In the field of cell biology, TNF-related apoptosis-inducing ligand (TRAIL), is a protein functioning as a ligand that induces ... Bucur O, Ray S, Bucur MC, Almasan A (May 2006). "APO2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in ... TNF-Related Apoptosis-Inducing Ligand). Vitamins & Hormones. Vol. 67. pp. 1-17. doi:10.1016/S0083-6729(04)67001-4. ISBN 978-0- ... "Identification and characterization of a new member of the TNF family that induces apoptosis". Immunity. 3 (6): 673-82. doi: ...
Abe K, Kurakin A, Mohseni-Maybodi M, Kay B, Khosravi-Far R (2001). "The complexity of TNF-related apoptosis-inducing ligand". ... This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and ... Kuang AA, Diehl GE, Zhang J, Winoto A (Aug 2000). "FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced ... and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway". Immunity. 7 (6): 821-30. doi:10.1016/s1074-7613(00 ...
2001). "The complexity of TNF-related apoptosis-inducing ligand". Ann. N. Y. Acad. Sci. 926 (1): 52-63. doi:10.1111/j.1749- ... Shu HB, Halpin DR, Goeddel DV (Jul 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751-63 ... CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene. Also called c-FLIP (FLICE- ... Overview of all the structural information available in the PDB for UniProt: O15519 (CASP8 and FADD-like apoptosis regulator) ...
TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL". J. Immunol. 160 (1 ... 2003). "TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction". Diabetologia. 45 (12): 1678- ... 2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain". J. ... 2002). "Apoptosis-mediating receptor-ligand systems in human retinal pigment epithelial cells". Graefes Arch. Clin. Exp. ...
2003). "TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction". Diabetologia. 45 (12): 1678- ... 2000). "Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL ... 2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain". J. ... syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand". J ...
"Adenovirus E1A oncogene expression in tumor cells enhances killing by TNF-related apoptosis-inducing ligand (TRAIL)". Journal ... Rao L, Debbas M, Sabbatini P, Hockenbery D, Korsmeyer S, White E (August 1992). "The adenovirus E1A proteins induce apoptosis, ... and induce apoptosis. When in coordination with E1B or other oncogenic genes such as activated ras, E1A is able to transform ... However, the structure of E1A can be fixed upon the ligand binding. The structure of cyclic-AMP response element binding ...
OPG also binds to TNF-related apoptosis-inducing ligand (TRAIL) and inhibits TRAIL induced apoptosis of specific cells, ... OPG has also been shown to bind and inhibit TNF-related apoptosis-inducing ligand (TRAIL) which is responsible for inducing ... "TRAF-6 dependent signaling pathway is essential for TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast ... between osteoprotegerin and receptor activator of NF-kappaB or tumor necrosis factor-related apoptosis-inducing ligand: ...
... "miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in ... Zhang H, Zuo Z, Lu X, Wang L, Wang H, Zhu Z (February 2012). "MiR-25 regulates apoptosis by targeting Bim in human ovarian ... Xie T, Liang J, Guo R, Liu N, Noble PW, Jiang D (May 2011). "Comprehensive microRNA analysis in bleomycin-induced pulmonary ... Kwok HH, Yue PY, Mak NK, Wong RN (August 2012). "Ginsenoside Rb₁ induces type I collagen expression through peroxisome ...
Myelomonocytic cell products that cause apoptosis include FasL, TNF-α, and TNF-related apoptosis-inducing ligand (TRAIL). ... Cancer cells induce apoptosis of activated T cells (a class of lymphocyte) by secreting exosomes containing death ligands such ... Another T cell inhibitor appears to be the apoptosis inducer Fas ligand (FasL) that is found in the tumor vasculature of tumor ... Both IDO and PD-L1 may induce T cell apoptosis. ... TAMs have been induced in vitro by exposing macrophage ...
Th1 and NK cells both contribute to killing of tumor cells via the TNF-related apoptosis-inducing ligand (TRAIL) pathway. NK ... For example, it was recently shown that CD4+ T cells primarily produce TNF after recognition of tumor-antigens in melanoma. TNF ... Th17 differentiation is induced by TGF-β and IL-6, and signature cytokines of Th17 cells include IL-17A and IL-17F. The ... In conjuncture with TNF (Tumor Necrosis Factors), IFN-γ can have direct cytotoxic effects on tumor cells (Franzen et al., 1986 ...
Koyama S, Koike N, Adachi S (2002). "Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric ... 2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain". J. ... This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell ... and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts". J. Biol. Chem. 275 ...
Elevated secretion of TNF-α and TNF-related apoptosis-inducing ligand (TRAIL) by neutrophils enhances the immune response and ... ① Bacterial toxins from S. Typhimurium, Listeria, and Clostridium can kill tumor cells directly by inducing apoptosis or ... kills tumor cells by inducing apoptosis. ⑧ The macrophage inflammasome is activated through contact with bacterial components ( ... Toxins delivered via Salmonella can upregulate Connexin 43 (Cx43), leading to bacteria-induced gap junctions between the tumor ...
2004). "IFNalpha-stimulated neutrophils and monocytes release a soluble form of TNF-related apoptosis-inducing ligand (TRAIL/ ... 2007). "Mechanism of apoptosis induced by IFN-alpha in human myeloma cells: role of Jak1 and Bim and potentiation by rapamycin ... 2005). "Cross-regulation of TNF and IFN-α in autoimmune diseases". Proc. Natl. Acad. Sci. U.S.A. 102 (9): 3372-7. Bibcode: ... 2006). "Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of ...
TNF-related apoptosis inducing ligand). TRAIL is a ligand native to the human body that is currently being developed as a ... Surprisingly, the authors found that each of the agents was able to induce apoptosis in all phases of the cell cycle, ... suggesting that the mechanism through which the drugs induce apoptosis may be independent of the drugs' biochemical targets. In ... Very little direct information is available on whether cells undergo apoptosis from a certain point in the cell cycle. One ...
TNF alpha) and receptors Fas ligand and receptors TNF-related apoptosis-inducing ligand (TRAIL; also called APO-2) and ... and increased numbers of secondary follicles as a result of the inability to induce apoptosis. TNF-related apoptosis-inducing ... "TNF-related apoptosis-inducing ligand (TRAIL) as the potential therapeutic target in hematological malignancies". Biomedicine ... mediates signals that induce apoptosis by binding Fas ligand and therefore plays an important role in follicular atresia. Lack ...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) (Figure 5) is a member of the tumor necrosis factor (TNF) ... Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995;3:673-82 Pitti RM, ... "Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway". British ... As a p53 inducible gene, NOXA is transcribed and translated to Noxa in response to DNA damage and hypoxia induced apoptosis. A ...
Also, FOXO1 regulates TNF-related apoptosis-inducing ligand (TRAIL), which caused FOXO1-induced apoptosis in the human prostate ... It suppresses survival of tumor cells by inducing apoptosis in prostate cancer cells and glioma cells by upregulating the ... Fatty acids in the beta cells activate FOXO1, resulting in apoptosis of the beta cells. FOXO1 activation plays a role in cell ... Additionally, FOXO1 trans-activate Bim protein, which a member of the Bcl-2 family that promotes apoptosis and plays a role in ...
Medications, such as fosbretabulin (a type of combretastatin), bortezomib and TNF-Related Apoptosis Induced Ligand (TRAIL), are ...
... increasing sensitivity to FAS mediated cell death and enhancement of TNF-related apoptosis inducing ligand. They have also been ... This effect is not related to TNF-α inhibition since potent TNF-α inhibitors such as rolipram and pentoxifylline did not ... Inhibition of TNF-α is not the mechanism of thalidomide's inhibition of angiogenesis since numerous other TNF-α inhibitors do ... is induced in the presence of TNF-α and the adhesion of MM cells to BMSC. In vitro proliferation of MM cell lines and ...
... and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this ... "Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase". Uhlén, Mathias; Fagerberg, Linn; Hallström, Björn M.; ... 2004). "Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive ...
... the CD95 ligand, TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors, and loss of heterozygosity. Evidence also ... Mutation of the p53 tumor suppressor gene, induced by UV radiation, has been identified as a crucial step in AK formation. This ... It works in two ways, first by disrupting cell membranes and mitochondria resulting cell death, and then by inducing antibody- ... This is suspected to be related to the abnormal keratinocyte proliferation and differentiation in AKs, which facilitate an ...
... receptor activator of NF-kappa-B ligand and tumor necrosis factor (TNF)-related apoptosis-inducing ligand protein have been ... Dao HH, Essalihi R, Bouvet C, Moreau P (May 2005). "Evolution and modulation of age-related medial elastocalcinosis: impact on ... This condition occurs as an age-related degenerative process. However, it can occur in pseudoxanthoma elasticum and idiopathic ...
"TNF-related apoptosis-inducing ligand" Pointertrails, or mouse trails, show where the GUI pointer has been recently Technical ...
TNF-related apoptosis inducing ligands, galectin-1 and DC-SIGN and production of immunosuppressive molecules such as IL-10, TGF ... These tolerogenic effects are mostly mediated through regulation of T cells such as inducing T cell anergy, T cell apoptosis ... Tol-DCs can be induced by various stimuli. It has been shown that following molecules induce/promote/favour induction of tol- ... "Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells". Blood. 102 (10): 3815-21 ...
TNF-related apoptosis-inducing ligands (TRAILs), and reactive oxygen species. Most of the tumor cells are destroyed in this ... In the second phase, newly synthesized IFN-gamma induces tumor death (to a limited amount) as well as promoting the production ... Tumor infiltration by lymphocytes is seen as a reflection of a tumor-related immune response. There is increasing evidence that ... This again promotes more tumor killing by these cells via apoptosis and the production of reactive oxygen and nitrogen ...
"Identification of Glucocorticoid-Induced TNF Receptor-Related Protein Ligand on Keratinocytes: Ligation by GITR Induces ... and rescue T cells from anti-CD3-induced apoptosis. GITR can be used as Treg marker and its signaling abrogates the suppressive ... 2007). "Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell ... "The glucocorticoid-induced TNF receptor family-related protein (GITR) is critical to the development of acute pancreatitis in ...
Tumor necrosis factor ligand superfamily member 12 also known as TNF-related weak inducer of apoptosis (TWEAK) is a protein ... a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis". The Journal of Biological Chemistry. ... TWEAK can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to ... The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ...
TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), ... RANKL is an apoptosis regulator gene, a binding partner of osteoprotegerin (OPG), a ligand for the receptor RANK and controls ... RANKL is identified as a part of the TNF family; RANKL is specifically categorized under the TNFSF11, the TNF ligand ... Receptor activator of nuclear factor kappa-Β ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 ( ...
Death receptor-mediated apoptosis occurs via activation of death ligands (Fas, TNF, and TRAIL) and death receptors. Upon ... which activates the downstream caspase cascade to induce apoptosis. The PERK-ATF4-CHOP pathway can induce apoptosis by binding ... Under most conditions, CHOP can directly bind to the promoters of downstream related genes. However, under specific condition, ... The overexpression of CHOP can lead to cell cycle arrest and result in cell apoptosis. At the same time, CHOP-induced apoptosis ...
... to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD ... Tartaglia, LA; Ayres, TM; Wong, GHW; Goeddel, DV (1993), "A novel domain within the 55 kd TNF receptor signals cell death", ... The PYD domain, also known as the Domain in Apoptosis and INterferon response (DAPIN) domain, is typically found in vertebrates ... DD-containing proteins are associated with apoptosis and inflammation, similar to the CARD domain. It has also been linked with ...