MicroRNAs (miRNAs) are small RNAs that typically are partially complementary to sequences in metazoan messenger RNAs. Binding ... A 5' cap (also termed an RNA cap, an RNA 7-methylguanosine cap, or an RNA m7G cap) is a modified guanine nucleotide that has ... that are targeted to specific messenger RNAs by a combination of cis-regulatory sequences on the RNA and trans-acting RNA- ... In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic ...
... , often abbreviated as mature mRNA is a eukaryotic RNA transcript that has been spliced and processed and ... Unlike the eukaryotic RNA immediately after transcription known as precursor messenger RNA, mature mRNA consists exclusively of ... Bienroth, S.; Keller, W.; Wahle, E. (February 1993). "Assembly of a processive messenger RNA polyadenylation complex". The EMBO ... As a part of the maturation process, RNA splicing removes the non-coding RNA introns leaving behind the exons, which are then ...
... (abbreviated tmRNA, also known as 10Sa RNA and by its genetic name SsrA) is a bacterial RNA molecule ... "Transfer-messenger RNA unfolds as it transits the ribosome". RNA. 11 (5): 668-73. doi:10.1261/rna.7269305. PMC 1370753. PMID ... "Semiautomated improvement of RNA alignments". RNA. 13 (11): 1850-9. doi:10.1261/rna.215407. PMC 2040093. PMID 17804647. Gur E, ... Subsequently, the ribosome moves from the 3' end of the truncated messenger RNA onto the resume codon of the MLR, followed by a ...
The process of messenger RNA decapping consists of hydrolysis of the 5' cap structure on the RNA exposing a 5' monophosphate. ... Sheth, Ujwal; Parker, Roy (2 May 2003). "Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies". Science ... Deana, Atilio; Celesnik, Helena; Belasco, Joel G. (17 January 2008). "The bacterial enzyme RppH triggers messenger RNA ... Meyer, Sylke; Temme, Claudia; Wahle, Elmar (January 2004). "Messenger RNA Turnover in Eukaryotes: Pathways and Enzymes". ...
A nucleoside-modified messenger RNA (modRNA) is a synthetic messenger RNA (mRNA) in which some nucleosides are replaced by ... Scholia has a profile for nucleoside-modified messenger RNA (Q103194381). Badieyan ZS, Evans T (August 2019). "Concise Review: ... January 2016). "Nucleotide modifications within bacterial messenger RNAs regulate their translation and are able to rewire the ... doi:10.4161/rna.20206. PMC 3495747. PMID 22617878. Karikó K, Buckstein M, Ni H, Weissman D (August 2005). "Suppression of RNA ...
The concept of messenger RNA emerged during the late 1950s, and is associated with Crick's description of his "Central Dogma of ... Messenger RNA precursors from a wide range of organisms can be edited before being translated into protein. In this process, ... Analysis of mature eukaryotic messenger RNA molecules showed that they are often much smaller than the DNA sequences that ... Geiduschek, E P; Haselkorn, R (June 1969). "Messenger RNA". Annual Review of Biochemistry. 38 (1): 647-676. doi:10.1146/annurev ...
The main types of RNA therapeutics are those based on messenger RNA (mRNA), antisense RNA (asRNA), RNA interference (RNAi), and ... RNA is synthesized from template DNA by RNA polymerase with messenger RNA (mRNA) serving as the intermediary biomolecule ... Messenger RNA (mRNA) is a single-stranded RNA molecule that is complementary to one of the DNA strands of a gene. An mRNA ... For RNA decoy aptamers, the synthetic RNA aptamer resembles a native RNA molecule. As such, proteins(s) which bind to the ...
Brenner on 15 April 1960 during a conversation with François Jacob that messenger RNA was not the same thing as ribosomal RNA. ... experiment Crick's wobble hypothesis History of RNA biology List of RNA biologists Molecular structure of Nucleic Acids ( ... "messenger" RNA molecule to carry the instructions for making one protein to the cytoplasm adaptor molecules ("they might ... "Who discovered messenger RNA?". Current Biology. 25 (13): R526-R532. doi:10.1016/j.cub.2015.05.032. PMID 26126273. Hayes, Brian ...
Following this adaptor insight, Brenner conceived of the concept of messenger RNA during an April 1960 conversation with Crick ... Cobb, Matthew (29 June 2015). "Who discovered messenger RNA?". Current Biology. 25 (13): R526-R532. doi:10.1016/j.cub.2015.05. ... This led Francis Crick to propose the concept of a hypothetical molecule (later identified as transfer RNA or tRNA) that ... 181; ISBN 978-0-87969-798-3 Crick, Francis (1955). "On Degenerate Templates and the Adaptor Hypothesis: A Note for the RNA Tie ...
Control of Messenger RNA Stability. 1993. doi:10.1016/c2009-0-03269-3. ISBN 9780120847822. Zuker M (July 2003). "Mfold web ... Paz I, Kosti I, Ares M, Cline M, Mandel-Gutfreund Y (July 2014). "RBPmap: a web server for mapping binding sites of RNA-binding ... SLC46A2 is involved in symporter activity and is a transporter of the immune second messenger 2'3'-cGAMP. SLC46A3 is a highly ... The dorsal horn shows considerable expression in the cervical spine of adult mouse (P56). RNA-binding proteins (RBPs) that bind ...
Tan completed his PhD in 1992 with a dissertation entitled "Regulation of erythropoietin messenger RNA". Upon graduation in ... Tan, Chorh Chuan (1992). Regulation of Erythropoietin Messenger RNA. National University of Singapore. Archived from the ...
... end of the messenger RNA chain and that it does not stimulate unformulated methionine. He further revealed that AUG is capable ... "Translation of Synthetic Messenger RNA". Cold Spring Harbor Symposia on Quantitative Biology. 31: 85-97. doi:10.1101/SQB. ... Subsequently, he demonstrated that the incorporation of N-formylmethionine is stimulated by oligonucleotide messengers that ...
... messenger RNA), transfer RNA and ribosomal RNA in a very wide range of living organisms. Following transcription into RNA, ... Kinniburgh AJ, Mertz JE, Ross J (July 1978). "The precursor of mouse beta-globin messenger RNA contains two intervening RNA ... Wan R, Bai R, Zhan X, Shi Y (2020). "How is precursor messenger RNA spliced by the spliceosome?". Annual Review of Biochemistry ... Padgett RA, Grabowski PJ, Konarska MM, Seiler S, Sharp PA (1986). "Splicing of messenger RNA precursors". Annual Review of ...
5 . - S. 321-338 . Spirin A.S., Belitsina N.V., Aitkhozhin M.A. (Spirin AS, Belitsina NV, Aitkhozhin MA). Messenger RNA in ... 6 . - S. 1062-1066 . Filimonov N.G., Aitkhozhin M.A., Gazaryan K.G. Poly (A) -containing RNA from germinating wheat germ // ... The group discovered classes of plant informosomes - free cytoplasmic, polysomal-linked, and nuclear, including RNA-binding ... Information RNA in early embryogenesis // Zh. total biol. - 1964. - T. 25, No. ...
Giorgi D, Bernard JP, Rouquier S, Iovanna J, Sarles H, Dagorn JC (1989). "Secretory pancreatic stone protein messenger RNA. ...
Giorgi D, Bernard JP, Rouquier S, Iovanna J, Sarles H, Dagorn JC (1989). "Secretory pancreatic stone protein messenger RNA. ...
1977). "Human beta-globin messenger RNA. I. Nucleotide sequences derived from complementary RNA". J. Biol. Chem. 252 (14): 5019 ... Chabot B, Black DL, LeMaster DM, Steitz JA (1986). "The 3' splice site of pre-messenger RNA is recognized by a small nuclear ... Proudfoot NJ, Brownlee GG (1976). "3' non-coding region sequences in eukaryotic messenger RNA". Nature. 263 (5574): 211-4. ...
messenger RNA (mRNA) Any of a class of single-stranded RNA molecules which function as molecular messengers, carrying sequence ... RNA See ribonucleic acid. RNA gene A gene that codes for any of the various types of non-coding RNA (e.g. rRNA and tRNA). RNA ... transcriptome The entire set of RNA molecules (often referring to all types of RNA but sometimes exclusively to messenger RNA) ... small interfering RNA (siRNA) small nuclear RNA (snRNA) small nucleolar RNA (snoRNA) small temporal RNA (stRNA) A subclass of ...
1977). "Human beta-globin messenger RNA. I. Nucleotide sequences derived from complementary RNA". J. Biol. Chem. 252 (14): 5019 ... Proudfoot NJ, Brownlee GG (1976). "3' non-coding region sequences in eukaryotic messenger RNA". Nature. 263 (5574): 211-4. ...
Gilbert WV, Bell TA, Schaening C (June 2016). "Messenger RNA modifications: Form, distribution, and function". Science. 352 ( ... Most of the RNA modifications are found on transfer-RNA and ribosomal-RNA, but also eukaryotic mRNA has been shown to be ... RNA editing is used for stability and generation of protein variants. Viral RNAs are transcribed by a virus-encoded RNA- ... RNA editing may include the insertion, deletion, and base substitution of nucleotides within the RNA molecule. RNA editing is ...
... is a process in molecular biology where a newly-made precursor messenger RNA (pre-mRNA) transcript is transformed ... Eukaryotes splice many protein-coding messenger RNAs and some non-coding RNAs. Prokaryotes, on the other hand, splice rarely ... This results in a mature messenger RNA with a missing section of an exon. In this way, a point mutation, which might otherwise ... into a mature messenger RNA (mRNA). It works by removing all the introns (non-coding regions of RNA) and splicing back together ...
Proudfoot NJ, Brownlee GG (September 1976). "3' non-coding region sequences in eukaryotic messenger RNA". Nature. 263 (5574): ... "Nucleotide sequences of human globin messenger RNA". Proceedings of the National Academy of Sciences of the United States of ...
Heterogeneous ribonucleoprotein particle Messenger RNA Precursor mRNA Hieronymus, Haley; Pamela A. Silver (2004-12-01). "A ... Messenger RNP (messenger ribonucleoprotein) is mRNA with bound proteins. mRNA does not exist "naked" in vivo but is always ... When mRNA is being synthesized by RNA polymerase, this nascent mRNA is already bound by RNA 5′ end 7-methyl-guanosine capping ... Spirin, Alexander (March 1979). "Messenger ribonucleoproteins (informosomes) and RNA-binding proteins". Molecular Biology ...
Rein Verbeke; Ine Lentacker; Stefaan C. De Smedt; Heleen Dewitte (October 2019). "Three decades of messenger RNA vaccine ... With Philip Felgner, he performed experiments on the transfection of RNA into human, rat, mouse, Xenopus, and Drosophila cells ... Robert Malone; Philip L. Felgner; Inder Verma (August 1, 1989). "Cationic liposome-mediated RNA transfection". Proceedings of ... Malone conducted studies on messenger ribonucleic acid (mRNA) technology, discovering in what Nature has described as a ...
N6-methyladenosine modulates messenger RNA translation efficiency. Cell 2015, 161, 1388. "Xiao Wang - MIT Department of ... YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA. Cell Research 2017, 27, 315. B S Zhao*, X Wang*, A ... She worked with Karl Deisseroth at Stanford and "developed comprehensive methods for analyzing RNA in intact tissues that merge ... from the University of Chicago where she worked with Chuan He on elucidating the cellular functions of RNA modifications. While ...
RNA vaccines often use nucleoside-modified messenger RNA. The delivery of mRNA is achieved by a coformulation of the molecule ... When introduced into human tissue, the vaccine contains either self-replicating RNA or messenger RNA (mRNA), which both cause ... Verbeke R, Lentacker I, De Smedt SC, Dewitte H (October 2019). "Three decades of messenger RNA vaccine development". Nano Today ... Platforms developed in 2020 involved nucleic acid technologies (nucleoside-modified messenger RNA and DNA), non-replicating ...
... methylation in mammalian messenger RNA (mRNA) in 2011. The existence of m6A in mRNA was discovered in 1974 in both eukaryotic ... "N6-methyladenosine modulates messenger RNA translation efficiency". Cell. 161 (6): 1388-1399. doi:10.1016/j.cell.2015.05.014. ... "N6-Methyladenosine-dependent regulation of messenger RNA stability". Nature. 505 (7481): 117-120. Bibcode:2014Natur.505..117W. ... He was awarded the 2023 Wolf Prize in Chemistry for his work in discovering and deciphering reversible RNA methylation in post- ...
van Hoof A, Parker R (2002). "Messenger RNA degradation: beginning at the end". Curr. Biol. 12 (8): R285-7. doi:10.1016/S0960- ... Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for ...
Tobin, Elaine M.; Klein, Attila O. (1 July 1975). "Isolation and Translation of Plant Messenger RNA". Plant Physiology. 56 (1 ... Tobin was able to isolate poly(A) RNA from duckweed, expose slab gels to x-ray film, and show that while some mRNAs decreased ...
Messenger RNA cloning and expression in pancreatic diseases". The Journal of Clinical Investigation. 90 (6): 2284-2291. doi: ...