Soluble urokinase plasminogen activator receptor
... (suPAR) (NCBI Accession no. AAK31795) is a protein and the soluble form of ... Soluble urokinase plasminogen activator receptor as a prognostic marker of all-cause and cardiovascular mortality in a black ... "Circulating Soluble Urokinase Plasminogen Activator Receptor Predicts Cancer, Cardiovascular Disease, Diabetes and Mortality in ... "Circulating Soluble Urokinase Plasminogen Activator Receptor Predicts Cancer, Cardiovascular Disease, Diabetes and Mortality in ...
Urokinase receptor
The Urokinase receptor, also known as urokinase plasminogen activator surface receptor (uPAR) or CD87 (Cluster of ... Soluble urokinase plasminogen activator receptor (suPAR) has been found to be a biomarker of inflammation. Elevated suPAR is ... Alfano M, Sidenius N, Blasi F, Poli G (November 2003). "The role of urokinase-type plasminogen activator (uPA)/uPA receptor in ... Kjøller L (January 2002). "The urokinase plasminogen activator receptor in the regulation of the actin cytoskeleton and cell ...
Plasminogen activator inhibitor-2
Ellis V, Wun TC, Behrendt N, Rønne E, Danø K (June 1990). "Inhibition of receptor-bound urokinase by plasminogen-activator ... "The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating ... "Expression and localization of the urokinase-type plasminogen activator receptor (uPAR) in the human placenta". The Kobe ... is a coagulation factor that inactivates tissue plasminogen activator and urokinase. It is present in most cells, especially ...
Three-finger protein
... family and the urokinase plasminogen activator receptor (uPAR). Other receptors with LU domains include members of the ... Ploug M, Ellis V (August 1994). "Structure-function relationships in the receptor for urokinase-type plasminogen activator. ... such as the activin type 2 receptor; and bone morphogenetic protein receptor, type IA. Other LU domain proteins are small ... such as the nicotinic acetylcholine receptors, muscarinic acetylcholine receptors, and acetylcholinesterase. Another large ...
Male accessory gland infection
"Soluble urokinase-type plasminogen activator receptor as a putative marker of male accessory gland inflammation". Andrology. 3 ... One study has proposed that elevated levels of soluble urokinase-type plasminogen activator receptor (SuPAR) in seminal plasma ...
LU domain
Urokinase plasminogen activator surface receptor InterPro: IPR003631 Cell-surface glycoprotein Ly-6/CD59 InterPro: IPR003632 ... "The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator". The Journal of Biological ... of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A ... Besides uPAR, other receptors with LU domains include members of the transforming growth factor beta receptor (TGF-beta) ...
Suparnostic
Soluble urokinase-type plasminogen activator receptor (suPAR) as an independent factor predicting worse prognosis and extra- ... Plasma concentrations of soluble urokinase-type plasminogen activator receptor are increased in patients with malaria and are ... Release of the soluble urokinase-type plasminogen activator receptor (suPAR) by activated neutrophils in rheumatoid arthritis. ... that measures the amount of soluble urokinase plasminogen activator receptor (suPAR) in blood. Elevated plasma suPAR levels ...
LDL-receptor-related protein-associated protein
... low density lipoprotein receptor mediates the cellular catabolism of lipoprotein lipase and urokinase-plasminogen activator ... It acts to inhibit the binding of all known ligands for these receptors, and may prevent receptor aggregation and degradation ... "39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein". The ... "The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2- ...
NFKB1
... endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor". J. Cell Sci. ... Na SY, Lee SK, Han SJ, Choi HS, Im SY, Lee JW (May 1998). "Steroid receptor coactivator-1 interacts with the p50 subunit and ... Yu Z, Zhang W, Kone BC (October 2002). "Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of ... Schmitz ML, Krappmann D (2006). "Controlling NF-kappaB activation in T cells by costimulatory receptors". Cell Death Differ. 13 ...
LYPD6B
As a prototoxin, LYPD6B also belongs to the protein family of Ly-6/urokinase plasminogen activator receptor (Ly6/uPAR). It has ... prostate and in the nervous system where it acts as a modulator of nicotinic acetylcholine receptor (nAChRs) activity. The ... "The prototoxin LYPD6B modulates heteromeric α3β4-containing nicotinic acetylcholine receptors, but not α7 homomers". FASEB ... as an enhancer of the activity of the neurotransmitter acetylcholine certain α7-containing nicotinic acetylcholine receptors, ...
ITGB3BP
... endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor". J. Cell Sci. ... endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor". J. Cell Sci. ... "NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors". Mol Cell Biol. 19 (10): 7191-202. ... an estrogen-inducible nuclear receptor coregulator". Mol. Cell. Biol. 24 (15): 6581-91. doi:10.1128/MCB.24.15.6581-6591.2004. ...
Gopal Kundu
"Osteopontin induces AP-1-mediated secretion of urokinase type plasminogen activator through c-Src dependent EGF receptor ... cell motility and urokinase type plasminogen activator secretion involves activation of epidermal growth factor receptor/ ... suppresses the cell motility and NF-kappa B mediated secretion of urokinase type plasminogen activator by inhibiting the ... p56lck regulates cell motility and NF-kB-mediated secretion of urokinase type plasminogen activator through tyrosine ...
Francesco Blasi
"Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor ...
MSR1
"Ligand binding to macrophage scavenger receptor-A induces urokinase-type plasminogen activator expression by a protein kinase- ... Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene. MSR1 has also ... Macrophage scavenger receptor has been shown to mediate adhesion of macrophages and other cell lines to tissue culture plastic ... These receptors or isoforms are trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated ...
PC3
"RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits ...
Vsevolod Tkachuk
In particular, a lot of research was focused on the role of urokinase-type plasminogen activator (Urokinase, uPA) in ... In the 90s, a group directed by V. A. Tkachuk published a number of papers on stretching receptors' involvement in specific ... Research of the biological functions of urokinase-type plasminogen activator (uPA) Since early 90s V. A. Tkachuk and his ... V. A. Tkachuk and his colleagues have also for the first time showed urokinase's ability to transport itself into the core and ...
Senescence-associated secretory phenotype
Soluble urokinase plasminogen activator surface receptor is part of SASP, and has been used to identify senescent cells for ... "Chemokine signaling via the CXCR2 receptor reinforces senescence". Cell. 133 (6): 1006-18. doi:10.1016/j.cell.2008.03.038. PMID ...
Protease-activated receptor 2
... serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as ... Protease-activated receptor Protease-activated receptor 1 Protease-activated receptor 3 GRCh38: Ensembl release 89: ... Protease activated receptor 2 (PAR2) also known as coagulation factor II (thrombin) receptor-like 1 (F2RL1) or G-protein ... "Protease-Activated Receptors: PAR2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
Formyl peptide receptor 2
... two cleaved soluble fragments of UPARAP which is the Urokinase-type plasminogen activator receptor (uPAR), D2D3(88-274) and ... Eicosanoid receptor Formyl peptide receptor Lipoxin Resolvin Formyl peptide receptor 1 Formyl peptide receptor 3 GRCh38: ... human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19". Genomics. 13 (2 ... human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19". Genomics. 13 (2 ...
Fibroblast activation protein, alpha
"Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: ...
DU145
"RNA Interference-directed Knockdown of Urokinase Plasminogen Activator and Urokinase Plasminogen Activator Receptor Inhibits ... "DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions ... but they still require regular androgen receptors (AR). NEK6 inhibition is a potential treatment for CRPC due to its role as an ... xanthatin induces the apoptosis of DU145 prostate carcinoma cells through signal transducer and activator of transcription 3 ...
Sepsis
A 2012 systematic review found that soluble urokinase-type plasminogen activator receptor (SuPAR) is a nonspecific marker of ... There are four families of PRRs: the toll-like receptors, the C-type lectin receptors, the NOD-like receptors, and the RIG-I- ... However, β2 adrenergic receptor agonists are not recommended to treat ARDS because it may reduce survival rates and precipitate ... This forced receptor interaction induces the production of pro-inflammatory chemical signals (cytokines) by T-cells. There are ...
Matrix metallopeptidase 12
2003). "Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose ... epitopes not present in the intact soluble receptor". Thromb. Haemost. 88 (2): 298-306. doi:10.1055/s-0037-1613202. PMID ...
ST14
... serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as ... and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other ... Lee SL, Dickson RB, Lin CY (2001). "Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, ... of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase". ...
Urokinase
August 2012). "Urokinase-type plasminogen activator-like proteases in teleosts lack genuine receptor-binding epidermal growth ... The most important inhibitors of urokinase are the serpins plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator ... Alfano M, Sidenius N, Blasi F, Poli G (November 2003). "The role of urokinase-type plasminogen activator (uPA)/uPA receptor in ... Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. ...
Plasminogen activator inhibitor-1
... that functions as the principal inhibitor of tissue-type plasminogen activator (tPA) and urokinase (uPA), the activators of ... the roles of peroxisome proliferator-activated receptor-γ and plasminogen activator inhibitor-1". PPAR Research. 2009: 345320. ... Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor (serpin E1) is a protein ... Harbeck N, Kates RE, Gauger K, Willems A, Kiechle M, Magdolen V, Schmitt M (March 2004). "Urokinase-type plasminogen activator ...
Pathophysiology of multiple sclerosis
Microvessels in periplaque areas coexpressed HLA-DR and VCAM-1, some others HLA-DR and urokinase plasminogen activator receptor ... "Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier". Journal of ... 2016). "Nuclear Receptor NR1H3 in Familial Multiple Sclerosis". Neuron. 90 (5): 948-954. doi:10.1016/j.neuron.2016.04.039. PMC ...
Jochen Reiser
Reiser discovered the role of suPAR (soluble urokinase plasminogen activator receptor) as a global, circulating risk factor for ... soluble urokinase plasminogen activator receptor (suPAR)- in the pathogenesis of focal segmental glomerulosclerosis (FSGS) to ... "Soluble Urokinase Receptor and Acute Kidney Injury". New England Journal of Medicine. nejm.org. 382 (5): 416-426. doi:10.1056/ ... "Soluble Urokinase Receptor and Chronic Kidney Disease". New England Journal of Medicine. nejm.org. 373 (20): 1916-1925. doi: ...
Somatomedin B
The SMB domain of vitronectin has been demonstrated to interact with both the urokinase receptor and the plasminogen activator ...
Anakinra
... soluble urokinase plasminogen activator receptor) of at least 6 ng per ml." In November 2022, the United States FDA approved ... to severe respiratory failure and likely to have an elevated plasma soluble urokinase plasminogen activator receptor (suPAR)." ... October 2021). "Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a ... It is a recombinant and slightly modified version of the human interleukin 1 receptor antagonist protein. It is marketed by ...