Tumor necrosis factor
"Tumor Necrosis Factor-alpha". Drug Information Portal. U.S. National Library of Medicine. Tumor Necrosis Factor-alpha at the U. ... Tumor necrosis factor (TNF, cachexin, or cachectin; formerly known as tumor necrosis factor alpha or TNF-α) is an adipokine and ... Ghada A. Abd El Latif, Tumor necrosis factor alpha and keratin 17 expression in oral submucous fibrosis in rat model, E.D.J. ... reported another cytotoxic factor produced by macrophages and named it tumor necrosis factor (TNF). Both factors were described ...
Severe cutaneous adverse reactions
... tumor necrosis factor alpha). AGEP: Key elements promoting tissue injury in AGEP are: neutrophils; recruiters and activators of ... None-genetic ADME factors are also associated with increased risks of developing SCARs. For example, allopurinol is metabolized ... Currently, it is suspected that the expression of particular HLA proteins and T-cell receptors interact with ADME factors to ... While these viral reactivations, particularly of human herpes virus 6, have been suggested to be an important factor in the ...
Tumor necrosis factor receptor 1
"Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells". Cell Growth ... Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and ... "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 ... This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription ...
ADAM 17 endopeptidase
Cleaves Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). ... ADAM 17 endopeptidase (EC 3.4.24.86, tumor necrosis factor alpha-converting enzyme, TACE) is an enzyme. This enzyme catalyses ... Black RA (January 2002). "Tumor necrosis factor-alpha converting enzyme". The International Journal of Biochemistry & Cell ...
ADAM17
"Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF ... ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and ... Zheng Y, Schlondorff J, Blobel CP (November 2002). "Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE ... Black RA (January 2002). "Tumor necrosis factor-alpha converting enzyme". The International Journal of Biochemistry & Cell ...
Colostrum
Rudloff HE, Schmalstieg FC, Mushtaha AA, Palkowetz KH, Liu SK, Goldman AS (January 1992). "Tumor necrosis factor-alpha in human ... tumor necrosis factor, chemokines, and others. Colostrum also contains a number of growth factors, such as insulin-like growth ... transforming growth factors alpha, beta 1 and beta 2, fibroblast growth factors, epidermal growth factor, granulocyte- ... platelet-derived growth factor, vascular endothelial growth factor, and colony-stimulating factor-1. Colustrum, which is ...
Sarcoidosis
Callejas-Rubio JL, López-Pérez L, Ortego-Centeno N (December 2008). "Tumor necrosis factor-alpha inhibitor treatment for ... Cathcart S, Sami N, Elewski B (May 2012). "Sarcoidosis as an adverse effect of tumor necrosis factor inhibitors". Journal of ... and anti-tumor necrosis factor treatment (such as infliximab, etanercept, golimumab, and adalimumab). In a clinical trial ... "Relationship between tumor necrosis factor-α (TNFA) gene polymorphisms and cardiac sarcoidosis". In Vivo. 28 (6): 1125-9. PMID ...
LRRFIP1
"GCF2/LRRFIP1 represses tumor necrosis factor alpha expression". Mol Cell Biol. 25 (20): 9073-81. doi:10.1128/MCB.25.20.9073- ... "GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury". Circ ... "Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor". J Biol Chem. 273 (34 ...
Howel-Evans syndrome
Mutations in RHBDF2 inhibit tumour necrosis factor alpha. RHBDL2 also acts on Epidermal growth factor and EphrinB3. ... RHBDF2 is involved in the regulation of the secretion of several ligands of the epidermal growth factor receptor. The rhomboid ... Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer. Fam Cancer ...
Sp7 transcription factor
"Inhibition of osteoblast differentiation by tumor necrosis factor-alpha". Endocrinology. 141 (11): 3956-64. doi:10.1210/endo. ... Transcription factor Sp7, also called osterix (Osx), is a protein that in humans is encoded by the SP7 gene. It is a member of ... Sp12+Transcription+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with short ... As a zinc-finger transcription factor, its relatively high homology with Sp1 seems to indicate that it might act in a similar ...
Nitric oxide synthase
Tumor necrosis factor alpha and Interferon gamma). Induction of the high-output iNOS usually occurs in an oxidative environment ... It is synthesized by many cell types in response to cytokines and is an important factor in the response of the body to attack ... These properties may define the roles of iNOS in host immunity, enabling its participation in anti-microbial and anti-tumor ... NO produced by eNOS has been shown to be a vasodilator identical to the endothelium-derived relaxing factor produced in ...
Testicular immunology
Lysiak JJ (2004). "The role of tumor necrosis factor-alpha and interleukin-1 in the mammalian testis and their involvement in ... Hutson JC (1993). "Secretion of tumor necrosis factor alpha by testicular macrophages". Journal of Reproductive Immunology. 23 ... Risk factors for the formation of antisperm antibodies in men include the breakdown of the blood‑testis barrier, trauma and ... Other immune factors found in the testis include the enzyme inducible nitric oxide synthase (iNOS), and its product nitric ...
Proteases in angiogenesis
ADAM17 is able to release active tumor necrosis factor-alpha (TNFα) and heparin-binding EGF-like growth factor (HB-EGF) from ... Black, R (2002). "Tumor necrosis factor-alpha converting enzyme". Int. J. Biochem. Cell Biol. 34 (1): 1-5. doi:10.1016/S1357- ... Abounader, R; Laterra, J (2005). "Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis". Neuro-Oncol ... Several growth factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) are trapped ...
TNFAIP8
Tumor necrosis factor, alpha-induced protein 8 is a protein that in humans is encoded by the TNFAIP8 gene. It is preferentially ... "Entrez Gene: TNFAIP8 tumor necrosis factor, alpha-induced protein 8". Li T, Wang W, et al. (May 2018). "Genome-wide analysis ... Kumar D, Whiteside TL, Kasid U (Feb 2000). "Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, ... "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions ...
Alpha-enolase
Rus HG, Niculescu F, Vlaicu R (August 1991). "Tumor necrosis factor-alpha in human arterial wall with atherosclerosis". ... Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha- ... ENO1 overexpression has been associated with multiple tumors, including glioma, neuroendocrine tumors, neuroblastoma, ... Alpha-enolase has been shown to interact with TRAPPC2. Enolase ENO2 ENO3 Alpha-Enolase Linked to Severe Asthma - medscape news ...
Oral submucous fibrosis
Tumor necrosis factor alpha and keratin 17 are interdependent regulators; they could be used as diagnostic markers and a ... Abd El Latif GA (January 2019). "Tumor necrosis factor alpha and keratin 17 expression in oral submucous fibrosis in rat model ...
TNFAIP3
Tumor necrosis factor, alpha-induced protein 3 or A20 is a protein that in humans is encoded by the TNFAIP3 gene. This gene was ... "Entrez Gene: TNFAIP3 tumor necrosis factor, alpha-induced protein 3". Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, ... 1990). "Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific ... Opipari AW Jr; Boguski MS; Dixit VM (October 1990). "The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type ...
Morpheein
Corti, A; Fassina, G; Marcucci, F; Barbanti, E; Cassani, G (1992). "Oligomeric tumour necrosis factor alpha slowly converts ... "Mechanism of suramin-induced deoligomerization of tumor necrosis factor .alpha". Biochemistry. 34 (19): 6344-50. doi:10.1021/ ... Hlodan, Roman; Pain, Roger H. (1995). "The Folding and Assembly Pathway of Tumour Necrosis Factor TNFalpha, a Globular Trimeric ... Schulz, Ju¨Rgen; Sparmann, Gisela; Hofmann, Eberhard (1975). "Alanine-mediated reversible inactivation of tumour pyruvate ...
TSG-6
"Entrez Gene: TNFAIP6 tumor necrosis factor, alpha-induced protein 6". Mittal M, Tiruppathi C, Nepal S, Zhao YY, Grzych D, Soni ... tumor necrosis factor, alpha-induced protein 6) gene. TSG-6 is a 30 kDa secreted protein that contains a hyaluronan-binding ... "NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1". ... Tumor necrosis factor-inducible gene 6 protein also known as TNF-stimulated gene 6 protein or TSG-6 is a protein that in humans ...
Hidradenitis suppurativa
Haslund P, Lee RA, Jemec GB (November 2009). "Treatment of hidradenitis suppurativa with tumour necrosis factor-alpha ... The mean time to the onset of this type of lesion is 10 years or more and the tumors are usually highly aggressive. Tumors of ... Several triggering factors should be taken into consideration: Obesity is an exacerbating rather than a triggering factor, ... Genetic factors: an autosomal dominant inheritance pattern has been proposed. Endocrine factors: sex hormones, especially an ...
TNF inhibitor
"FDA Alert: Tumor Necrosis Factor-alpha (TNFα) Blockers: Label Change - Boxed Warning Updated for Risk of Infection from ... Scheinfeld N (September 2004). "A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha ... Haslund P, Lee RA, Jemec GB (November 2009). "Treatment of hidradenitis suppurativa with tumour necrosis factor-alpha ... October 1994). "Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus ...
SERPINB10
Schleef RR, Chuang TL (August 2000). "Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced cell death. Evidence ... Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices. A ... "Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins". Biochemistry. 28 ...
Interleukin 1-alpha
It is on the pathway that activates tumor necrosis factor-alpha. Interleukin 1 was discovered by Gery in 1972. He named it ... IL-1α is also known as fibroblast-activating factor (FAF), lymphocyte-activating factor (LAF), B-cell-activating factor (BAF), ... Constine LS, Harwell S, Keng P, Lee F, Rubin P, Siemann D (Mar 1991). "Interleukin 1 alpha stimulates hemopoiesis but not tumor ... Interleukin-1 alpha (IL-1 alpha) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is ...
P2RX7
"Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia". Journal of Neurochemistry. 75 (3): 965-72. ... "Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT". Journal of ...
Laminin subunit gamma-1
Davis JM, Narachi MA, Alton NK, Arakawa T (1987). "Structure of human tumor necrosis factor alpha derived from recombinant DNA ... 2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha ... Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are ... Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they ...
TNFAIP1
"Entrez Gene: TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)". Wolf FW, Marks RM, Sarma V, et al. (1992 ... This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein ... "Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific ... "Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene". J. Biol. Chem. 267 (2): ...
Risk factors for tuberculosis
Mutlu G, Mutlu E, Bellmeyer A, Rubinstein I (2006). "Pulmonary adverse events of anti-tumor necrosis factor-alpha antibody ... Some drugs, including rheumatoid arthritis drugs that work by blocking tumor necrosis factor-alpha (an inflammation- ... HIV is a major risk factor for tuberculosis. The risk of developing TB is estimated to be between 20 and 37 times greater in ... There are a number risk factors for tuberculosis infection; worldwide the most important of these is HIV. Co-infection with HIV ...
Yersinia pseudotuberculosis
Boland A, Cornelis GR (1998). "Role of YopP in suppression of tumor necrosis factor alpha release by macrophages during ... Correlation with its inhibitory effect on tumor necrosis factor-alpha production". J. Biol. Chem. 272 (25): 15920-7. doi: ... Structurally, it is unlike any other superantigen, but is remarkably similar to the tumour necrosis factor and viral capsid ... Since this pathway gives secretion selectivity, it is a virulence factor. In contrast to the ysc and yop genes listed above, ...
Oncolytic adenovirus
... tumor necrosis factor alpha (TNFα), and interleukin 12 (IL-12) have been integrated into oncolytic adenovirus to enhance immune ... "Immunological Effects of a Tumor Necrosis Factor Alpha-Armed Oncolytic Adenovirus". Human Gene Therapy. 26 (3): 134-144. doi: ... Most tumours studied, have defects in the p53 tumor suppressor pathway. p53 is a transcription factor that plays a role in ... Phase I of the trial recruited patients with metastatic solid tumors and showed evidence for virus replication within tumour ...
ZFP36
Carballo E, Lai WS, Blackshear PJ (August 1998). "Feedback inhibition of macrophage tumor necrosis factor-alpha production by ... It is a member of the TIS11 (TPA-induced sequence) family, along with butyrate response factors 1 and 2. TTP binds to AU-rich ... DuBois RN, McLane MW, Ryder K, Lau LF, Nathans D (Dec 1990). "A growth factor-inducible nuclear protein with a novel cysteine/ ... For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA ...
Role of microglia in disease
"Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia". Journal of Neurochemistry. 75 (3): 965-72. ... Crosstalk between tumor cells and TAMs is characterized by the release of growth factors and cytokines by TAMs in response to ... Tumor-associated macrophages/microglia (TAMs) are the main infiltrate in gliomas, comprising up to 40% of the tumor mass. TAMs ... Not only tumor cells, but also non-tumor cells of the microenvironment contribute to cancer progression and response to ...
SH3BGRL3
2001). "A novel tumor necrosis factor-alpha inhibitory protein, TIP-B1". Int. J. Immunopharmacol. 22 (12): 1137-42. doi:10.1016 ... reported SH3BGRPL3 protein as a post-translational modification of the 27kDa tumor necrosis factor alpha (TNF-α) inhibitory ... 1999). "Identification, characterization, and cloning of TIP-B1, a novel protein inhibitor of tumor necrosis factor-induced ... Conversely, the related protein SH3BGRL is reported to be downregulated in fibroblasts, lymphoid cells, and splenic tumor cells ...