... a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single ... It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51-related DNA recombination ... RAD52 homolog (S. cerevisiae), also known as RAD52, is a protein which in humans is encoded by the RAD52 gene. The protein ... If DNA repair is deficient, DNA damage tends to accumulate. Such excess DNA damage may increase mutational errors during DNA ...

RAD52, RAD55, and RAD57 factors. This group is believed to be involved in DNA recombination events and repair mechanisms, ... DNA repair and recombination protein RAD54-like is a protein that in humans is encoded by the RAD54L gene. The protein encoded ... and stimulate DNA recombination. RAD54 is one of the key proteins necessary for homologous recombination and DNA repair in many ... a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in ...

"SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination". DNA Repair. 42: 11-25. doi:10.1016/j. ... the effect of post-translational modification of diverse HR proteins by Sumo protein (examples include: Rad52., Rad59, PCNA); ( ... "Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities". DNA Repair. 10 (6): 567- ... "Laboratory of Recombination and DNA Repair (LORD)". www.med.muni.cz. Retrieved 2018-12-03. Taylor, Martin R. G.; Špírek, Mário ...

The process by which oocyte DNA damage can be corrected is referred to as homology directed homologous recombination repair. ... A different nucleotide sequence in the DNA strand results in a different protein expressed in the cell. This protein error may ... "Mechanisms of Rad52-independent spontaneous and UV-induced mitotic recombination in Saccharomyces cerevisiae". Genetics. 179 (1 ... When a double strand DNA lesion is repaired by NHEJ there is no validating DNA template present so it may result in a novel DNA ...

... is a 339-amino acid protein that plays a major role in homologous recombination of DNA during double strand break repair ... This protein can interact with the ssDNA-binding protein RPA, BRCA2, PALB2 and RAD52. The structural basis for Rad51 filament ... DNA repair protein RAD51 homolog 1 is a protein encoded by the gene RAD51. The enzyme encoded by this gene is a member of the ... Many cancers have epigenetic deficiencies in various DNA repair genes (see Frequencies of epimutations in DNA repair genes in ...

"Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes". Nature Communications. 8 (1): 857 ... Lok, BH; Powell, SN (2012). "Molecular Pathways: Understanding the Role of Rad52 in Homologous Recombination for Therapeutic ... "The interaction of p53 with replication protein a mediates suppression of homologous recombination". Oncogene. 23 (56): 9025-33 ... His career has centered on understanding DNA repair alterations in cancer and how they can be used for the basis of selective ...

In yeast, the D-loop is formed by strand invasion with the help of proteins Rad51 and Rad52, and is then acted on by DNA ... of DSBs are repaired by CO recombination, suggesting that most DSBs are repaired by NCO recombination. Data based on tetrad ... "DNA double-strand break repair: from mechanistic understanding to cancer treatment". DNA Repair. 6 (7): 923-35. doi:10.1016/j. ... Resnick MA (June 1976). "The repair of double-strand breaks in DNA; a model involving recombination". Journal of Theoretical ...

Nickoloff, Jac A.; Haber, James E. (2011). "Mating-Type Control of DNA Repair and Recombination in Saccharomyces cerevisiae". ... For instance, gene rad52 is required for both meiotic recombination and mitotic recombination. Rad52 mutants have increased ... these proteins include cell cycle proteins, signaling proteins, and protein-processing enzymes. S. cerevisiae is currently the ... These findings suggest that recombination repair during meiosis and mitosis is needed for repair of the different damages ...

... and stress response such as DNA repair. Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the ... "Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl". J. Biol. Chem. 274 (18): 12748-52 ... "BCR-ABL stimulates mutagenic homologous DNA double-strand break repair via the DNA-end-processing factor CtIP". Carcinogenesis ... 2021). "Targeting DNA Homologous Repair Proficiency With Concomitant Topoisomerase II and c-Abl Inhibition". Frontiers in ...

... replication of DNA with a broken sugar-phosphate backbone is most likely facilitated by the homologous recombination proteins ... rev3 and rad52 mutations". Molecular & General Genetics. 184 (3): 471-8. doi:10.1007/bf00352525. PMID 7038396. S2CID 22330052. ... An arsenal of DNA repair mechanisms exists to repair various forms of damaged DNA and minimize genomic instability. Most DNA ... Postreplication repair is the repair of damage to the DNA that takes place after replication. Some example genes in humans ...

For example, sumoylation may affect a protein's localization in the cell, its ability to interact with other proteins or DNA. ... A possible repair response to topoisomerase-mediated DNA damage". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4046-51. Bibcode: ... "Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes ... Shen Z, Pardington-Purtymun PE, Comeaux JC, Moyzis RK, Chen DJ (1997). "Associations of UBE2I with RAD52, UBL1, p53, and RAD51 ...

... a protein complex consisting of Mre11, Rad50 and Nbs1), RAD51 and the ATM kinase. Further DNA repair components, such as RAD52 ... "Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage". EMBO J. 21 (8): 2030-7. doi: ... "RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins". Cell. 131 (5): 887-900. doi: ... To allow DNA repair, the chromatin must be remodeled. γH2AX, the phosphorylated form of H2AX, is involved in the steps leading ...

"RecFOR proteins load RecA protein onto gapped DNA to accelerate DNA strand exchange: a universal step of recombinational repair ... A protein called Rad52 then binds each of the repeat sequences on either side of the break, and aligns them to enable the two ... Homologous recombination repairs DNA before the cell enters mitosis (M phase). It occurs during and shortly after DNA ... Homologous recombination repairs double-strand breaks in DNA caused by ionizing radiation or DNA-damaging chemicals. Left ...

... a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is ... To confirm this they tested a double mutant of rad9 with DNA repair deficient-strain rad52 and found that the cell failed to ... and homologous recombination (HR) Normally, cells possess many checkpoints and repair mechanisms to fix the DNA and regain ... the cell was able to repair DNA and divide normally. This result suggested that Rad9 is not necessary to repair DNA. They ...

... damage DNA DNA adduct DNA damage theory of aging DNA repair DNA replication Free radical damage to DNA Homologous recombination ... At least 17 DNA repair proteins, distributed among five DNA repair pathways, have a "dual role" in response to DNA damage. With ... which are deficient in DNA repair, exhibit a markedly different response. For instance, rad52 cells, which cannot repair double ... While most DNA damages can undergo DNA repair, such repair is not 100% efficient. Un-repaired DNA damages accumulate in non- ...

It can activate DNA repair proteins when DNA has sustained damage. Thus, it may be an important factor in aging. It can arrest ... "p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction". The EMBO Journal. 15 (8): ... Shen Z, Pardington-Purtymun PE, Comeaux JC, Moyzis RK, Chen DJ (October 1996). "Associations of UBE2I with RAD52, UBL1, p53, ... "DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D". Genes & Development. 12 ( ...

"Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52". ... Wright WD, Shah SS, Heyer WD (July 2018). "Homologous recombination and the repair of DNA double-strand breaks". The Journal of ... halting transcription and activating DNA repair mechanisms. Proteins such as the proteins ATM, ATR and DNA-dependent protein ... such as the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), DNA Ligase IV and X-ray cross complementing protein 4 ( ...

... show that inhibition of RAD52 is synthetically lethal with BRCA-deficiency. Mutations in genes employed in DNA mismatch repair ... Hanash SM (September 2000). "Operomics: molecular analysis of tissues from DNA to RNA to protein". Clin. Chem. Lab. Med. 38 (9 ... synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination ... Un-repaired DNA damage is a major cause of mutations that drive carcinogenesis. If DNA repair is deficient, DNA damage tends to ...

Deficiencies in DNA repair proteins that function in accurate DNA repair pathways increase the risk of mutation. Mutation rates ... referred to 6 DNA repair genes that are directly targeted by the miRNAs indicated in parentheses: ATM (miR-421), RAD52 (miR-210 ... In cancer cells "global hypomethylation" due to disruption in DNA methyltransferases (DNMTs) may promote mitotic recombination ... a DNA repair gene; APC, a cell cycle regulator; MLH1, a DNA-repair gene; and BRCA1, another DNA-repair gene. Indeed, cancer ...