorylating and activating Cdc25 and thus promote its own activation, resulting in a ...

Once activated, CHK2 phosphorylates downstream targets including CDC25 phosphatases, responsible for dephosphorylating and ... CHK2's inhibition of the CDC25 phosphatases prevents entry of the cell into mitosis. Furthermore, the CHK2 protein interacts ... "A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase". Current Biology. 9 (1): 1-10. doi:10.1016 ... "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. 18 (44): 6029-36. doi:10.1038/sj. ...

... including Cdc25 phosphatase catalytic domain. non-catalytic domains of eukaryotic dual-specificity MAPK-phosphatases non- ... M-phase inducer phosphatase: CDC25A; CDC25B; CDC25C; Dual specificity protein phosphatase: DUSP; DUSP1; DUSP2; DUSP4; DUSP5; ... This domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases. This ... catalytic domains of yeast PTP-type MAPK-phosphatases non-catalytic domains of yeast Ubp4, Ubp5, Ubp7 non-catalytic domains of ...

... desorption/ionization-mass spectrometry screening test to evidence reversible and irreversible inhibitors of CDC25 phosphatases ... The algal toxin microcystin is also a peptide and is an inhibitor of protein phosphatases. This toxin can contaminate water ... "Molecular enzymology underlying regulation of protein phosphatase-1 by natural toxins". Current Medicinal Chemistry. 9 (22): ...

"Discovery and Biological Evaluation of a New Family of Potent Inhibitors of the Dual Specificity Protein Phosphatase Cdc25". ...

"Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain ... Tanoue T, Moriguchi T, Nishida E (July 1999). "Molecular cloning and characterization of a novel dual specificity phosphatase, ... for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1". J. ...

"Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain ... Pettiford SM, Herbst R (February 2000). "The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP ... "Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human ... 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating ...

2001). "Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology ... 2007). "Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution". Proteins ... "Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain ... Dual specificity protein phosphatase 22 is an enzyme that in humans is encoded by the DUSP22 gene. DUSP22 has been shown to ...

... but promotes the inactivation of Cdc2 by down-regulating Cdc25 phosphatase. Cdc14 of Candida albicans is also involved in ... Human Cdc14 phosphatases are not essential for viability and do not regulate mitotic exit. Ph.D. thesis, Weill Medical College ... It is possible that Cdc14 acts as a phosphatase on all Clb-Cdk1 targets, acting to reverse the effects of the mitotic cyclins. ... Cdc14 was later shown to encode a protein phosphatase. Cdc14 is dual-specificity, which means it has serine/threonine and ...

... is activated by Cdc25, a protein phosphatase. As mitosis starts, the nuclear envelope disintegrates, chromosomes condense and ... Cdk1 and Cdc25 off, Wee1 on) and a second stable steady state in M phase (Cdk1 and Cdc25 active, Wee1 off). However, Wee1 is ... Cdc25 Cell biology Cell cycle Cell cycle checkpoint Cell cycle mathematical model Mitosis Spindle checkpoint Morgan D. (2006), ... At later phase, downregulation of Cdk1 and activation of Cdc14, a Cdh1-activating phosphatase, promotes formation of APC in ...

CyclinB-Cdc2 activates the phosphatase Cdc25 which in turn deactivates the CyclinB-Cdc2 inhibitors, Wee1 and Myt1. Cdc25 ... Absence of Cdc25 arrests cells in G2, but still allows activation of the G2-M checkpoint, implicating that both the activation ... The increase in the amount of Wee1 and the decrease in the amount of Cdc25 contributes to the increase in the cyclin B ... Inactivation of both Wee1 and Cdc25 abolishes the G2-M DNA damage checkpoint. Absence of Wee1 or removal of the tyrosine-15 ...

When cells have reached sufficient size during G2, the phosphatase Cdc25 removes the inhibitory phosphorylation, and thus ... A balance of Wee1 and Cdc25 activity with changes in cell size is coordinated by the mitotic entry control system. It has been ...

At the G2/M transition, Cdk1 is activated by Cdc25 through dephosphorylation of Tyr15. At the same time, Wee1 is inactivated ... It is inactivated by phosphorylation through Wee1 and activated by the phosphatase Cdc25C. Cdc25C in turn is activated by Polo ... Also, the active MPF will promote its own activity by activating Cdc25 and inactivating Wee1, creating a positive feedback loop ... Cdc25 homologue). Nim1/Cdr1 homologue in S. cerevisiae, Hsl1, together with its related kinases Gin4 and Kcc4 localize Swe1 to ...

... and de-phosphorylation by Cdc25 family phosphatases. In response to DNA damage, a cell's DNA repair reaction is a cascade of ... Cdks, associated cyclin counterparts, protein kinases, and phosphatases regulate cell growth and division from one stage to ...

... and phosphatases (such as Cdc25). Once the CDKs are active, they phosphorylate other proteins to change their activity, which ... These kinases, in conjunction with phosphatases, play a major role in protein and enzyme regulation as well as signalling in ... nor with phosphatases, which remove phosphate groups (dephosphorylation). The phosphorylation state of a molecule, whether it ... protein kinase Cell signaling Cyclin-dependent kinase G protein-coupled receptor Nucleoside-diphosphate kinase Phosphatase ...

... of Myt 1 and Wee 1 decrease substantially which allows for the dephosphorylation activity of phosphatases in the Cdc 25 family ... This hyperphosphorylation activates Cdc25 and inhibits Myt 1 and Wee 1. The activation of Cdc25 causes an increase in its ... This dephosphorylation of inhibitory sites is done by the Cdc25 family. In vertebrates, the Cdc25 enzymes are Cdc25A which ... and Cdc25 lies in a positive feedback loop with Cdk 1. To regulate these three proteins, Cdk 1 hyperphosphorylates the N- ...

... pTyr-specific phosphatases dual specificity phosphatases (dTyr and dSer/dThr) Cdc25 phosphatases (dTyr and/or dThr) LMW (low ... "The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1". Protein Sci. 15 (6): 1500-5. ... Tyrosine-specific protein phosphatases (PTPase; EC) catalyse the removal of a phosphate group attached to a tyrosine residue, ... Wang WQ, Sun JP, Zhang ZY (2003). "An overview of the protein tyrosine phosphatase superfamily". Curr Top Med Chem. 3 (7): 739- ...

The class II PTPs contain only one member, low-molecular-weight phosphotyrosine phosphatase (LMPTP). Cdc25 phosphatases (dTyr ... LMW (low-molecular-weight) phosphatases, or acid phosphatases, act on tyrosine phosphorylated proteins, low-MW aryl phosphates ... and include phosphatases specific to pTyr and pSer/Thr as well as small molecule phosphatases and other enzymes. The subfamily ... 11 MAPK phosphatases (MPKs) 3 Slingshots 3 PRLs 4 CDC14s 19 atypical DSPs 5 phosphatase and tensin homologs (PTENs) 16 ...