Steroidogenic factor 1
The steroidogenic factor 1 (SF-1) protein is a transcription factor involved in sex determination by controlling the activity ... suggesting roles beyond steroidogenic maintenance. RT-PCR approaches have detected transcripts of mice FTZ-F1 gene in the ... Mutations to CDK7 prevent interaction with the basal transcription factor, TFIIH, and formation of CDK-activating kinase ... For example, SF-1 controls expression of Amh gene in Sertoli cells, whereby the presence or absence of the gene product affects ...
Marion Sewer
"Steroidogenic factor-1 is a sphingolipid binding protein". Molecular and Cellular Endocrinology. 265-266: 174-178. doi:10.1016/ ... for an important regulator of steroid hormone biosynthesis called steroidogenic factor 1 (SF-1). This showed that nuclear ... Protein-Associated Splicing Factor, and SF-1, a Complex That Also Participates in Repression of Transcription". Endocrinology. ... Sewer, Marion B.; Waterman, Michael R. (2003-03-07). "cAMP-dependent Protein Kinase Enhances CYP17 Transcription via MKP-1 ...
Liver receptor homolog-1
"Cloning and sequence analysis of the human gene encoding steroidogenic factor 1". Journal of Molecular Endocrinology. 17 (2): ... Brendel C, Gelman L, Auwerx J (Jun 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that ... Galarneau L, Drouin R, Bélanger L (1998). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome ... also known as totipotency pioneer factor NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is ...
Genetics of infertility
"Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: A link to the sex determination ... "Comprehensive sequence analysis of the NR5A1 gene encoding steroidogenic factor 1 in a large group of infertile males". ... "Human Male Infertility Associated with Mutations in NR5A1 Encoding Steroidogenic Factor 1". The American Journal of Human ... The underlying causative factors in the male infertility can be attributed to environmental toxins, systemic disorders such as ...
DAX1
Burris TP, Guo W, Le T, McCabe ER (Sep 1995). "Identification of a putative steroidogenic factor-1 response element in the DAX- ... DAX1 has been shown to interact with: COPS2, NRIP1, Steroidogenic factor 1, and SREBF1. GRCh38: Ensembl release 89: ... Proteins that control the activity of other genes are known as transcription factors. DAX1 also plays a role in regulating ... protein acts as a dominant-negative regulator of transcription of other nuclear receptors including steroidogenic factor 1. ...
TRERF1
... has been shown to interact with Steroidogenic factor 1, EP300 and CREB-binding protein. GRCh38: Ensembl release 89: ... enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells". The Journal of ... enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells". The Journal of ... Transcriptional-regulating factor 1 is a protein that in humans is encoded by the TRERF1 gene. This gene encodes a zinc-finger ...
Androgen insensitivity syndrome
In one patient, the underlying cause for presumptive PAIS was a mutant steroidogenic factor-1 (SF-1) protein. In another ... "Heterozygous mutation of steroidogenic factor-1 in 46,XY subjects may mimic partial androgen insensitivity syndrome". J. Clin. ... or other genetic variations such as a mutant steroidogenic factor-1 protein. The degree of variation, however, does not appear ... narrowed down the locus of the human androgen receptor gene (or a factor controlling the androgen receptor gene) to somewhere ...
SOX9
... has been shown to interact with Steroidogenic factor 1, MED12, MAF, SWI/SNF, MLL3 and MLL4. SOX genes Ninomiya S, Narahara ... November 1998). "Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human ... November 1998). "Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human ... The process starts when the transcription factor Testis determining factor (encoded by the sex-determining region SRY of the Y ...
DGKQ
2008). "Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of ... 33 (1): 145-6. doi:10.1006/geno.1996.0174. PMID 8617502. Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, ... 287 (1): 143-54. doi:10.1016/S0014-4827(03)00115-0. PMID 12799190. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). " ...
Anti-Müllerian hormone
Shen WH, Moore CC, Ikeda Y, Parker KL, Ingraham HA (June 1994). "Nuclear receptor steroidogenic factor 1 regulates the ... Viger RS, Mertineit C, Trasler JM, Nemer M (July 1998). "Transcription factor GATA-4 is expressed in a sexually dimorphic ... Trbovich AM, Martinelle N, O'Neill FH, Pearson EJ, Donahoe PK, Sluss PM, Teixeira J (October 2004). "Steroidogenic activities ... Seifer DB, Maclaughlin DT (September 2007). "Mullerian Inhibiting Substance is an ovarian growth factor of emerging clinical ...
Organozirconium and organohafnium chemistry
1988: 1-19. doi:10.1055/s-1988-27453. "Discovery of ZACA reaction − Zr-catalyzed asymmetric carboalumination of alkenes". ... doi:10.1016/B978-0-08-052349-1.00149-9. ISBN 978-0-08-052349-1. Thomas, E.; Dixon, S.; Whitby, R. J. (2006). "A Rearrangement ... Kasatkin, A.; Whitby, R. J. (1999). "Insertion of 1-Chloro-1-lithioalkenes into Organozirconocenes. A Versatile Synthesis of ... 1-[(tert-Butyldiphenylsilyl)oxy]-dec-3-en-5-ol". Organic Syntheses. 74: 205. doi:10.15227/orgsyn.071.0083. Fillery, Shaun F.; ...
GATA6
"Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal". Mol. ... Transcription factor GATA-6, also known as GATA-binding factor 6 (GATA6), is protein that in humans is encoded by the GATA6 ... Kiiveri S, Liu J, Heikkilä P, Arola J, Lehtonen E, Voutilainen R, Heikinheimo M (2005). "Transcription factors GATA-4 and GATA- ... Keijzer R, van Tuyl M, Meijers C, Post M, Tibboel D, Grosveld F, Koutsourakis M (February 2001). "The transcription factor ...
Infertility
Mutations to NR5A1 gene encoding steroidogenic factor 1 (SF-1) have been found in a small subset of men with non-obstructive ... Ferraz-de-Souza B, Lin L, Achermann JC (April 2011). "Steroidogenic factor-1 (SF-1, NR5A1) and human disease". Molecular and ... In approximately one-third of these cases the man is the factor, in one third the woman is the factor, and in the remaining ... Factors that can cause male as well as female infertility are: DNA damage DNA damage reduces fertility in female ovocytes, as ...
Mir-383 microRNA precursor family
"Transactivation of microRNA-383 by steroidogenic factor-1 promotes estradiol release from mouse ovarian granulosa cells by ... 1 (11): e94. doi:10.1038/cddis.2010.70. PMC 3032325. PMID 21368870.. Lian J, Zhang X, Tian H, Liang N, Wang Y, Liang C, Li X, ... "MiR-224 targets the 3'UTR of type 1 5'-iodothyronine deiodinase possibly contributing to tissue hypothyroidism in renal cancer ...
Melanocortin 2 receptor accessory protein
... of the mouse steroidogenic acute regulatory protein gene by the cAMP response-element binding protein and steroidogenic factor ... "Prolonged treatment with the synthetic glucocorticoid methylprednisolone affects adrenal steroidogenic function and response to ... 371 (1-2): 62-70. doi:10.1016/j.mce.2012.10.011. PMC 3582781. PMID 23138111. Gibbison B, Spiga F, Walker JJ, Russell GM, ... 59 (1): 169-87. doi:10.1111/j.1601-5223.1968.tb02169.x. PMID 5662632. Roy S, Rached M, Gallo-Payet N (July 2007). "Differential ...
Wilms tumor protein
In combination with Cited2 activates WT1 the Steroidogenic factor 1 There is some evidence for RNA editing of human WT1 mRNA. ... The WT1 protein has been found to bind a host of cellular factors, e.g. p53, a known tumor suppressor. Despite the name, WT1 ... This gene encodes a transcription factor that contains four zinc finger motifs at the C-terminus and a proline / glutamine-rich ... Davies RC, Calvio C, Bratt E, Larsson SH, Lamond AI, Hastie ND (October 1998). "WT1 interacts with the splicing factor U2AF65 ...
Sterol regulatory element-binding protein 1
... receptor through interaction with positive regulators sterol regulatory element-binding protein-1a and steroidogenic factor-1 ... The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. SREBP-1a regulates ... Ferré P, Foufelle F (Oct 2010). "Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c". ... "Entrez Gene: SREBF1 sterol regulatory element binding transcription factor 1". Eberlé D, Hegarty B, Bossard P, Ferré P, ...
TCF21 (gene)
TCF21 transcriptionally represses steroidogenic factor 1 (Sf1), a gene expression regulator that mediates sexual ... In an effort to identify novel bHLH factors related to dHAND and eHAND (a novel subclass of cell type-restricted bHLH factors ... Transcription factor 21 (TCF21), also known as pod-1, capsuling, or epicardin, is a protein that in humans is encoded by the ... Lu J, Chang P, Richardson JA, Gan L, Weiler H, Olson EN (August 2000). "The basic helix-loop-helix transcription factor ...
UBP1
Huang N, Miller WL (2000). "Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1- ... Yoon JB, Li G, Roeder RG (Mar 1994). "Characterization of a family of related cellular transcription factors which can modulate ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Zhao H, Li J, Jiang L (2004). "Inhibition of HIV-1 TAR RNA-Tat peptide ... Upstream-binding protein 1 is a protein that in humans is encoded by the UBP1 gene. GRCh38: Ensembl release 89: ENSG00000153560 ...
Catenin beta-1
... synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors". Molecular and Cellular ... June 2006). "The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress- ... Kennell JA, O'Leary EE, Gummow BM, Hammer GD, MacDougald OA (August 2003). "T-cell factor 4N (TCF-4N), a novel isoform of mouse ... Pai R, Dunlap D, Qing J, Mohtashemi I, Hotzel K, French DM (July 2008). "Inhibition of fibroblast growth factor 19 reduces ...
TFAP2A
... activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element". Molecular ... "Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor ... Analysis of transcription factor binding site analysis showed that the risk allele disrupt a binding site for AP-2 alpha. ... Transcription factor AP-2 alpha (Activating enhancer binding Protein 2 alpha), also known as TFAP2A, is a protein that in ...
STAR (gene)
"The steroidogenic response and corpus luteum expression of the steroidogenic acute regulatory protein after human chorionic ... Steroidogenic acute regulatory protein is a protein that in humans is encoded by the STAR gene. The protein encoded by this ... Kim HJ, Kim JE, Ha M, Kang SS, Kim JT, Park IS, Paek SH, Jung HW, Kim DG, Cho GJ, Choi WS (July 2003). "Steroidogenic acute ... Tajima K, Dantes A, Yao Z, Sorokina K, Kotsuji F, Seger R, Amsterdam A (May 2003). "Down-regulation of steroidogenic response ...
PNRC1
... steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)". Mol. Endocrinol. 14 (7): 986-98. doi:10.1210/mend. ... Zhou D, Chen B, Ye JJ, Chen S (2004). "A novel crosstalk mechanism between nuclear receptor-mediated and growth factor/Ras- ... Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene. PNRC1 functions as a ... 1264 (1): 19-22. doi:10.1016/0167-4781(95)00159-e. PMID 7578250. "Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator ...
COUP-TFII
... correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle". J. Clin. ... Sato Y, Suzuki T, Hidaka K, Sato H, Ito K, Ito S, Sasano H (2003). "Immunolocalization of nuclear transcription factors, DAX-1 ... COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein ... Overview of all the structural information available in the PDB for UniProt: P24468 (COUP transcription factor 2) at the PDBe- ...
Sex-determining region Y protein
It's been shown that binding of three transcription factors, steroidogenic factor 1 (SF1), specificity protein 1 (Sp1 ... Once in the nucleus, SRY and SF1 (steroidogenic factor 1, another transcriptional regulator) complex and bind to TESCO (testis- ... SRY acts as a transcription factor that causes upregulation of other transcription factors, most importantly SOX9. Its ... WT1 is transcription factor that has four C-terminal zinc fingers and an N-terminal Pro/Glu-rich region and primarily functions ...
Cholesterol side-chain cleavage enzyme
The trophic hormones increase CYP11A1 gene expression through transcription factors such as steroidogenic factor 1 (SF-1), by ... Steroidogenic cells include a diverse array of antioxidant systems to cope with the radicals generated by the steroidogenic ... In each steroidogenic cell, the expression of the P450scc system proteins is regulated by the trophic hormonal system specific ... The system is also expressed at high levels in steroidogenic theca cells in the ovary, and Leydig cells in the testis. During ...
SF1
Steroidogenic factor 1 Star Fox (1993 video game), the first game in the Star Fox series Street Fighter (video game), the first ... All pages with titles containing Sf1 All pages with titles containing sf-1 SF (disambiguation) SFI (disambiguation) SFL ( ... a television monitor sold by Sharp Corporation with a built-in Super NES SRF 1, a Swiss television channel formerly known as ' ... SF 1' Summary File 1, a United States Census report Search for "SF1" or "sF-1" on Wikipedia. ...
PNRC2
... steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)". Mol. Endocrinol. 14 (7): 986-98. doi:10.1210/mend. ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and ... Hentschke M, Borgmeyer U (2004). "Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 1, Gene expression, ...
FATE1
Upregulation of FATE1 by a transcription factor steroidogenic factor-1 (SF-1), involved in adrenal and gonadal development as ... showing high similarity to the mitochondrial fission factor (MFF) protein which is involved in mitochondrial and peroxisomal ... 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. Olesen C, Silber J, Eiberg H, Ernst E, Petersen K, ... 7 (1): 11-20. doi:10.1093/molehr/7.1.11. PMID 11134355. Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S ( ...
SAE1
... modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic ... 453 (1): 70-4. doi:10.1016/j.abb.2006.03.002. PMID 16620772. Pan X, Li H, Zhang P, Jin B, Man J, Tian L, Su G, Zhao J, Li W, ... 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Komatsu T, Mizusaki H, Mukai T, Ogawa H, Baba D, Shirakawa M, Hatakeyama S, ...