β-catenin activates the transcription factor stat3. Stat3 coordinates cell movements during gastrulation and contributes to ... These transcription factors regulate other transcription factors, cell surface molecules with roles in cell adhesion, and other ... VegT acts as a transcription factor to activate genes specifying endodermal fate while Vg1 acts as a paracrine factor. β- ... Bicoid functions as a graded morphogen transcription factor that localizes to the nucleus. The head of the embryo forms at the ...

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 ... Chung YH, Cho NH, Garcia MI, Lee SH, Feng P, Jung JU (June 2004). "Activation of Stat3 transcription factor by Herpesvirus ... STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor- ... STAT3 caused upregulation in E-selectin, a factor in metastasis of cancers. Hyperactivation of STAT3 occurs in COVID-19 ...

STAT3 is the main transcription factor activated with IL20R signaling. IL20R subunit gene mutations and differences in gene ... STATs then dimerize and move to the nucleus to act as transcription factors. The specific genes expressed are dependent on the ... along with other factors, such as intraocular pressure. Rutz S, Wang X, Ouyang W (December 2014). "The IL-20 subfamily of ... Growth Factor Reviews. IL-10 Family of Cytokines. 21 (5): 353-363. doi:10.1016/j.cytogfr.2010.08.001. PMID 20864382. Chen J, ...

Giraud S, Bienvenu F, Avril S, Gascan H, Heery DM, Coqueret O (Mar 2002). "Functional interaction of STAT3 transcription factor ... nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ... "Activation of PPARgamma coactivator-1 through transcription factor docking". Science. 286 (5443): 1368-1371. doi:10.1126/ ... NCOA1, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA1 assists nuclear ...

MET activates the STAT3 transcription factor directly, through an SH2 domain. The beta-catenin pathway, a key component of the ... "Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway". ... Hypoxia also activates transcription factor AP-1, which is involved in MET transcription. MET pathway plays an important role ... ETS1 activates MET transcription in vitro. MET transcription is activated by hypoxia-inducible factor 1 (HIF1), which is ...

2004). "Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein". J. Virol. 78 (12): 6489-97. doi: ... "Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein". J. Virol. United States. 78 (12): 6489-97. ... "Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor/scatter factor in ... TRIP10 has been shown to interact with STAT3, Wiskott-Aldrich syndrome protein, Huntingtin, CDC42, AKAP9 and RHOQ. GRCh38: ...

Levy C, Nechushtan H, Razin E (January 2002). "A new role for the STAT3 inhibitor, PIAS3: a repressor of microphthalmia ... Most transcription factors function in cooperation with other factors by protein-protein interactions. Association of MITF with ... November 1994). "microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family". ... "The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate ...

Zhang X, Wrzeszczynska MH, Horvath CM, Darnell JE (October 1999). "Interacting regions in Stat3 and c-Jun that participate in ... nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ... Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, ... c-jun was the first oncogenic transcription factor discovered. The proto-oncogene c-Jun is the cellular homolog of the viral ...

... was isolated and characterized as an inhibitory domain that binds and inhibits both the MITF and STAT3 transcription factors. ... Subsequently, PIAS3 was also found to be a regulator protein of other key transcription factors, including MITF, NFκB, SMAD and ... The PIAS family contains more than 60 proteins, most of them transcription factors that can be either positively or negatively ... It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced ...

The key THαβ transcription factors are STAT1 and STAT3 as well as IRFs. IL-10 from CD4 T cells activate NK cells' ADCC to ... The key Th1 transcription factors are STAT4 and T-bet. IFN-γ secreted by CD4 T cells can activate macrophages to phagocytose ... The key Th2 transcription factors are STAT6 and GATA3. IL-4 is the positive feedback cytokine for Th2 cells differentiation. ... These are defined by the presence of a lineage-determining (or lineage-specifying) transcription factor (also called master ...

Key factors in the differentiation of Th17 cells are signal transducer and the activator of transcription 3 (Stat3) and ... 22 in this subset of Th17 cells is regulated by AhR and Treg17 cells are depend on activation of the transcription factor Stat3 ... Similar to Th17 cells the Treg17 development depended on the transcription factor Stat3. Th17 cells play a role in adaptive ... Intensive research starting in 2004 in mouse models elucidated its transcription factors and the cytokines that provoke ...

The phosphorylation leads to association with JAK/Tyk tyrosine kinases and STAT protein transcription factors. In particular, ... STAT-3 is activated which leads to the activation of many downstream genes. Other pathways activated include RAS and MAPK ... Liu F, Liu Y, Li D, Zhu Y, Ouyang W, Xie X, Jin B (March 2002). "The transcription co-repressor TLE1 interacted with the ... There are many other proteins which associate with gp130, such as cardiotrophin 1 (CT-1), leukemia inhibitory factor (LIF), ...

... was also found to inhibit NOTCH and STAT3, two transcription factors which lead to differentiation. Therefore, Rex1 ... Ben-Shushan E, Thompson JR, Gudas LJ, Bergman Y (April 1998). "Rex-1, a gene encoding a transcription factor expressed in the ... Rex1 participates in a network of transcription factors that all work to regulate each other via varying expression levels. The ... April 2005). "Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine ...

Transcription factor 'Signal inducer and activator of transcription 3' (STAT3) is continuously activated in cancer cells. It ... This inhibits the phosphorylation of STAT3 and increases the S-glutathionylation of STAT3 and therefore deactivating it. This ... These adhesion molecules are essential factors in regulating the inflammatory process. It is linked to the inhibition of ... "Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic ...

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which is encoded by the STAT3 gene in ... STAT3 is a transcription factor that once activated, moves into the nucleus and binds to specific areas of DNA. By binding to ... STAT3". www.omim.org. Retrieved 2015-09-15. Database, GeneCards Human Gene. "STAT3 Gene - GeneCards , STAT3 Protein , STAT3 ... STAT3 maps to human chromosome 17q21.2, has 24 exons, and encodes for the 770 amino acid protein, STAT3. STAT3 is part of a ...

... he demonstrated that tumors turn off immune cell activity using a transcription factor, STAT3. His studies characterized STAT3 ... "STAT3: the "Achilles" heel for AML?". ashpublications.org. Retrieved 2023-09-04. "A STAT3 decoy lures AML out of hiding". ... His research has shown that the STAT3 protein plays a role in protecting cancers from immune responses and contributes to ... "STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration- ...

Several different transcription factors regulate the expression of the C8orf34 gene. Many of these transcription factors are ... "STAT3 - Signal transducer and activator of transcription 3 - Homo sapiens (Human) - STAT3 gene & protein". www.uniprot.org. ... Zuo J, Rungger D, Voellmy R (August 1995). "Multiple layers of regulation of human heat shock transcription factor 1". ... The nearest protein-encoding gene to C8orf34 is PREX2, a guanine-nucleotide exchange factor for the Rac family of G proteins. ...

Also involved are the STAT1 and STAT3 transcription factors that bind specifically to the receptor subunits, IL-27ɑ and ... are induced by IL-27 through the transcription factor c-Maf. Treg cells are inhibited by IL-27 through STAT1 and STAT3. IL-10 ... Th2 cells, which express IL-4, are inhibited by IL-27 through the transcription factor GATA-3. Th17 cells, which express IL-17 ... are inhibited by IL-27 through STAT1 and expression of transcription factor RORγt. Tr1 cells, which express IL-10, ...

PELP1 also functions as a coregulator of several other transcription factors, including AP1, SP1, NFkB, STAT3, and FHL2. PELP1 ... is transcription coregulator and modulates functions of several hormonal receptors and transcription factors. PELP1 plays ... PELP1 enhances transcription functions of ESR1, ESR2, AR, GR, E2F and STAT3. PELP1 participates in activation of ESR1 extra- ... and transcription factor HMX3 is a protein that in humans is encoded by the PELP1 gene. is a transcriptional corepressor for ...

This path involves the activation of a transcription factor called signal transducer and activator of transcription 3 (STAT3). ... Survivor Activating Factor Enhancement (SAFE) is a metabolic pathway. It is an intrinsic protective signaling programme to ... "Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go ... "Reperfusion Injury Salvage Kinase and Survivor Activating Factor Enhancement Prosurvival Signaling Pathways in Ischemic ...

He identified the transcription factors NF-IL-6 and STAT3, both central to the action of IL-6. He further discovered a family ... Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated ... and transcription factors. He has developed anti-IL6 receptor therapy for several immune disorders including Castleman's ... Enhancing soluble factors for IgG and IgE antibody response. J. Immunol. 111:1194-1205, 1973. Hirano, T., K. Yasukawa, H. ...

BBS17 was found to function in the regulation of LebRb activating Stat3 transcription factor in relation to leptin sensitivity ... Arl6 is an ARF(ADP Ribosylation Factor)-like GTPase that helps recruit the BBSome to the ciliary membranes. It is comparable to ... BBS7 interacts with LZTFL1 (Leucine Zipper Transaction Factor-Like 1) to regulate the entry of the BBSome into the primary ... Rabin8 is a guanine nucleotide exchange factor for Rab8 necessary for ciliogenesis in primary cilia. Rab family GTPases usually ...

The transcription factor signal transducer and activator of transcription 3 (STAT3) was identified as the therapeutic target ... Betacellulin, is a part of an Epidermal Growth Factor (EGF) family and functions as a ligand for the epidermal growth factor ... Sethi, G; Ahn, K S; Chaturvedi, M M; Aggarwal, B B (15 November 2007). "Epidermal growth factor (EGF) activates nuclear factor- ... Betacellulin is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which ...

"Entrez Gene: NFIX nuclear factor I/X (CCAAT-binding transcription factor)". Singh SK, Bhardwaj R, Wilczynska KM, Dumur CI, ... Kordula T (November 2011). "A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the ... for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66-73. doi:10.1006/geno.1995.1107. PMID 7590749 ... "Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of ...

IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the ... Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells. Nat Med 7 ...

Direct binding of transcription factors STAT3 and STAT5 to the Pim-1 promoter results in the transcription of Pim-1. The Pim-1 ... Because Pim-1 transcription is initiated by STAT3 and STAT5, its production is regulated by the cytokines that regulate the ... a transcription factor believed to regulate 15% of all genes, and their synergy has been in prostate tumorigenesis. Pim-1 is ... Other known substrates/binding partners of Pim-1 include proteins involved in transcription regulation (nuclear adaptor protein ...

... control cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3 ... Growth Factor Reviews. 23 (6): 323-31. doi:10.1016/j.cytogfr.2012.08.004. PMID 22981288. Wang M, Tan Z, Zhang R, Kotenko SV, ... with simultaneous activation of the JAK/signal transducer and activator of transcription (STAT) pathway within their ... simultaneous activation of the JAK/signal transducer and activator of transcription (STAT) pathway within their cytoplasmic ...

Phosphorylation STATs form transcription factors and activate transcription of appropriate genes. The β chain of IL-15R ... which leads to phosphorylation and activation of signal transducer and activator of transcription 3 (STAT3) and STAT5. Due to ... It also activates phosphatidylinositol 3-kinase (PI3K) and AKT signaling pathway and induce expression of transcription factors ... and STAT6 transcription factors are activated to elicit downstream signaling events. IL-15 and its receptor subunit alpha (IL- ...

... and transcription factors, especially STAT3. It can induce IL-20 and IL-24 signaling when IL-22R1 pairs with IL-20R2. IL-22 ... Dumoutier L, Van Roost E, Colau D, Renauld JC (August 2000). "Human interleukin-10-related T cell-derived inducible factor: ... Growth Factor Reviews. 21 (4): 237-51. doi:10.1016/j.cytogfr.2010.04.002. PMID 20655797. Weger W, Hofer A, Wolf P, El-Shabrawi ... Growth Factor Reviews. 24 (1): 51-7. doi:10.1016/j.cytogfr.2012.07.002. PMC 4003867. PMID 22906768. Moore KW, de Waal Malefyt R ...

... and the transcription factor c/EBP regulates development of MDSCs in bone marrow and in tumors. STAT3 also promotes development ... and it has been shown that the c/EBPβ transcription factor plays a key role in the generation of in vitro bone marrow-derived ... Another important factor influencing the activity of MDSC is oppressive ROS. MDSCs can also play a positive regulatory role. It ... Tumor cell lines overexpressing colony stimulating factors (e.g. G-CSF and GM-CSF) have long been used in vivo models of MDSC ...