The key Th1 transcription factors are STAT4 and T-bet. IFN-γ secreted by CD4 T cells can activate macrophages to phagocytose ... "Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation ... The key Th2 transcription factors are STAT6 and GATA3. IL-4 is the positive feedback cytokine for Th2 cells differentiation. ... The key THαβ transcription factors are STAT1 and STAT3 as well as IRFs. IL-10 from CD4 T cells activate NK cells' ADCC to ...

Signal transducer and activator of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family, ... STAT4+Transcription+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (CS1: long volume value, ... "STAT4 - Signal transducer and activator of transcription 4 - Homo sapiens (Human) - STAT4 gene & protein". www.uniprot.org. ... There are two known STAT4 transcripts, STAT4α and STAT4β, differing in the levels of interferon-gamma (IFN-γ )production ...

Additionally, transcription factors, including STAT4 and RUNX family transcription factors play a role in the introduction of ... "Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses". Science Immunology. 2 (18 ... January 2019). "Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear ...

was the identification of STAT4 as a key transcription factor responsible for influencing the regulation of many target genes ... The addition of methyl groups to DNA nucleotides inhibits transcription by creating a surface that transcription factors are ... STAT4 is a very important transcription factory as it is correlated with the pathogenesis and this the progression of DLE, many ... Fli1 is a transcription factor that negatively regulates collagen production such that the higher the Fli gene expression, the ...

These are important in activating critical transcription factor proteins such as STAT4 that are implicated in IL-12 signaling ... It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the ... Growth Factor Reviews. 11 (4): 321-33. doi:10.1016/s1359-6101(00)00010-1. PMID 10959079. Newport MJ, Holland SM, Levin M, ... production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and natural killer (NK) cells, and ...

T-bet also recruits other transcription factors like HLX, RUNX1, RUNX3 which aid it in setting Th1 transcription profile. Apart ... Rorc is also silenced by epigenetic changes promoted by T-bet and STAT4. T-bet also performs function in cytotoxic T cells and ... "T-bet transcription factor in cardiovascular disease: Attenuation or inflammation factor?". Journal of Cellular Physiology. 234 ... T-box transcription factor TBX21, also called T-bet (T-box expressed in T cells) is a protein that in humans is encoded by the ...

Like many other transcription factors, STATs are capable of recruiting co-activators such as CBP and p300, and these co- ... For example, STAT1 can enable the transcription of genes which inhibit cell division and stimulate inflammation. Also, STAT4 is ... Also, since many cytokines function through the STAT3 transcription factor, STAT3 plays a significant role in maintaining skin ... Serine phosphorylation of STATs has been shown to reduce gene transcription. It is also required for the transcription of some ...

Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors ... There are seven mammalian STAT family members that have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B ... STAT+Transcription+Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Drosophila Signal- ... Originally, STAT proteins were described as latent cytoplasmic transcription factors as phosphorylation was thought to be ...

These two transcription factors then combine with IRF9 to form a complex known as the interferon stimulated gene factor 3 ... STAT-4, and STAT-5. In addition to the JAK/STAT pathway, other pathways such as the MAPK and PI3 kinase pathways have been ... complex (ISGF3). This enters the nucleus and binds to promoter regions, causing transcription of various genes called ...

... +Transcription+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) FactorBook STAT2 This ... Farrar JD, Smith JD, Murphy TL, Leung S, Stark GR, Murphy KM (July 2000). "Selective loss of type I interferon-induced STAT4 ... "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Molecular ... "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Molecular ...

Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 ... "Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells". The ... Spiekermann K, Biethahn S, Wilde S, Hiddemann W, Alves F (August 2001). "Constitutive activation of STAT transcription factors ... or heterodimers and finally translocate to nucleus to work as transcription factors. Specifically STAT1 can be activated by ...

These signaling pathways lead to activation of many transcription factors, such as NF-κB, AP-1, c-Jun N-terminal kinase (JNK) ... The effector cytokines mediated by this signalization are IL-17A, IL-4 and IL-6. IL-18 with IL-12, which is a STAT4 activator, ... Its expression is induced by transcription factor NF-κB after exposure of innate immune cells to alarmins. This occurs, for ... This up-regulation is directly controlled by GATA3 transcription factor. IL-33 combined with IL-2, IL-7 or TSLP also stimulates ...

... stat2 transcription factor MeSH D12.776.476.024.421.300 - stat3 transcription factor MeSH D12.776.476.024.421.400 - stat4 ... stat5 transcription factor MeSH D12.776.476.024.421.600 - stat6 transcription factor MeSH D12.776.476.024.500.500 - tnf ... stat1 transcription factor MeSH D12.776.476.024.381.500.750 - stat2 transcription factor MeSH D12.776.476.024.381.750 - ... tnf receptor-associated factor 2 MeSH D12.776.476.024.500.875 - tnf receptor-associated factor 3 MeSH D12.776.476.024.500.937 ...

... stat2 transcription factor MeSH D12.776.157.057.186.300 - stat3 transcription factor MeSH D12.776.157.057.186.400 - stat4 ... stat5 transcription factor MeSH D12.776.157.057.186.600 - stat6 transcription factor MeSH D12.776.157.057.500.500 - tnf ... stat1 transcription factor MeSH D12.776.157.057.061.500.750 - stat2 transcription factor MeSH D12.776.157.057.061.750 - ... MeSH D12.776.157.057.030.124 - interferon regulatory factor-1 MeSH D12.776.157.057.030.249 - interferon regulatory factor-2 ...

... stat2 transcription factor MeSH D12.644.360.024.342.300 - stat3 transcription factor MeSH D12.644.360.024.342.400 - stat4 ... stat5 transcription factor MeSH D12.644.360.024.342.600 - stat6 transcription factor MeSH D12.644.360.024.374 - suppressor of ... stat1 transcription factor MeSH D12.644.360.024.301.500.750 - stat2 transcription factor MeSH D12.644.360.024.301.750 - ... stat transcription factors MeSH D12.644.360.024.342.100 - stat1 transcription factor MeSH D12.644.360.024.342.200 - ...

... which in turn activates oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) and ... "Stat3 and Stat4 direct development of IL-17-secreting Th cells". Journal of Immunology. 178 (8): 4901-7. doi:10.4049/jimmunol. ... Other than the monoclonal antibodies, highly specific and potent inhibitors targeting Th17 specific transcription factor RORγt ... Kolls JK, Khader SA (December 2010). "The role of Th17 cytokines in primary mucosal immunity". Cytokine & Growth Factor Reviews ...

Polarisation to a Th17 phenotype is triggered by IL-6 and TGF-β, which activate the Th17 transcription factor RORγt. IL-23 ... Janus kinase 2 and Tyrosine kinase 2 transduce the signal and phosphorylate STAT3 and STAT4. STATs dimerise and activate ... STAT3 is responsible for key Th17 development attributes such as RORγt expression and transcription of Th17 cytokines. Oppmann ...

The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide ... "Entrez Gene: IL12A interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)". ... "Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells". Nature. 382 (6587): 171-4. Bibcode: ... "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and ...

These were due to DNAse1 inhibiting factors, or NET protecting factors in people's serum, rather than abnormalities in the ... Other genes which contain risk variants for SLE are IRF5, PTPN22, STAT4, CDKN1A, Integrin alpha M, Tyrosine-protein kinase BLK ... gene transcription, and alternative splicing. The cytokines B-lymphocyte stimulator (BLyS), also known as B-cell activating ... One of the factors associated with SLE is vitamin D deficiency. SLE does run in families, but no single causal gene has been ...

... and the transcription of transcription factors which in turn regulate the transcription of clock genes. Translocations between ... The FIP1L1 component of FIP1L1-PDGFRA is required for the fusion protein to activate STAT4 and protein kinase B. The age- ... Factor interacting with PAPOLA and CPSF1 (i.e, FIP1L1; also termed Pre-mRNA 3'-end-processing factor FIP1) is a protein that in ... end-processing factor. FIP1L1 gene fusions between it and either the platelet-derived growth factor receptor, alpha (PGDFRA) or ...

showed that CXCL9, drove increased transcription of T-bet and RORγ, leading to the polarization of Foxp3− type 1 regulatory ( ... Farber JM (July 1990). "A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 ... Tr1) cells or T helper 17 (Th17) from naive T cells via STAT1, STAT4, and STAT5 phosphorylation. Several studies have shown ... and acts as functional receptor for platelet factor 4". The Journal of Experimental Medicine. 197 (11): 1537-49. doi:10.1084/ ...

... transcription activation and apoptosis. MAP2K6 has been shown to interact with TAOK2, ASK1, MAPK14 and MAP3K7. GRCh38: Ensembl ... "Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity". Blood ... "Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor". The ...