... +receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) "Chemokine Receptors: CCR4". IUPHAR ... C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. CCR4 has also recently been designated ... "Entrez Gene: CCR4 chemokine (C-C motif) receptor 4". Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (June 1997). " ... FDA grants priority review to mogamulizumab for cutaneous T-cell lymphoma Nov 2017 Human CCR4 genome location and CCR4 gene ...

CCR2 and CCR4 are two cell surface receptors that bind CCL2. CCL2 exhibits a chemotactic activity for monocytes and basophils. ... Kim MS, Day CJ, Morrison NA (April 2005). "MCP-1 is induced by receptor activator of nuclear factor-κB ligand, promotes human ... Foresti ML, Arisi GM, Katki K, Montañez A, Sanchez RM, Shapiro LA (December 2009). "Chemokine CCL2 and its receptor CCR2 are ... "Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI family heart study follow- ...

Pease JE, Horuk R (May 2014). "Recent progress in the development of antagonists to the chemokine receptors CCR3 and CCR4". ... afucosylated monoclonal antibody targeting CC chemokine receptor 4 (CCR4). The U.S. Food and Drug Administration (FDA) approved ... The precursor to mogamulizumab was a mouse anti-human CCR4 IgG1 mAb (KM2160), that was made in 1996 in a collaboration between ... Carroll J (25 August 2017). "After a long clinical odyssey, the FDA tapped this PhIII anti-CCR4 as a 'breakthrough' lymphoma ...

CCR4-NOT transcription complex subunit 3 is a protein that in humans is encoded by the CNOT3 gene. It is a subunit of the CCR4- ... "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8-9 ... "Entrez Gene: CNOT3 CCR4-NOT transcription complex, subunit 3". Wende H, Volz A, Ziegler A (2000). " ... "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809-17. doi: ...

CCR4 is expressed on Th2 T lymphocytes and is up-regulated by T cell receptor activation. However, some reports suggest a role ... chemokine receptor. CCR10 is receptor for CCL27 and CCL28 that was originally called orphan receptor GPR2. CCR10 has been ... The CC chemokine receptors all work by activating the G protein Gi. CCR1 was the first CC chemokine receptor identified and ... This receptor is well defined as a major coreceptor implicated in susceptibility to HIV-1 infection and disease. This receptor ...

"Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription". EMBO J. 25 (13): 3089-99. ... CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene. It is a part of the CCR4-Not ... "Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction". Mol. Cell. 48 (2): 207-18. ... "Entrez Gene: CNOT1 CCR4-NOT transcription complex, subunit 1". Garneau NL, Wilusz J, Wilusz CJ (Feb 2007). "The highways and ...

Scheu S, Ali S, Ruland C, Arolt V, Alferink J (November 2017). "The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in ... They do this by binding to CCR4, a chemokine receptor expressed on type 2 helper T cells, cutaneous lymphocyte skin-localizing ... A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4". International ... "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". ...

Resting human Tr1 cells express Th1 associated chemokine receptors CXCR3 and CCR5, and Th2-associated CCR3, CCR4 and CCR8. Upon ... CD49b belongs to the integrin family and is a receptor for many (extracellular) matrix and non-matrix molecules. CD49b provides ... Tr1 cells express high levels of regulatory factors, such as glucocorticoid-induced tumor necrosis factor receptor (GITR), OX40 ... the aryl hydrocarbon receptor (AhR) interferon regulatory factor 4 (IRF4) the repressor of GATA-3 (ROG) early growth response ...

Garapaty S, Mahajan MA, Samuels HH (March 2008). "Components of the CCR4-NOT complex function as nuclear hormone receptor ... CCR4-NOT transcription complex subunit 9 is a protein that in humans is encoded by the CNOT9 gene. This gene encodes a member ... "Entrez Gene: CCR4-NOT transcription complex subunit 9". Retrieved 2020-04-15. Hiroi N, Ito T, Yamamoto H, Ochiya T, Jinno S, ... The encoded protein is a transcriptional cofactor and a core protein of the CCR4-Not deadenylation complex. It may be involved ...

2007). "Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell ... 2000). "Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the ... "Chemokine Receptors: CCR10". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... CCR10 is a chemokine receptor. Its ligands are CCL27 and CCL28. This receptor is normally expressed by melanocytes, plasma ...

Although it can bind to receptors CCR1, CCR3, CCR4 and CCR5, belonging to seven transmembrane G-protein coupled receptor (GPCRs ... They can act as mitogens and they are not dependent on binding to the receptor. Activated T-cells (or other cells, for instance ... CCL5 also activates the G-protein coupled receptor GPR75. CCL5 has two mechanisms of action according to its concentration. The ... Thus, CCL5 in nanomolar concentration acts as classical chemokine and binds to its receptor. For the acting as classical ...

... the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling ... the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex". The Journal of Biological Chemistry. ... with a Caf1 component of the CCR4 transcriptional regulatory complex". Japanese Journal of Cancer Research. 92 (6): 592-6. doi: ...

"Cc Chemokine Receptor (Ccr)3/Eotaxin Is Followed by Ccr4/Monocyte-Derived Chemokine in Mediating Pulmonary T Helper Lymphocyte ... Her group demonstrated that T helper cells were the initial responders to CCR3 and CCR4 pathways, but the increase in CCR4 ...

CCR4 and CCR5. Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and ... the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes through binding to the receptors ...

CCR4 that are associated with cutaneous T cell homing, and platelet-derived growth factor receptor (PGDFR). Th22 cells ... CCR5 and α4β7 molecules expressed by Th22 cells were able to bind to the circulating HIV receptor, and thus via interleukin-22 ... Additionally, they could be characterized by their cell surface expression of CD3, CD4, CD28, number of chemokine receptors ... can also induce the differentiation of naive T cells into Th22 cells via the endogenous toll-like receptor 4 ligand (TLR4), ...

... receptor 2 (CCR2, CKR2) Chemokine (C-C motif) receptor 3 (CCR3, CKR3) Chemokine (C-C motif) receptor 4 (CCR4, CKR4) Chemokine ( ... chemokine receptor (DARC, DUFF) G Protein-coupled Receptor 30 (GPER, CML2, GPCR estrogen receptor) Angiotensin II receptor ... Opioid receptor InterPro: IPR001418 delta Opioid receptor (OPRD1, OPRD) kappa Opioid receptor (OPRK1, OPRK) mu Opioid receptor ... Motilin receptor (MLNR, GPR38) Anaphylatoxin receptors InterPro: IPR002234 C3a receptor (C3AR1, C3AR) C5a receptor (C5AR1, C5AR ...

... and elicits its effects on its target cells by interacting with cell surface chemokine receptors such as CCR4. The gene for ... 1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". J. Biol. Chem. 273 (3): 1764-8. ... Campbell JD, Stinson MJ, Simons FE, HayGlass KT (2003). "Systemic chemokine and chemokine receptor responses are divergent in ... Gear AR, Camerini D (2003). "Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense". ...

... and perhaps other CCR4-receptor bearing cells. Preliminary findings suggest that the actions of CKLF1 on these CCR4-bearing ... and tissue samples indicate that CKLF1 is a chemokine-like chemotactic factor that acts through the CCR4 receptors on human ...

Th22 cells are known to secrete IL-22, IL-13, IL-26, TNF-α, and granzyme B. Th22 cells express the chemokine receptors CCR4, ... Rothhammer V, Quintana FJ (March 2019). "The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in ... are a derivative of naïve CD4+ T cells induced by the ligand activation of the transcription factor aryl hydrocarbon receptor ( ...

4 receptor Interleukin-5 receptor Interleukin-6 receptor Interleukin-7 receptor Interleukin-7 receptor-α Interleukin-8 receptor ... CCR4 CCR5 CCR8 (gene) CCR9 CCRL1 CCRL2 CD117 CD32B CD4 CD4+ T cells and antitumor immunity CD74 CD94/NKG2 Cell-mediated ... receptor Interleukin-22 receptor Interleukin-23 receptor Interleukin-27 receptor Interleukin-28 receptor Interleukin-3 receptor ... receptor Interleukin-1 receptor Interleukin-1 receptor family Interleukin-1 receptor-associated kinase Interleukin-10 receptor ...

Mast cells: on their surface express several receptors for chemokines: CCR1, CCR2, CCR3, CCR4, CCR5, CXCR2, and CXCR4. Ligands ... Chemokine receptors are G protein-coupled receptors containing 7 transmembrane domains that are found on the surface of ... G proteins are coupled to the C-terminal end of the chemokine receptor to allow intracellular signaling after receptor ... associated with binding receptor and inflammatory chemokines. This often complicates research on receptor-specific therapeutics ...

... the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling ... CCR4-NOT transcription complex subunit 8 is a protein that in humans is encoded by the CNOT8 gene. It is a subunit of the CCR4- ... the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling ... "Entrez Gene: CNOT8 CCR4-NOT transcription complex, subunit 8". Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, ...

... the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling ... CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene. It is a subunit of the CCR4- ... the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling ... "Entrez Gene: CNOT7 CCR4-NOT transcription complex, subunit 7". Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA ...

... the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling ... the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling ... March 2005). "Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation ... December 1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and ...

Treg infiltration into the tumor microenvironment is facilitated by the binding of the chemokine receptor CCR4, which is ... Antigen-activated T cells produce IL-2 which then acts on IL-2 receptors on regulatory T cells alerting them to the fact that ... Recirculating T reg cells in thymus express high amount of high affinity IL-2 receptor α chain (CD25) encoded by Il2ra gene ... Peters VA, Joesting JJ, Freund GG (August 2013). "IL-1 receptor 2 (IL-1R2) and its role in immune regulation". Brain, Behavior ...

Mogamulizumab is a CCR4 monoclonal antibody which has been shown to improve progression-free survival. It was approved by the ... In 2010, the U.S. Food and Drug Administration granted orphan drug designation for naloxone lotion, a topical opioid receptor ... In transformed cells, presence of the CD30 receptor is associated with improved survival To stage the disease, various tests ...

Chemokine receptor CXCR3 is a Gαi protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G ... CXCR3 and CCR5 are preferentially expressed on Th1 cells, whereas Th2 cells favor the expression of CCR3 and CCR4. CXCR3 ... "Chemokine Receptors: CXCR3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... "Entrez Gene: CXCR3 chemokine (C-X-C motif) receptor 3". Yates CC, Whaley D, Kulasekeran P, Hancock WW, Lu B, Bodnar R, Newsome ...

... repeat containing 18 TRBC1 encoding protein T cell receptor beta constant 1 TRBC2 encoding protein T cell receptor beta ... CCR4-NOT transcription complex, subunit 4 CPED1: cadherin like and PC-esterase domain containing 1 CPVL: carboxypeptidase, ... scavenger receptor cysteine rich family member with 4 domains STEAP1: six transmembrane epithelial antigen of the prostate 1 ... B-cell receptor-associated protein 29 BCC6: encoding protein basal cell carcinoma, susceptibility to, 6 BRAT1: BRCA1-associated ...

"BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms". J. ... "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 ...

2000). "Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the ... Soler D, Humphreys TL, Spinola SM, Campbell JJ (2003). "CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking". Blood ... 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated ... which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor- ...