"Ambler class A beta-lactamases: TEM". Beta-Lactamase DataBase (BLDB. "Ambler class A beta-lactamases: SHV". Beta-Lactamase ... The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases ... Beta-lactamases (β-lactamases) are enzymes (EC 3.5.2.6) produced by bacteria that provide multi-resistance to beta-lactam ... OXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze ...

... may refer to: Beta-Lactamase Database (BLAD) Beta-Lactamase Database (BLDB) This disambiguation page ... lists articles associated with the title Beta-Lactamase Database. If an internal link led you here, you may wish to change the ...

Beta-Lactamase Database also known as BLDB is a database that documents beta-lactamase structure and function. It is a ... "Beta-lactamase database (BLDB) - structure and function". Journal of Enzyme Inhibition and Medicinal Chemistry. 32 (1): 917-919 ...

... beta-lactamase. It hosts sequences from all classes of metallo and non-metallo beta-lactamases. The resource has approximately ... The Beta-Lactamase Database (BLAD) is a web-based antimicrobial resistance database that provides structural and phenotypic ... Under the resistance tab, information about beta-lactamases that confer resistance to antimicrobial drugs is available. PDBS, ... Lastly, the genome tab provides information of the plasmids that contain the beta-lactamase gene and identifying ...

"Crystal structure and kinetic analysis of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase". Nat. ... Beta-Lactamase Inhibitor Proteins (BLIPs) are a family of proteins produced by bacterial species including Streptomyces. BLIP ... BLIP is able to inhibit a variety of class A beta-lactamases, possibly through flexibility of its two domains. The two tandemly ... "A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex ...

New Delhi metallo-beta-lactamase González, JM (2021). "Visualizing the superfamily of metallo-β-lactamases through sequence ... Carfi A, Pares S, Duée E, Galleni M, Duez C, Frère JM, Dideberg O (1995). "The 3-D structure of a zinc metallo-beta-lactamase ... Metallo-beta-lactamases are important enzymes because they are involved in the breakdown of antibiotics by antibiotic-resistant ... Daiyasu H, Osaka K, Ishino Y, Toh H (2001). "Expansion of the zinc metallo-hydrolase family of the beta-lactamase fold". FEBS ...

The NDM-1 enzyme is one of the class B metallo-beta-lactamase; other types of carbapenemase are class A or class D beta- ... The gene for NDM-1 is one member of a large gene family that encodes beta-lactamase enzymes called carbapenemases. Bacteria ... ISBN 978-953-176-637-1.[page needed] Muir A, Weinbren MJ (July 2010). "New Delhi metallo-beta-lactamase: a cautionary tale". J ... However, the blaNDM-1 gene produces NDM-1, which is a carbapenemase beta-lactamase - an enzyme that hydrolyzes and inactivates ...

After earning her doctorate, she moved to the University of Bristol, where she studied beta-lactamase. She completed a ... "Metalo-beta-lactamases". Jornal brasileiro de patologia e medicina laboratorial. 42 (2): 103-113. doi:10.1590/S1676- ... "Emergence of the Extended-Spectrum β-Lactamase GES-1 in a Pseudomonas aeruginosa Strain from Brazil: Report from the SENTRY ...

Queenan AM, Bush K (July 2007). "Carbapenemases: the versatile beta-lactamases". Clinical Microbiology Reviews. 20 (3): 440-58 ... Vaborbactam is a boronic acid β-lactamase inhibitor with a high affinity for serine β-lactamases, including Klebsiella ... "The structures and catalytic mechanisms of active-site serine beta-lactamases". Biotechnology & Genetic Engineering Reviews. 12 ... Beta-lactamase inhibitors, Carboxylic acids, Thiophenes, Boronate esters). ...

Beta-lactamases are characterized on CBMAR using the Ambler Classification system. CBMAR organizes beta-lactamases according to ... beta$. -Lactamases". Philosophical Transactions of the Royal Society B: Biological Sciences. 289 (1036): 321-331. doi:10.1098/ ... β-lactamase Molecular Annotation Resource is a database focused on the annotation and discovery of novel beta-lactamase genes ... a comprehensive β-lactamase molecular annotation resource". Database. 2014: bau111. doi:10.1093/database/bau111. ISSN 1758-0463 ...

... as strains of bacteria that produce extended-spectrum beta-lactamases have become more common. These beta-lactamase enzymes ... Extended-spectrum beta-lactamase-producing E. coli (ESBL E. coli) are highly resistant to an array of antibiotics, and ... In 2009, a gene called New Delhi metallo-beta-lactamase (shortened NDM-1) that even gives resistance to intravenous antibiotic ... Paterson DL, Bonomo RA (2005). "Extended-spectrum beta-lactamases: a clinical update". Clin. Microbiol. Rev. 18 (4): 657-86. ...

... s are not resistant to beta-lactamases.[citation needed] They are used parenterally, and are particularly ...

They secrete their beta-lactamases into the periplasmic space between the inner and outer membrane so they can't easily escape ... There are many beta lactamases which vary in substrate specificity and host range. The enzymes active site is easily ... This gave an increased resistance to β-lactamases due to stereochemical blocking of the beta-lactam ring. Cefuroxime was the ... Gram-positive bacteria, such as a staphylococci, have a high release of beta-lactamases into their extracellular space, where ...

Beta-lactamases (such as penicillinases) formed by gram-positive and gram-negative bacteria can stabilize doripenem to ... However, carbapenem-hydrolyzing beta-lactamases are an exception.[citation needed] On average, about 8.1% of plasma proteins ... It is stable against beta-lactamases including those with extended spectrum, but it is susceptible to the action of ... It is a beta-lactam antibiotic drug able to kill Pseudomonas aeruginosa. Doripenem can be used for bacterial infections such as ...

Klebsiella possesses beta-lactamase giving it resistance to ampicillin, many strains have acquired an extended-spectrum beta- ... Klebsiella species with the ability to produce extended-spectrum beta-lactamases (ESBL) are resistant to virtually all beta- ... These include hyperproduction of ampC beta-lactamase with an outer membrane porin mutation, CTX-M extended-spectrum beta- ... In 2009, strains of K. pneumoniae with gene called New Delhi metallo-beta-lactamase ( NDM-1) that even gives resistance against ...

More than 10% produced extended-spectrum beta-lactamases. Type species for this genus are: Raoultella electrica 1GBT Raoultella ...

Evans, J.; Galindo, E.; Olarte, J.; Falkow, S. (October 1968). "Beta-lactamase of R factors". Journal of Bacteriology. 96 (4): ...

... bacteria that make beta-lactamases will increase their production and secretion to cleave the beta lactam ring. As a cephamycin ... This followed a 2012 French study on the same E. coli strain with CTX-M-15 extended release beta-lactamase. Lepeule et al. ... Cephamycin C was the first cephem discovered but while it was highly resistant to several beta-lactamases, as is its derivative ... It is a strong beta-lactamase inducer, as are certain other antibiotics (such as imipenem). However, cefoxitin is a better ...

"Entrez Gene: Lactamase, beta 2". Retrieved 2015-07-07. Dominski Z (2007-03-01). "Nucleases of the metallo-beta-lactamase family ... The metallo beta-lactamases were first identified in bacteria; they give some strains antibiotic resistance by degrading beta- ... Lactamase, beta 2 is a protein that in humans is encoded by the LACTB2 gene. LACTB2 is located on the 8th chromosome, with its ... The LACTB2 protein has a metallo β-lactamase (MBL) fold, with two zinc ions in the active site. ...

Serine beta-lactamase-like protein LACTB, mitochondrial is an enzyme that in humans is encoded by the LACTB gene. This gene ... "Entrez Gene: LACTB lactamase, beta". Peitsaro N, Polianskyte Z, Tuimala J, Pörn-Ares I, Liobikas J, Speer O, Lindholm D, ... LACTB shares sequence similarity to the beta-lactamase/penicillin-binding protein family of serine proteases that are involved ... encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain". Genomics. 78 (1-2): 12-4. doi: ...

... non beta-lactam beta-lactamase inhibitor), and instead binds reversibly. Ambler Class B beta-lactamases cleave beta-lactams by ... C and some Class D beta-lactamases (avibactam). Like beta-lactam antibiotics, they are processed by beta-lactamases to form an ... Thus the spread of bacterial strains expressing metallo beta-lactamases such as the New Delhi metallo-beta-lactamase 1 has ... In bacterial resistance to beta-lactam antibiotics, the bacteria have beta-lactamase which degrade the beta-lactam rings, ...

Meyer, M; Hochrein, L.; Arnold, F (2006). "Structure-guided SCHEMA recombination of distantly related beta-lactamases". Protein ... SCHEMA algorithm has been applied in the recombinant libraries of distantly related β-lactamases. Voigt, CA; Martinez, C; Wang ...

Beta-lactam antibiotics, Beta-lactamase inhibitors, Sulfones, Triazoles, All stub articles, Antibiotic stubs). ... Ceftolozane Sulbactam Clavulanate Yang Y, Rasmussen BA, Shlaes DM (August 1999). "Class A beta-lactamases--enzyme-inhibitor ... Tazobactam is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 ... Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express β-lactamase and would ...

"Molecular structures of penicillin-binding proteins and beta-lactamases". Trends in Microbiology. 2 (10): 372-80. doi:10.1016/ ... Kinetically, the interaction between the DD-peptidase and beta-lactams is a three-step reaction: E + I ⇌ E ⋅ I → E − I ∗ → E + ... Spratt BG (May 1983). "Penicillin-binding proteins and the future of beta-lactam antibiotics. The Seventh Fleming Lecture". ... P {\displaystyle E+I\rightleftharpoons E\cdot I\rightarrow E-I*\rightarrow E+P} Beta-Iactams may form an adduct E-I* of high ...

Drawz SM, Bonomo RA (January 2010). "Three decades of beta-lactamase inhibitors". Clinical Microbiology Reviews. 23 (1): 160- ... For example, β-lactam antibiotics may be used in combination with β-lactamase inhibitors, such as clavulanic acid or sulbactam ... For example, NDM-1 is a newly identified enzyme conveying bacterial resistance to a broad range of beta-lactam antibacterials. ... New cephalosporin-lactamase inhibitor combinations also approved include ceftazidime-avibactam and ceftolozane-avibactam for ...

However, some bacterial cells have the enzyme β-lactamase, which hydrolyzes the beta-lactam ring, rendering the drug inactive. ... Drawz SM, Bonomo RA (January 2010). "Three decades of beta-lactamase inhibitors". Clinical Microbiology Reviews. 23 (1): 160- ... Cefalexin is a beta-lactam antibiotic of the cephalosporin family. It is bactericidal and acts by inhibiting synthesis of the ... Cefalexin is a beta-lactam antibiotic within the class of first-generation cephalosporins. It works similarly to other agents ...

ISBN 978-1-4511-1221-4. Akova M (January 2008). "Sulbactam-containing beta-lactamase inhibitor combinations". Clinical ... a drug that inhibits beta lactamase, an enzyme produced by bacteria to inactivate ampicillin and related antibiotics. It is ... Ampicillin is in the penicillin group of beta-lactam antibiotics and is part of the aminopenicillin family. It is roughly ... Petri WA (2011). "Penicillins, Cephalosporins, and Other Beta-Lactam Antibiotics". In Brunton L, Chabner B, Knollman B (eds.). ...

The carboxypenicillins are beta-lactamase sensitive.[citation needed] Aminopenicillin "Mayo Clinic Proceedings". Retrieved 2015 ... The carboxypenicillins feature the beta-lactam backbone of all penicillins but also feature a carboxylic acid or carboxylic ...

... is resistant to beta-lactamase. Chemically, its zwitterionic structure can facilitate rapid penetration across ... by selecting bacteria which have acquired beta-lactamases. The use may cause resistance in Salmonella present in the intestinal ... The reactive site is a beta-lactam nucleus, while the main peripheral functional groups are a quaternary quinolinium, an ... they are active against bacteria carrying the AmpC-type β-lactamase resistance mechanism. Since the late 1990s, the US and EU ...

... spending her first 5 years in the analytical chemistry department beginning her research on beta-lactamases and beta-lactamase ... Bush's research into the mechanisms of action for beta-lactamases has provided key insights in development of beta-lactamase ... She co-curated a website for this family of enzymes that has named over 2000 beta lactamases. During her 36 years of antibiotic ... Izumenolide-a novel beta-lactamase inhibitor produced by Micromonospora. II. Biological properties. J Antibiot (Tokyo). 1980;33 ...

1992). "Beta-lactamase TEM1 of E. coli. Crystal structure determination at 2.5 A resolution". FEBS Lett. 299 (2): 135-42. doi: ... 1996). "The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme". Proc. ... β-lactamases such as TEM-1 use a lysine residue as the base. Because lysine's pKa is so high (pKa=11), a glutamate and several ... 2017). "Alpha/beta-hydrolases: A unique structural motif coordinates catalytic acid residue in 40 protein fold families". ...