Absorption: Stavudine has rapid absorption and good oral bioavailability (F = 0.86). Distribution: Stavudine does not bind to ... Stavudine is in the nucleoside analog reverse-transcriptase inhibitor (NRTI) class of medication. Stavudine was first described ... "Stavudine". Discontinuations Reported to FDA. U.S. Food and Drug Administration. 30 April 2018. "Stavudine". Drug Information ... Stavudine was submitted under the FDA's accelerated approval process. Through this process, Stavudine's effectiveness was ...

Combining zidovudine with stavudine does not increase the mitochondrial toxicity compared to stavudine alone. Both of these ... Since stavudine and zidovudine are OAT1 substrates, they may have similar effects on proximal renal tubule cells as they do on ... The use of stavudine, didenosine, abacavir, adefovir, cidofovir and tenofovir has been associated with Fanconi syndrome. ... Nelson M, Azwa A, Sokwala A, Harania RS, Stebbing J (2008). "Fanconi syndrome and lactic acidosis associated with stavudine and ...

Stavudine (d4T) was an early application of the ProTide approach. This was a rational choice based on the known kinetics of ...

Stavudine, also called d4T, has trade names Zerit and Zerit XR. Lamivudine, also called 3TC, has the trade name Zeffix and ... A virus with Q151M alone is intermediately resistant to zidovudine (AZT), didanosine (ddI), zalcitabine (ddC), stavudine (d4T ... and stavudine (d4T) Cytidine analogues: zalcitabine (ddC), lamivudine (3TC), and emtricitabine (FTC) Guanosine analogues: ...

Lactic acidosis associated with the use of stavudine (Zerit, for HIV therapy) or metformin (for diabetes) Mania caused by ... Mokrzycki MH, Harris C, May H, Laut J, Palmisano J (January 2000). "Lactic acidosis associated with stavudine administration: a ...

Administration with drugs with overlapping toxicity, such as zalcitabine and stavudine, is not recommended. Alcohol can ...

"Lactic Acidosis and Hepatic Steatosis Associated with Use of Stavudine: Report of Four Cases". Annals of Internal Medicine. 133 ...

The patent claims to cover Stavudine, a nucleoside analog reverse-transcriptase (NARTI) active against HIV. This was the first ...

... stavudine and nevirapine in human plasma". Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life ...

Further modification of the dideoxy framework led to the development of 2´,3´-didehydro-3´-deoxythymidine (stavudine, d4T). ... NRTIs approved by the FDA are zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir and emtricitabine and the ... Activity of stavudine was shown to be similar to that of zidovudine, although their phosphorylation patterns differ; the ... whereas the affinity for stavudine is 700-fold weaker. 2',3'-dideoxy-3'-thiacytidine (lamivudine, 3TC) was discovered by ...

Deaths from lactic acidosis and liver failure have been primarily associated with two specific NRTIs, stavudine and didanosine ...

... such as didanosine and stavudine. The most common adverse events at the beginning of treatment are nausea and headache. More ...

... and stavudine (d4T). The diagnosis is a clinical diagnosis, established by an experienced endocrinologist. A genetic ... 48-week study of switching stavudine and/or protease inhibitors to combivir/abacavir to prevent or reverse lipoatrophy in HIV- ...

Horwitz was also first to synthesize stavudine (d4T) and zalcitabine (ddC) - two other reverse-transcriptase inhibitors used in ...

In zidovudine (AZT; ATC:J05AF01) the 3'-hydroxyl group has been replaced by an azido group, in stavudine (ATC: J05AF04) it has ... Chemical structures of thymidine kinase substrate analogs AZT Stavudine Idoxuridine Aciclovir Ganciclovir Other thymidine ...

In patients who are given the drug stavudine to treat HIV, Haplogroup L0a2 is associated with a higher likelihood of peripheral ... Mitochondrial DNA subhaplogroups L0a2 and L2a modify susceptibility to peripheral neuropathy in malawian adults on stavudine ...

... and has been designed to avoid dependence on the rate limiting step of phosphorylation of stavudine to stavudine monophosphate ... This is governed by the supply of thymidine kinase that is available, and stavudine is poorly phosphorylated to its ... It is a derivative of stavudine (d4T, brand name Zerit), ... and sub-Saharan Africa with resistance to stavudine, adefovir ...

In August 2003, Aspen launched Aspen Stavudine - its first generic ARV drug, building an Oral Solid Dosage drug facility in ...

... and discovered the anti-HIV effect of stavudine (D4T) Juan Rosai (1985-1991): professor of pathology and Director of the ...

... and Stavudine (d4T), the third and fourth drugs approved to treat AIDS Adrian Kantrowitz, MD, performed the world's first ...

Abacavir Amprenavir Atazanavir Darunavir Delavirdine Didanosine (ddI) Dolutegravir Efavirenz Enfuvirtide Stavudine (d4T) ...

... tenofovir disoproxil and efavirenz J05AR07 Stavudine, lamivudine and nevirapine J05AR08 Emtricitabine, tenofovir disoproxil and ... Darunavir J05AE30 Nirmatrelvir and ritonavir J05AF01 Zidovudine J05AF02 Didanosine J05AF03 Zalcitabine J05AF04 Stavudine ...

The molecular formula C10H12N2O4 (molar mass: 224.21 g/mol, exact mass: 224.0797 u) may refer to: 3-Hydroxykynurenine Stavudine ...

115 million securitization of a single Yale patent with claims covering Stavudine, which is a reverse transcriptase inhibitor ...

Schinazi has also had a hand in the development of the other FDA-approved drugs Stavudine, Lamivudine, and Telbivudine. In 2018 ...

... stavudine - stellate - stem cell - stem cell factor - stem cell transplantation - stent - stereotactic biopsy - stereotactic ...

... stavudine (d4T) telbivudine (hepatitis B) zidovudine (azidothymidine, or AZT)(HIV) deoxyuridine analogues: idoxuridine ...

Integral involvement in new antiretroviral drug development: Zidovudine, Zalcitabine, Didanosine, Stavudine, nevirapine, ...

... stavudine, one of the earliest AIDS drugs, in the mid-1980s. William Prusoff attended the University of Miami. After receiving ...

Staphcillin Starlix Starnoc Statex Staticin Statobex Statrol stavudine (INN) stearylsulfamide (INN) steffimycin (INN) Stelazine ...