The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. This receptor and its ... Ciliary+Neurotrophic+Factor+Receptor+alpha+Subunit at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t ... Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD, Wiegand SJ (2000). "The ciliary neurotrophic factor and its receptor, ... "The receptor for ciliary neurotrophic factor". Science. 253 (5015): 59-63. Bibcode:1991Sci...253...59D. doi:10.1126/science. ...
Human ciliary neurotrophic factor has been shown to interact with the Interleukin 6 receptor. Ciliary neurotrophic factor ... "Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for ... 2000). "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharmaceutica Acta Helvetiae. 74 (2-3): 265-72. doi: ... 1995). "Nonradioactive receptor binding assay for ciliary neurotrophic factor". Anal. Biochem. 221 (2): 387-91. doi:10.1006/ ...
July 1991). "The receptor for ciliary neurotrophic factor". Science. 253 (5015): 59-63. Bibcode:1991Sci...253...59D. doi: ... March 1990). "Neurotrophin-3: a neurotrophic factor related to NGF and BDNF". Science. 247 (4949 Pt 1): 1446-51. Bibcode: ... December 1997). "An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors". Molecular ... May 1996). "The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo". Cell. 85 (4): 501-12. ...
"Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for ... Interleukin-6 receptor has been shown to interact with Interleukin 6 and ciliary neurotrophic factor. Cluster of ... Schooltink H, Stoyan T, Roeb E, Heinrich PC, Rose-John S (Dec 1992). "Ciliary neurotrophic factor induces acute-phase protein ... Schooltink H, Stoyan T, Roeb E, Heinrich PC, Rose-John S (1992). "Ciliary neurotrophic factor induces acute-phase protein ...
"Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for ... ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC), leukemia inhibitory factor (LIF ... BDNF is a neurotrophic factor implicated in spine formation, density, and morphology on neurons. Downregulation of BDNF, ... The effects of IL-6 on depression are mediated through the repression of brain-derived neurotrophic factor (BDNF) expression in ...
CNTF: Ciliary neurotrophic factor is another protein that acts as a survival factor for motor neurons. CNTF acts via a receptor ... GDNF: Glial derived neurotrophic factor is a member of the TGFb family of proteins, and is a potent trophic factor for striatal ... The Trk proteins act as receptors for NGF and related factors. Trk is a receptor tyrosine kinase. Trk dimerization and ... The survival of neurons is regulated by survival factors, called trophic factors. The neurotrophic hypothesis was formulated by ...
Young WJ, Smith SM, Chang C (Jan 1997). "Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor ( ... The testicular receptor 4 is a member of the nuclear receptor family of transcription factors. Testicular receptor 4 has been ... shown to interact with Androgen receptor, Estrogen receptor alpha, and Hepatocyte nuclear factor 4 alpha. Testicular receptor ... Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is ...
"Regulation of ciliary neurotrophic factor receptor alpha in sciatic motor neurons following axotomy". Neuroscience. 91 (4): ... Schwann cells play an important role in not only producing neurotrophic factors such as nerve growth factor (NGF) and ciliary ... Neurotrophic factors are those that promote survival and growth of neurons. A trophic factor can be described as a factor that ... growing neurons that are contacted with a trophic factor to promote further growth and regeneration Ciliary neurotrophic factor ...
... including the ciliary neurotrophic factor, growth hormone and prolactin. Leukemia inhibitory factor receptor has been shown to ... Boulton TG, Stahl N, Yancopoulos GD (April 1994). "Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/ ... "The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to ... "The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome ...
... a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors ... a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient". Proc. Natl. ... specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component". J. Biol. Chem. 276 ( ... Cytokine receptor-like factor 1 is a protein that in humans is encoded by the CRLF1 gene. This gene encodes a member of the ...
... of Ciliary Neurotrophic Factor and Related Helical Type 1 Cytokines Targeting the gp130/Leukemia Inhibitory Factor Receptor β ... Glerup, S.; Nykjaer, A.; Vaegter, C. B. (2014), "Sortilins in Neurotrophic Factor Signaling", Neurotrophic Factors, Springer ... brain-derived neurotrophic factor) and TrkB (BDNF receptor tyrosine kinase) inside neurons in the hippocampal region of the ... Examples of ligands are neurotrophic factors, amyloid precursor protein (APP), lipoproteins, and cytokines. In addition to ...
2001). "The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional ... 2006). "Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold- ... specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component". J. Biol. Chem. 276 ( ... CLCF1 is closely related to other proteins called cardiotrophin-1 and ciliary neurotrophic factor. GRCh38: Ensembl release 89: ...
... ciliary neurotrophic factor, cardiotrophin 1, cardiotrophin-like cytokine, and LIF, TYK2 might also affect signaling through ... "The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2". The Journal of Biological ... Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. TYK2 was the first member of ... Since, IL-6 signals through the gp-130 receptor-chain that is common to a large family of cytokines, including IL-6, IL-11, IL- ...
This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2- ... Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. Interleukin 11 is ... This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. ... 1999). "Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis". Eur. J. Biochem ...
... cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R ... "Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor". ... 1994). "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine- ... It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e. ...
EBI3 is a homologue to IL-12 p40 and to the ciliary neurotrophic factor receptor, whose expression is induced in B ... IL-35 receptor consists of IL-12Rβ2 (part of the IL-12R) and gp130 (part of IL-27R) chains. Compared to these two related ... This was proven in vivo when absence of either of the receptor chains did not influence effects of IL-35. On regulatory B-cells ... Intraperitoneal injection of IL-35 in the tested subjects lowered expression of several factors linked to this disease (such as ...
... ciliary neurotrophic factor (CNTF), oncostatin M (OSM), and IL-11. There are also several other proteins which have structural ... Glycoprotein 130 has been shown to interact with: Grb2, HER2/neu, Janus kinase 1 Leukemia inhibitory factor receptor, PTPN11, ... It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. It is often referred to as the common ... leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation". J. Immunol. 165 (5): ...
This family includes IL-6, IL-11, IL-27, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor ( ... IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR) subunits. ... The receptor for IL-31 is a heterodimer of the interleukin 31 receptor alpha (IL-31RA) and OSMR. IL-31RA was originally ... IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and ...
The CNTF family of neurotrophic factors includes ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), ... The ephrins are a family of neurotrophic factors that signal through eph receptors, a class of receptor tyrosine kinases; the ... Most neurotrophic factors belong to one of three families: (1) neurotrophins, (2) glial cell-line derived neurotrophic factor ... "Neurotrophic factors". Nature Publishing Group. Retrieved 31 May 2016. Neurotrophic factors are molecules that enhance the ...
JAK/STAT signaling is also known to promote gliogenesis Significant levels of the ciliary neurotrophic factor (CNTF) are ... As noted for receptor-proteins, in vivo interactions among different growth factor responsible for gliogenesis and other cell ... The vesicle-receptor complex generated will be targeted back to the cell membrane and the membrane receptor will be recycled to ... These transcription factors function to interact with transcription factors generated from Notch signaling. Consequently, this ...
... derived neurotrophic factor (BDNF). Due to the relationship between the presence of BDNF and ciliary neurotrophic factor and ... These σ1 receptors play a key role in the modulation of Ca2+ release and apoptosis. Cutamesine's activation of the σ1 receptor ... Cutamesine exhibits high binding affinity for the σ1 receptor, with greatly reduced affinity for the σ2 receptor. It acts as a ... Cutamesine (SA 4503) is a synthetic sigma receptor agonist which is selective for the σ1 receptor, a chaperone protein mainly ...
The term neurotrophic factor generally refers to these four neurotrophins, the GDNF family of ligands, and ciliary neurotrophic ... Neurotrophin-4 (NT-4) is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase. It is also ... Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor found originally in the brain, but also found in the ... Growth factors such as neurotrophins that promote the survival of neurons are known as neurotrophic factors. Neurotrophic ...
... ciliary neurotrophic factor (CNTF), and leukemia inhibitory factor (LIF). Although many of these specific modulatory ... Receptors for these molecules have been identified on astrocytes, and the molecules, when exogenously introduced, have been ... Neuroprotective effects - Reactive astrocytes release neurotrophic factors, such as glial cell-derived neurotrophic factor ( ... In addition, active microglia release anti-inflammatory factors and other molecules, such as IL-6 and TGF-β, which regulate ...
Ciliary neurotrophic factor family Ciliary neurotrophic factor (CNTF) Leukemia inhibitory factor (LIF) Interleukin-6 (IL-6) ... Angiogenesis Bone growth factor Cytokine Growth factor receptor Human Genome Organisation Mitogen Neurotrophic factor Receptor ... Fibroblast growth factor 1(FGF1) Fibroblast growth factor 2(FGF2) Fibroblast growth factor 3(FGF3) Fibroblast growth factor 4( ... Fibroblast growth factor 6(FGF6) Fibroblast growth factor 7(FGF7) Fibroblast growth factor 8(FGF8) Fibroblast growth factor 9( ...
Ciliary neurotrophic factor (CNTF) is a cytosolic protein that is not secreted. CNTF has been shown to promote the survival of ... Blockade of IL-6 receptors decreased the number of astrocytes present at the spinal cord lesion and this decrease was ... 1995). "A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system ... and neurotrophic factors. The expression of these molecules depends on the location of the microglial cells relative to the ...
... human glial precursor cells and astrocytes generated from these cells by being in contact with ciliary neurotrophic factors, ... and neurokinin 1 receptor (NK1R), as well as activation of metabotropic glutamate receptors and release of BDNF. Persistent ... Just as with neuronal cell specification, canonical signaling factors like sonic hedgehog (SHH), fibroblast growth factor (FGFs ... brain-derived neurotrophic factor (BDNF), somatostatin, vasoactive intestinal peptide (VIP), galanin, and vasopressin are all ...
... hepatocyte growth factor (HGF), Notch-1, sonic hedgehog (SHH), noggin, ciliary neurotrophic factor (CNTF), and a soluble ... The inhibitory ligands bind to growth cone receptors on a damaged neuron, which causes repulsion and collapse of the growth ... fibroblast growth factors (FGFs), epidermal growth factor (EGF), neuregulins (NRGs), vascular endothelial growth factor (VEGF ... Enhancing neurogenesis can be done by injecting growth factors such as fibroblast growth factor-2 (FGF-2) and epidermal growth ...
... receptor, ciliary neurotrophic factor MeSH D12.776.543.750.750.400.550.500 - receptor, nerve growth factor MeSH D12.776.543.750 ... receptors, nerve growth factor MeSH D12.776.543.750.750.400.550.124 - glial cell line-derived neurotrophic factor receptors ... receptors, tumor necrosis factor, type i MeSH D12.776.543.750.705.852.760.798 - receptors, tumor necrosis factor, type ii MeSH ... receptor, fibroblast growth factor, type 1 MeSH D12.776.543.750.060.092 - receptor, fibroblast growth factor, type 2 MeSH ...
A combination of NGF, glial cell-line derived neurotrophic factor (GDNF), and ciliary neurotrophic factor (CNTF) was presented ... The new olfactory receptor neurons must project their axons through the CNS to an olfactory bulb in order to be functional. ... fibroblast growth factor-2 (FGF-2), nerve growth factor (NGF), neurotrophin-3 (NT-3), and ciliary neurotrophic factor (CNTF). ... Neurotrophic factors such as NGF and growth differentiation factor 5 (GDF-5), however, are well established as promoters of ...
... ciliary neurotrophic factor, leukemia inhibitory factor, insulin-like growth factor, and fibroblast growth factor. These ... Possible sources of proliferation signal are attributed to the ErbB2 receptors and the ErbB3 receptors. This proliferation ... Other neurotrophic molecules produced by Schwann cells and fibroblasts together include brain-derived neurotrophic factor, ... Another factor that affects degradation rate is the diameter of the axon: larger axons require a longer time for the ...