"The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1". Protein Sci. 15 (6): 1500- ... The class II PTPs contain only one member, low-molecular-weight phosphotyrosine phosphatase (LMPTP). Cdc25 phosphatases (dTyr ... a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate Protein tyrosine (pTyr) phosphorylation is a common post ... Protein tyrosine phosphatases (EC 3.1.3.48, systematic name protein-tyrosine-phosphate phosphohydrolase) are a group of enzymes ...

Receptor tyrosine kinases; Tyrosine kinase associated receptors; Receptor-like tyrosine phosphatases; Receptor serine/threonine ... Two most abundant classes of transmembrane receptors are GPCR and single-pass transmembrane proteins. In some receptors, such ... Adrenergic receptor Olfactory receptors Receptor tyrosine kinases Epidermal growth factor receptor Insulin Receptor Fibroblast ... Nerve Growth Factor Receptor NMDA receptor Several Immune receptors Toll-like receptor T cell receptor CD28 SCIMP protein ...

Tyrosine-protein phosphatase non-receptor type 13 is an enzyme that in humans is encoded by the PTPN13 gene. The protein ... Lin D, Gish GD, Songyang Z, Pawson T (1999). "The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif ... "Entrez Gene: PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)". Gross, C; ... "The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP- ...

The PI3K is activated by G protein-coupled receptors and tyrosine kinase receptors. Class I PI3Ks are heterodimeric molecules ... P3 phosphatase PTEN that antagonises PI3K signaling is absent from many tumours. In addition, the epidermal growth factor ... The PI3K family is divided into four different classes: Class I, Class II, Class III, and Class IV. The classifications are ... Class II comprises three catalytic isoforms (C2α, C2β, and C2γ), but, unlike Classes I and III, no regulatory proteins. Class ...

"Identification of a mutated receptor-like protein tyrosine phosphatase kappa as a novel, class II HLA-restricted melanoma ... The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Protein tyrosine phosphatases ... "The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1". Protein Sci. 15 (6): 1500-5. ... "Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function". J Biol Chem. 280 (52): ...

... the bradykinin receptor B2 has been shown to interact directly with a protein tyrosine phosphatase. The presence of a tyrosine- ... G protein-coupled receptors database List of MeSH codes (D12.776) Metabotropic receptor Orphan receptor Pepducins, a class of ... transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors ( ... October 2002). "A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved ...

For instance, the MAPKKK ASK-1 is activated by a receptor-tyrosine kinase specific for a tumor necrosis factor. Since MAPKKK ... Mitogen Activated Protein (MAP) kinase kinase kinase (MAPKKK, MKKK, M3K, or, MAP3K) is a serine/threonine-specific protein ... Several classes of MAPKKK exist, and all of them are upstream of MAP kinases. There are three main classes of MAP Kinases and ... A common phosphatase used in ASK-1 regulation is PP5. MAPKKKs contain a docking domain which is different from their active ...

A-5 protein, and receptor protein-tyrosine phosphatase mu) C-terminal neuropilin The structure of B1 domain (coagulation factor ... first documented to regulate neurogenesis and angiogenesis by complexing with Plexin receptors/class-3 semaphorin ligands and ... Neuropilin is a protein receptor active in neurons. There are two forms of Neuropilins, NRP-1 and NRP-2. Neuropilins are ... Neuropilin-1 is a therapeutic target protein in the treatment for leukemia and lymphoma, since It has been shown that there is ...

... that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion". Mol. Cell. ... Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling ... Malik KF, Jaffe H, Brady J, Young WS (1997). "The class III POU factor Brn-4 interacts with other class III POU factors and the ... "Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins". Biochemistry. ...

Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), ... "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". Eur. J. Immunol. 28 (11 ... "Entrez Gene: PTPN6 protein tyrosine phosphatase, non-receptor type 6". Amin S, Kumar A, Nilchi L, Wright K, Kozlowski M (August ... "Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase". J. Biol. ...

Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6". The Journal of ... September 2004). "Control of vesicle fusion by a tyrosine phosphatase". Nature Cell Biology. 6 (9): 831-9. doi:10.1038/ncb1164 ... "Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex". Biochemical and Biophysical ... The protein domain Syntaxin 6 N terminal protein domain is a soluble N-ethylmaleimide-sensitive factor attachment protein ...

The protein encoded by this gene belongs to the non-receptor class of the protein-tyrosine phosphatase family. The encoded ... protein has both protein-tyrosine phosphatase activity and serine/threonine-specific phosphatase activity, and therefore is ... 2006). "Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase". Proteins. 61 (3): 694- ... Dual specificity protein phosphatase 15 is an enzyme that in humans is encoded by the DUSP15 gene. ...

Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. TYK2 was the first member of ... prototype of a novel class of non-receptor tyrosine kinase genes". Oncogene. 5 (9): 1329-1336. PMID 2216457. Partanen J, Mäkelä ... "Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase". The Journal of ... "The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein". The Journal of Biological ...

2000). "Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the ... 2000). "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins". Nature. 403 (6769 ... 1996). "Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha". J. Biol. ... 1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1". J. Leukoc ...

... homeobox protein transcription factor CDX2; e) Protein tyrosine phosphatase receptor-type R gene PTPRR; f) transcriptional ... Education Program. 2013: 118-25. doi:10.1182/asheducation-2013.1.118. PMID 24319172. S2CID 24762855. Kar A, Gutierrez-Hartmann ... The table includes abbreviations for tyrosine kinase receptor (TK receptor), non-receptor tyrosine kinase (non-receptor TK), ... "PTPRR protein tyrosine phosphatase, receptor type R (human0". Entrez Gene. "IGH immunoglobulin heavy locus (human )". Entrez ...

Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS ... Dopamine receptors can also transactivate Receptor tyrosine kinases. Beta Arrestin recruitment is mediated by G-protein kinases ... cAMP mediated protein kinase A activity also results in the phosphorylation of DARPP-32, an inhibitor of protein phosphatase 1 ... The D2 class of receptors produce the opposite effect, as they are Gαi and/or Gαo coupled receptors, which blocks the activity ...

Controlling mechanisms are mainly aimed at inhibition of JAK kinase activity by SHP-1 tyrosine phosphatase with SH2 binding ... and GM-CSF alpha and beta receptor messenger ribonucleic acid and protein in human ovarian tissue". Biology of Reproduction. 53 ... Geijsen N, Koenderman L, Coffer PJ (Mar 2001). "Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5 ... which can be found in other cytokine receptors (growth hormone receptor, erythropoietin receptor). In the membrane distant part ...

Harrod TR, Justement LB (2003). "Evaluating function of transmembrane protein tyrosine phosphatase CD148 in lymphocyte biology ... Bass MD, Humphries MJ (2002). "Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor ... Lin D, Gish GD, Songyang Z, Pawson T (1999). "The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif ... Syntenin-1 is a protein that in humans is encoded by the SDCBP gene. The protein encoded by this gene was initially identified ...

"Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of ... "The B-cell antigen receptor of the five immunoglobulin classes". Nature. 352 (6338): 777-81. Bibcode:1991Natur.352..777V. doi: ... "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45". The Journal ... "Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor ...

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have ... "Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 ... "Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation". J. Biol. Chem. 277 (42 ... an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases". Mol. Cell. Biol. 10 (12): 6316- ...

... these two proteins comprise one of the four classes of heterotrimeric G protein alpha subunits. Heterotrimeric G proteins ... G12/G13 alpha subunits G protein-coupled receptor Heterotrimeric G protein Rho family of GTPases GRCh38: Ensembl release 89: ... interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353-8. doi ... Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia ...

... D recognizes mostly stress-induced proteins, namely human MHC class-I-chain related protein (MIC-A) and MIC-B, and also ... NKG2D is an activating receptor on the NK cell surface. NKG2A dimerizes with CD94 to make an inhibitory receptor (CD94/NKG2). ... ITAMs, included in DAP-12, on the other hand, recruite the Src homology domain containing kinases Syk (spleen tyrosine kinase) ... Inhibitory NKG2 molecules containing ITIMs recruite the Src homology 2 domain containing phosphatases SHP-1 and SHP-2, which ...

April 2022). "Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor". Cell Metabolism. 34 (4): 549 ... Members of this class are derived from a cleavage event that also generates a much larger, functionally unrelated, nonhormonal ... Asprosin's orexigenic effects are mediated through binding to protein tyrosine phosphatase receptor delta (PTPRD). Genetic ... The first indication that asprosin was in fact a cerebrospinal fluid (CSF) protein, in addition to being a plasma protein, was ...

"Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of ... It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action ... "Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of ... "Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin". The Journal of ...

When JAKs are activated and phosphorylate tyrosine residues on receptors, proteins with SH2 domains (such as STATs) are able ... Interleukin-4-mediated IgE Class Switch Recombination in Human B Cells through Its Function as a Janus Kinase Phosphatase". ... STATs may also be tyrosine-phosphorylated directly by receptor tyrosine kinases - but since most receptors lack built-in kinase ... Xu, Dan; Qu, Cheng-Kui (2008). "Protein tyrosine phosphatases in the JAK/STAT pathway". Frontiers in Bioscience. 13 (1): 4925- ...

"The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase ... belongs to a new class of ubiquitin-binding proteins". J. Biol. Chem. 271 (34): 20235-7. doi:10.1074/jbc.271.34.20235. PMID ... Also known as the ubiquitin-binding protein p62, it is an autophagosome cargo protein that targets other proteins that bind to ... of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor ...

Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (May 1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine ... Combined Scissor-Like Rotation and Self-Rotation of Receptor Dimer Induced by Class I Cytokine". PLOS Computational Biology. 8 ... "Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways". The ... Zang H, Sato K, Nakajima H, McKay C, Ney PA, Ihle JN (Jun 2001). "The distal region and receptor tyrosines of the Epo receptor ...

The Protein Man. "Protein Kinases and Phosphatases: drivers of phosphorylation and dephosphorylation". info.gbiosciences.com. ... A signaling pathway begins at the cell surface where a hormone or protein binds to a receptor at the extracellular matrix. The ... 2. Pearson Education, Inc. v t e (Articles lacking in-text citations from December 2015, All articles lacking in-text citations ... In order to regulate its functions so it does not cause chaos, it can only be active when both tyrosine and threonine/serine ...

... encoding protein putative tyrosine-protein phosphatase TPTE TRPM2: encoding protein transient receptor potential cation channel ... encoding glutamine amidotransferase-like class 1 domain-containing protein 3A, mitochondrial GRIK1: encoding glutamate receptor ... encoding protein coxsackievirus and adenovirus receptor CYYR1: encoding protein cysteine and tyrosine rich 1 DIP2A: Disco- ... encoding protein encoding protein encoding protein Trafficking protein particle complex subunit 10 TMPRSS2: encoding enzyme ...

Kamakura S, Moriguchi T, Nishida E (September 1999). "Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. ... Buschbeck M, Eickhoff J, Sommer MN, Ullrich A (August 2002). "Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 ... lessons from knockout mice". Journal of Molecular Medicine. 82 (12): 800-808. doi:10.1007/s00109-004-0602-8. PMID 15517128. ... It is involved in the downstream signaling processes of various receptor molecules including receptor tyrosine kinases, and G ...