... is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. The ... "An interleukin-4-induced transcription factor: IL-4 Stat". Science. 265 (5179): 1701-6. Bibcode:1994Sci...265.1701H. doi: ... Similarly as other STAT family proteins, STAT6 is also activated by growth factors and cytokines. STAT6 is mainly activated by ... STAT6+Transcription+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with short ...

Spiekermann K, Biethahn S, Wilde S, Hiddemann W, Alves F (August 2001). "Constitutive activation of STAT transcription factors ... Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 ... "ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". The Journal of Biological ... a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway". Cell. ...

... is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family. All STAT ... "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Molecular ... Spiekermann K, Biethahn S, Wilde S, Hiddemann W, Alves F (August 2001). "Constitutive activation of STAT transcription factors ... "ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". The Journal of Biological ...

Spiekermann K, Biethahn S, Wilde S, Hiddemann W, Alves F (August 2001). "Constitutive activation of STAT transcription factors ... 1994). "Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130". ... "An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT". Oncogene. 14 (7): ... Guo D, Dunbar JD, Yang CH, Pfeffer LM, Donner DB (March 1998). "Induction of Jak/STAT signaling by activation of the type 1 TNF ...

Kinase activity phosphorylates STAT proteins which then are recruited by transcription factors. The STAT complex is targeted to ... These transcription factors function to interact with transcription factors generated from Notch signaling. Consequently, this ... Transcription factors synthesized as a result of the Notch signaling cascade bind to promoters of genes responsible for glial ... Upon binding of Delta or Jagged, the notch-mediated signaling cascades are activated leading to gliogenic transcription factor ...

LIFRβ acts as a docking site for the STAT transcription factors. JAK kinase phosphorylates STAT proteins, which dissociate from ... Nerve Growth Factor (NGF): Rita Levi Montalcini and Stanley Cohen purified the first trophic factor, Nerve Growth Factor (NGF ... CNTF: Ciliary neurotrophic factor is another protein that acts as a survival factor for motor neurons. CNTF acts via a receptor ... These induce sensory interneurons by activating Sr/Thr kinases and altering SMAD transcription factor levels. Signals that ...

"Cytokine receptor signal transduction through Jak tyrosine kinases and Stat transcription factors". APMIS. 105 (7): 497-509. ... platelet-derived growth factor receptor (PDGFR), stem cell factor receptor, and colony-stimulating factor-1 receptor (Burstein ... Tyrosine kinase activity in the nucleus involves cell-cycle control and properties of transcription factors. In this way, in ... Major changes are sometimes induced when the tyrosine kinase enzyme is affected by other factors. One of the factors is a ...

These phosphorylated receptors in turn recruit STAT transcription factors which modulate gene transcription. The first JAK ... The committee also recommends using JAK inhibitors with caution in people with risk factors for blood clots in the lungs and in ... Harel S, Higgins CA, Cerise JE, Dai Z, Chen JC, Clynes R, Christiano AM (October 2015). "Pharmacologic inhibition of JAK-STAT ... thereby interfering with the JAK-STAT signaling pathway in lymphocytes. It is used in the treatment of cancer and inflammatory ...

It has been seen that in some contexts, mda-7 activates STAT transcription factors. However, the STAT pathway is not always ... The p53 protein is a tumor-suppressing transcription factor (TF), which can recognize when there is an alteration in a cell's ... p53 is unique as a transcription factor in that it can recognize and bind response elements (RE) in many different environments ... Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) (Figure 5) is a member of the tumor necrosis factor (TNF) ...

"ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". The Journal of Biological ... "Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 ( ... Fak is not required for stat-mediated transcription". The Journal of Biological Chemistry. 273 (17): 10682-9. doi:10.1074/jbc. ... and on the RUSH transcription factors. Janus kinase inhibitor, medical drugs under development Ruxolitinib GRCh38: Ensembl ...

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth ... "ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". J. Biol. Chem. 274 (24): ... Liao, Z; Lutz, J; Nevalainen, MT (February 2010). "Transcription factor Stat5a/b as a therapeutic target protein for prostate ... Articles with short description, Short description matches Wikidata, Genes on human chromosome 17, Transcription factors). ...

"ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". The Journal of Biological ... including epidermal growth factor and transforming growth factor alpha (TGF-α). ErbB2 has no known direct activating ligand, ... "Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor". Biochemistry. ... "ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation". The ...

Direct binding and activation of STAT transcription factors by the herpesvirus saimiri protein Tip. J. Biol. Chem. 275:16925- ... Mammalian transcription factor LSF is a target of ERK signaling. J. Cell. Biochem. 89:733-746. Hartley, D. and Cooper, G.M. ... Identification of transcription factor binding sites upstream of human genes regulated by the phosphatidylinositol 3-kinase and ... apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFkappaB transcription factors ...

This signaling pathway leads STAT to act as a transcription factor, which can gene expression. IL20RB mRNA is present in some ... After a cytokine binds both the IL20RB and the alpha subunit of the IL20 receptor, a signal is sent through the JAK-STAT ... Dumoutier L, Leemans C, Lejeune D, Kotenko SV, Renauld JC (October 2001). "Cutting edge: STAT activation by IL-19, IL-20 and ... Growth Factor Reviews. 21 (5): 353-363. doi:10.1016/j.cytogfr.2010.08.001. PMID 20864382. Kragstrup TW, Andersen T, Heftdal LD ...

The phosphorylation leads to association with JAK/Tyk tyrosine kinases and STAT protein transcription factors. In particular, ... Liu F, Liu Y, Li D, Zhu Y, Ouyang W, Xie X, Jin B (March 2002). "The transcription co-repressor TLE1 interacted with the ... There are many other proteins which associate with gp130, such as cardiotrophin 1 (CT-1), leukemia inhibitory factor (LIF), ... Glycoprotein 130 has been shown to interact with: Grb2, HER2/neu, Janus kinase 1 Leukemia inhibitory factor receptor, PTPN11, ...

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth ... "An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT". Oncogene. 14 (7): ... factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that ... Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene. STAT5B orthologs ...

It has been reported to inhibit nuclear import of the STAT transcription factor, inhibiting interferon activation. Studies of ... "SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling". Proceedings of the National ...

For example, PARP14, a mono (ADP-ribosyl)transferase, has been shown to affect STAT transcription factor binding. Other (ADP- ... PARPs have been shown to affect transcription factor structure and cause recruitment of many transcription factors to form ... Mono(ADP-ribosyl)transferases are also shown to affect transcription factor binding at promoters. ... transcription factor recruitment and binding, and mRNA processing. The organization of nucleosomes is key to regulation of gene ...

The transcription factors STAT, NF-κB, p73, and p53 are among the many proteins that PIAS interacts with. The seven proteins ... Nuclear receptors are transcription factors that regulate transcription upon ligand binding. The Pro-Ile-Asn-Ile-Thr (PINIT) ... This interaction can either upregulate or downregulate transcription. For example, the activity of transcription factor p53 was ... PIAS proteins regulate STAT transcription through several mechanisms, and genetic studies in rodents have shown that PIAS1 ...

The canonical pathway involves Janus kinase-signal transducer and activator of transcription-interferon regulatory factor (JAK- ... STAT-IRF) signaling. This leads to induction of classical interferon stimulated genes (ISGs). The noncanonical signaling ... Spencer TE, Ott TL, Bazer FW (May 1998). "Expression of interferon regulatory factors one and two in the ovine endometrium: ... It was observed that IFN-τ decreased intracellular HIV RNA in human macrophages and inhibited reverse transcription of viral ...

... phosphorylates specific tyrosine residues on the cytokine receptor subunits which then activate STAT transcription factors. ...

This phosphorylation recruits STAT transcription factors, predominantly STAT5, which dimerize and migrate to the cell nucleus ... PLC activates 3 major transcription factors and their pathways: NFAT, NFkB and AP-1. In addition and after costimulation from ... It cooperates with other transcription factors including NFkB and Oct. NFkB is translocated to the nucleus after costimulation ... The proteins expressed by means of the three pathways include bcl-6 (the PI3K/Akt/mTOR pathway), CD25 & prdm-1 (the JAK-STAT ...

"Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Molecular ... "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Molecular ... The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT ... STAT2+Transcription+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) FactorBook STAT2 This ...

"Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. ... "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. ... "Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of ... "Entrez Gene: ISGF3G interferon-stimulated transcription factor 3, gamma 48kDa". Horvath, C M; Stark G R; Kerr I M; Darnell J E ...

Once activated, the JAKs create docking sites for the STAT transcription factors by phosphorylation of specific tyrosine ... After undergoing JAK-mediated phosphorylation, the STAT transcription factors dimerize, translocate to the nucleus, bind DNA at ... STATs (signal transduction and activators of transcription) are members of a family of transcription factors, and they have src ... Cytokine receptors selectively activate particular JAK-STAT pathways to induce transcription of different genes. IL-2 and IL-4 ...

... activation requires NF-κB interaction with other transcription factors, such as STAT (see STAT6), AP-1 (JUN), and NFAT (see ... NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by ... Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which ... "Entrez Gene: NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon". Whiteside ST, ...

Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription ... COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein ... Sato Y, Suzuki T, Hidaka K, Sato H, Ito K, Ito S, Sasano H (2003). "Immunolocalization of nuclear transcription factors, DAX-1 ... Overview of all the structural information available in the PDB for UniProt: P24468 (COUP transcription factor 2) at the PDBe- ...

... are drugs which target signal transducer and activator of transcription (STAT) proteins, a family of ... cytoplasmic induction factors. Inhibitors of STAT proteins are being developed for use in cancer therapy. JAK-STAT signaling ... pathway Furqan, Muhammad; Akinleye, Akintunde; Mukhi, Nikhil; Mittal, Varun; Chen, Yamei; Liu, Delong (2013-12-05). "STAT ...

This leads to activation of the Drosophila STAT, Stat92E, a transcription factor which effects GSC adhesion to the hub cells, ... Placenta-Like Growth Factor (PLGF), Platelet-Derived Growth Factor (PDGF) and Epidermal Growth Factor. But there is evidence ... The maintaining of the hypoxic state is under control of Hypoxia-Inducible transcription Factors (HIFs). HIFs contribute to ... All of these factors contribute to a cancer stem cell phenotype which is why it is often referred to as a hypoxic stem cell ...

... ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not ... activating transcription factor 1 (ATF1), serum response factor (SRF), and mRNA-binding protein tristetraprolin (TTP) In ... Janknecht R (Nov 2001). "Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase ... Yang SH, Galanis A, Sharrocks AD (Jun 1999). "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors ...