... flanking region of the beta-globin gene. The CoTC core is highly conserved in the 3' UTR of other primate beta-globin genes. ... Page for Beta-globin co-transcriptional cleavage ribozyme at Rfam v t e v t e (Orphaned articles from May 2016, All orphaned ... The Beta-globin co-transcriptional cleavage ribozyme (CotC ribozyme) was proposed to be an RNA enzyme known as a ribozyme. ... This process is also referred to as co-transcriptional cleavage (CoTC). The CoTC process in the human beta-globin gene was ...
This locus contains not only the beta globin gene but also delta, gamma-A, gamma-G, and epsilon globin. Expression of all of ... The order of the genes in the beta-globin cluster is: 5' - epsilon - gamma-G - gamma-A - delta - beta - 3'. The arrangement of ... Frischknecht H, Dutly F (Mar 2007). "A 65 bp duplication/insertion in exon II of the beta globin gene causing beta0-thalassemia ... Levings PP, Bungert J (Mar 2002). "The human beta-globin locus control region". European Journal of Biochemistry. 269 (6): 1589 ...
The order of the genes in the beta-globin cluster is: 5' - epsilon - gamma-G - gamma-A - delta - beta - 3'. GRCh38: Ensembl ... 1977). "Human beta-globin messenger RNA. I. Nucleotide sequences derived from complementary RNA". J. Biol. Chem. 252 (14): 5019 ... 1993). "Normal delta-globin gene sequences in Sardinian nondeletional delta beta-thalassemia". Hemoglobin. 16 (6): 503-9. doi: ... 1994). "Reexamination of the African hominoid trichotomy with additional sequences from the primate beta-globin gene cluster". ...
The globin gene family is an elaborate network of genes consisting of alpha and beta globin genes including genes that are ... Goodman M, Koop BF, Czelusniak J, Weiss ML (December 1984). "The eta-globin gene. Its long evolutionary history in the beta- ... These globin genes in the globin family are all well conserved and only differ by a small portion of the gene, indicating that ... An example of a gene family that may have been created due to copy number variations is the globin gene family. ...
I. Helical regions of human alpha and beta globins". Biochemical and Biophysical Research Communications. 97 (3): 868-874. doi: ...
The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5' - epsilon - gamma- ... Tuan D, Solomon W, Li Q, London IM (1985). "The "beta-like-globin" gene domain in human erythroid cells". Proc. Natl. Acad. Sci ... 1977). "Human beta-globin messenger RNA. I. Nucleotide sequences derived from complementary RNA". J. Biol. Chem. 252 (14): 5019 ... Ruskin B, Greene JM, Green MR (1985). "Cryptic branch point activation allows accurate in vitro splicing of human beta-globin ...
Isolation and characterization of the complete chicken beta-globin gene region: frequent deletion of the adult beta-globin ... Villeponteau, B., Landes, G.M., Pankratz, M.J., and Martinson, H.G. (1982). The chicken beta globin gene region. Delineation of ... Lois, R., Freeman, L., Villeponteau, B., and Martinson, H.G. (1990). Active beta-globin gene transcription occurs in methylated ... Gamma rays and bleomycin nick DNA and reverse the DNase I sensitivity of beta-globin gene chromatin in vivo. Molecular and ...
This test is used to investigate deletions and mutations in the alpha- and beta-globin-producing genes. Family studies can be ... Beta thalassemia minor can also present as beta thalassemia silent carriers; those who inherit a beta thalassemic mutation but ... Beta thalassemia trait (also known as beta thalassemia minor) involves heterozygous inheritance of a beta-thalassemia mutation ... Most often, mutations occur in the promoter regions preceding the beta-globin genes. Less often, abnormal splice variants are ...
... (beta globin, β-globin, haemoglobin beta, hemoglobin beta) is a globin protein, coded for by the HBB ... Expression of beta globin and the neighbouring globins in the β-globin locus is controlled by single locus control region (LCR ... Beta thalassemia is an inherited genetic mutation in one (Beta thalassemia minor) or both (Beta thalassemia major) of the Beta ... The order of the genes in the beta-globin cluster is 5' - epsilon - gamma-G - gamma-A - delta - beta - 3'. HBB interacts with ...
These studies determined that the LCR was required for normal regulation of beta-globin gene expression. Evidence of the ... The β-globin LCR in mice and humans is found 6-22 kb upstream of the first globin gene (epsilon). It controls the following ... Levings PP, Bungert J (March 2002). "The human beta-globin locus control region". European Journal of Biochemistry. 269 (6): ... Although the name implies that the LCR is limited to a single region, this implication only applies to the β-globin LCR (HBB- ...
Voon HP, Vadolas J (Dec 2008). "Controlling alpha-globin: a review of alpha-globin expression and its impact on beta- ... Sharma V, Kumar B, Kumar G, Saxena R (Oct 2009). "Alpha globin gene numbers: an important modifier of HbE/beta thalassemia". ... The human alpha globin gene cluster is located on chromosome 16 and spans about 30 kb, including seven alpha like globin genes ... "alpha-thalassaemia masked by beta gene defects and a new polyadenylation site mutation on the alpha2-globin gene". European ...
Differences in the regulated expression of cloned human alpha globin and beta globin genes introduced into MEL cells: the role ... Basis for regulating the expression of human alpha- and beta-globin genes. Discovery of a family of vertebrate genes encoding ... Transcriptional regulation of globin gene expression in the human erythroid cell line K562 », Science, (1983), 220, p. 1281- ... where he studied the molecular basis for the regulation of globin gene expression. In 1984, he joined the European Molecular ...
This model has been demonstrated by the previous work on the beta-globin locus. The binding of CTCF has been shown to have many ... Farrell CM, West AG, Felsenfeld G (2002). "Conserved CTCF insulator elements flank the mouse and human beta-globin loci". Mol. ... Vostrov AA, Quitschke WW (1998). "The zinc finger protein CTCF binds to the APBbeta domain of the amyloid beta-protein ...
"Nonuniform recombination within the human beta-globin gene cluster". American Journal of Human Genetics. 36 (6): 1239-1258. ... Phillips, J. A.; Snyder, P. G.; Kazazian, H. H. (September 1977). "Ratios of α-to β-globin mRNA and regulation of globin ... "Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster". ... Orkin, Stuart H.; Kazazian, Haig H. (1 December 1984). "The mutation and polymorphism of the human β-globin gene and its ...
Banerji J, Rusconi S, Schaffner W (December 1981). "Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences ... high-level expression of the human beta-globin gene in transgenic mice". Cell. 51 (6): 975-85. doi:10.1016/0092-8674(87)90584-8 ... Evans T, Felsenfeld G, Reitman M (1990). "Control of globin gene transcription". Annual Review of Cell Biology. 6: 95-124. doi: ...
"Polymorphism of DNA sequence in the beta-globin gene region. Application to prenatal diagnosis of beta 0 thalassemia in ...
"Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination". Nature. 317 (6034): 230-4 ...
Tito published the sequence of the messenger RNA coding for beta-globin, the first complete primary structure of a eukaryotic ... "The structure and evolution of the human beta-globin gene family". Cell. 21 (3): 653-68. doi:10.1016/0092-8674(80)90429-8. ISSN ... "The structure and evolution of the human beta-globin gene family". Cell. 21 (3): 653-668. doi:10.1016/0092-8674(80)90429-8. ... In 1979, his research group isolated the gene for epsilon-globin (HBE1), a component of human embryonic hemoglobin. He was one ...
... beta-globins and alpha-globins. Beta-hemoglobin is created from the genetic information on the HBB, or "hemoglobin, beta" gene ... The single nucleotide change in the beta-globin means that even the smallest of exertions on the part of the carrier results in ... The single replacement of the sixth amino acid in the beta-globin, glutamic acid, with valine results in deformed red blood ... The β-globin gene is found on the short arm of chromosome 11. The association of two wild-type α-globin subunits with two ...
Onishi Y, Kiyama R (2003). "Interaction of NF-E2 in the human beta-globin locus control region before chromatin remodeling". J ... Blank V, Kim MJ, Andrews NC (1997). "Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression". ... Strauss EC, Andrews NC, Higgs DR, Orkin SH (1992). "In vivo footprinting of the human alpha-globin locus upstream regulatory ... analysis of its role in globin and GCSl genes regulation". Blood Cells Mol. Dis. 29 (2): 145-58. doi:10.1006/bcmd.2002.0550. ...
Tanabe O, Katsuoka F, Campbell AD, Song W, Yamamoto M, Tanimoto K, Engel JD (Jul 2002). "An embryonic/fetal beta-type globin ...
Her dissertation was titled The organization of repetitive sequences in two cloned mouse beta-globin clusters. Haigwood ... Haigwood, Nancy Logan (1980). "The organization of repetitive sequences in two cloned mouse beta-globin clusters". The ...
The Beta-Globin Gene Cluster Distribution Revisited-Patterns in Native American Populations. Archived September 10, 2008, at ...
... and beta-globin loci. ACHs are formed through extensive DNA looping to form a "hub" of regulatory elements in order to ... "Looping and interaction between hypersensitive sites in the active beta-globin locus". Molecular Cell. 10 (6): 1453-65. doi: ...
Costantini F, Lacy E (November 1981). "Introduction of a rabbit beta-globin gene into the mouse germ line". Nature. 294 (5836 ... "Cloned transgenic cattle produce milk with higher levels of beta-casein and kappa-casein". Nature Biotechnology. 21 (2): 157-62 ...
... and delta-genes influences beta-globin gene expression in man". Nature. 283 (5748): 637-42. Bibcode:1980Natur.283..637V. doi: ... For example, in tissues that express globin genes, the β-globin locus control region forms a loop with these genes. This loop ... "Looping and interaction between hypersensitive sites in the active beta-globin locus". Molecular Cell. 10 (6): 1453-65. doi: ... Beta thalassemia is a certain type of blood disorder caused by a deletion of LCR enhancer element. Holoprosencephaly is ...
"The structure and transcription of four linked rabbit beta-like globin genes". Cell. 18 (4): 1285-1297. doi:10.1016/0092-8674( ...
Costantini F, Lacy E (November 1981). "Introduction of a rabbit beta-globin gene into the mouse germ line". Nature. 294 (5836 ... It has been engineered with three genes that biosynthesise beta-carotene, a precursor of vitamin A, in the edible parts of rice ... Jefferson RA, Kavanagh TA, Bevan MW (December 1987). "GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion ... beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm". Science. 287 (5451): 303-5. Bibcode:2000Sci...287.. ...
... beta InterPro: IPR002337 Hemoglobin, alpha InterPro: IPR002338 Myoglobin, trematode type InterPro: IPR011406 Globin, nematode ... The globin fold is found in its namesake globin families as well as in phycocyanins. The globin fold was thus the first protein ... Globin E: a globin responsible for storing and delivering oxygen to the retina in birds Globin-coupled sensors: chimeric, with ... Eight globins are known to occur in vertebrates: androglobin (Adgb), cytoglobin (Cygb), globin E (GbE, from bird eye), globin X ...
Nagai, K.; Thøgersen, H. C. (1984). "Generation of beta-globin by sequence-specific proteolysis of a hybrid protein produced in ...