... , or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and ... Masi AT (1980). "Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma ... "Juvenile Scleroderma Network". Retrieved 2008-05-11. "Scleroderma Foundation". Retrieved 2008-05-11. "Scleroderma Research ... and is thought to keep the disease at bay by reducing the circulation of scleroderma autoantibodies. Systemic scleroderma is a ...

Scleroderma, also known as systemic sclerosis, is a chronic systemic autoimmune disease characterised by hardening (sclero) of ... "Scleroderma". Medscape Reference. WebMD. Retrieved 5 March 2014. Hajj-ali RA (June 2013). "Systemic Sclerosis". Merck Manual ... and blockade of the mTORC pathway is under investigation as a treatment for scleroderma. mTOR inhibitors, e.g. rapamycin, are ... Implications for Scleroderma". The Journal of Investigative Dermatology. 135 (11): 2873-6. doi:10.1038/jid.2015.252. PMC ...

It can occur alone or with rheumatoid arthritis, scleroderma, or systemic lupus erythematosus. Nine out of 10 cases occur in ... "Systemic scleroderma". Genetics Home Reference. Retrieved 2019-11-19. Reference, Genetics Home. "Sjögren syndrome". Genetics ... such as systemic lupus erythematosus or scleroderma. Latent lupus and incomplete lupus are alternative terms that have been ... such as systemic lupus erythematosus (SLE); systemic sclerosis (SSc); dermatomyositis (DM); polymyositis (PM); anti-synthetase ...

... and systemic immunosuppressive drugs when the condition is part of systemic scleroderma[citation needed]. Localized treatment ... Sclerodactyly is often preceded by months or even years by Raynaud's phenomenon when it is part of systemic scleroderma.[ ... It is generally associated with systemic scleroderma and mixed connective tissue disease, and auto-immune disorders. ... "Systemic sclerosis , DermNet NZ". dermnetnz.org. Retrieved 2022-08-12. Fett, Nicole M. (2013-09-01). "Morphea (Localized ...

Pope, Janet (November 2011). "Measures of Systemic Sclerosis (Scleroderma)". Arthritis Care & Research. 63 (S11): S98-S111. doi ...

Morphea profunda Linear scleroderma Systemic scleroderma CREST syndrome Progressive systemic sclerosis No cure for scleroderma ... the systemic form can, and the diffuse systemic form carries a worse prognosis than the limited form. The major scleroderma- ... As of 2012[update], the five-year survival rate for systemic scleroderma was about 85%, whereas the 10-year survival rate was ... Affected individuals may experience systemic organ involvement. No single test for scleroderma works all of the time, hence ...

Majeed M, Al-Mayouf SM, Al-Sabban E, Bahabri S (2000). "Coexistent linear scleroderma and juvenile systemic lupus erythematosus ... Frontal linear scleroderma (also known as en coup de sabre or morphea en coup de sabre) is a type of linear scleroderma ... 171 Linear scleroderma is a type of localised scleroderma which is an autoimmune disease characterized by a line of thickened ... Morphea is a form of scleroderma that is more common in women than men, in a ratio 3:1. Morphea occurs in childhood as well as ...

It can also be a feature of systemic scleroderma. Hagberg and Benumof's Airway Management (4e ed.). Elsevier. pp. 608-639. ...

The presentation is similar to that of scleroderma or systemic sclerosis. However, unlike scleroderma, eosinophilic fasciitis ... the characteristic and severe effects of scleroderma and systemic sclerosis, such as Raynaud's syndrome, involvement of the ... Falanga, Vincent; Medsger, Thomas A. (1987). "Frequency, levels, and significance of blood eosinophilia in systemic sclerosis, ... localized scleroderma, and eosinophilic fasciitis". Journal of the American Academy of Dermatology. 17 (4): 648-656. doi: ...

Steen VD, Medsger TA, Rodnan GP (November 1982). "D-Penicillamine therapy in progressive systemic sclerosis (scleroderma): a ... Penicillamine has been used to treat scleroderma. Penicillamine can be used as a disease-modifying antirheumatic drug (DMARD) ... ISBN 978-1-4160-2973-1. Chalmers A, Thompson D, Stein HE, Reid G, Patterson AC (November 1982). "Systemic lupus erythematosus ... Underwood JC (2009). General and Systemic Pathology. Elsevier Limited. ISBN 978-0-443-06889-8. Taylor PJ, Cumming DC, Corenblum ...

... scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts". Journal of Immunology. 167 ... Zhou X, Tan FK, Xiong M, Milewicz DM, Feghali CA, Fritzler MJ, Reveille JD, Arnett FC (Dec 2001). "Systemic sclerosis ( ... Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. Fibrillarin is a ... in patients with systemic sclerosis". Arthritis and Rheumatism. 35 (1): 95-100. doi:10.1002/art.1780350114. PMID 1731817. ...

In systemic lupus erythematosus ATA are associated with nephritis. Increases in ATA+ in scleroderma and SLE are associated with ... HLA-DR2 (DR15 and DR16) are associated with scleroderma and systemic sclerosis. It has been found that patients with ATA that ... is a type of antinuclear autoantibody seen mainly in diffuse systemic scleroderma, but is also seen the more limited form of ... Scleroderma results from the overproduction of collagen in affected tissues, one study claims that there is an increased ...

"Type III collagen aminopropeptide levels in serum of patients with progressive systemic scleroderma". The Journal of ... Increased amounts of type III collagen are found in many fibrotic conditions such as liver and kidney fibrosis, and systemic ... The fourth mouse model with defective COL3A1 gene is the tight skin mouse (Tsk2/+), which resembles the human systemic ... "Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts". ...

Luderschmidt C, Scholz S, Mehlhaff E, König G, Albert E (1987). "Association of progressive systemic scleroderma to several HLA ... systemic sclerosis, childhood epilepsy, early-onset alopecia areata, short-ragweed Ra6 allergy, primary antiphospholipid ... "Autoantibodies and immunogenetics in 30 patients with systemic sclerosis and their families". J Rheumatol. 14 (4): 760-5. PMID ...

Ian succumbed to Systemic Sclerosis (Scleroderma), an autoimmune disease on 18 October 2022. Indianapolis Monthly. Emmis ...

Journal of Scleroderma and Related Disorders. 3 (2): 132-152. doi:10.1177/2397198318758606. PMC 8892860. PMID 35382237. "One ... "Therapeutic plasma exchange for the treatment of systemic sclerosis: A comprehensive review and analysis". ... scleroderma) Thrombotic thrombocytopenic purpura (TTP) / hemolytic uremic syndrome Toxic epidermal necrolysis (TEN) Transverse ... vulgaris Recurrent focal and segmental glomerulosclerosis in the transplanted kidney Refsum disease Rhabdomyolysis Systemic ...

... of patients with limited systemic scleroderma and in 15% of those with the diffuse form of scleroderma. The specificity of this ... They occur in some autoimmune diseases, frequently in limited systemic scleroderma (formerly called CREST syndrome), and ... a positive anti-centromere antibody finding is strongly suggestive of limited systemic scleroderma. Anti-centromere antibodies ... Al-Mughales JA (2022). "Anti-Nuclear Antibodies Patterns in Patients With Systemic Lupus Erythematosus and Their Correlation ...

Watermelon stomach also occurs particularly with scleroderma, and especially the subtype known as systemic sclerosis. A full ... Scleroderma Association website Archived 2015-05-07 at the Wayback Machine. Accessed September 29, 2010. Marie, I.; Ducrotte, P ... Ingraham, KM; O'Brien, MS; Shenin, M; Derk, CT; Steen, VD (2010). "Gastric antral vascular ectasia in systemic sclerosis: ... Thonhofer, R; Siegel, C; Trummer, M; Gugl, A (2010). "Clinical images: Gastric antral vascular ectasia in systemic sclerosis". ...

These disorders include: systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjögren syndrome, scleroderma, polymyositis ... Barnett, AJ; McNeilage, LJ (May 1993). "Antinuclear antibodies in patients with scleroderma (systemic sclerosis) and in their ... Anti-Scl-70 antibodies are linked to scleroderma. The sensitivity of the antibodies for scleroderma is approximately 34%, but ... In addition to scleroderma, these antibodies are found in approximately 5% of individuals with SLE. The antigenic target of ...

Rudnicka's early work was related to the role of Natural Killer Cells and adhesion molecules in systemic sclerosis (scleroderma ... Adhesion of peripheral blood mononuclear cells to vascular endothelium in patients with systemic sclerosis (scleroderma). ... "Adhesion of peripheral blood mononuclear cells to vascular endothelium in patients with systemic sclerosis (scleroderma)". ... She is the author of the hypothesis linking etiology of systemic sclerosis to a mutation in the topoisomerase I gene and ...

... and systemic scleroderma. All diseases ranging with scores 10.0 to 9.7 and non-proliferative fibrocystic that changes the ...

In systemic scleroderma, the incidence has been estimated to be 8 to 12% of all patients; in rheumatoid arthritis it is rare. ... However, in systemic lupus erythematosus it is 4 to 14%, and in sickle cell disease, it ranges from 20 to 40%. Up to 4% of ... Signs of systemic congestion resulting from right-sided heart failure include jugular venous distension, ascites, and ... York M, Farber HW (November 2011). "Pulmonary hypertension: screening and evaluation in scleroderma". Current Opinion in ...

There is some evidence implicating M. hyorhinis in the pathogenesis of scleroderma, a chronic systemic disease of humans. One ... However, more research is needed to confirm or refute the link between M. hyorhinis and scleroderma. Antibiotics are the ... Another study found that injecting M. hyorhinis into mice induces a scleroderma-like autoimmune disease. ... "Mycoplasma infection induces a scleroderma-like centrosome autoantibody response in mice". Clin Exp Immunol. 137 (2): 288-97. ...

Redness and scleroderma-like induration occurs on the skin. In addition, the mobility of the lips, hands, arms, and legs is ... and hoarseness are among the notable systemic symptoms. If viscera is involved, the disease will be fatal. The dermatoneuro ...

Trichloroethylene can cause scleroderma which is a systemic autoimmune disease that causes joint pain, skin stiffness, and ...

"The HLA-DR and DQ genes control the autoimmune response to DNA topoisomerase I in systemic sclerosis (scleroderma)". J. Clin. ... DR52 serotype is positively associated with systemic sclerosis, inflammatory myopathies, inclusion body myositis, DRB3*01 is ... II alleles associations of anticardiolipin and antibeta2GPI antibodies in a large series of European patients with systemic ...

Systemic autoimmune diseases include coeliac disease, lupus erythematosus, Sjögren syndrome, sarcoidosis, scleroderma, ... In systemic lupus there are autoantibodies to DNA, which cannot evoke a T cell response, and limited evidence for T cell ... Autoimmune diseases can be broadly divided into systemic and organ-specific or localised autoimmune disorders, depending on the ... Agmon-Levin, Nancy; Theodor, Emanuel; Segal, Ramit Maoz; Shoenfeld, Yehuda (2013-10-01). "Vitamin D in Systemic and Organ- ...

Also found with Sjögren syndrome, rheumatoid arthritis, inherited complement deficiencies (esp C3 deficiency), scleroderma, ... prominently systemic lupus erythematosus (SLE), Class IV. ...

... without systemic disease can be a result of trauma or cold. Panniculitis with systemic disease can be caused by[ ... citation needed]: connective tissue disorders such as lupus erythematosus or scleroderma; lymphoproliferative disease such as ... Forms associated with use of high doses of systemic corticosteroids during rapid corticosteroid withdrawal, and from the ... Panniculitis can also be classified based on the presence or absence of systemic symptoms. ...

Onset of this disease can be attributed to steroid usage, systemic lupus erythematosus, or trauma. In some cases, it is ... or scleroderma. It can also affect patients living with congenital short digits or atypical anatomical epiphyseal blood supply ... Onset of Dieterich's disease can possibly be attributed to steroid usage, trauma, systemic lupus erythematosus, renal ...