... is contraindicated with pregnancy, breastfeeding, and liver disease. Pregnancy must be avoided while on simvastatin ... "Simvastatin - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022. Pedersen TR, Tobert JA (December 2004). "Simvastatin ... the patent for simvastatin had expired by 2004.[citation needed] Simvastatin was initially marketed by Merck & Co under the ... later to be named simvastatin). In 1994, publication of the results of the Scandinavian Simvastatin Survival Study (4S) ...
A follow-up of treatment with simvastatin for up to eight years was published in 2000. Ten years after the start of the 4S ... The Scandinavian Simvastatin Survival Study (also known as the 4S study), was a multicentre, randomized, double-blind, placebo- ... After 5.4 years, compared to the group that were given placebo, the simvastatin group demonstrated a 35% reduction in LDL-C and ... The objective of the study was to assess the effect of a cholesterol-lowering drug called simvastatin on mortality and ...
... simvastatin acid, it was significantly higher (~60%). Thus, the increased bioavailability of active simvastatin acid ... However, for simvastatin the point estimate of Cmax, AUC0-t and AUC0-∞ for Ln-transformed data were significantly lower (~25%) ... Three of the groups of 200 received only aspirin, simvastatin or thiazide respectively; Three groups received two of the three ... Polycap combines 100 milligrams of aspirin, with simvastatin (a generic version of Zocor, the cholesterol-lowering statin; 20 ...
Simvastatin and pravastatin appear to have a reduced incidence of side-effects. A comparison of simvastatin, pravastatin, and ... and simvastatin. Combination preparations of a statin and another agent, such as ezetimibe/simvastatin, are also available. The ... Researchers tested simvastatin, later sold by Merck as Zocor, on 4,444 patients with high cholesterol and heart disease. After ... Wolozin B, Wang SW, Li NC, Lee A, Lee TA, Kazis LE (July 2007). "Simvastatin is associated with a reduced incidence of dementia ...
... when simvastatin is used with amiodarone. This interaction is dose-dependent with simvastatin doses exceeding 20 mg. This drug ... "Information on Simvastatin/Amiodarone". Food and Drug Administration. Archived from the original on 21 September 2008. ... Ciclosporin Digoxin Flecainide Procainamide Quinidine Sildenafil Simvastatin Theophylline Warfarin In 2015, Gilead Sciences ... combination especially with higher doses of simvastatin should be avoided. Excretion is primarily via the liver and the bile ...
Flores NA (September 2004). "Ezetimibe + simvastatin (Merck/Schering-Plough)". Current Opinion in Investigational Drugs. 5 (9 ... and simvastatin (Zocor). Red yeast rice extract, one of the fungal sources from which the statins were discovered, contains ... Vytorin is drug that combines the use simvastatin and ezetimibe, which slows the formation of cholesterol by every cell in the ...
Statins (predominantly simvastatin) have been trialled in combination with fibrates to manage dyslipidemia in patients who also ... Scandinavian Simvastatin Survival Study Group (November 1994). "Randomised trial of cholesterol lowering in 4444 patients with ... June 2011). "The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease ( ... Early results comparing atorvastatin to simvastatin demonstrated that atorvastatin appeared more potent and with fewer side ...
"Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment". PLOS ONE. 7 (7): e38386. doi: ... "Enteric Microbiome correlates with response to simvastatin treatment". PLOS ONE. 6 (10): e25482. doi:10.1371/journal.pone. ... "Lipidomics analysis of variation in response to simvastatin in the cholesterol and pharmacogenetics study". Metabolomics. 6 (2 ...
The combination niacin/simvastatin was approved by the FDA in 2008. Subsequently, large outcome trials using these niacin and ... "Drug Approval Package: Simcor (Niacin/Simvastatin) NDA #022078". U.S. Food and Drug Administration (FDA). 31 July 2008. ... "Drugs.com, Abbott Receives FDA Approval for Simcor (Niaspan / simvastatin), a Novel Combination Medicine for Comprehensive ... Extended release niacin was combined with lovastatin (Advicor), and with simvastatin (Simcor), as prescription drug ...
"Annotation of CPIC Guideline for simvastatin and SLCO1B1". PharmGKB. Barbarino, Julia M.; Whirl-Carrillo, Michelle; Klein, Teri ... and SLCO1B1 rs4149056 and myopathy in patients taking simvastatin CPIC guidelines are published in the journal Clinical ...
"Pharmacokinetic interactions between simvastatin and setipiprant, a CRTH2 antagonist". European Journal of Clinical ...
Examples of statins include atorvastatin, lovastatin, rosuvastatin, and simvastatin. They are used in the treatment of ...
April 2008). "Simvastatin with or without ezetimibe in familial hypercholesterolemia" (PDF). N. Engl. J. Med. 358 (14): 1431-43 ...
However, people can also combine ezetimibe with either simvastatin or atorvastatin and other agents on their own, for somewhat ... As of 2006[update] some published information for comparing rosuvastatin, atorvastatin, and ezetimibe/simvastatin results is ... 2003). "Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses ( ... The main competitors to rosuvastatin are atorvastatin and simvastatin. ...
Heart Protection Study Scandinavian Simvastatin Survival Study Myat, Aung; Gershlick, A. H.; Gershlick, Tony (2012). Landmark ...
"Simvastatin augmentation for recent-onset psychotic disorder: A study protocol". BBA Clinical. 4: 52-58. doi:10.1016/j.bbacli. ...
As cancer appeared more frequently in patients treated with simvastatin-ezetimibe combination therapy in one clinical trial, it ... SEAS Investigators) (September 2008). "Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis". The New ...
Concomitant use with cholesterol medications such as lovastatin or simvastatin. Hypersensitivity to clarithromycin or any ...
Vytorin (ezetimibe/simvastatin) tablets can cause steatorrhea in some people. Some studies have shown that stool lipids are ...
Moreyra, Abel E. (23 May 2005). "Effect of Combining Psyllium Fiber With Simvastatin in Lowering Cholesterol". Archives of ...
Liu S, Uppal H, Demaria M, Desprez PY, Campisi J, Kapahi P (December 2015). "Simvastatin suppresses breast cancer cell ... Glucocorticoids as potent suppressors of selected components of the SASP Statins such as simvastatin, that can reduce the ...
The study compared a combination of simvastatin and niacin with antioxidant vitamin therapy. Using angiography, coronary artery ... Heart Protection Study Scandinavian Simvastatin Survival Study "HDL-Atherosclerosis Treatment Study". American College of ... "Simvastatin and Niacin, Antioxidant Vitamins, or the Combination for the Prevention of Coronary Disease". New England Journal ... stenosis progressed when using placebo or antioxidant alone, and regressed with the combination of simvastatin and niacin. The ...
Robins, Douglas N. (September 2007). "Alopecia Universalis: Hair Growth following Initiation of Simvastatin and Ezetimibe ...
LCT has supported trials in ambroxol, exenatide, simvastatin, liraglutide, and others. In October, the institute announced a ...
"Simvastatin protects bladder and renal functions following spinal cord injury in rats". Journal of Inflammation. Subach, BR; ...
The statins lovastatin, mevastatin, and simvastatin precursor monacolin J, are fungal isolates. Additional fungal isolates that ...
... is a precursor to simvastatin and has potential neuroprotective activities.[unreliable medical source?] It can be ...
IDL Composition and Angiographically Determined Progression of Atherosclerotic Lesions During Simvastatin Therapy.' ...
2008). "Simvastatin vs therapeutic lifestyle changes and supplements: randomized primary prevention trial". Mayo Clin. Proc. 83 ...
The increased cholesterol levels are due to simvastatin's effect on the expression of different genes. Simvastatin increases ... Simvastatin is a known inhibitor of HMG-CoA reductase, and most importantly is able to cross the blood-brain barrier. It has ... It is still unknown if simvastatin will improve the behavioural or learning deficits in SLOS. Antioxidants are those which ... For individuals that show no residual DCHR7 activity, such as those homozygous for null alleles or mutations, simvastatin ...