Pyruvate synthase
In enzymology, a pyruvate synthase (EC 1.2.7.1) is an enzyme that catalyzes the interconversion of pyruvate and acetyl-CoA. It ... pyruvate oxidoreductase, pyruvate synthetase, pyruvate:ferredoxin oxidoreductase, pyruvic-ferredoxin oxidoreductase. PFOR ... An PFOR reaction starts with the nucleophilic attack of C2 of TPP on the 2-oxo carbon of pyruvate, which forms a lactyl-TPP ... Chen PYT, Aman H, Can M, Ragsdale SW, Drennan CL (2018). "Binding site for coenzyme A revealed in the structure of pyruvate: ...
Pyruvate oxidase (CoA-acetylating)
Pyruvate synthase and a new acetate thiokinase". J. Biol. Chem. 252 (2): 726-31. doi:10.1016/S0021-9258(17)32778-3. PMID 13076 ... In enzymology, a pyruvate oxidase (CoA-acetylating) (EC 1.2.3.6) is an enzyme that catalyzes the chemical reaction pyruvate + ... Reeves RE, Warren LG, Susskind B, Lo HS (1977). "An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. ... The systematic name of this enzyme class is pyruvate:oxygen 2-oxidoreductase (CoA-acetylating). This enzyme participates in ...
Acetate-CoA ligase (ADP-forming)
Pyruvate synthase and a new acetate thiokinase". J. Biol. Chem. 252 (2): 726-31. PMID 13076. Portal: Biology v t e (Articles ... This enzyme participates in pyruvate metabolism and propanoate metabolism. Reeves RE, Warren LG, Susskind B, Lo HS (1977). "An ... energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. ...
Indolepyruvate ferredoxin oxidoreductase
... pyruvate synthase (ferredoxin), and IOR. Mai X, Adams MW (1994). "Indolepyruvate ferredoxin oxidoreductase from the ... The systematic name of this enzyme class is 3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole- ... pyruvate, CoA, and oxidized ferredoxin, whereas its 3 products are S-2-(indol-3-yl)acetyl-CoA, CO2, and reduced ferredoxin. ... pyruvate + CoA + oxidized ferredoxin ⇌ {\displaystyle \rightleftharpoons } S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ...
Mitochondrial matrix
NADH can act as an inhibitor for α-ketoglutarate, isocitrate dehydrogenase, citrate synthase, and pyruvate dehydrogenase. The ... The oxidation of pyruvate by pyruvate dehydrogenase in the matrix produces CO2, acetyl-CoA, and NADH. Beta oxidation of fatty ... The citric acid cycle is facilitated by pyruvate dehydrogenase, citrate synthase, aconitase, isocitrate dehydrogenase, α- ... β-Oxidation uses pyruvate carboxylase, acyl-CoA dehydrogenase, and β-ketothiolase. Amino acid production is facilitated by ...
Unique properties of hyperthermophilic archaea
The only unique enzymes to this pathway are pyruvate synthase, pyruvate:water dikinase, and PEP carboxylase. Because so many of ... The acetyl-CoA is then converted to pyruvate, then PEP. The DC/4-HP cycle then follows the rTCA cycle, converting PEP to ...
Thorarchaeota
They are missing the genes for hexokinases, however they have the genes for pyruvate kinases and phosphoenolpyruvate synthase. ...
N-acetylneuraminate synthase
N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating), and NeuAc synthase. This enzyme participates in aminosugars ... In enzymology, a N-acetylneuraminate synthase (EC 2.5.1.56) is an enzyme that catalyzes the chemical reaction ... Komaki E, Ohta Y, Tsukada Y (1997). "Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1 ...
Amino acid synthesis
It begins with the condensation of two equivalents of pyruvate catalyzed by acetohydroxy acid synthase yielding α-acetolactate ... Enzymes involved in this biosynthesis include acetolactate synthase (also known as acetohydroxy acid synthase), acetohydroxy ... phosphohydroxyl-pyruvate → phosphoserine → serine The conversion from 3-phosphoglycerate to phosphohydroxyl-pyruvate is ... Anthranilate synthase is regulated by the gene products of trpE and trpG. trpE encodes the first subunit, which binds to ...
1-deoxy-D-xylulose-5-phosphate synthase
Other names in common use include 1-deoxy-d-xylulose-5-phosphate pyruvate-lyase (carboxylating), and DXP-synthase. This enzyme ... In enzymology, a 1-deoxy-d-xylulose-5-phosphate synthase (EC 2.2.1.7) is an enzyme in the non-mevalonate pathway that catalyzes ... SV, Begley TP; Bringer-Meyer S; Sahm H (1997). "Identification of a thiamin-dependent synthase in Escherichia coli required for ... Kuzuyama T, Takagi M, Takahashi S, Seto H (2000). "Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from ...
PCK2
This drives the TCA cycle, converting PEP to pyruvate to acetyl-CoA for the citrate synthase reaction. Since nearly all of the ... PCK2 regulates glucose-stimulated insulin secretion by recycling GTP generated from the succinyl-CoA synthase reaction. ...
Glucose-1,6-bisphosphate synthase
The enzyme is also inhibited by PEP, which is a reagent of pyruvate kinase. The product of glucose-1,6-bisphosphate synthase ( ... glucose-1,6-bisphosphate) activates pyruvate kinase. Glucose-1,6-bisphosphate synthase appears to be activated by the presence ... In other words, two molecules involved with glucose-1,6-bisphosphate synthase are able to be both created and recycled in the ... The product's inhibition of hexokinase and activation of PFK-1 and pyruvate kinase is indicative of its role in glycolysis. ...
1D-chiro-Inositol
DCI accelerates the dephosphorylation of glycogen synthase and pyruvate dehydrogenase, rate limiting enzymes of non-oxidative ...
Biosynthesis
4-hydroxy-tetrahydrodipicolinate synthase adds a pyruvate group to the β-aspartyl-4-semialdehyde, and a water molecule is ... Dihydrodipicolinate synthase catalyzes the condensation reaction of aspartate-β-semialdehyde with pyruvate to yield ... The enzyme CTP synthase catalyzes the next reaction step: the conversion of UTP to CTP by transferring an amino group from ... The next reaction is catalyzed by the enzyme pyrroline-5-carboxylate synthase (P5CS), which catalyzes the reduction of the ϒ- ...
Pyruvate, water dikinase
... pyruvate, water phosphotransferase. Other names in common use include phosphoenolpyruvate synthase, pyruvate-water dikinase ( ... In enzymology, a pyruvate, water dikinase (EC 2.7.9.2) is an enzyme that catalyzes the chemical reaction ATP + pyruvate + H2O ... This enzyme participates in pyruvate metabolism and reductive carboxylate cycle (CO2 fixation). It employs one cofactor, ... Cooper RA, Kornberg HL (1965). "Net formation of phosphoenolpyruvate from pyruvate by Escherichia coli". Biochim. Biophys. Acta ...
Thermales
... citrate synthase, phosphoribosylformylglycinamidine synthase, pyruvate dehydrogenase and alpha-glucan phosphorylase. 51 CSPs ...
Phenylacetylcarbinol
There are also biochemical reactions where enzymes such as acetohydroxyacid synthase I from E. coli condense pyruvate and ... and the enzyme pyruvate decarboxylase in a vat. The yeast is left to grow for a period of time, after which the benzaldehyde is ... "Column flow reactor using acetohydroxyacid synthase I from Escherichia coli as catalyst in continuous synthesis of R- ...
E1
... a hormone Pyruvate dehydrogenase (E1), the first component enzyme of pyruvate dehydrogenase complex Acireductone synthase, an ...
Citramalate lyase
... citramalic synthase, (S)-citramalate lyase, (+)-citramalate pyruvate-lyase, citramalate pyruvate lyase, (3S)-citramalate ... Other names in common use include citramalate pyruvate-lyase, citramalate synthase, citramalic-condensing enzyme, citramalate ... The systematic name of this enzyme class is (2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase (acetate-forming). ... pyruvate-lyase, and (2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase. This enzyme participates in c5-branched dibasic acid ...
Ferredoxin
... like the reaction carried out by pyruvate synthase. Ferredoxin can also be reduced by using NADH (-320 mV) or H 2 (-414 mV), ... such as glutamate synthase, nitrite reductase, sulfite reductase, and the cyclase of chlorophyll biosynthesis. Since the ...
List of EC numbers (EC 1)
... pyruvate synthase EC 1.2.7.2: Now included with EC 1.2.7.1, pyruvate synthase. EC 1.2.7.3: 2-oxoglutarate synthase EC 1.2.7.4: ... berbamunine synthase EC 1.1.3.35: Now EC 1.14.21.4, salutaridine synthase EC 1.1.3.36: Now EC 1.14.21.5, (S)-canadine synthase ... clavaminate synthase EC 1.14.11.22: Now EC 1.14.20.5, flavone synthase EC 1.14.11.23: Now EC 1.14.20.6, flavonol synthase EC ... anthocyanidin synthase * EC 1.14.20.5: flavone synthase I * EC 1.14.20.6: flavonol synthase * EC 1.14.20.7: 2-oxoglutarate/L- ...
Halobacterium noricense
... of pyruvate that is converted to acetyl Co-A by pyruvate synthase enters the Citric acid cycle while the other 10% is converted ...
Glucagon
... stimulation of PKA inactivates the glycolytic enzyme pyruvate kinase, inactivates glycogen synthase, and activates ... Feliú JE, Hue L, Hers HG (August 1976). "Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated ... often from muscle-derived pyruvate/glutamate transamination (see alanine transaminase reaction). Acetylcholine Cholecystokinin ...
Deinococcus marmoris
... pyruvate kinase, and citrate synthase. The D. marmoris genome also contains genes necessary for the glycolysis and ... Deinococcus marmoris contains genes involved in the citric acid cycle such as pyruvate dehydrogenase, phosphoenolpyruvate ...
Anthranilate synthase
... pyruvate + L-glutamate Anthranilate synthase creates anthranilate, an important intermediate in the biosynthesis of indole, and ... The subunits of anthranilate synthase are encoded by the trpE and trpD genes in E. coli, both of which appear in the trp operon ... Anthranilate synthase catalyzes the change from chorismate to anthranilate. As its other substrate, it can use either glutamine ... The enolpyruvyl group gains a proton to form pyruvate. It has been shown that the proton comes from the surrounding water and ...
2-ethylmalate synthase
... propylmalate synthase, and propylmalic synthase. This enzyme participates in pyruvate metabolism. Strassman M, Ceci LN (1967 ... In enzymology, a 2-ethylmalate synthase (EC 2.3.3.6) is an enzyme that catalyzes the chemical reaction acetyl-CoA + H2O + 2- ...
Edward I. Solomon
... mandelate synthase and (4-hydroxyphenyl)pyruvate dioxygenase. He is an expert in magnetic circular dichroism spectroscopy. ...
Indole-3-glycerol-phosphate synthase
It employs one cofactor, pyruvate. In some bacteria, IGPS is a single chain enzyme. In others, such as Escherichia coli, it is ... indoleglycerol phosphate synthase, indole-3-glycerophosphate synthase, 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate ... The enzyme indole-3-glycerol-phosphate synthase (IGPS) (EC 4.1.1.48) catalyzes the chemical reaction 1-(2-carboxyphenylamino)-1 ... Pyruvate enzymes, Enzymes of known structure, All stub articles, EC 4.1 stubs). ...
Fructolysis
... fatty acid synthase, as well as pyruvate dehydrogenase. Although not a consistent finding among metabolic feeding studies, ... or can be oxidized to pyruvate and reduced to lactate, or be decarboxylated to acetyl CoA in the mitochondria and directed ... Excess dietary fructose can be converted to pyruvate, enter the Krebs cycle and emerges as citrate directed toward free fatty ... in the gluconeogenic pathway for glycogen replenishment and/or the complete metabolism in the fructolytic pathway to pyruvate, ...
Homocitrate synthase
This enzyme participates in lysine biosynthesis and pyruvate metabolism. Strassman M, Ceci LN (1964). "Enzymatic formation of ... In enzymology, a homocitrate synthase (EC 2.3.3.14) is an enzyme that catalyzes the chemical reaction acetyl-CoA + H2O + 2- ... H; Miyazaki, J; Kobashi, N; Nishiyama, M; Hoshino, T; Yamane, H (2002). "Characterization of bacterial homocitrate synthase ... Andi B, West AH, Cook PF (2004). "Kinetic mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae". ...