SMAD3 is a polypeptide with a molecular weight of 48,080 Da. It belongs to the SMAD family of proteins. SMAD3 is recruited by ... The SMAD3 complex with the GGCGC site reveals that the protein-DNA interface is highly complementary and that one MH1 protein ... "SMAD3 Gene". Ross KR, Corey DA, Dunn JM, Kelley TJ (May 2007). "SMAD3 expression is regulated by mitogen-activated protein ... which stabilized the SMAD3/SMAD4 complex. FOXM1 is a key player in the activity of the SMAD3/SMAD4 complex, promoting SMAD3 ...

Guo X, Ramirez A, Waddell DS, Li Z, Liu X, Wang XF (January 2008). "Axin and GSK3- control Smad3 protein stability and modulate ... "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent ... Pal R, Bondar VV, Adamski CJ, Rodney GG, Sardiello M (June 2017). "Inhibition of ERK1/2 Restores GSK3β Activity and Protein ... Hong YR, Chen CH, Cheng DS, Howng SL, Chow CC (August 1998). "Human dynamin-like protein interacts with the glycogen synthase ...

Guo X, Ramirez A, Waddell DS, Li Z, Liu X, Wang XF (January 2008). "Axin and GSK3- control Smad3 protein stability and modulate ... "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ... Polyubiquitin-C is a protein encoded by the UBC gene in humans. Polyubiquitin-C is one of the sources of ubiquitin, along with ... Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y (August 2008). "Protein phosphatase 4 negatively regulates LPS cascade by ...

EID-2 interacts constitutively with Smad proteins, and most strongly with Smad3. Stable expression of EID-2 in the TGF-beta1- ... The protein encoded by this gene may function as an endogenous suppressor of TGF-beta signaling and inhibits differentiation by ... Ji A, Dao D, Chen J, MacLellan WR (October 2003). "EID-2, a novel member of the EID family of p300-binding proteins inhibits ... v t e (Articles with short description, Short description is different from Wikidata, Protein pages needing a picture, Genes on ...

... protein was found to interact with proteins PLEKAH5, Ezra, GAMMAHV.ORF23, and SMAD3. Orthologous sequences of CCDC186 ... "CCDC186 - Coiled-coil domain-containing protein 186 - Homo sapiens (Human) - CCDC186 gene & protein". "BLAST: Basic Local ... CCDC186 is a protein that in humans is encoded by the CCDC186 gene The CCDC186 gene is also known as the CTCL-tumor associated ... The protein of CCDC186 (NP_060487) is 898 amino acids in length. The predicted molecular weight is 103.7kdal and the ...

2003). "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3". J ... E3 SUMO-protein ligase PIAS4 is one of several protein inhibitor of activated STAT (PIAS) proteins. It is also known as protein ... "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3". J. Biol. ... "Entrez Gene: PIAS4 Protein inhibitor of activated STAT, 4". Imoto, Seiyu; Sugiyama Kenji; Muromoto Ryuta; Sato Noriko; Yamamoto ...

"Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3". J. Biol. ... The SMAD proteins are homologs of both the drosophila protein, mothers against decapentaplegic (MAD) and the C. elegans protein ... SMAD family member 6, also known as SMAD6, is a protein that in humans is encoded by the SMAD6 gene. SMAD6 is a protein that, ... Developmental genes and proteins, MH1 domain, MH2 domain, Human proteins, All stub articles, Human chromosome 15 gene stubs, ...

This then interacts with and then phosphorylates SMAD2 and SMAD3, two of the cytoplasmic SMAD proteins. Smad3 then translocates ... Activin, inhibin and a number of other structurally related proteins such as anti-Müllerian hormone, bone morphogenetic protein ... and growth differentiation factor belong to the TGF-β protein superfamily. The activin and inhibin protein complexes are both ... In addition, both complexes are derived from the same family of related genes and proteins but differ in their subunit ...

Receptor I is then able to bind proteins Smad2 and Smad3, which form a complex with Smad4. This complex accumulates in the ... In rats, oxymatrine also inhibits the expression of the Smad3 ligand which binds to TGF-β1 type I and activates the signal ... Journal of Asian Natural Products Research 13: 215-224 Kacimi, R., Gerdes, A. (2003) Alterations in G protein and MAP kinase ... which acts as a trans-membrane protein serine/threonine kinase. A receptor assembly factor first activates TGF-β1 type I ...

"Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3" (PDF). J. ... Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. SMAD7 is a protein ... calmodulin-dependent protein kinase II (CamKII) and protein kinase C (PKC). Smad7 does not have the MH1 domain. A proline- ... Developmental genes and proteins, MH1 domain, MH2 domain, Transcription factors, Human proteins). ...

Dong Y, Tang L, Letterio JJ, Benveniste EN (July 2001). "The Smad3 protein is involved in TGF-beta inhibition of class II ... TGF-β1 was first identified in human platelets as a protein with a molecular mass of 25 kilodaltons with a potential role in ... Custo, S; Baron, B; Felice, A; Seria, E (5 July 2022). "A comparative profile of total protein and six angiogenically-active ... Saharinen J, Keski-Oja J (August 2000). "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates ...

"Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins". Mol. Biol. Cell. 12 (5): ... This gene encodes a protein that is a member of the SCF ubiquitin ligase protein complex. It binds to F-box proteins (proteins ... The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134 ...

"Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins". Molecular Biology of the ... RING-box protein 1 is a protein that in humans is encoded by the RBX1 gene. This gene encodes an evolutionarily conserved ... The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin ... It also may be involved in the regulation of protein turn-over. RBX1 has been shown to interact with: CAND1, CUL1, CUL2, CUL4A ...

"Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its ... IL-37b interacts with IL-18 binding protein (IL-18BP), that is an antagonist of IL-18. The binding of IL-37b enhances the IL- ... Binding to SMAD3 receptor - Mature intracellular IL-37 can form functional complexes with phosphorylated or unphosphorylated ... January 2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp". Cytokine. 13 (1): 1-7. doi:10.1006/ ...

"Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. ... The protein sequence comprises 748 amino acid residues and consists of a C-terminal hydrophobic segment that spans the ... Junctophilin-3 is a protein in humans that is encoded by the JPH3 gene. The gene is approximately 97 kilobases long and is ...

2001). "Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins". Mol. Biol. Cell. ... This protein plays an important role in protein degradation and protein ubiquitination. This is an essential component of the ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ... This protein is a part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. It also interacts with RNF7. Part of a complex ...

2004). "Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its ... Keratin 2A also known as keratin 2E or keratin 2 is a protein that in humans is encoded by the KRT2A gene. Keratin 2A is a type ... It is found largely in the upper spinous layer of epidermal keratinocytes and mutations in the gene encoding this protein have ... an epidermal cytoskeletal protein synthesized late during differentiation". Exp. Cell Res. 202 (1): 132-41. doi:10.1016/0014- ...

2005). "Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ... 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and ... transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMC 403697. PMID ...

2005). "Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its ... General transcription factor II-I repeat domain-containing protein 1 is a protein that in humans is encoded by the GTF2IRD1 ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... 2000). "Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription ...

EWSR1-SMAD3-positive fibroblastic tumor: These tumors, which are a recently characterized neoplasm with distinct ... The FET protein family (also known as the TET protein family) consists of three similarly structured and functioning proteins. ... the EWSR1 protein encoded by the EWSR1 gene (also termed the Ewing sarcoma RNA binding protein, EWS RNA binding protein 1, or ... FET proteins are abundantly expressed in virtually all tissues examined. They are RNA-binding proteins. By binding to their RNA ...

"Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/ ... CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene. The protein encoded by this ... It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes ... "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". ...

Zhang Y, Feng XH, Derynck R (August 1998). "Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced ... Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (October 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 ... "Detection and modulation in vivo of helix-loop-helix protein-protein interactions". J. Biol. Chem. 268 (1): 5-8. doi:10.1016/ ... Protein c-Fos is a proto-oncogene that is the human homolog of the retroviral oncogene v-fos. It is encoded in humans by the ...

Exportin-4 is a protein that in humans is encoded by the XPO4 gene. Chromosome 13 (human) Protein transport Ran (gene) SMAD3 ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347-55. doi: ... 2006). "The Mechanism of Nuclear Export of Smad3 Involves Exportin 4 and Ran". Mol. Cell. Biol. 26 (4): 1318-32. doi:10.1128/ ...

The SKI protein and the CPB protein compete for binding with the Smad proteins, specifically competing with the Smad-3 and CReB ... The SnoN protein was identified as a similar protein and is often discussed in conjugation with the Ski protein in publications ... TGF- β is a protein which regulates cell growth. Signaling is regulated by a family of proteins called the Smad proteins. SKI ... are consistent with the fact that the protein must have domains that allow it to interact with other proteins. The protein also ...

... that protein expression of collagen type IV in human vascular smooth muscle cells is regulated by both SMAD3 protein and TGFβ ... Lastly, the type IV collagen molecules bind together to form a complex protein network. To summarize, the process of collagen ... These, along with other proteins, will form unique basement membranes in tissue-specific manners. Through interactions with ... October 2015). "Functional interaction between COL4A1/COL4A2 and SMAD3 risk loci for coronary artery disease". Atherosclerosis ...

... that protein expression of collagen type IV in human vascular smooth muscle cells is regulated by both SMAD3 protein and TGFβ ... Collagen alpha-1(IV) chain (COL4A1) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. It is ... Type IV collagen is the major structural component of basement membranes, which contains two or three COL4A1 proteins. Thus, ... Hinek A (July 1994). "Nature and the multiple functions of the 67-kD elastin-/laminin binding protein". Cell Adhesion and ...

This suggests while Smad3 is necessary for TGF-B cytostatic effect, the ratio of Smad3 to Smad2 modulates the intensity of the ... Despite evidence showing that Smad3 is more critical than Smad2 in TGF-B signaling, the rate of Smad3 mutations in cancer is ... suggesting that Smad2 works antagonistically to Smad3 in the progression of renal fibrosis. Unlike the R-Smads, Smad7 protein ... "The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3". Molecular Biology of the Cell. 16 (10): ...

SKI protein, SKIL, SMAD3, SMURF2, SNW1, STRAP WWTR1 GRCh38: Ensembl release 89: ENSG00000175387 - Ensembl, May 2017 GRCm38: ... The SMAD proteins are homologs of both the drosophila protein, mothers against decapentaplegic (MAD) and the C. elegans protein ... protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces ... Developmental genes and proteins, MH1 domain, MH2 domain, R-SMAD, Transcription factors, Human proteins). ...

... smad1 protein MeSH D12.644.360.024.334.500.200 - smad2 protein MeSH D12.644.360.024.334.500.300 - smad3 protein MeSH D12.644. ... 14-3-3 proteins MeSH D12.644.360.024.318 - proto-oncogene proteins c-crk MeSH D12.644.360.024.326 - proto-oncogene proteins c- ... ral gtp-binding proteins MeSH D12.644.360.525.462 - ran gtp-binding protein MeSH D12.644.360.525.475 - rap gtp-binding proteins ... wnt proteins MeSH D12.644.276.996.500 - wnt1 protein MeSH D12.644.276.996.750 - wnt2 protein MeSH D12.644.360.011 - activating ...

No known protein-protein interactions have been established thus far. In a study that used pre-made kits to predict cardiac ... SMAD3, KLF3, EGR1, SOX/SRY, PAX2/PAX5 and two SNP regions have been identified as well. The transcription factors predicted to ... The protein side groups in this protein do not necessarily interact in a manner to form tertiary and quaternary structures. The ... spanning amino acids 218 to 359 in the C-terminus of the protein. There are nine transmembrane regions in this protein. The ...