... is a method of inducible gene expression where transcription is reversibly ... "Transcriptional activation by tetracyclines in mammalian cells". Science. 268 (5218): 1766-9. Bibcode:1995Sci...268.1766G. doi: ... It is also human codon optimized and composed of three minimal VP16 activation domains. However, the Tet-On 3G protein has five ... In the Cre and FRT systems, activation or knockout of the gene is irreversible once recombination is accomplished, whereas, in ...

Ptashne M, Gann A (April 1997). "Transcriptional activation by recruitment". Nature. 386 (6625): 569-77. Bibcode:1997Natur.386 ... molecular strategies for transcriptional activation". Molecular Endocrinology. 17 (10): 1901-9. doi:10.1210/me.2002-0384. PMID ... Jin J, He K, Tang X, Li Z, Lv L, Zhao Y, Luo J, Gao G (July 2015). "An Arabidopsis Transcriptional Regulatory Map Reveals ... ISSN 0032-0889 Jin J, He K, Tang X, Li Z, Lv L, Zhao Y, Luo J, Gao G (2015). "An Arabidopsis Transcriptional Regulatory Map ...

... thereby promoting transcriptional activation. ALY has key roles in 3'-end processing of polyadenylated mRNAs and in nuclear ... 1999). "Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus". Hum ... and transcriptional activity of bZIP proteins". Mol. Cell. 4 (2): 219-28. doi:10.1016/S1097-2765(00)80369-X. PMID 10488337. Le ...

C-terminal transcriptional activation domains. Selective modulation of transcription mediated by members of the steroid ... Tsuchiya H, Orimoto K, Kobayashi K, Hino O (February 1996). "Presence of potent transcriptional activation domains in the ...

"Transcriptional activators and activation mechanisms". Protein & Cell. 2 (11): 879-888. doi:10.1007/s13238-011-1101-7. ISSN ... Activation domains also come in a variety of types that are categorized based on the domain's amino acid sequence, including ... A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. ... The breakdown of maltose in Escherichia coli is controlled by gene activation. The genes that code for the enzymes responsible ...

Miyamoto K, Gurdon JB (Sep 2011). "Nuclear actin and transcriptional activation". Communicative & Integrative Biology. 4 (5): ... When an activation signal (i.e. an action potential) arrives at the muscle fiber, it triggers the release of Ca2+ from the ... It has been suggested that these centres may play a role in the polymerization of actin by acting during the activation stage. ... Wolyniak MJ, Sundstrom P (Oct 2007). "Role of actin cytoskeletal dynamics in activation of the cyclic AMP pathway and HWP1 gene ...

de Caestecker, Mark P. (2000). "The Smad4 Activation Domain (SAD) Is a Proline-rich, p300-dependent Transcriptional Activation ... Inman GJ (February 2005). "Linking Smads and transcriptional activation". The Biochemical Journal. 386 (Pt 1): e1-e3. doi: ... Smad-Activation Domain). Second, MAPK primes Smad4 for GSK3-mediated phosphorylations that cause transcriptional inhibition and ... it allows Smad4 to reach its peak of transcriptional activity by activating a growth factor-regulated transcription activation ...

Shibuya K, Fukushima S, Takatsuji H (February 2009). "RNA-directed DNA methylation induces transcriptional activation in plants ... "Small dsRNAs induce transcriptional activation in human cells". Proceedings of the National Academy of Sciences of the United ... and CTR9 to form an RNA-induced transcriptional activation (RITA) complex. RITA can directly interacts with RNAP II to ... RNA activation (RNAa) is a small RNA-guided and Argonaute (Ago)-dependent gene regulation phenomenon in which promoter-targeted ...

Kaiso regulates Znf131-mediated transcriptional activation. (2010) Exp. Cell Res. 316: 1692-1705. 19. Brown ST, Kelly KF, ... Wang H, Liu W, Black S, Turner O, Daniel JM, Dean-Colomb W, He QP, Davis M and Yates C. Kaiso, a transcriptional repressor, ... Nuclear Import of the BTB/POZ Transcriptional Regulator Kaiso. (2004) J. Cell Sci. 117: 6143-6152. 28. Rodova M, Kelly KF, ... Non-Canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. (2004) Nat. Cell Biol. 6: 1212 ...

Transcriptional activators have a DNA binding domain and a domain for activation of transcription. The activation domain can ... However, CRISPR activation systems are fused to transcriptional activators to increase expression of genes of interest. Such ... The dCas9 activation system can be used to control exactly which cells are activated and at what time activation occurs. dCas9 ... Park JJ, Dempewolf E, Zhang W, Wang ZY (2017). "RNA-guided transcriptional activation via CRISPR/dCas9 mimics overexpression ...

... 1 is associated with transcriptional activation. H4K20me2 is similar to H4K20me1 but has a different distribution and ... combinatorial transcriptional output. It is thought that a Histone code dictates the expression of genes by a complex ...

"Evidence for a transcriptional activation function for BRCA1 C-terminal region." (1996) Proc. Natl. Acad. Sci. 93: 13595. A.N.A ... "Common BRCA1 Variants and Transcriptional Activation." (1997) Am. J. Human. Genet. 61:761. T. Ouchi, A.N.A. Monteiro, A. August ... "Src induced activation of Inducible T cell Kinase (ITK) requires PI3 kinase activity and the Pleckstrin Homology domain of ... A. August (GS). "On the molecular basis of the two signal hypothesis of T cell activation: Signaling by CD3 and CD28". Ph.D. ...

Doris Wagner; Robert W. M. Sablowski; Elliot M. Meyerowitz (1 July 1999). "Transcriptional activation of APETALA1 by LEAFY". ...

"MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300". The EMBO Journal. 22 (2 ... While these means of transcriptional regulation also exist in eukaryotes, the transcriptional landscape is significantly more ... This means that transcriptional regulation in the form of protein repressors and positive control elements can either increase ... However, transcriptional silencing may be of more importance than mutation in causing progression to cancer. For example, in ...

Nguyen T, Huang HC, Pickett CB (May 2000). "Transcriptional regulation of the antioxidant response element. Activation by Nrf2 ... Similar to other sMafs, MafK lacks any canonical transcriptional activation domains. MAFK is broadly but differentially ... "One enhancer mediates mafK transcriptional activation in both hematopoietic and cardiac muscle cells". The EMBO Journal. 19 (12 ... Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity". The Journal ...

Gossen M, Freundlieb S, Bender G, Müller G, Hillen W, Bujard H (June 1995). "Transcriptional activation by tetracyclines in ... tetracycline-controlled transcriptional activation to regulate transgene expression in organisms and cell cultures. Doxycycline ... Some studies suggest that doxycycline can also suppress the activation of the nuclear factor-kappa B (NF-κB) pathway, which is ... cells and organisms with inducible protein expression systems using tetracycline-controlled transcriptional activation. The ...

"Three functional classes of transcriptional activation domain". Molecular and Cellular Biology. 16 (5): 2044-55. doi:10.1128/ ... Yankulov K, Bentley D (June 1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Current Biology. 8 ... Zhou Q, Sharp PA (October 1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 ( ... January 2020). "Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers ...

Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (1996). "Three functional classes of transcriptional activation ... Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447 ...

Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (1996). "Three functional classes of transcriptional activation ... Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447 ... Chen D, Riedl T, Washbrook E, Pace PE, Coombes RC, Egly JM, Ali S (July 2000). "Activation of estrogen receptor alpha by S118 ... Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): ...

Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (1996). "Three functional classes of transcriptional activation ... Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447 ... Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): ...

Evidence for a role in transcriptional activation". J. Biol. Chem. 272 (52): 33353-9. doi:10.1074/jbc.272.52.33353. PMID ... Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in ... Dunn KL, Davie JR (2003). "The many roles of the transcriptional regulator CTCF". Biochem. Cell Biol. 81 (3): 161-7. doi: ... CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and ...

Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (1996). "Three functional classes of transcriptional activation ... Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447 ... Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): ... Identification of hormone-regulated sites and examination of their influence on transcriptional activity". J. Biol. Chem. 269 ( ...

"Three functional classes of transcriptional activation domain". Molecular and Cellular Biology. 16 (5): 2044-55. doi:10.1128/ ... Yankulov K, Bentley D (Jun 1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Current Biology. 8 ( ... Zhou Q, Sharp PA (Oct 1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287 ... They participate in two different transcriptional regulation processes, suggesting an important link between basal ...

Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (1996). "Three functional classes of transcriptional activation ... Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447 ... Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): ...

Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. ... while MED25 is required for the transcriptional activation of jasmonate and shade signalling responses. Two components of the ... "Mediator Undergoes a Compositional Change during Transcriptional Activation". Molecular Cell. 64 (3): 443-454. doi:10.1016/j. ... which the kinase module dissociates from the complex to allow association with RNA polymerase II and transcriptional activation ...

... that target gene promoters to induce transcriptional gene activation in a process known as RNA activation (RNAa). Small dsRNAs ... "Small dsRNAs induce transcriptional activation in human cells". Proceedings of the National Academy of Sciences of the United ... By targeting selected sequences in gene promoters, saRNAs induce target gene expression at the transcriptional/epigenetic level ... New Scientist 16 November 2006 Bladder cancer: Intravesical RNA activation-a new treatment concept. Nature Review Urology ...

characterization of nuclear targeting and transcriptional activation domain". The Journal of Biological Chemistry. 276 (22): ... Oven I, Brdicková N, Kohoutek J, Vaupotic T, Narat M, Peterlin BM (December 2007). "AIRE recruits P-TEFb for transcriptional ... The specific makeup of AIRE includes a caspase activation and recruitment domain (CARD), nuclear localization signal (NLS), ... Aasland R, Gibson TJ, Stewart AF (February 1995). "The PHD finger: implications for chromatin-mediated transcriptional ...

"Small dsRNAs induce transcriptional activation in human cells". Proceedings of the National Academy of Sciences of the United ... "RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing". Nature Genetics. 36 ... SiRNA acts on the post-transcriptional stage of gene expression, so it does not modify or change DNA in a deleterious effect. ... The other anti-guide strand or passenger strand is degraded during RISC activation. Although it was first believed that an ATP- ...

"Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth". Science. 356 (6343): 1188-1192. doi: ... "Transcriptional activation of lysosomal exocytosis promotes cellular clearance". Developmental Cell. 21 (3): 421-30. doi: ... TFEB constitutive activation, due to FLCN mutations, drives renal cystogenesis and tumorigenesis in Birt-Hogg-Dubé syndrome. ... Martina JA, Chen Y, Gucek M, Puertollano R (Jun 2012). "MTORC1 functions as a transcriptional regulator of autophagy by ...

FasL is primarily regulated at the transcriptional level. (The other option is regulation of the signal emanating from the ... T cell activation-induced transcription of FasL is further regulated by c-Myc-MAX heterodimers, and can be blocked by c-Myc ... AICD (activation-induced cell death) is programmed cell death caused by the interaction of Fas receptors (Fas, CD95) and Fas ... 2000), Activation-induced cell death in B lymphocytes. Cell Res. 10(3):179-92 Nagata S. (1997), Apoptosis by death factor. Cell ...