Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL (December 1998). "SARA, a FYVE domain protein that recruits Smad2 to ... Zinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is ... It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors. It facilitates the ... SARA contains a double zinc finger (FYVE domain). SARA is an anchoring protein involved in TGF beta signaling. ...
This then interacts with and then phosphorylates SMAD2 and SMAD3, two of the cytoplasmic SMAD proteins. Smad3 then translocates ... Activin, inhibin and a number of other structurally related proteins such as anti-Müllerian hormone, bone morphogenetic protein ... and growth differentiation factor belong to the TGF-β protein superfamily. The activin and inhibin protein complexes are both ... In addition, both complexes are derived from the same family of related genes and proteins but differ in their subunit ...
Receptor I is then able to bind proteins Smad2 and Smad3, which form a complex with Smad4. This complex accumulates in the ... Journal of Asian Natural Products Research 13: 215-224 Kacimi, R., Gerdes, A. (2003) Alterations in G protein and MAP kinase ... which acts as a trans-membrane protein serine/threonine kinase. A receptor assembly factor first activates TGF-β1 type I ... Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells. Eur J ...
... encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an ... Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene. ... FOXH1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... Liu B, Dou CL, Prabhu L, Lai E (January 1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth ...
... also known as SMAD family member 2 or SMAD2 is a protein that in humans is encoded by ... The SMAD proteins are homologs of both the drosophila protein, mothers against decapentaplegic (MAD) and the C. elegans protein ... SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD2 mediates ... Alternatively spliced transcript variants encoding the same protein have been observed. Like other Smads, Smad2 plays a role in ...
... "c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity". J. Biol. Chem. 277 (32): 29094-100. ... The SKI protein and the CPB protein compete for binding with the Smad proteins, specifically competing with the Smad-3 and CReB ... The SnoN protein was identified as a similar protein and is often discussed in conjugation with the Ski protein in publications ... TGF- β is a protein which regulates cell growth. Signaling is regulated by a family of proteins called the Smad proteins. SKI ...
Thus, the two proteins could be caught in a "vicious cycle" of regulation. Pin1 causes both itself and Smad2 to be associated ... Pin1 was found to co-localize with Smad2/3 and phosphorylated tau proteins within the cytoplasmic granules, suggesting a ... Smad2 then promotes Pin1 RNA synthesis to try and compensate, which only drives more Smad2 degradation and association with ... Conversely, inhibiting Smad2 in kidney cells (full Smad2 knockouts are embryonic lethal) actually leads to more severe fibrosis ...
... smad1 protein MeSH D12.644.360.024.334.500.200 - smad2 protein MeSH D12.644.360.024.334.500.300 - smad3 protein MeSH D12.644. ... 14-3-3 proteins MeSH D12.644.360.024.318 - proto-oncogene proteins c-crk MeSH D12.644.360.024.326 - proto-oncogene proteins c- ... ral gtp-binding proteins MeSH D12.644.360.525.462 - ran gtp-binding protein MeSH D12.644.360.525.475 - rap gtp-binding proteins ... wnt proteins MeSH D12.644.276.996.500 - wnt1 protein MeSH D12.644.276.996.750 - wnt2 protein MeSH D12.644.360.011 - activating ...
The family of proteins is known to possess ubiquitin-protein ligase activity. The encoded protein contains 4 tandem WW domains ... WWP2-FL interacts with SMAD2, SMAD3 and SMAD7 in the TGF-β pathway. The WWP2-N isoform interacts with SMAD2 and SMAD3, whereas ... NEDD4-like E3 ubiquitin-protein ligase WWP2 also known as atrophin-1-interacting protein 2 (AIP2) or WW domain-containing ... The WW domain may mediate specific protein-protein interactions. Three alternatively spliced transcript variants encoding ...
... the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals ... Homeobox protein TGIF1 is a protein that, in humans, is encoded by the TGIF1 gene. Alternative splicing has been observed at ... The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains ... It has also been associated with risk of otitis media (inflammation of the middle ear) Homeobox protein TGIF1 has been shown to ...
Also, the downstream TGF-beta/bone morphogenic protein (BMP) signaling pathway, which includes Smad1 and Smad2/3, were ... "ENG Gene - , EGLN Protein , EGLN Antibody". GeneCards. Fernández-Ruiz E, St-Jacques S, Bellón T, Letarte M, Bernabéu C (1993 ... The cytoplasmic tail contains a PDZ-binding motif that allows it to bind to PDZ containing proteins and interact with them. It ... It has a crucial role in angiogenesis, therefore, making it an important protein for tumor growth, survival and metastasis of ...
... binding of Nodal proteins to activin or activin-like serine/threonine kinase receptors results in the phosphorylation of Smad2 ... Unlike Lefty proteins, DAN proteins bind directly to extracellular Nodal proteins and prevent signaling. Further, not all DAN ... Subsequently, Smad2/3 is transported outside the nucleus with the help of RanBP2. Smad2/3/4 can associate to different ... The Lefty proteins, divergent members of the TGFβ superfamily of proteins, act as extracellular antagonists of Nodal signaling ...
This protein will then attach itself to Smad4 and relocate to the nucleus where the mesendoderm genes will begin to be ... These ligands will signal transmembrane serine/threonine kinase receptors, and this will then phosphorylate Smad2 and Smad3. ... Fibroblast growth factors (FGF), canonical Wnt pathway, bone morphogenetic protein (BMP), and retinoic acid (RA) are all ...
The E3 ubiquitin-protein ligases SMURF1 and SMURF2 regulate the levels of SMADs. They accept ubiquitin from an E2 conjugating ... TGFβs, Activins, Nodals and some GDFs are mediated by SMAD2 and SMAD3, while BMPs, AMH and a few GDFs are mediated by SMAD1, ... Two such proteins that mediate the TGFβ pathway include SARA (the SMAD anchor for receptor activation) and HGS (Hepatocyte ... These proteins contain nine conserved cysteines which can form disulfide bridges. It is believed that DAN antagonizes GDF5, ...
CCDC25 was shown by a yeast-two-hybrid assay to interact with Smad2, a latent transcription factor that is part of the TGF-β ... The protein is a predicted substrate of Casein Kinase 1, Casein Kinase 2, cGMP-dependent protein kinase, and the Insulin ... The Coiled-Coil Domain Containing Protein - 25 (CCDC25) is a human protein whose function is not presently understood. The gene ... The protein is highly conserved among mammals as well as eukaryotes as diverse as Arabidopsis thaliana. CCDC25 is made up of a ...
The SMAD proteins are homologs of both the Drosophila protein MAD and the C. elegans protein SMA. The name is a combination of ... The complex of two SMAD3 (or of two SMAD2) and one SMAD4 binds directly to DNA though interactions of their MH1 domains. These ... It also belongs to the Darwin family of proteins that modulate members of the TGFβ protein superfamily, a family of proteins ... is a highly conserved protein present in all metazoans. It belongs to the SMAD family of transcription factor proteins, which ...
SDCBP is regulated by TGFB1-mediated SMAD2/3. A number of other cell signaling proteins physically associated with TMEM239, ... "An inter-species protein-protein interaction network across vast evolutionary distance". Molecular Systems Biology. 12 (4): 865 ... protein". www.uniprot.org. Retrieved 2016-04-25. "TAE1 - Alpha N-terminal protein methyltransferase 1 - Saccharomyces ... Lastly, the protein Alpha-N-methyltransferease (TAE1) was found to interact with TMEM239. TAE1 catalyzes the methylation of ...
The Hp53int1 protein has a molecular weight of 13.3 kdal and is 118 amino acids in length. It is a basic protein. There is one ... Transcription factors SMAD2, SRY, and ETV7 had Basewise Conservation Scores of 2.99, 2.73, and 3.03 respectively, with value of ... Human protein 53 intron 1 (Hp53int1) is a protein encoded by the Hp53int1 gene in humans. The Hp53int1 gene is located on ... Hp53int1 protein is predicted to contain one alpha helix and five beta sheets. There are eight possible protein binding sites. ...
The SMAD proteins are homologs of both the Drosophila protein "mothers against decapentaplegic" (MAD) and the C. elegans ... Petersen M, Pardali E, van der Horst G, Cheung H, van den Hoogen C, van der Pluijm G, Ten Dijke P (March 2010). "Smad2 and ... The SMAD3 complex with the GGCGC site reveals that the protein-DNA interface is highly complementary and that one MH1 protein ... Developmental genes and proteins, MH1 domain, MH2 domain, R-SMAD, Transcription factors, Human proteins). ...
... regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and ... February 2004). "Identification of a protein that interacts with the golli-myelin basic protein and with nuclear LIM interactor ...
... regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and ... Synaptonemal complex protein 3 is a protein that in humans is encoded by the SYCP3 gene. It is a component of the synaptonemal ... October 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758-65. doi: ... Several SYCP3-like proteins are found on mice sex chromosomes. They are assigned names starting with Slx or Sly depending on ...
... or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. SMAD7 is a protein ... It blocks TGFβ1 and activin associating with the receptor, blocking access to SMAD2. It is an inhibitory SMAD (I-SMAD) and is ... calmodulin-dependent protein kinase II (CamKII) and protein kinase C (PKC). Smad7 does not have the MH1 domain. A proline- ... Developmental genes and proteins, MH1 domain, MH2 domain, Transcription factors, Human proteins). ...
Expression protein ligation (known as EPL) was used to synthesize to form Smad2-MH2-CSpSM-photo-Met (1). The product was ... Protein was studied using a protein nanoprobe (that enables cross-linking) that introduced photo-methionine within the protein ... Proteins can interact with each other (protein-protein interactions or PPI) and with these interactions, affects cellular ... As it was previously mentioned, L-Photo-Methionine can be used to study protein-protein interactions with the proteins in their ...
Activin receptor type-1B is a protein that in humans is encoded by the ACVR1B gene. ACVR1B or ALK-4 acts as a transducer of ... These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1; however, unlike ... Liu F, Ventura F, Doody J, Massagué J (1995). "Human type II receptor for bone morphogenic proteins (BMPs): extension of the ... Birkey Reffey S, Wurthner JU, Parks WT, Roberts AB, Duckett CS (2001). "X-linked inhibitor of apoptosis protein functions as a ...
GDF9 specifically activates SMAD2 and SMAD3 which form a complex with SMAD4, a common partner of all SMAD proteins, that is ... 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi: ... Ligand receptor activation allows the downstream phosphorylation and activation of SMAD proteins. SMAD proteins are ... 2000). "Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/ ...
Furthermore, multiple proteins were involved in ubiquitination. Some of the interacting yeast proteins with the higher ... SMAD2, PHB, and CTNNB1 were found in an experiment investigating transcriptional factor networks. The BABAM1 interaction was ... I2D Protein Interaction Database [5] STRING 9.0 Protein Interaction Predictor Miyamoto-Sato E, Fujimori S, Ishizaka M, Hirai N ... The yeast protein RPN11, which interacts with YPL225W, has a homolog in humans that is a metalloprotease component of 26S ...
SRY-box 17 is a protein that in humans is encoded by the SOX17 gene. The gene encodes a member of the SOX (SRY-related HMG-box ... Especially the correct phosphorylation of SMAD2/3 within the respective cell cycle (early G1 phase) is crucial for the ... The encoded protein acts downstream of TGF beta signaling (Activin) and canonical WNT signaling (Wnt3a). ... TIGs per definition are single protein coding genes (PCGs) within CTCF loop domains, that are mainly enriched in developmental ...
E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene which is located at chromosome ... Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL (Jun 2001). "TGF-beta induces assembly of a Smad2-Smurf2 ... Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A (Oct 2003). "The RING-H2 protein ... "Entrez Gene: SMURF2 SMAD specific E3 ubiquitin protein ligase 2". Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K ...
The p53 protein binds to the promoters of early mesodermal genes. p53 is maternally deposited transcript that forms a ... When the TGFβ ligands bind to TGFβ receptors, they cause the activation of the signal transducers R-Smads (Smad2, Smad3). Smad4 ... Since XFDL156 is a factor that interacts with p53, the localization of this protein is in the nucleus (Sasai et al., 2008). The ... In the early blastula stage of the embryo, Ectodermin mRNA and protein forms a gradient that goes from the animal pole (highest ...
... smad1 protein MeSH D12.776.157.057.170.500.200 - smad2 protein MeSH D12.776.157.057.170.500.300 - smad3 protein MeSH D12.776. ... rap1 gtp-binding proteins MeSH D12.776.157.325.515.500 - ras proteins MeSH D12.776.157.325.515.500.300 - oncogene protein p21( ... smad proteins, inhibitory MeSH D12.776.157.057.170.249.600 - smad6 protein MeSH D12.776.157.057.170.249.700 - smad7 protein ... gtp-binding protein alpha subunits, g12-g13 MeSH D12.776.157.325.332.100.200 - gtp-binding protein alpha subunits, gi-go MeSH ...