longest telomeres. Telomeres also exist as a possible drug target. While telomeres serve a vital function in humans, telomerase ... Although leukocyte telomeres shorten with age, sperm telomeres lengthen with age. Shorter telomeres are theorized to impose ... These function in both telomere maintenance and capping. Telomeres form large loop structures called telomere loops, or T-loops ... At the very end of the T-loop, the single-stranded telomere DNA is held onto a region of double-stranded DNA by the telomere ...

... , also known as protelomerase, is an enzyme found in bacteria which contain linear plasmids. In order to ... Telomere resolvase then cuts the structure and reforms the hairpin turns, forming two new, identical linear plasmids. Shi, Ke; ... Huang, Wai Mun; Aihara, Hideki (2013). "An enzyme-catalyzed multistep DNA refolding mechanism in hairpin telomere formation". ...

A telomere is a region of repetitive nucleotide sequences at each end of a chromosome. Telomere may also refer to: Telomere ( ... Telomerization This disambiguation page lists articles associated with the title Telomere. If an internal link led you here, ... insect morphology), a type of genital clasper Telomere resolvase, an enzyme found in bacteria which contain linear plasmids. ...

A mega-telomere (also known as an ultra-long telomere or a class III telomere), is an extremely long telomere sequence that ... Telomeres are identified by telomere arrays. A telomere array is a unique arrangement of telomeres within a sample (cell, ... Telomere shortening). While the chromosomes in most eukaryotic organisms are capped with telomeres, mega-telomeres are only ... Like regular telomeres, mega-telomeres are made of a repetitive sequence of DNA and associated proteins, and are located on the ...

... s not present may cause the exposed telomeres to undergo a DNA repair response, having mistakenly ... Telomere-binding proteins can generate a T-loop to protect chromosome ends. TRFs are double-stranded proteins which are known ... Telomere-binding proteins function to generate a T-loop, which is a specialized loop structure to cap the telomeric ends. ... By targeting the telomere-binding proteins which serve to protect the ends, it may prove fruitful in future drug therapy. ...

A telomere (pl.; telomeres or telomeron), literally "end piece", is a term in insect morphology, and refers to a type of " ... The telomere may have sensilla.[citation needed] Present in higher insect orders from Orthoptera to Hymenoptera. In adult ... insects of these orders, genital claspers may develop in two segments, a proximal basimere and a distal telomere. v t e ( ...

... is a protein that in humans is encoded by the RIF1 gene. RIF1 and RIF2 cap the chromosome ends ... v t e (Articles with short description, Short description is different from Wikidata, Genes on human chromosome 2, Telomere- ... "Entrez Gene: RIF1 RAP1 interacting factor homolog (yeast)". Ribeyre C, Shore D (2012). "Anticheckpoint pathways at telomeres in ... Xu L, Blackburn EH (December 2004). "Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules ...

Importantly, because telomeres are highly repetitive, invasion between or within telomeres is not limited by the requirement ... The main alternative lengthening mechanism for telomeres is a type of homologous recombination called Break-induced Telomere ... this mechanism is used to extend telomeres. Because telomeres are by nature repetitive, matching sequences are widely available ... Alternative Lengthening of Telomeres (also known as "ALT") is a telomerase-independent mechanism by which cancer cells avoid ...

They then used α factor to block cells with induced short telomeres in late G1 phase and measured the change in telomere length ... telomere-shortening every S phase. Measurements of telomere lengths across cell types at various ages suggest that this gradual ... Almost all cancer cells have shortened telomeres. This may seem counter-intuitive, as short telomeres should activate the ATR/ ... cancer cells have short telomeres because they progress through an intermediate stage of telomere shortening-caused by division ...

Telomere diseases. N Engl J Med. 2009 Dec 10;361(24):2353-65[4] Young NS. Aplastic Anemia. N Engl J Med. 2018 Oct 25;379(17): ... Telomere diseases. N Engl J Med. 2009 Dec 10;361(24):2353-65. Young NS. Aplastic Anemia. N Engl J Med. 2018 Oct 25;379(17):1643 ... Danazol Treatment for Telomere Diseases. N Engl J Med. 2016 May 19;374(20):1922-31. Townsley DM, Scheinberg P, Winkler T, ... 2021 May 27;384(21):2039-2052[6] Danazol Treatment for Telomere Diseases. N Engl J Med. 2016 May 19;374(20):1922-31.[7] ...

"Telomere-to-Telomere". NHGRI. Retrieved 2022-08-16. Nurk S, Koren S, Rhie A, Rautiainen M, Bzikadze AV, Mikheenko A, et al. ( ... The Telomere-to-Telomere (T2T) consortium not only is an open, community-based effort to generate the first complete assembly ... In 2022, the Telomere-to-Telomere (T2T) Consortium published the first completely assembled reference genome (version T2T-CHM13 ... The gaps are mostly in areas such as telomeres, centromeres, and long repetitive sequences, with the biggest gap along the long ...

Again, it can be presumed that a reduction in TERC results in aberrant telomere maintenance and thus shortened telomeres. Those ... the telomere, during development. Telomeres are placed by telomerase on both ends of linear chromosomes as a way to protect ... Dyskeratosis congenita is a disorder of poor telomere maintenance mainly due to a number of gene mutations that give rise to ... March 2010). "Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients". Nature. 464 (7286): ...

They examined the telomeres and telomerase in women. Their results indicated that doctors could monitor telomere length and ... The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer. While studying telomeres and the ... The Telomere Effect: the New Science of Living Younger (2017) The Stress Prescription: Seven Days to More Joy and Ease (The ... Since telomeres shorten with every division of a cell, replenishing these caps is essential to long-term cell growth. Through ...

... end of telomeres. A telomere is a region of repetitive sequences at each end of the chromosomes of most eukaryotes. Telomeres ... Telomerase reverses telomere shortening. Telomerase restores short bits of DNA known as telomeres, which are otherwise ... Cherif H, Tarry JL, Ozanne SE, Hales CN (March 2003). "Ageing and telomeres: a study into organ- and gender-specific telomere ... A comparative biology study of mammalian telomeres indicated that telomere length of some mammalian species correlates ...

Telomeres When telomeres of chromosomes shorten with continued cell divisions, the chromosome ends may also fuse, forming ... Chromosomal inversion Telomeres Cytogenetics Nuclear radiation Intellectual disorders Nussbaum, Robert; McInnes, Roderick; ... Boukamp, Petra; Popp, Susanne; Krunic, Damir (2005-11-01). "Telomere-Dependent Chromosomal Instability". Journal of ...

Telomere is a mysterious terrorist organization that is behind the attacks on The Bund. Katie Maurice A female vampire who ... It is later revealed that he is a mole for Telomere. The Eight Elite consists of the best hunters in the Earth Clan. Each ... Hysterica had a habit of referring to her slaves as "Pigs." In the anime, she worked for Telomere, but still tried to contact ... In the anime, it is heavily suggested one or all of them are controlling Telomere, a terrorist group created to kill Mina. Also ...

... even when telomeres are short. Therefore, alterations in telomere length have great potential as a biomarker in cancer. ... Length of Telomeres, and the Role of Experiential Avoidance and Compassion Prenatal Undernutrition and Leukocyte Telomere ... Many studies link long telomeres and a slower rate of telomere shortening with greater longevity. For example, research done on ... on Proliferation Rate and Telomere Length In Vitro and Possible Mechanism of Action The Telomere Gestational Clock: Increasing ...

Gomes, Nuno M. V.; Shay, Jerry W.; Wright, Woodring E. (2010). "Telomere biology in Metazoa". FEBS Letters. 584 (17): 3741-3751 ...

Telomere Cairns, John (1975). "Mutation selection and the natural history of cancer". Nature. 255 (5505): 197-200. Bibcode: ...

"Entrez Gene: POT1 POT1 protection of telomeres 1 homolog (S. pombe)". Bauman P, Carolyn P (2010). "Pot1 and telomere ... POT1 is required for telomere protection because it allows for telomere inhibition of DNA damage response factors. The protein ... that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate ... Protection of telomeres protein 1 is a protein that in humans is encoded by the POT1 gene. This gene is a member of the ...

i.e., telomere length variation); epigenomics/epigenetics, organismal and corresponding cell specific transcriptomic regulating ...

In 1999 it was reported that telomeres, which cap the end of chromosomes, terminate in a lariat-like structure termed a T-loop ... Griffith, J. D.; Comeau, L.; Rosenfield, S.; Stansel, R. M.; Bianchi, A.; Moss, H.; De Lange, T. (1999). "Mammalian telomeres ... Greider, C. W. (1999). "Telomeres do D-loop-T-loop". Cell. 97 (4): 419-422. doi:10.1016/s0092-8674(00)80750-3. PMID 10338204. ... Maestroni L, Matmati S, Coulon S (2017). "Solving the Telomere Replication Problem". Genes. 8 (2): E55. doi:10.3390/ ...

January 2014). "Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced ... Thus, reprogramming leads to the restoration of embryonic telomere length, and hence increases the potential number of cell ... It was found that reprogramming leads to telomere lengthening and subsequent shortening after their differentiation back into ... West MD, Vaziri H (July 2010). "Back to immortality: the restoration of embryonic telomere length during induced pluripotency ...

The study was halted early, after telomere attrition was reduced in all 12 patients who could be evaluated. 12 of 27 patients ... A 2016 phase I/II prospective study orally administered 800 mg per day to 27 patients with telomere diseases. The primary ... May 2016). "Danazol Treatment for Telomere Diseases". The New England Journal of Medicine. 374 (20): 1922-1931. doi:10.1056/ ... efficacy endpoint was a 20% reduction in the annual rate of telomere attrition measured. Toxic effects formed the primary ...

When that chromosome subsequently replicates it forms two sister chromatids which both lack a telomere. Since telomeres appear ... Since the two resulting chromatids lack telomeres, when they replicate the BFB cycle will repeat, and will continue every ... The BFB cycle begins when the end region of a chromosome, called its telomere, breaks off. ... Murnane, John P. (2012). "Telomere dysfunction and chromosome instability". Mutation Research. 730 (1-2): 28-36. doi:10.1016/j. ...

Telomeres are regions of repetitive DNA at the end of a chromosome, which provide protection from chromosomal deterioration ... Most of the highly repetitive DNA is found in centromeres and telomeres (see above) and most of it is functional although some ... The genome also contains telomere sequences and centromeres as expected. Much of the repetitive DNA seen in other eukaryotes ... Recent studies have shown that telomeres function to aid in its own stability. Telomeric repeat-containing RNA (TERRA) are ...

In plants, the telomere sequence is conserved, which implies that this strategy can be utilized to successfully construct ... Yu, W.; Lamb, J. C.; Han, F.; Birchler, J. A. (2006). "Telomere-mediated chromosomal truncation in maize". Proceedings of the ... A minichromosome is a small chromatin-like structure resembling a chromosome and consisting of centromeres, telomeres and ... The minimum constituent parts of a chromosome (centromere, telomeres, and DNA replication sequences) are assembled by using ...

Another example related to aging is the Telomere theory. Telomere theory proposes that telomeres shorten with repeated cell ... However, there is still the question whether telomere length causes these diseases or if the diseases cause shortened telomeres ... Telomere shortening is common in somatic cells. However, germ line and stem cells prevent the end replication problem with the ... The trade-off exists as the cell benefits from telomerase which prevents permanent growth arrest but telomere shortening is ...

Telomeres form the terminal region of mammalian chromosomes and are essential for stability and aging and play central roles in ... Telomeres have been long considered transcriptionally inert DNA-protein complexes until it was shown in the late 2000s that ... These ncRNAs are heterogeneous in length, transcribed from several sub-telomeric loci and physically localise to telomeres. ... Blasco MA (October 2007). "Telomere length, stem cells and aging". Nature Chemical Biology. 3 (10): 640-649. doi:10.1038/ ...

Kuznetsova, Valentina; Grozeva, Snejana; Gokhman, Vladimir (2020). "Telomere structure in insects: A review". Journal of ...