Ubeda M, Habener JF (October 2003). "CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional ... "Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF". ... Allende-Vega N, McKenzie L, Meek D (September 2008). "Transcription factor TAFII250 phosphorylates the acidic domain of Mdm2 ... "Casein kinase II interacts with the bZIP domains of several transcription factors". Nucleic Acids Res. 26 (16): 3854-61. doi: ...

"The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation". Journal of Cell Science. 134 ( ... "FEV FEV transcription factor, ETS family member [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Durer, S.; Shaikh ... arm of chromosome 22 with part of the FLI1 ETS transcription factor family gene normally located on band 24 of the long arm of ... have tumor cells that express a fusion gene that merges part of a FET family gene with part of an ETS transcription factor ...

1993). "Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)". Genes Chromosomes ... "The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation". Journal of Cell Science. 134 ( ... Rabbitts TH, Forster A, Larson R, Nathan P (1993). "Fusion of the dominant negative transcription regulator CHOP with a novel ... arm of chromosome 16 with part of the DDIT3 ETS transcription factor family gene normally located at band 13.3 on the long (or ...

... indicating that JNK activation is also involved in the modulation of CHOP levels. As a transcription factor, CHOP can regulate ... eukaryotic initiation factor 2α (eIF2α), and induction of a transcription factor, activation transcription factor 4 (ATF4), ... CHOP also interacts with the phosphorylated transcription factor JUN to form a complex that binds to the promoter region of DR4 ... June 2014). "The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 ...

Ubeda M, Vallejo M, Habener JF (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 ... nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ... Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, ... c-jun was the first oncogenic transcription factor discovered. The proto-oncogene c-Jun is the cellular homolog of the viral ...

Cui K, Coutts M, Stahl J, Sytkowski AJ (2000). "Novel interaction between the transcription factor CHOP (GADD153) and the ... "Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis". ... Transcript variants utilizing alternative transcription start sites have been described. This gene is co-transcribed with the ... 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, ...

He identified the transcription factor CHOP and discovered its role in deregulating adipose tissue development in liposarcoma. ...

Hu, Hai; Tian, Mingxing; Ding, Chan; Yu, Shengqing (2019-01-04). "The C/EBP Homologous Protein (CHOP) Transcription Factor ... XBP1 mRNA cleavage leads to the translation of a transcription factor for genes that resolve ER stress. Measuring the rate at ... The UPR is also activated by cytokines ER-stress activates Apoptosis through C/EBP Homologous Protein (CHOP) ER Stress can be ... ER stress can be activated by a variety of factors. In experimental conditions, excessive lipid (which can happen following ...

A murine DCM study found an increase in apoptosis due to the high levels of CHOP expression. CHOP is a transcription factor ... Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H, Stevens JL, Ron D (April 1998). "CHOP is implicated in ... Increase pressure load/mechanical stress in KDEL D193N mice caused an even greater synthesis of BiP, CHOP and other proteins ...

ATF4 will work together with other transcription factors, such as CHOP and ATF3, by forming homodimers or heterodimers, ... The ATF4 transcription factor has the ability to form dimers with many different proteins that influence gene expression and ... The main intrinsic factor is endoplasmic reticulum stress due to the accumulation of unfolded proteins. It has also been ... On the other hand, ATF4 and CHOP work together to induce cell death, as well as regulating amino acid biosynthesis, transport ...

Immediately upstream of the PEDF gene lies a 200bp promoter region with putative binding sites for the transcription factors ... HNF4, CHOP, and USF. The PEDF gene consists of 8 exons and 7 introns. The PEDF gene is present in vertebrates from human to ... In humans, pigment epithelium-derived factor is encoded by the SERPINF1 gene. Pigment epithelium-derived factor (PEDF) was ... "Down-regulation of vascular endothelial growth factor and up-regulation of pigment epithelium-derived factor: a possible ...

Recently,[when?] it has been shown that trabectedin blocks DNA binding of the oncogenic transcription factor FUS-CHOP and ... By reversing the genetic program created by this transcription factor, trabectedin promotes differentiation and reverses the ... interferes directly with activated transcription, poisons the transcription-coupled nucleotide excision repair complex, ...

"The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS". J. Biol. Chem. 273 (9): 4838-42. doi: ... Rabbitts TH, Forster A, Larson R, Nathan P (Sep 1993). "Fusion of the dominant negative transcription regulator CHOP with a ... "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS". J. Biol. Chem. 273 (9): 4838-42. doi: ... and with gene-specific transcription factors such as Spi-1/PU.1. or NF-κB. It also associates with the general transcriptional ...

MAPK can regulate transcription factors directly or indirectly. Its major transcriptional targets include ATF-2, Chop, c-Jun, c ... For example, growth hormone, epidermal growth factor, platelet-derived growth factor, and insulin are all considered mitogenic ... While they are most known for their function in cell cycle control, CDKs also have roles in transcription, metabolism, and ... which can go on to regulate transcription and translation. Whereas RAF and MAPK are both serine/threonine kinases, MAPKK is a ...

Ron D, Habener JF (1992). "CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/ ... EBP and LAP and functions as a dominant-negative inhibitor of gene transcription". Genes Dev. 6 (3): 439-53. doi:10.1101/gad. ...

"The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP". Nucleic Acids Res ... growth factor-beta regulates DNA binding activity of transcription factor Fli1 by p300/CREB-binding protein-associated factor- ... Korzus E, Torchia J, Rose DW, Xu L, Kurokawa R, McInerney EM, Mullen TM, Glass CK, Rosenfeld MG (1998). "Transcription factor- ... There are various protein targets of PCAF's acetyltransferase activity including transcription factors such as Fli1, p53 and ...

... has been found to bind to transcription factor binding sites AREB6, GATA-1, GATA-2, GATA-3, ATF6, c-Myc, Max, CHOP-10 ...

2007). "The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP". Nucleic ... Membrane transporters Transcription factors from the basic region/leucine zipper (bZIP) superfamily Growth factors Metabolic ... Articles with short description, Short description matches Wikidata, Transcription factors). ... and results in an increase in activating transcription factor ATF4, which in turn affects many processes by sundry pathways to ...

... nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ... Ubeda M, Vallejo M, Habener JF (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 ... c-Fos encodes a 62 kDa protein, which forms heterodimer with c-jun (part of Jun family of transcription factors), resulting in ... Glover JN, Harrison SC (January 1995). "Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to ...

... activating transcription factor 4) and uniquely responsive to ER stress. CHOP causes downregulation of the anti-apoptotic ... ATF6 (activating transcription factor 6) is a basic leucine zipper transcription factor. Upon Grp78 dissociation, the entire ... The activated transcription factor upregulates UPR 'stress genes' by directly binding to stress element promoters in the ... These transcription factors then proceed to alter the expression of exercise-regulated muscle genes. PGC-1alpha, a ...

... the transcription factor Chop and the kinases c-Jun N-terminal kinase (JNK) and the interferon-induced, double-stranded RNA- ... manages the unfolded proteins through heat shock factor 1 (HSF1). HSF-1 is a transcription factor that, upon increases in ... The appropriately named activating transcription factor associated with stress (ATFS-1) is one of the primary transcription ... The UPRmt progresses through the bZIP transcription factor ATFS-1 (in C. elegans; ATF5 in mammals). AFTS-1 is usually imported ...

CHOP-10 (C/EBP homologous protein 10), POU3F1 (POU domain, class 3, transcription factor 1, aka Oct-6), Areb6 (ZEB1, Zinc ... nuclear factor, erythroid 2-like1), MAX1, C/EBPα, ...

... activating transcription factor 1 (ATF1), serum response factor (SRF), and mRNA-binding protein tristetraprolin (TTP) In ... via downstream targets STAT1, CHOP, FAK, SMAD, cytochrome c, NF-κB, PTEN, and p53. p38 MAPK can also target IRS-1 mediated AKT ... Janknecht R (Nov 2001). "Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase ... Yang SH, Galanis A, Sharrocks AD (Jun 1999). "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors ...

Histone nuclear factor P (HNFP) NKX homeodomain factors (NKXH) C/EBP homologous protein (CHOP) X-box binding factors (XBBF) ... The predictions included the following transcription factors: Sine oculis homeodomain factors (SIXF) p53 tumor suppressor (P53F ... Fork head domain factors (FKHD) RNA Polymerase II transcription factor II B (TF2B) TGF-beta induced apoptosis proteins (TAIP) ... A total of 428 transcription factor binding sites were predicted to be located within the predicted promoter sequence. ...

"Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription". Cell. 96 (1): 143-52. doi: ... Ubeda M, Vallejo M, Habener JF (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 ... "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription". Cell. 96 (1): 143-52. doi: ... Transcription factor JunD is a protein that in humans is encoded by the JUND gene. The protein encoded by this intronless gene ...

... blocks cell migration and invasion through the degradation of metal regulatory transcription factor 1 (MTF1) and YY2 ... Elevated levels of STAU1 in neural cells have been shown to promote apoptosis by activating the PERK-CHOP pathway and lead to ... transcription factor (YY2) through SMD in glioma cell lines. In contrast, in RD cell lines, elevated STAU1 promotes cell ... SMD of transcriptional factor retina and anterior neural fold homobox2 (RAX2) transcript has shown to be required for the ...

Upregulation of the DNA repair protein EYA3 in this tumour is mediated by the fusion protein transcription factor EWS/FLI1, ... Behrman S, Acosta-Alvear D, Walter P (March 2011). "A CHOP-regulated microRNA controls rhodopsin expression". The Journal of ... "Identification of novel stress-induced genes downstream of chop". The EMBO Journal. 17 (13): 3619-30. doi:10.1093/emboj/17.13. ...

... transcription factor chop MeSH D12.776.930.127.124.937 - Y box binding protein 1 MeSH D12.776.930.127.500.061 - maf ... transcription factor brn-3b MeSH D12.776.930.632.625.875 - transcription factor brn-3c MeSH D12.776.930.635.600.100 - ets- ... mafg transcription factor MeSH D12.776.930.127.656.750.750 - mafk transcription factor MeSH D12.776.930.127.656.770 - nf-e2 ... mafg transcription factor MeSH D12.776.930.316.750.750.750 - mafk transcription factor MeSH D12.776.930.316.750.770 - nf-e2 ...

... transcription factor chop MeSH D12.776.260.108.124.937 - Y box binding protein 1 MeSH D12.776.260.108.500.061 - maf ... nf-e2 transcription factor, p45 subunit MeSH D12.776.260.235.750.750 - maf transcription factors, small MeSH D12.776.260.235. ... transcription factor brn-3b MeSH D12.776.260.655.625.500 - transcription factor brn-3c MeSH D12.776.260.665.600.100 - ets- ... mafg transcription factor MeSH D12.776.260.235.750.750.750 - mafk transcription factor MeSH D12.776.260.235.750.770 - nf-e2 ...

"Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP ... ATF5 is a transcription factor that contains a bZip domain. Activating transcription factor ATF5 has been shown to interact ... biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors ... "Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity". Biochem. Biophys ...