Thymidine monophosphate
... (TMP), also known as thymidylic acid (conjugate base thymidylate), deoxythymidine monophosphate (dTMP ... Unlike the other deoxyribonucleotides, thymidine monophosphate often does not contain the "deoxy" prefix in its name; ... It is an ester of phosphoric acid with the nucleoside thymidine. dTMP consists of a phosphate group, the pentose sugar ... Dorland's Illustrated Medical Dictionary provides an explanation of the nomenclature variation at its entry for thymidine. As a ...
Kinase
It phosphorylates thymidine to create thymidine monophosphate (dTMP). This kinase uses an ATP molecule to supply the phosphate ... Because of this, thymidine kinase activity is closely correlated with the cell cycle and used as a tumor marker in clinical ... November 2008). "Thymidine kinase 2 defects can cause multi-tissue mtDNA depletion syndrome". Brain. 131 (Pt 11): 2841-2850. ... Thymidine kinase is one of the many nucleoside kinases that are responsible for nucleoside phosphorylation. ...
Thymidylate kinase
... monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium: ATP + thymidine 5'-phosphate ... Nelson DJ, Carter CE (1969). "Purification and characterization of Thymidine 5-monophosphate kinase from Escherichia coli B". J ... Thymidine kinase Thymidylate synthase Thymidine kinase in clinical chemistry Li C, Huang SH, Tang A, Drisco B, Zhang SQ, Seeger ... Kielley RK (1970). "Purification and properties of thymidine monophosphate kinase from mouse hepatoma". J. Biol. Chem. 245 (16 ...
Thymidine kinase in clinical chemistry
ATP ---> + ADP Thymidine reacts with ATP to give thymidine monophosphate and ADP. Thymidine monophosphate, the product of the ... Thymidine kinase 1 is such a salvage enzyme, whereas thymidine kinase 2 is not cell cycle-dependent. Thymidine kinase is a ... Thymidine monophosphate is produced by the cell in two different reactions - either by phosphorylation of thymidine as ... Thymidine kinase is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, ...
Thymidine kinase
ATP ---> + ADP Thymidine reacts with ATP to give thymidine monophosphate and ADP. Thymidine monophosphate, the product of the ... thymidine, ATP is adenosine triphosphate, TMP is (deoxy)thymidine monophosphate and ADP is adenosine diphosphate. Thymidine ... As analogs of thymidine, this type of drugs are readily phosphorylated to 5'-monophosphates. The monophosphate is further ... The unfused cells from the thymidine kinase-deficient cell line die because they have no source of thymidine monophosphate. The ...
Fluorouracil
Thymidylate synthase methylates deoxyuridine monophosphate (dUMP) to form thymidine monophosphate (dTMP). Administration of 5- ...
Arsenic poisoning
"Antigen binding characteristics of antibodies against hydroxyl radical modified thymidine monophosphate". Immunology Letters. ...
Valganciclovir
Ganciclovir is first phosphorylated to ganciclovir monophosphate by a viral thymidine kinase encoded by the cytomegalovirus ( ...
HAT medium
... which creates thymidine monophosphate (TMP) from deoxyuridine monophosphate (dUMP). By additional phosphorylation reactions, ... The alternative source is the thymidine present in the HAT medium that can be absorbed by the cells and phosphorylated by ... HAT Medium (hypoxanthine-aminopterin-thymidine medium) is a selection medium for mammalian cell culture, which relies on the ... and thymidine (a deoxynucleoside) which are intermediates in DNA synthesis. The trick is that aminopterin blocks DNA de novo ...
Nucleoside-diphosphate kinase
Nucleoside Nucleotide Nucleoside monophosphate Nucleoside triphosphate Thymidine kinase Thymidylate kinase Thymidine kinase in ... thymidine triphosphate (TTP). Behind this apparently simple reaction is a multistep mechanism. The key steps of ...
5,10-Methylenetetrahydrofolate
... to 2-deoxy-thymidine-5-monophosphate (dTMP). The coenzyme is necessary for the biosynthesis of thymidine and is the C1-donor in ... It is the one-carbon donor for thymidylate synthase, for methylation of 2-deoxy-uridine-5-monophosphate (dUMP) ...
Stampidine
... and stavudine is poorly phosphorylated to its monophosphate form in thymidine kinase-deficient cells. Stampidine exhibited: ... This is governed by the supply of thymidine kinase that is available, ... and has been designed to avoid dependence on the rate limiting step of phosphorylation of stavudine to stavudine monophosphate ...
Thymidine kinase from herpesvirus
... of thymidine kinases that catalyses the transfer of phospho group of ATP to thymidine to generate thymidine monophosphate, ... Frobert E, Ooka T, Cortay JC, Lina B, Thouvenot D, Morfin F (March 2005). "Herpes simplex virus thymidine kinase mutations ... August 1998). "Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes ... October 1995). "Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ...
TS
Thymidylate synthase, the enzyme used to generate thymidine monophosphate Tourette syndrome, a neurological condition involving ...
Capecitabine
... hence inhibiting the synthesis of thymidine monophosphate (ThMP), the active form of thymidine which is required for the de ...
TMP
... an organic chemistry reagent Thymidine monophosphate, a nucleotide Trimethoprim, an antibiotic Trimethyl phosphate, a solvent ...
Nucleoside
... such as the thymidine monophosphate) into nucleosides (such as thymidine) and phosphate. The nucleosides, in turn, are ...
List of MeSH codes (D13)
... thymidine monophosphate MeSH D13.695.462.200 - cyclic amp MeSH D13.695.462.200.225 - 8-bromo cyclic adenosine monophosphate ... thymidine monophosphate MeSH D13.695.740.850 - uracil nucleotides MeSH D13.695.740.850.210 - deoxyuracil nucleotides MeSH ... cytidine monophosphate MeSH D13.695.740.246.370.250 - cytidine monophosphate n-acetylneuraminic acid MeSH D13.695.740.246.400 ... cytidine monophosphate MeSH D13.695.827.232.370.250 - cytidine monophosphate n-acetylneuraminic acid MeSH D13.695.827.232.400 ...
Nucleotide salvage
Thymidine kinase can then phosphorylate the 5'-carbon of this compound into thymidine monophosphate (TMP). Thymidylate kinase ... Alternatively, uridine-cytidine kinase can phosphorylate them into cytidine monophosphate (CMP) or deoxycytidine monophosphate ... Thymidine phosphorylase or pyrimidine-nucleoside phosphorylase adds 2-deoxy-alpha-D-ribose 1-phosphate to thymine, with thymine ... can phosphorylate TMP into thymidine diphosphate, which nucleoside diphosphate kinase can phosphorylate into thymidine ...
Glycosidic bond
... thymidine diphosphate (TDP), or cytidine monophosphate (CMP). These activated biochemical intermediates are known as sugar ...
Uridine monophosphate synthase
... thymidine phosphorylase, and orotate phosphoribosyl transferase in prostate cancer". Prostate Cancer and Prostatic Diseases. 8 ... monophosphate, which derivates into barbiturate ribonucleoside-5'-monophosphate, xantosine-5'-monophosphate. P. falciparum ... These two sites catalyze the last two steps of the de novo uridine monophosphate (UMP) biosynthetic pathway. After addition of ... The enzyme Uridine monophosphate synthase (EC 4.1.1.23, UMPS) (orotate phosphoribosyl transferase and orotidine-5'- ...
Thymidylate synthase
... to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of ... Pyrimidine analogues Thymidylate synthase inhibitor Thymidine kinase Thymidine kinase in clinical chemistry Thymidylate kinase ... Thymidylate synthase (TS) (EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) ... The most widely used inhibitor is 5-fluorouracil (5-FU) and its metabolized form 5-fluorodeoxyuridine monophosphate (5-FdUMP), ...
Thymidine
... deoxythymidine monophosphate), dTDP, or dTTP (for the di- and tri- phosphates, respectively). It exists in solid form as small ... Radiolabeled thymidine (TdR), such as tritiated thymidine (3H-TdR), is commonly used in cell proliferation assays. The ... Before the boom in thymidine use caused by the need for thymidine in the production of the antiretroviral drug azidothymidine ( ... an excess of thymidine availability increases mutation. A deficiency of thymidine during growth also increases mutation. A ...
Thymine
Thymidine can be phosphorylated with up to three phosphoric acid groups, producing dTMP (deoxythymidine monophosphate), dTDP, ... Thymine combined with deoxyribose creates the nucleoside deoxythymidine, which is synonymous with the term thymidine. ... "Stimulation of mutation in phage T 4 by lesions in gene 32 and by thymidine imbalance". Mutat. Res. 16 (2): 113-119. doi: ...
HSV epigenetics
Aciclovir acts as a nucleoside analog which specifically target herpes virus-infected cells using viral thymidine kinase (TK). ... Viral TK phosphorylates aciclovir into its monophosphate form, which is subsequently phosphorylated to active aciclovir ...
Orotidine 5'-phosphate decarboxylase
It catalyzes the decarboxylation of orotidine monophosphate (OMP) to form uridine monophosphate (UMP). The function of this ... and thymidine triphosphate. OMP decarboxylase has been a frequent target for scientific investigation because of its ... Many studies investigated the binding of a potent inhibitor of OMP decarboxylase, 6-hydroxy uridine monophosphate (BMP, a ... Lee JK, Houk KN (May 1997). "A proficient enzyme revisited: the predicted mechanism for orotidine monophosphate decarboxylase ...
Nucleic acid metabolism
Similarly, nucleoside-monophosphate kinase carries out the phosphorylation of nucleoside-monophosphates. Adenylate kinase is a ... Thymidine synthesis first requires reduction of the uridine to deoxyuridine (see next section), before the base can be ... After synthesizing uridine-monophosphate, it can react with 2 ATP to form uridine-triphosphate or UTP. UTP can be converted to ... In order to synthesize thymidine, a component of DNA which only exists in the deoxy form, uridine is converted to deoxyuridine ...
Enzyme inhibitor
Methotrexate blocks the action of dihydrofolate reductase and thereby halts thymidine biosynthesis. This block of nucleotide ... the enzyme that degrades the signalling molecule cyclic guanosine monophosphate. This signalling molecule triggers smooth ...
DTYMK
1989). "Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity ... "Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases". Pharmacol. Ther. 87 (2-3 ...
Purine nucleoside phosphorylase
Thymidine can be phosphorylated by thymidine kinase (TK). Uridine can be phosphorylated by uridine kinase (UK). Cytidine can be ... These pathways allow the cell to produce nucleotide monophosphates when the de novo synthesis pathway has been interrupted or ...