All RGS proteins contain an RGS-box (or RGS domain), which is required for activity. Some small RGS proteins such as RGS1 and ... Thus G proteins and GTPase accelerating proteins appear to have evolved before any known G protein activator. RGS domains can ... Regulators of G protein signaling (RGS) are protein structural domains or the proteins that contain these domains, that ... Whereas receptors stimulate GTP binding, RGS proteins stimulate GTP hydrolysis. RGS proteins have been conserved in evolution. ...

His earliest publications discuss the RGS protein superfamily, and determinations of their varied protein structures and ... "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". ... Siderovski DP, Strockbine B, Behe CI (1999). "Whither goest the RGS proteins?". Crit Rev Biochem Mol Biol. 34 (4): 215-51. doi: ... Snow BE, Antonio L, Suggs S, Siderovski DP (January 1998). "Cloning of a retinally abundant regulator of G-protein signaling ( ...

Berman, DM; Gilman, AG (1998). "Mammalian RGS proteins: barbarians at the gate". Journal of Biological Chemistry. 273 (3): 1269 ... Examples include the NACHT proteins of its own superclass and McrB protein of the AAA+ superclass. G protein-coupled receptors ... regions that in the active state are able to make protein-protein contacts with partner proteins that alter the function of ... For heterotrimeric G proteins and many small GTP-binding proteins, GEF activity is stimulated by cell surface receptors in ...

RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins ... All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the ... Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) ... Tu Y, Wang J, Ross EM (Nov 1997). "Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha ...

"GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins". ... RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins ... All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain which conveys GAP activity. Regulator of G ... RGP4 regulates G protein signaling. Regulator of G protein signalling (RGS) family members are regulatory molecules that act as ...

"GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins". ... Chen C, Zheng B, Han J, Lin SC (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and ... Chen C, Zheng B, Han J, Lin SC (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and ... Regulator of G-protein signaling 16 is a protein that in humans is encoded by the RGS16 gene. The protein encoded by this gene ...

Members of the RGS family, such as RGS9, are signaling proteins that suppress the activity of G proteins by promoting their ... RGS9-2 is of particular interest as the most important RGS protein involved in terminating signalling by the mu opioid receptor ... Sánchez-Blázquez P, Rodríguez-Muñoz M, Montero C, Garzón J (January 2005). "RGS-Rz and RGS9-2 proteins control mu-opioid ... Regulator of G-protein signalling 9, also known as RGS9, is a human gene, which codes for a protein involved in regulation of ...

RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase- ... Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene. Regulator of G protein signaling ... Wang J, Ducret A, Tu Y, Kozasa T, Aebersold R, Ross EM (October 1998). "RGSZ1, a Gz-selective RGS protein in brain. Structure, ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. ...

The most important regulatory proteins for the MOR are the β-arrestins arrestin beta 1 and arrestin beta 2, and the RGS ... Hooks SB, Martemyanov K, Zachariou V (January 2008). "A role of RGS proteins in drug addiction". Biochemical Pharmacology. 75 ( ... as opposed to the more short-term desensitisation induced by β-arrestins or RGS proteins. Another long-term adaptation to ... "Morphine alters the selective association between mu-opioid receptors and specific RGS proteins in mouse periaqueductal gray ...

It is part of a larger family of RGS proteins that control signalling through G-protein coupled receptors (GPCR). RGS2 is ... Chatterjee TK, Fisher RA (2000). "Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS ... Cho H, Harrison K, Schwartz O, Kehrl JH (2003). "The aorta and heart differentially express RGS (regulators of G-protein ... 2002). "Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart ...

Kozasa T (April 2001). "Regulation of G protein-mediated signal transduction by RGS proteins". Life Sciences. 68 (19-20): 2309- ... also function as RGS family GTPase-activating proteins (GAPs) to increase the rate of GTP hydrolysis of G12/G13 alpha proteins ... Fukuhara S, Chikumi H, Gutkind JS (March 2001). "RGS-containing RhoGEFs: the missing link between transforming G proteins and ... Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP. But when acted on by Rho GEF proteins ...

Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and ... Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and ... Natochin M, Lipkin VM, Artemyev NO (1997). "Interaction of human retinal RGS with G-protein alpha-subunits". FEBS Lett. 411 (2- ... Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene. Mutations in ...

Kozasa T (April 2001). "Regulation of G protein-mediated signal transduction by RGS proteins". Life Sciences. 68 (19-20): 2309- ... also function as RGS family GTPase-activating proteins (GAPs) to increase the rate of GTP hydrolysis of G12/G13 alpha proteins ... Fukuhara S, Chikumi H, Gutkind JS (March 2001). "RGS-containing RhoGEFs: the missing link between transforming G proteins and ... Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP. But when acted on by Rho GEF proteins ...

Kozasa T (2001). "Regulation of G protein-mediated signal transduction by RGS proteins". Life Sci. 68 (19-20): 2309-17. doi: ... Nakayama M, Kikuno R, Ohara O (Nov 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a ... also function as RGS family GTPase-activating proteins (GAPs) to increase the rate of GTP hydrolysis of G12/G13 alpha proteins ... Fukuhara S, Chikumi H, Gutkind JS (2001). "RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?". ...

RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and ... "GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins". ... Popov S, Yu K, Kozasa T, Wilkie TM (1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10 and GAIP retain ... Regulator of G-protein signaling 8 is a protein that in humans is encoded by the RGS8 gene. This gene is a member of the ...

Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene. Members of the RGS (regulator of G ... Role of the RGS domain in stress-induced trafficking of RGS proteins". The Journal of Biological Chemistry. 278 (32): 30272-82 ... Seki N, Hattori A, Hayashi A, Kozuma S, Hori T, Saito T (April 1999). "The human regulator of G-protein signaling protein 6 ... "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11". ...

Whereas G proteins are activated by G protein-coupled receptors, they are inactivated by RGS proteins (for "Regulator of G ... 5 Gβ proteins, and 12 Gγ proteins. G protein can refer to two distinct families of proteins. Heterotrimeric G proteins, ... turning the G protein on). RGS proteins stimulate GTP hydrolysis (creating GDP, thus turning the G protein off). All eukaryotes ... G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside ...

G proteins are subsequently inactivated by GTPase activating proteins, known as RGS proteins. GPCRs include one or more ... For the most part, the RGS proteins are promiscuous in their ability to deactivate G-proteins, while which RGS is involved in a ... or RGS proteins, which are a type of GTPase-Activating Protein, or GAP. In fact, many of the primary effector proteins (e.g., ... Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain coming from the G protein (that was ...

This protein contains a conserved 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of ... Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene. This gene encodes a member of the ... "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system". Brain Research. Molecular ... Nagata Y, Oda M, Nakata H, Shozaki Y, Kozasa T, Todokoro K (May 2001). "A novel regulator of G-protein signaling bearing GAP ...

RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is ... "Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction". ... but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also ... Regulator of G-protein signaling 3 is a protein that in humans is encoded by the RGS3 gene. This gene encodes a member of the ...

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a ... Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene. ... "Molecular Cloning of Regulators of G-Protein Signaling Family Members and Characterization of Binding Specificity of RGS 12 PDZ ... "Entrez Gene: RGS12 regulator of G-protein signalling 12". Kimple, R J; De Vries L; Tronchère H; Behe C I; Morris R A; Gist ...

This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein ... "Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in ... Regulator of G-protein signaling 17 is a protein that in humans is encoded by the RGS17 gene. This gene encodes a member of the ... "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system". Brain Research. Molecular ...

"The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling". Cell Biochemistry and Biophysics. 54 (1-3 ... Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene. RGS7 is highly enriched in the ... Snow BE, Betts L, Mangion J, Sondek J, Siderovski DP (1999). "Fidelity of G protein β-subunit association by the G protein γ- ... RGS7 is a GTPase-activating protein (GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation ...

Kozasa T (April 2001). "Regulation of G protein-mediated signal transduction by RGS proteins". Life Sciences. 68 (19-20): 2309- ... A-kinase anchor protein 13 is a protein that in humans, is encoded by the AKAP13 gene. This protein is also called AKAP-Lbc ... November 2001). "Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling". FEBS ... Unlike the other three members, AKAP13 does not function as RGS family GTPase-activating proteins (GAPs) to increase the rate ...

RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. RGS5 has been shown to ... Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and ... Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene. The regulator of G protein ... "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. ...

1996 (over 500 citations) Chen, Ching-Kang; Wieland, Thomas; Simon, Melvin I. (1996). "RGS-r, a retinal specific RGS protein, ... Gautam, N.; Northup, J.; Tamir, H.; Simon, M. I. (1990). "G protein diversity is increased by associations with a variety of ... Simon and his Caltech group gained an international reputation for their research on G-proteins and the molecular mechanisms of ... Strathmann, M.; Simon, M. I. (1990). "G protein diversity: A distinct class of alpha subunits is present in vertebrates and ...

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as ... Gold SJ, Ni YG, Dohlman HG, Nestler EJ (1997). "Regulators of G-protein signaling (RGS) proteins: region-specific expression of ... "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proc ... signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha ...

... involvement of DOK-2 and phosphorylation of RGS proteins". Blood. 103 (6): 2088-95. doi:10.1182/blood-2003-07-2392. PMID ... Docking protein 2 is a protein that in humans is encoded by the DOK2 gene. The protein encoded by this gene is constitutively ... 2004). "Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase". Oncogene. 23 ( ... This encoded protein binds p120 (RasGAP) from CML cells. DOK2 has been shown to interact with INPP5D and TEK tyrosine kinase. ...

"Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in ... Kimple AJ, Willard FS, Giguère PM, Johnston CA, Mocanu V, Siderovski DP (September 2007). "The RGS protein inhibitor CCG-4986 ... Regulators of G protein signalling are proteins which act to limit and shorten the response produced inside a cell following ... this makes it possible for selective inhibitors of RGS proteins to be developed, which should be able to enhance the activity ...

May 2003). "Instability of GGL domain-containing RGS proteins in mice lacking the G protein β-subunit Gβ5". Proc. Natl. Acad. ... domain found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling RGS proteins ... v t e (Protein domains, Peripheral membrane proteins, All stub articles, Membrane protein stubs). ... "A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gβ5 subunits". Proc. Natl. ...