... is a receptor for granulocyte-macrophage colony-stimulating factor, which stimulates the production of white blood cells. In ... The granulocyte-macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), ... Lia F, Rajotte D, Clark SC, Hoang T (Nov 1996). "A dominant negative granulocyte-macrophage colony-stimulating factor receptor ... It is associated with Surfactant metabolism dysfunction type 4. The granulocyte-macrophage colony-stimulating factor receptor ...

Fixe P, Praloran V (June 1997). "Macrophage colony-stimulating-factor (M-CSF or CSF-1) and its receptor: structure-function ... The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine ... It is one of the three experimentally described colony-stimulating factors. M-CSF binds to the colony stimulating factor 1 ... "Direct stimulation of cells expressing receptors for macrophage colony-stimulating factor (CSF-1) by a plasma membrane-bound ...

Secondary structure analysis has suggested similarity to IL4 and granulocyte-macrophage colony stimulating factor (GMCSF). ... In addition, it acts on some B cells, via receptor-specific binding, as a growth factor and antibody production stimulant. The ... These include granulocyte colony-stimulating factor (GCSF) and myelomonocytic growth factor (MGF). GCSF acts in hematopoiesis ... "Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor". Archives of ...

... of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5) receptor complexes ... IL-3 shares the β subunit with IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF). This β subunit sharing ... Sometimes also called colony-stimulating factor, multi-CSF, mast cell growth factor, MULTI-CSF, MCGF; MGC79398, MGC79399: the ... Granulocyte macrophage colony-stimulating factor (GM-CSF), and IL-6. IL-3 is secreted by basophils and activated T cells to ...

... also known as macrophage colony-stimulating factor receptor (M-CSFR), with potential antineoplastic and immunomodulating ... is a humanized monoclonal antibody directed against colony stimulating factor 1 receptor (CSF-1R) expressed on macrophages and ... Upon administration, emactuzumab binds to CSF1R expressed on macrophages and inhibits the binding of colony-stimulating factor- ... Emactuzumab is a humanized monoclonal antibody directed against the tyrosine kinase receptor colony stimulating factor 1 ...

Interleukin-5, granulocyte-macrophage colony stimulating factor, and interleukin-33 enhance anti-Siglec-8 mediated destruction ... Siglec-8 is an inhibitory receptor present on eosinophils and mast cells, with low level expression on basophils. ...

... a granulocyte colony-stimulating factor (G-CSF) analog) Granulocyte-macrophage colony-stimulating factor receptor Lenzilumab ... Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric ... Root RK, Dale DC (March 1999). "Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor: ... "Granulocyte-macrophage colony-stimulating factor: not just another haematopoietic growth factor". Medical Oncology. 31 (1): 774 ...

... (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 ( ... "c-Cbl associates directly with the C-terminal tail of the receptor for the macrophage colony-stimulating factor, c-Fms, and ... "Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates ... Colony stimulating factor 1 receptor has been shown to interact with: Cbl gene, FYN, Grb2, Suppressor of cytokine signaling 1, ...

"Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates ... "Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates ... Colony stimulating factor 1 receptor Growth hormone receptor, IRS2, Janus kinase 2, and TEC. SOCS JAK-STAT signaling pathway ... 2 with the insulin-like growth factor-I receptor". The Journal of Biological Chemistry. 273 (37): 24095-101. doi:10.1074/jbc. ...

... colony-stimulating factor-1 receptor (CSF-1R) and granulocyte macrophage colony-stimulating factor (GM-CSF) in preclinical ... A similar outcome was achieved by neutralizing macrophage colony-stimulating factor 1, which impaired the intratumoral ... platelet-derived growth factor receptor α (PDGFR-α), platelet-derived growth factor receptor β (PDGFR-β), fibroblast specific ... December 2010). "Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes ...

Interleukin-4 (IL-4) and granulocyte-macrophage colony stimulating factor (GMCSF) both upregulate PD-L2 expression in DCs in ... PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1). PD-L2 is a cell surface receptor belonging to the ... PD-L2 binds to its receptor PD-1 with dissociation constant Kd of 11.3 nM. Binding to PD-1 can activate pathways inhibiting TCR ... May 2006). "No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell ...

... a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in ... Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling". The Journal of Biological Chemistry. 275 (30 ... "Expression of the Grb2-related protein of the lymphoid system in B cell subsets enhances B cell antigen receptor signaling ... a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28". Journal of ...

... a human monoclonal igG4 antibody to the alpha chain of granulocyte macrophage colony-stimulating factor (GM-CSF Receptor). In ... "TRAIL Receptor Antibodies - HGS". Hgsi.com. Archived from the original on 16 May 2008. Retrieved 12 May 2010. Pukac, L; ... In addition, the committee voted 18 - 0 in favour of the risk-benefit profile of raxibacumab". Two anti-TRAIL receptor ... These included: Adalimumab (D2E7) - a human monoclonal antibody to tumor necrosis factor-alpha (TNF alpha). This drug went on ...

... and the beta subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human ... "JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation ... The interleukin-5 receptor is a type I cytokine receptor. It is a heterodimer of the interleukin 5 receptor alpha subunit and ... In fact, the β-subunit of the IL-5 receptor is also found in IL-3 and GM-CSF receptors where it is associated with IL-3Rα and ...

... macrophage colony stimulating factor (M-CSF), the interleukins IL-1, IL-6, and IL-8, and TNF-α. Receptors for these molecules ... Neuroprotective effects - Reactive astrocytes release neurotrophic factors, such as glial cell-derived neurotrophic factor ( ... ciliary neurotrophic factor (CNTF), and leukemia inhibitory factor (LIF). Although many of these specific modulatory ... These components, along with activated macrophages they carry, are known to have a role in beginning the formation of the glial ...

... in the granulocyte-macrophage colony-stimulating factor receptor or anti-granulocyte-macrophage colony-stimulating factor ... The GATA2 protein is a transcription factor critical for the embryonic development, maintenance, and functionality of blood- ... Crispino JD, Horwitz MS (April 2017). "GATA factor mutations in hematologic disease". Blood. 129 (15): 2103-2110. doi:10.1182/ ...

... receptor activator of nuclear factor κβ ligand) and M-CSF (Macrophage colony-stimulating factor). These membrane-bound proteins ... M-CSF acts through its receptor on the osteoclast, c-fms (colony-stimulating factor 1 receptor), a transmembrane tyrosine ... PTH stimulates the osteoblasts to secrete the cytokine called osteoclast-stimulating factor, which is a potent stimulator of ... RANKL activates NF-κβ (nuclear factor-κβ) and NFATc1 (nuclear factor of activated t cells, cytoplasmic, calcineurin-dependent 1 ...

... protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor ... G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belong to a ... family of cytokine receptors known as the hematopoietin receptor family. The granulocyte colony-stimulating factor receptor is ... "Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, ...

... cells prepared in vitro using receptor activator of nuclear factor-kappaB ligand and macrophage colony-stimulating factor". ... "Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product ... The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in ... "Calcitonin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ...

... and the gene product can also be referred to as granulocyte macrophage colony-stimulating factor receptor. The diagnosis of PAP ... Consequently, a messenger molecule known as granulocyte/macrophage-colony stimulating factor (GM-CSF) is unable to stimulate ... the most common cause of PAP is an autoimmunity to granulocyte-macrophage colony stimulating factor (GM-CSF), a critical factor ... June 1994). "Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but ...

"Interleukin-3 and Granulocyte-Macrophage Colony-stimulating Factor Inhibits Tumor Necrosis Factor (TNF)-α-induced Osteoclast ... Inhibits Receptor Activator of NF-κB Ligand-Induced Osteoclast Differentiation by Diverting the Cells to Macrophage Lineage". ... Differentiation by Down-regulation of Expression of TNF Receptors 1 and 2". Journal of Biological Chemistry. 280 (12): 11759- ...

... that targets colony stimulating factor 2 (CSF2)/granulocyte-macrophage colony stimulating factor (GM-CSF). Pre-clinical ... 2016). "Mechanisms of Acute Toxicity in NKG2D Chimeric Antigen Receptor T Cell-Treated Mice". J. Immunol. 197 (12): 4674-4685. ... 2008). "Monocyte chemoattractant protein-1 expression is enhanced by granulocyte-macrophage colony-stimulating factor via Jak2- ... and its receptor (CCR2). GM-CSF knockout CAR-T cells protect mice from CRS; however, IL-6 knockout mice receiving wild-type CAR ...

... site is essential for the activity of the promoter of the IL-3/IL-5/granulocyte-macrophage colony-stimulating factor receptor ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ... Glucocorticoid receptor, HMGA1, HSF1, Nucleolar phosphoprotein p130, RELA, Serum response factor, SMARCA2, Sp1 transcription ... "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid ...

... and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are often co-expressed in Th2 cells. IL-5 is also ... Through binding to the interleukin-5 receptor, interleukin 5 stimulates B cell growth and increases immunoglobulin secretion- ... and granulocyte-macrophage colony-stimulating factor (GM-CSF). Glycosylation of the Asn196 residue of the Rα subunit appears to ... An eosinophil-specific colony-stimulating factor with activity for human cells". J. Exp. Med. 163 (5): 1085-1099. doi:10.1084/ ...

This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene ... and granulocyte-macrophage colony-stimulating factor in human blood eosinophils". J. Immunol. 160 (9): 4427-32. PMID 9574547. ... colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta ... The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for ...

Specifically a "granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-15 (IL-15) 'fusokine' (GIFT15) exerts ... and estrogen receptors(ER): Estrogens have been shown to be anti-inflammatory and neuroprotective in a variety of neurological ... "A granulocyte-macrophage colony-stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with ... nuclear factor erythroid 2(NF-E2)-related factor 2) transcription factor: Dimethyl fumarate (Tecfidera), Diroximel fumarate ( ...

... a neurologic disease associated with mutations in the macrophage colony-stimulating factor receptor gene. Complete blood count ... monocytes can differentiate into dendritic cells by adding the cytokines granulocyte macrophage colony-stimulating factor (GM- ... Many factors produced by other cells can regulate the chemotaxis and other functions of monocytes. These factors include most ... Monocytes can migrate into tissues and replenish resident macrophage populations. Macrophages have a high antimicrobial and ...

The gene is flanked by the genes for granulocyte-macrophage colony-stimulating factor and Colony stimulating factor 1 receptor ... those for granulocyte-macrophage colony-stimulating factor, PDGFRB, and Colony stimulating factor 1 receptor, cause the ... also termed macrophage-colony stimulating factor receptor), all three of which may be lost together by a single deletional ... platelet derived growth factor receptor A or alpha-type-platelet derived growth factor receptor) gene with the FIP1L1 gene (see ...

... "c-Cbl associates directly with the C-terminal tail of the receptor for the macrophage colony-stimulating factor, c-Fms, and ... which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl". ... "Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ... "c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination". J. ...

... is a human monoclonal antibody that inhibits human granulocyte macrophage colony-stimulating factor receptor (GM- ... a human monoclonal antibody targeting GM-CSF receptor-α, in subjects with rheumatoid arthritis: a randomised, double-blind, ...