"Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor". Growth ... "Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor". Biochemistry. ... The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor ... "Bi-directional signaling between gastrointestinal peptide hormone receptors and epidermal growth factor receptor". Growth ...

... has been shown to interact with epidermal growth factor receptors. Recombinant human epidermal growth ... Polypeptide growth factors include: EGF acts by binding with high affinity to epidermal growth factor receptor (EGFR) on the ... Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. ... Dreux AC, Lamb DJ, Modjtahedi H, Ferns GA (May 2006). "The epidermal growth factor receptors and their family of ligands: their ...

... epidermal growth factor; EGFR, epidermal growth factor receptor; MoAbs, monoclonal antibodies; VEGF, vascular endothelial ... factor for BPA in skin of 2.5. A relative biological effectiveness (RBE) or CBE factor of 3.2 has been used in all tissues for ... growth factor. The major challenge in the development of boron delivery agents has been the requirement for selective tumor ... The RBE factor is used to compare the biologic effectiveness of different types of ionizing radiation. The high-LET components ...

Herbst RS (2004). "Review of epidermal growth factor receptor biology". International Journal of Radiation Oncology, Biology, ... Epidermal growth factor (EGF) Saliva eliminates caesium, which can substitute for potassium in the cells. Various enzymes; most ... Saliva limits the growth of bacterial pathogens and is a major factor in sustaining systemic and oral health through the ... Researchers at the University of Florida at Gainesville have discovered a protein called nerve growth factor (NGF) in the ...

Vertebrate hepatocyte growth factor-regulated tyrosine kinase substrate (HRS). Mammalian epidermal growth factor receptor ... Mammalian epidermal growth factor receptor substrate EPS15R. Drosophila melanogaster (Fruit fly) liquid facets (lqf), an epsin ... substrate 15 (EPS15), which is involved in cell growth regulation. ...

October 2003). "Aldosterone stimulates epidermal growth factor receptor expression". J. Biol. Chem. 278 (44): 43060-66. doi: ... and also by epidermal growth factor (EGF), which is a target of the signaling pathway activated by aldosterone Reduced ... Many of these remodelling effects seem to be mediated by transforming growth factor beta (TGF-beta), which is a common ... Binding to beta-1 receptors in the myocardium increases the heart rate and makes contractions more forceful in an attempt to ...

Herbst RS (2004). "Review of epidermal growth factor receptor biology". International Journal of Radiation Oncology, Biology, ... Effects of EGF Epidermal growth factor (EGF) results in cellular proliferation, differentiation, and survival. EGF is a low- ... Stomach as nutrition sensor The human stomach has receptors responsive to sodium glutamate and this information is passed to ... The presence of chyme in the duodenum activates receptors that inhibit gastric secretion. This prevents additional chyme from ...

... growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth ... Identification of high affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. Proc Natl Acad ... "Targeting the epidermal growth factor receptor for cancer therapy". Journal of Clinical Oncology. Retrieved March 2, 2011. " ... "Epidermal growth factor receptor family and chemosensitization". Journal of the National Cancer Institute. Archived from the ...

... including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular ... June 2007). "Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647". Clinical Cancer ... June 2007). "Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647". Clinical Cancer ... endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4). The drug activity was initially studied in non-small cell ...

... and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using ... "Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor α". ... "Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor ... There are 11 growth factors that activate ErbB receptors. The ability ('+') or inability ('-') of each growth factor to ...

"Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK ... "Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and ... "cbl-b inhibits epidermal growth factor receptor signaling". Oncogene. 18 (10): 1855-66. doi:10.1038/sj.onc.1202499. PMID ... "Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ...

September 2006). "Assessment of epidermal growth factor receptor (EGFR) expression in primary colorectal carcinomas and their ... Harari PM (December 2004). "Epidermal growth factor receptor inhibition strategies in oncology". Endocrine-Related Cancer. 11 ( ... estrogens and progesterone receptor (ER & PR) staining are used both diagnostically (breast and gyn tumors) as well as ... The presence of hormone receptors can be used to determine if a tumor is potentially responsive to antihormonal therapy. One of ...

EPH receptor A2, ETV6, Epidermal growth factor receptor, Erythropoietin receptor, FRS2, Fas ligand, GAB1, GAB2, Glycoprotein ... The protein encoded by this gene binds receptors such as the epidermal growth factor receptor and contains one SH2 domain and ... Grb2 is best known for its ability to link the epidermal growth factor receptor tyrosine kinase to the activation of Ras and ... Liu YF, Deth RC, Devys D (March 1997). "SH3 domain-dependent association of huntingtin with epidermal growth factor receptor ...

Beyond this, exons 2-6 code the ligand binding region; 7-14 code the epidermal growth factor (EGF) domain; 15 codes the ... There are three "growth factor" repeats; A, B and C. A and B are closely linked while C is separated by the YWTD repeat region ... Description of LDL receptor pathway at the Brown - Goldstein Laboratory webpage LDL+Receptor at the U.S. National Library of ... This precludes the movement of the receptor from the ER to the Golgi, and leads to degradation of the receptor protein. Class 3 ...

2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK ... 1999). "Cbl-b inhibits epidermal growth factor receptor signaling". Oncogene. 18 (10): 1855-66. doi:10.1038/sj.onc.1202499. ... CBLC has been shown to interact with FYN and Epidermal growth factor receptor. GRCh38: Ensembl release 89: ENSG00000142273 - ... 2002). "C-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination". J ...

It binds to the epidermal growth factor receptor (EGFR). The US FDA approved necitumumab under the brand name Portrazza for use ...

CBLB has been shown to interact with: CRKL, Epidermal growth factor receptor, Grb2, NEDD4, PIK3R1, and SH3KBP1. GRCh38: Ensembl ... 2001). "Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex". J. Biol. Chem. 276 ... 1999). "cbl-b inhibits epidermal growth factor receptor signaling". Oncogene. 18 (10): 1855-66. doi:10.1038/sj.onc.1202499. ... "cbl-b inhibits epidermal growth factor receptor signaling". Oncogene. 18 (10): 1855-66. doi:10.1038/sj.onc.1202499. PMID ...

"Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma". Nature Reviews Cancer. 15 (5): 302-310 ... "Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling". Cell ... "EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer". Cell Metabolism ... including alterations in glucose and lipid metabolism that drive tumor growth, progression and drug resistance. These studies, ...

Argos is a secreted protein that is an inhibitor of the epidermal growth factor receptor (EGFR) pathway in Drosophila ... Klein DE, Nappi VM, Reeves GT, Shvartsman SY, Lemmon MA (August 2004). "Argos inhibits epidermal growth factor receptor ... Argos binds the epidermal growth factor domain of Spitz, preventing interaction between Spitz and EGFR. Argos does not directly ... receptor. EGFR inhibitor Freeman M, Klämbt C, Goodman CS, Rubin GM (June 1992). "The argos gene encodes a diffusible factor ...

Sakaguchi K, Okabayashi Y, Kasuga M (2001). "Shc mediates ligand-induced internalization of epidermal growth factor receptors ... Rotem-Yehudar R, Galperin E, Horowitz M (2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". J ... 1999). "A beta-turn endocytic code is required for optimal internalization of the growth hormone receptor but not for alpha- ... 2001). "Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor ...

... the epidermal growth factor receptor, the neurotrophin receptor, and the insulin receptors. All growth factor receptors are ... A growth factor receptor is a receptor that binds to a growth factor. Growth factor receptors are the first stop in cells where ... Epidermal growth factor receptors are involved heavily with oncogene activity. Once growth factors bind to their receptor, a ... Growth factors, which are ligands that bind to the receptor are the initial step to activating the growth factor receptors and ...

Riely GJ, Politi KA, Miller VA, Pao W (December 2006). "Update on epidermal growth factor receptor mutations in non-small cell ... Shigematsu H, Gazdar AF (January 2006). "Somatic mutations of epidermal growth factor receptor signaling pathway in lung ... "Epidermal growth factor receptor mutations in small cell lung cancer". Clinical Cancer Research. 14 (19): 6092-6. doi:10.1158/ ... "Epidermal growth factor receptor mutation status and clinicopathological features of combined small cell carcinoma with ...

Epidermal growth factor receptor kinase substrate 8 is an enzyme that in humans is encoded by the EPS8 gene. This gene encodes ... "Entrez Gene: EPS8 epidermal growth factor receptor pathway substrate 8". Offenhäuser N, Borgonovo A, Disanza A, Romano P, ... a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals". EMBO J. 12 (10): 3799- ... Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor- ...

1995). "Pachydermoperiostosis, study of epidermal growth factor and steroid receptors". Br J Dermatol. 133 (1): 128-133. doi: ... platelet-derived growth factor (PDGF) and epidermal growth factor (EGF). It has not been described yet what role these ... such as Von Willebrand factor and vascular endothelial growth factor (VEGF). These substances could also have a role in PDP ... 2000). "Vascular endothelial growth factor and hypertrophic osteoarthropathy". Clin Exp Rheumatol. 18 (1): 57-62. PMID 10728444 ...

"EGFR epidermal growth factor receptor [Homo sapiens (Human)] - Gene - NCBI". Ellington N, Park JY, King K, Josephs S, Rakheja D ... The EGFR gene which codes for the production of the epidermal growth factor receptor protein is located at band 11.2 on the ... Articles with short description, Short description matches Wikidata, Dermal and subcutaneous growths, Connective and soft ... a growth of cells which is uncoordinated with that of the normal surrounding tissue and persists in growing abnormally even if ...

Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene. This gene encodes a ... "Entrez Gene: EPS15 epidermal growth factor receptor pathway substrate 15". "Salmonella infection data for Eps15". Wellcome ... "Parallel dimers and anti-parallel tetramers formed by epidermal growth factor receptor pathway substrate clone 15". J. Biol. ... The protein is present at clathrin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is ...

... which then inhibits the epidermal growth factor receptor pathway. Over-expression of epidermal growth factor receptors ... and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor". ... Spitz binds to and regulates the epidermal growth factor receptor. EGFR exists as a dimer, and two Spitz proteins bind to the ... Spitz is a protein in Drosophila species which is the major activator of their epidermal growth factor receptor (EGFR). Spitz ...

Epidermal growth factor receptor (EGFR) is constitutively bound to TLR9. It can be activated by CpG Oligodeoxynucleotides such ... Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene. TLR9 has also been designated as CD289 (cluster ... TLR9 also controls the release of IgA and IFN-a in SLE, and loss of the receptor leads to higher levels of both molecules. In ... Omiya S, Omori Y, Taneike M, Protti A, Yamaguchi O, Akira S, Shah AM, Nishida K, Otsu K (December 2016). "Toll-like receptor 9 ...

Epidermal growth factor receptor (EGFR) is another validated target in NSCLC. Additionally, the T790M "gatekeeper" mutation is ... Brigatinib acts as both an anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR) inhibitor.[medical ... Receptor tyrosine kinase inhibitors, Aminopyrimidines, Takeda Pharmaceutical Company brands, Orphan drugs). ...

Cancer growth blockers at the Cancer Research UK website. Status of Epidermal Growth Factor Receptor Antagonists in the Biology ... Growth factor receptor inhibitors (growth factor inhibitors, growth factor receptor blockers, growth factor blockers, growth ... They interfere with binding of the growth factor to the corresponding growth factor receptors, impeding cell growth and are ... factor receptor antagonists, growth factor antagonists) are drugs that target the growth factor receptors of cells. ...